Whipple's disease. A classic case report and review of the literature.

Roman Vangoitsenhoven, Jo Nijs, H Verbrugge, J Van Meerbeek, L. Van den Bergh

Research output: Contribution to journalArticle

3 Citations (Scopus)


We report the case of a 43-year-old carpenter with abdominal complaints and progressive weight loss. The HLA-B27 positive male had been suffering migratory arthropathy for five years, only partially under control with corticosteroids and methotrexate therapy. Endoscopic investigation showed dark staining of the duodenal mucosa and the ileal mucosa had an erythematous aspect with multiple white spots. Abundant periodic acid Schiff positive macrophages were seen on histologic examination of biopsy samples. This is a classic presentation of Whipple's disease, a rare multisystemic disease caused by the Tropheryma whipplei. Typical symptoms are arthropathy, weight loss, abdominal pain and diarrhea, but also systemic and neurological manifestations may occur. The otherwise lethal disease can be treated with long term antibiotics.
Original languageEnglish
Pages (from-to)392-396
JournalActa Gastro-Enterologica Belgica
Issue number3
Publication statusPublished - Jul 2010


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