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Abstract
Dispersion (the broadening or spreading) of analyte zones (peaks) outside of chromatography columns can seriously erode the resolution provided by good columns. Understanding the relationship between the level of dispersion associated with a given instrument relative to the intrinsic efficiency of a given column can help avoid disappointing results, especially when switching to new column technologies. In this instalment. we focus on basic concepts in extracolumn dispersion as a prelude to future instalments that will focus on dispersion in specific elements of high performance liquid chromatography (HPLC) systems.
| Original language | English |
|---|---|
| Pages (from-to) | 181-188 |
| Number of pages | 7 |
| Journal | LC-GC Europe |
| Volume | 34 |
| Issue number | 5 |
| Publication status | Published - May 2021 |
Keywords
- Extracolumn Peak Broadening
- performance
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Dive into the research topics of 'Where Has My Efficiency Gone? Impacts of Extracolumn Peak Broadening on Performance, Part 1: Basic Concepts'. Together they form a unique fingerprint.Projects
- 1 Finished
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SRP6: Strategic Research Programme: Exploiting the Advantages of Order and Geometrical Structure for a Greener Chemistry
Desmet, G., Denayer, J., Denayer, J., Desmet, G. & Denayer, J.
1/11/12 → 31/10/22
Project: Fundamental