Description
In this talk, current insights will be presented into the genetic regulation of stress response in Sulfolobus acidocaldarius, a thermoacidophilic model crenarchaeon thriving in volcanic hot springs. The impact of heat shock on the transcriptomic and proteomic landscape is highlighted, revealing prominent roles of both transcriptional and post-transcriptional/post-translational regulation. These findings underscore the prevalence of alternative mechanisms beyond classical transcription factor regulation in Crenarchaeota. Notably, the presence of RNA thermometer-like elements is proposed as one such mechanism, as exemplified by their identification in a gene encoding a thermosome subunit. Furthermore, the significance of chromatin restructuring, particularly mediated by proteins from the Lrs14 family, is emphasized. These abundant small non-specific DNA-binding proteins are hypothesized to be involved in various stress responses beyond heat shock, as well as exerting a control over pleiotropic physiological switches, such as the transition between planktonic and biofilm growth.| Periode | 3 jun 2024 |
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| Evenementstitel | 7th Joint Microbiology & Infection Conference of the German Society for Hygiene and Microbiology (DGHM) and the Association of General and Applied Microbiology (VAAM) |
| Evenementstype | Conference |
| Locatie | Würzburg, Germany |
| Mate van erkenning | International |
Gerelateerde inhoud
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projecten
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Riboregulatie in respons op temperatuurstress in thermoacidofiele archaea
Project: Fundamenteel