TY - JOUR
T1 - Xanthones and Cancer
T2 - from Natural Sources to Mechanisms of Action
AU - Klein-Júnior, Luiz C
AU - Campos, Adriana
AU - Niero, Rivaldo
AU - Corrêa, Rogério
AU - Vander Heyden, Yvan
AU - Filho, Valdir Cechinel
N1 - © 2019 Wiley-VHCA AG, Zurich, Switzerland.
PY - 2020/2
Y1 - 2020/2
N2 - Xanthones are a class of heterocyclic natural products that have been widely studied for their pharmacological potential. In fact, they have been serving as scaffolds for the design of derivatives focusing on drug development. One of the main study targets of xanthones is their anticancer activity. Several compounds belonging to this class have already demonstrated cytotoxic and antitumor effects, making it a promising group for further exploration. This review therefore focuses on recently published studies, emphasizing their natural and synthetic sources and describing the main mechanisms of action responsible for the anticancer effect of promising xanthones.
AB - Xanthones are a class of heterocyclic natural products that have been widely studied for their pharmacological potential. In fact, they have been serving as scaffolds for the design of derivatives focusing on drug development. One of the main study targets of xanthones is their anticancer activity. Several compounds belonging to this class have already demonstrated cytotoxic and antitumor effects, making it a promising group for further exploration. This review therefore focuses on recently published studies, emphasizing their natural and synthetic sources and describing the main mechanisms of action responsible for the anticancer effect of promising xanthones.
UR - http://www.scopus.com/inward/record.url?scp=85078857086&partnerID=8YFLogxK
U2 - 10.1002/cbdv.201900499
DO - 10.1002/cbdv.201900499
M3 - Scientific review
C2 - 31794156
VL - 17
JO - Chemistry & Biodiversity
JF - Chemistry & Biodiversity
SN - 1612-1872
IS - 2
M1 - e1900499
ER -