Description
Computational fluid dynamics (CFD) software provides a generic approach to solve and analyze fluid flow problems in industries such as aerospace, automotive, energy, environmental engineering, and biomedical engineering to gain insights into complex flow phenomena that are difficult to study experimentally.The present contribution will provide an overview of our recent work on the use of CFD to identify current bottlenecks in the performance of LC systems and propose solutions to overcome these hurdles and boost LC’s performance. Topics include the modelling of band broadening in random packed media as a way to provide column manufacturers a better understanding of the effect of particle and packing quality on the peak widths; the study of connection tubing dispersion losses to design better nano-LC instruments; as well as the design of micromachined and 3D-printed chromatographic media. These future approaches to column fabrication offer a broad design freedom. To guide future research in this area, it is hence important to understand how the shape of the chromatographic support influences its speed/efficiency-characteristics. To provide a maximal insight, each problem will be discussed via the link between the computed velocity fields and the resulting dispersion behaviour.
| Periode | 7 okt. 2024 |
|---|---|
| Evenementstitel | 34th International Symposium on Chromatography (ISC 2024) |
| Evenementstype | Conference |
| Locatie | Liverpool, United KingdomToon op kaart |
| Mate van erkenning | International |