Projecten per jaar
Organisatieprofiel
Organisation profile
De In Vivo Cellular and Molecular Imaging (ICMI) Core Facility is gespecialiseerd in nucleaire en optische beeldvorming van kleine dieren. Het lab is uitgerust met een groot aantal multimodale camera's en ex vivo analysetechnieken om de biodistributie, farmacokinetiek, dosimetrie en therapeutische werkzaamheid van radiofarmaceutica te bestuderen. Het laboratorium bevindt zich in een bioveiligheidsniveau 2 omgeving met directe toegang tot het animalarium.
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
Profielen
projecten
- 4 Actief
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HERC73: Upgrade van confocale FLIM-microscoop met excitatie- en detectiemodules met twee fotonen
1/01/25 → 31/01/28
Project: Fundamenteel
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FWOSB194: NAIROBI: iNjecteerbare suprAmoleculaire peptIde hydRogelen voor gecOntroleerde afgifte van BoactIeve moleculen
Robberechts, I., Martin, C., Ballet, S. & Hernot, S.
1/11/24 → 31/10/28
Project: Fundamenteel
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HERC66: 3D-CELLMAP: Onthullen van complexe celinteracties in weefsels door middel van 3D super-resolutie proteïne multiplex beeldvorming.
Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.
1/05/24 → 31/05/28
Project: Fundamenteel
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IOF3030: Vooruitbrengen van beeldvormingstechnologieën en hun toepassingen in de context van life sciences, gezondheidszorg, medisch onderzoek en verder.
Hernot, S., Kuijk, M., Ingelberts, H., Van Eetvelde, E., Stijns, J. & Stroet, M.
1/01/24 → 31/12/28
Project: Toegepast
Onderzoeksoutput
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Bimodal PET/fluorescence imaging with Nanobody tracers: comparison of MOMIP platforms
Saliën, J., Floru, S., Vizier, R., Delalieux, S., Bridoux, J., Goncalves, V., Denat, F. & Hernot, S., 14 mrt. 2025.Onderzoeksoutput: Poster
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Breaking the Nanosecond Barrier: Antibody-Based Tumor Imaging with Extended-Lifetime Fluorescent Tracers – A Promise for Enhanced Multiplexing
Mateusiak, L., Chazeau, E., Al-Sabea, H., Samuelsen Fosse, V., Kleinmanns, K., Goze, C., McCormack, E., Lapauw, T., Van Den Dries, T., Ingelberts, H., Denat, F. & Hernot, S., 12 mrt. 2025.Onderzoeksoutput: Poster
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Cetuximab enhances tumor-to-background ratio during Nanobody-based fluorescence guided surgery in dogs with EGFR-expressing tumors
Herreira do Valle, N. C., Debacker, J., De Cock, H., Pollenus, S., Hernot, S. & de Rooster, H., 14 mrt. 2025.Onderzoeksoutput: Poster
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Evaluation of a single domain antibody targeting uPAR for molecular imaging of atherosclerosis in ApoE-/-mice
Dumas, L., Raes, F., Adoumou-Limoune, B., André, C., Bezot, M., Bacot, S., Ahmadi, M., N'guessan, E., Mateusiak, L., Ghezzi, C., Hernot, S. & Broisat, A., 2025.Onderzoeksoutput: Poster
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Fluorescent Imaging with Single-Domain Antibodies labeled with Next-Generation FNIR-Tag-Dyes
Chigoho, D. M., Stroet, M., Floru, S., Schnermann, M. J. & Hernot, S., 15 mrt. 2025.Onderzoeksoutput: Poster
Activiteiten
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Towards contrast between tissue biomarkers with single-wavelength dyes: A first NIR-I in vivo FLT multiplex study using the VUB tauCAMTM
Simone Janssen (Speaker), Thomas Van Den Dries (Contributor), Sevada Sahakian (Contributor), Thomas Lapauw (Contributor), Sam Floru (Contributor), Lukasz Mateusiak (Contributor), Irina Okkelman (Contributor), Marcus Stroet (Contributor), Jeroen De Geeter (Contributor), Ruslan Dmitriev (Contributor), Maarten Kuijk (Contributor), Hilde de Rooster (Contributor), Hans Ingelberts (Contributor) & Sophie Hernot (Speaker)
31 mrt. 2025Activiteit: Talk or presentation at a conference
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Near-Infrared azaBODIPY Based Probe with Extended Lifetime to Unlock the Potential of Fluorescence Lifetime Imaging In Vivo
Elisa Chazeau (Speaker), Hassan Al-Sabea (Contributor), Simone Janssen (Contributor), Lukasz Mateusiak (Contributor), Thomas Van Den Dries (Contributor), Thomas Lapauw (Contributor), Hans Ingelberts (Contributor), Marcus Stroet (Contributor), Sophie Hernot (Contributor), Anthony Romieu (Contributor), Christine Goze (Contributor) & Frank Denat (Contributor)
12 mrt. 2025Activiteit: Talk or presentation at a conference
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Near-Infrared azaBODIPY Based Probe with Extended Lifetime to Unlock the Potential of Fluorescence Lifetime Imaging In Vivo
Elisa Chazeau (Speaker), Hassan Al-Sabea (Contributor), Simone Janssen (Contributor), Lukasz Mateusiak (Contributor), Thomas Van Den Dries (Contributor), Thomas Lapauw (Contributor), Hans Ingelberts (Contributor), Marcus Stroet (Contributor), Sophie Hernot (Contributor), Anthony Romieu (Contributor), Christine Goze (Contributor) & Franck Denat (Contributor)
12 mrt. 2025Activiteit: Talk or presentation at a workshop/seminar
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Educational talk: Tracer Design: Enhancing Intraoperative Imaging for Precision Surgery.
Sophie Hernot (Speaker)
11 mrt. 2025Activiteit: Talk or presentation at a conference
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Imaging with Nanobody-based bimodal PET/fluorescence tracers for improved clinical decision making
Jelena Saliën (Speaker), Sam Floru (Contributor), Romane Vizier (Contributor), Marcus Stroet (Contributor), Jessica Bridoux (Contributor), Sophie Hernot (Contributor), Victor Goncalves (Contributor) & Franck Denat (Contributor)
mei 2025Activiteit: Talk or presentation at a conference
Uitrusting
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Intravital imaging as tool to bridge the gap between macroscopic in vivo imaging and microscopic tissue analysis.
Sophie Hernot (Scientific coordinator)
In Vivo Cellular and Molecular ImagingUitrusting/faciliteit: no e-resource/single sited
Datasets
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Generation and Characterization of Novel Pan-Cancer Anti-uPAR Fluorescent Nanobodies as Tools for Image-Guided Surgery
Mateusiak, L. (Creator), Floru, S. (Researcher), De Groof, T. (Researcher), Wouters, J. (Researcher), Declerck, N. (Researcher), Debie, P. (Researcher), Janssen, S. (Researcher), Zeven, K. (Researcher), Puttemans, J. (Researcher), Vincke, C. (Researcher), Breckpot, K. (Project Member), Devoogdt, N. (Project Member) & Hernot, S. (Supervisor), Zenodo, 26 mrt. 2025
DOI: https://zenodo.org/records/15089920
Dataset
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Fluorescent Nanobodies for enhanced guidance in digestive tumors and liver metastasis surgery
Mateusiak, L. (Creator), Hakuno, S. (Researcher), de Jonge-Muller, E. (Researcher), Floru, S. (Researcher), Sier, C. F. M. (Supervisor), Hawinkels, L. J. (Supervisor) & Hernot, S. (Supervisor), Zenodo, 27 mrt. 2025
DOI: https://zenodo.org/records/15096527
Dataset
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Dataset related to article "Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting"
Movahedi, K. (Creator), Allavena, P. (Creator), Erreni, M. (Creator), Debie, P. (Creator), Mantovani, A. (Creator), D'Autilia, F. (Creator), Doni, A. (Creator), van Leeuwen, F. W. B. (Creator), Avigni, R. (Creator), Arnouk, S. (Creator), Vincke, C. (Creator), Van Ginderachter, J. (Creator), Anselmo, A. (Creator), Parente, R. (Creator), Hernot, S. (Creator), Garlanda, C. (Creator) & Bolli, E. (Creator), Zenodo, 4 dec. 2023
DOI: 10.5281/zenodo.10254683, https://zenodo.org/records/10254683
Dataset