Radiochemistry of Nanobodies

Activiteit: Talk or presentation at a workshop/seminar


At ICMI, radiolabeled Nanobodies are a produced to be used as therapeutic or diagnostic agents. In this lecture we will discuss the techniques to radiolabel Nanobodies. We will first describe the different radionuclides, their related radiochemistry and how the different chemistries can be applied to Nanobodies. In particular, we will discuss two possible approaches: 1/ a random approach where the radionuclide is coupled onto the Nanobody’s structure, or 2/ a site-specific approach where the radionuclide is coupled to the Nanobody in a controlled manner. Finally, we will focus on how to analyze the radiolabeled Nanobodies and see how the techniques can be applied clinical settings. The goal of the lecture is to understand the radiosynthesis process of Nanobodies and the specifications of the obtained radiopharmaceutical for pre-clinical or clinical applications.
Periode20 apr 2021
EvenementstitelImmuno-imaging and Molecular Therapy workshop
LocatieBrussel, Belgium
Mate van erkenningInternational