Growth and Separation of Crystals and Protein Aggregates in Acoustofluidics

Gelin, P. P. (Speaker), Ziemecka, I. (Contributor), Pauwels, K. (Contributor), Marzena Krzek (Contributor), Özlem Sardan Sukas (Contributor), Tompa, P. (Contributor), Maes, D. (Contributor), De Malsche, W. (Contributor)

Activiteit: Talk or presentation at a conference


Microfluidic devices offer a well-controlled environment for crystal nucleation and growth. Important parameters are mixing and the associated shear. Incomplete or insufficient mixing results in a wide crystal size distribution and might affect the morphology and purity of the product. Bulk acoustic waves offer the possibility to quickly mix two liquid streams and to manipulate particles in the microfluidic channel. In this contribution, fast mixing of two liquid streams by acoustic streaming is demonstrated. Miconazole nitrate crystals were grown in the presence of the acoustic field, once a desired size is reached the crystals focus rapidly on the pressure node. Growth and focusing of amyloid fibrils in the microfluidic channel has also been demonstrated.
Periode11 nov 201815 nov 2018
Evenementstitel22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2018)
LocatieKaohsiung, Taiwan, Province of China
Mate van erkenningInternational