BOCK: Biological networks and Oligogenic Combinations as a Knowledge graph

BOCK is a new knowledge graph integrating oligogenic disease information (originally from the Oligogenic Disease Database (Natchtegael et al. 2022)) together with multiple biological networks and ontologies.

Compared to more generic knowledge graphs, we selected specifically networks relevant to understand the molecular mechanisms of epistasis, placing genes as the central entities, and focused on trusted resources describing a large set of human genes and their interactions.

All entities in the KG are linked to their source database entry via an URI (Uniform Resource Identifier) to facilitate integrations within larger bioinformatics linked data repositories.