Geometric model of unilateral coronal synostosis: shape variability, morphological growth model and severity analysis

Activiteit: Talk or presentation at a conference


The specific cranial shape can vary amongst children with unilateral coronal synostosis. Geometric analysis holds the potential to elucidate natural progression and guide treatment decisions.

Based on cranial CT scans of patients with non-syndromic unilateral coronal synostosis younger than 500 days, a statistical shape model was constructed by means of principal component analysis (PCA). This model captures the variability of cranial shape and was correlated to patient characteristics and severity indices. It served as a basis to simulate the progression of the deformation with age.

A total of 106 baseline scans (71 right-sided, 35 left-sided) were included. Female to male ratio was 2,8:1. Median age of the cohort was 208 days (range 3-459 days).
The first 4 PCs explained 81% of the shape variance. We found PCs that correlated significantly with age, gender and laterality. Specific shape PCs were correlated with cranial vault asymmetry index and cephalic index. Based on a quadratic regression of PC1, we predicted skull shape evolution for a set of 8 patients that had a second preoperative scan. When compared with the observed skull shape, the average distance error vertex-wise was 3.9┬▒1.3mm.

We demonstrate the utility of a statistical shape model for the analysis of cranial shape and its potential for use in surgical planning and prediction of natural evolution in unilateral coronal synostosis.
Periode11 mrt 2023
EvenementstitelBSN Annual Meeting
LocatieBruges, Belgium
Mate van erkenningNational