Medische Biochemie

2024

Harnessing Beta Cell Regeneration Biology for Diabetes Therapy

Bourgeois, S., Coenen, S., Degroote, L., Willems, L., Van Mulders, A., Pierreux, J. A., Heremans, Y., De Leu, N. & Staels, W., nov 2024, In: Trends in Endocrinology and Metabolism. 35, 11, blz. 951-966 16 blz.

Onderzoeksoutput: Scientific review › peer review

Open Access

2 Citaten (Scopus)

2020

Retraction Note: Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice

Baeyens, L., Lemper, M., Leuckx, G., De Groef, S., Bonfanti, P., Stangé, G., Shemer, R., Nord, C., Scheel, D. W., Pan, F. C., Ahlgren, U., Gu, G., Stoffers, D. A., Dor, Y., Ferrer, J., Gradwohl, G., Wright, C. V. E., Van de Casteele, M., German, M. S., Bouwens, L. & 1 anderen, Heimberg, H., mrt 2020, In: Nature Biotechnology. 38, 3, blz. 374-374 1 blz., 374.

Onderzoeksoutput: Article › peer review

Open Access

2 Citaten (Scopus)

Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence

Claudinot, S., Sakabe, J-I., Oshima, H., Gonneau, C., Mitsiadis, T., Littman, D., Bonfanti, P., Martens, G., Nicolas, M., Rochat, A. & Barrandon, Y., 6 nov 2020, In: Nature Communications. 11, 1, 5645.

Onderzoeksoutput: Article › peer review

Open Access

13 Citaten (Scopus)

2018

F-18-PBR111 PET Imaging in Healthy Controls and Schizophrenia: Test-Retest Reproducibility and Quantification of Neuroinflammation: Test - Retest Reproducibility and Quantification of Neuroinflammation

Ottoy, J., De Picker, L., Verhaeghe, J., Deleye, S., Wyffels, L., Kosten, L., Sabbe, B., Coppens, V., Timmers, M., Van Nueten, L., Ceyssens, S., Stroobants, S., Morrens, M. & Staelens, S., 1 aug 2018, In: Journal of Nuclear Medicine. 59, 8, blz. 1267-1274 8 blz.

Onderzoeksoutput: Article › peer review

Open Access

45 Citaten (Scopus)

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

Scott, C. L., T'Jonck, W., Martens, L., Todorov, H., Sichien, D., Soen, B., Bonnardel, J., De Prijck, S., Vandamme, N., Cannoodt, R., Saelens, W., Vanneste, B., Toussaint, W., De Bleser, P., Takahashi, N., Vandenabeele, P., Henri, S., Pridans, C., Hume, D. A., Lambrecht, B. N. & 8 anderen, De Baetselier, P., Milling, S. W. F., Van Ginderachter, J. A., Malissen, B., Berx, G., Beschin, A., Saeys, Y. & Guilliams, M., 21 aug 2018, In: IMMUNITY. 49, 2, blz. 312-325.e5

Onderzoeksoutput: Article › peer review

Open Access

181 Citaten (Scopus)

2017

De impact van stemmingsstabiliserende geneesmiddelen op cytokineconcen-traties bij patiënten met een bipolaire stoornis: Een systematisch literatuur-onderzoek

Van Den Ameele, S., van Diermen, L., Staels, W., Coppens, V., Dumont, G., Sabbe, B. & Morrens, M., 17 nov 2017, In: Tijdschrift voor Psychiatrie. 59, 11, blz. 682-692 11 blz.

Onderzoeksoutput: Article

How stable is repression of disallowed genes in pancreatic islets in response to metabolic stress?

Lemaire, K., Granvik, M., Schraenen, A., Goyvaerts, L., Van Lommel, L., Gómez-Ruiz, A., In 'T Veld, P., Gilon, P. & Schuit, F., 2017, In: PLoS ONE. 12, 8, 16 blz., e0181651.

Onderzoeksoutput: Article › peer review

Open Access

16 Citaten (Scopus)

2016

Accessory cells for beta cell transplantation

Staels, W., De Groef, S., Heremans, Y., Coppens, V., Van Gassen, N., Leuckx, G., Van de Casteele, M., Van Riet, I., Luttun, A., Heimberg, H. & De Leu, N., feb 2016, In: Diabetes, Obesity and Metabolism. 18, 2, blz. 115-124 9 blz.

Onderzoeksoutput: Article › peer review

20 Citaten (Scopus)

Prediction of Impending Type 1 Diabetes through Automated Dual-Label Measurement of Proinsulin:C-Peptide Ratio

Van Dalem, A., Demeester, S., Balti Vounsia, E., Keymeulen, B., Gillard, P., Lapauw, B., De Block, C., Abrams, P., Weber, E., Vermeulen, I., De Pauw, P., Pipeleers, D., Weets, I., Gorus, F. K. & Belgian Diabetes Registry, 2016, In: PLoS ONE. 11, 12, 14 blz., e0166702.

Onderzoeksoutput: Article › peer review

Open Access

15 Citaten (Scopus)

Sources of beta cells inside the pancreas

De Groef, S., Staels, W., Van Gassen, N., Lemper, M., Yuchi, Y., Sojoodi, M., Bussche, L., Heremans, Y., Leuckx, G., De Leu, N., Van de Casteele, M., Baeyens, L. & Heimberg, H., 6 apr 2016, In: Diabetologia. 59, 9, blz. 1834-1837 5 blz.

Onderzoeksoutput: Article › peer review

2 Citaten (Scopus)

The effect of mood-stabilizing drugs on cytokine levels in bipolar disorder: A systematic review

van den Ameele, S., van Diermen, L., Staels, W., Coppens, V., Dumont, G., Sabbe, B. & Morrens, M., 2016, In: Journal of Affective Disorders. 203, blz. 364-373 9 blz.

Onderzoeksoutput: Article › peer review

61 Citaten (Scopus)

2015

Pre-existing insulin autoantibodies predict efficacy of otelixizumab in preserving residual beta cell function in recent-onset type 1 diabetes

Demeester, S., Keymeulen, B., Kaufman, L., Van Dalem, A., Balti Vounsia, E., Van De Velde, U., Goubert, P., Verhaeghen, K., Davidson, H., Wenzlau, J., Weets, I., Pipeleers, D. & Gorus, F., apr 2015, In: Diabetes Care. 38, 4, blz. 644-651

Onderzoeksoutput: Article › peer review

Open Access

22 Citaten (Scopus)

Prolactin receptors and placental lactogen drive male mouse pancreatic islets to pregnancy-related mRNA changes

Goyvaerts, L., Lemaire, K., Arijs, I., Auffret, J., Granvik, M., Van Lommel, L., Binart, N., In 'T Veld, P., Schuit, F. & Schraenen, A., 2015, In: PLoS ONE. 10, 3, 19 blz., e0121868.

Onderzoeksoutput: Article › peer review

39 Citaten (Scopus)

Surgical Injury to the Mouse Pancreas through Ligation of the Pancreatic Duct as a Model for Endocrine and Exocrine Reprogramming and Proliferation

De Groef, S., Leuckx, G., Van Gassen, N., Staels, W., Cai, Y., Yuchi, Y., Coppens, V., De Leu, N., Heremans, Y., Baeyens, L., Van de Casteele, M. & Heimberg, H., 2015, In: Journal of Visualized Experiments. 102, 10 blz., e52765.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

14 Citaten (Scopus)

212 Downloads (Pure)

2014

Age-dependent decline of beta-cell function in type 1 diabetes after diagnosis: a multi-centre longitudinal study

Barker, A., Lauria, A., Schloot, N. C., Hosszufalusi, N., Ludvigsson, J., Mathieu, C., Mauricio, D., Nordwall, M., Van Der Schueren, B., Mandrup-Poulsen, T., Scherbaum, W., Weets, I., Gorus, F., Wareham, N., Leslie, R. & Pozzilli, P., 2014, In: Diabetes Obes Metab. 16, blz. 262-267 6 blz.

Onderzoeksoutput: Article › peer review

81 Citaten (Scopus)

Clinical and biological characteristics of diabetic patients under age 40 in Cameroon: Relation to autoantibody status and comparison with Belgian patients

Asanghanwa, M., Gorus, F., Weets, I., Van Der Auwera, B., Aminkeng, F., Mbunwe, E., Goubert, P., Verhaeghen, K., Sobngwi, E., Wenzlau, J., Hutton, J. C., Pipeleers, D., Keymeulen, B., Mbanya, J-C. & Van Schravendijk, C., 2014, In: Diabetes Res Clin Pract. 103, blz. 97-105 9 blz.

Onderzoeksoutput: Article › peer review

Open Access

15 Citaten (Scopus)

Downregulation of Sox9 expression associates with hepatogenic differentiation of human liver mesenchymal stem/progenitor cells

Paganelli, M., Nyabi, O., Sid, B., Evraerts, J., El Malmi, I., Heremans, Y., Dollé, L., Benton, C., Calderon, P-B., van Grunsven, L., Heimberg, H., Campard, D., Sokal, E. & Najimi, M., 15 jun 2014, In: Stem Cells and Development. 23, 12, blz. 1377-1391 15 blz.

Onderzoeksoutput: Article › peer review

26 Citaten (Scopus)

Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression

Brouwers, B., de Faudeur, G., Osipovich, A. B., Goyvaerts, L., Lemaire, K., Boesmans, L., Cauwelier, E. J. G., Granvik, M., Pruniau, V. P. E. G., Van Lommel, L., Van Schoors, J., Stancill, J. S., Smolders, I., Goffin, V., Binart, N., In 'T Veld, P., Declercq, J., Magnuson, M. A., Creemers, J. W. M., Schuit, F. & 1 anderen, Schraenen, A., 2 dec 2014, In: Cell Metabolism. 20, 6, blz. 979-990 12 blz.

Onderzoeksoutput: Article › peer review

142 Citaten (Scopus)

Partial duct ligation: β-cell proliferation and beyond

Van de Casteele, M., Leuckx, G., Cai, Y., Yuchi, Y., Coppens, V., De Groef, S., Van Gassen, N., Baeyens, L., Heremans, Y., Wright, C. V. E. & Heimberg, H., aug 2014, In: Diabetes. 63, 8, blz. 2567-2577 11 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

30 Citaten (Scopus)

184 Downloads (Pure)

Pre-existing insulin autoantibodies predict efficacy of otelixizumab in preserving residual beta cell function in recent-onset type 1 diabetes

Demeester, S., Keymeulen, B., Kaufman, L., Van Dalem, A., Balti Vounsia, E., Van De Velde, U., Goubert, P., Verhaeghen, K., Weets, I., Pipeleers, D. & Gorus, F., 2014, In: Diabetologia. 57, blz. 1-452 452 blz.

Onderzoeksoutput: Meeting abstract (Journal)

Relation between glycemic variability, functional beta cell mass and glucose disposal rate in (pre)type 1 diabetes

Van Dalem, A., Demeester, S., Balti Vounsia, E., Decochez, K., Weets, I., Vandemeulebroucke, E., Keymeulen, B., Pipeleers, D. & Gorus, F., 2014, In: Diabetologia. 57, blz. 1-288 288 blz.

Onderzoeksoutput: Meeting abstract (Journal)

13 Citaten (Scopus)

2013

Alternative splicing and differential expression of the islet autoantigen IGRP between pancreas and thymus contributes to immunogenicity of pancreatic islets but not diabetogenicity in humans.

De Jong, V. M., Abreu, J. R. F., Verrijn Stuart, A. A., Van Der Slik, A. R., Verhaeghen, K., Engelse, M. A., Blom, B., Staal, F. J. T., Gorus, F. & Roep, B., 13 sep 2013, In: Diabetologia. 56, blz. 2651-2658 7 blz.

Onderzoeksoutput: Article › peer review

22 Citaten (Scopus)

Association of Cytokine and Toll-Like Receptor Gene Polymorphisms with Severe Malaria in Three Regions of Cameroon

Apinjoh, T. & Mbunwe, E., 2013, In: PLoS ONE. 8, blz. 81071 1 blz.

Onderzoeksoutput: Article › peer review

30 Citaten (Scopus)

Gene expression profiling of early hepatic stellate cell activation reveals a role for Igfbp3 in cell migration

Mannaerts, I., Schroyen, B., Verhulst, S., Van Lommel, L., Schuit, F., Nyssen, M. & van Grunsven, L. A., 2013, In: PLoS ONE. 8, 12, 13 blz., e84071.

Onderzoeksoutput: Article › peer review

40 Citaten (Scopus)

HLA-A*24 is an independent predictor of 5-year progression to diabetes in autoantibody positive first-degree relatives of type 1 diabetic patients.

Belgian Diabetes Registry & Keymeulen, B., 2013, In: Diabetes. 62, blz. 1345-1350 5 blz.

Onderzoeksoutput: Article › peer review

Open Access

23 Citaten (Scopus)

In antibody-positive first-degree relatives of patients with type 1 diabetes, HLA-A24 and HLA-B18, but not HLA-B*39, are predictors of impending diabetes with distinct HLA-DQ interactions

Mbunwe, E., Van Der Auwera, B., Weets, I., Pipeleers, D., Gorus, F. & Belgian Diabetes Registry, 2013, In: Diabetologia. 56, blz. 1964-1970 7 blz.

Onderzoeksoutput: Article › peer review

Open Access

16 Citaten (Scopus)

Mice Deficient in the Respiratory Chain Gene Cox6a2 Are Protected against High-Fat Diet-Induced Obesity and Insulin Resistance

Quintens, R., Singh, S., Lemaire, K., De Bock, K., Granvik, M., Schraenen, A., Vroegrijk, I. O. C. M., Costa, V., Van Noten, P., Lambrechts, D., Lehnert, S., Van Lommel, L., Thorrez, L., De Faudeur, G., Romijn, J. A., Shelton, J. M., Scorrano, L., Lijnen, H. R., Voshol, P. J., Carmeliet, P. & 2 anderen, Mammen, P. P. A. & Schuit, F., 27 feb 2013, In: PLoS ONE. 8, 2, 14 blz., e56719.

Onderzoeksoutput: Article › peer review

60 Citaten (Scopus)

Mouse beta cell proliferation is inhibited by thymidine analogue labelling

Van de Casteele, M., Cai, Y., Leuckx, G. & Heimberg, H., dec 2013, In: Diabetologia. 56, 12, blz. 2647-2650 4 blz.

Onderzoeksoutput: Article › peer review

6 Citaten (Scopus)

Neurogenin 3+ cells contribute to β-cell neogenesis and proliferation in injured adult mouse pancreas

Van De Casteele, M., Leuckx, G., Baeyens, L., Cai, Y., Yuchi, Y., Coppens, V., De Groef, S., Eriksson, M., Svensson, C., Ahlgren, U., Ahnfelt-Ronne, J., Madsen, O., Waisman, A., Dor, Y., Jensen, J. N. & Heimberg, H., 2013, In: Cell Death Dis. 2013, 4, 11 blz., e523.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

88 Citaten (Scopus)

196 Downloads (Pure)

Oral presentation: Validation and implementation of an enzyme-linked immunosorbent assay for C-peptide analysis in Cameroon, a sub-Saharan developing country

Van Genderen, F., 13 feb 2013.

Onderzoeksoutput: Unpublished paper

Poster presentation: Validation and implementation of an enzyme-linked immunosorbent assay for C-peptide analysis in Cameroon, a sub-Saharan developing country.

Van Genderen, F., 13 feb 2013, Diagnostics Forum, Uppsala, Sweden. Uppsala, Sweden, (Poster presentation: Validation and implementation of an enzyme-linked immunosorbent assay for C-peptide analysis in Cameroon, a sub-Saharan developing country).

Onderzoeksoutput: Meeting abstract (Book)

Potential of protein phosphatase inhibitor 1 as biomarker of pancreatic beta cell injury in vitro and in vivo

Jiang, L., Brackeva, B., Ling, Z., Kramer, G., Aerts, J., Schuit, F., Keymeulen, B., Pipeleers, D., Gorus, F. & Martens, G., 2013, In: Diabetes. 62, blz. 2683-2688 6 blz.

Onderzoeksoutput: Article › peer review

Open Access

Reversal of hyperglycaemia in diabetic mice by a marginal islet mass together with human blood outgrowth endothelial cells is independent of the delivery technique and blood clot-induced processes

Coppens, V., Heremans, Y., Leuckx, G., Suenens, K., Jacobs-Tulleneers-Thevissen, D., Verdonck, K., Luttun, A., Heimberg, H. & De Leu, N., 2013, In: Islets. 5, 5, blz. 196-200 5 blz.

Onderzoeksoutput: Article › peer review

5 Citaten (Scopus)

Reversible, moderate and early alteration of kidney function in non-euremic type 1 diabetes ilset recipients under tacrolimus-mycophenolate maintenance therapy

Gillard, P., Gorus, F., Pipeleers, D. & Keymeulen, B., 2013, Transplantation. Vol. 96.

Onderzoeksoutput: Meeting abstract (Book) › Research

Screening for IA-2 and zinc transporter 8 antibodies identifies relatives of type 1 diabetic patients with a high and age-dependent progression rate to clinical onset.

Balti Vounsia, E., Demeester, S., Van Dalem, A., Costa, O., Dorchy, H., Tenoutasse, S., Mouraux, T., De Block, C., Gillard, P., Decochez, K., Wenzlau, J., Hutton, J. C., Pipeleers, D., Weets, I. & Gorus, F., 2013, In: Diabetologia. 55, blz. (Suppl 1) S118 1 blz.

Onderzoeksoutput: Meeting abstract (Journal)

Screening for insulinoma antigen 2 and zinc transporter 8 autoantibodies: a cost-effective strategy to identify relatives of type 1 diabetic patients with a high and age-independent progression rate to clinical onset.

Gorus, F., Balti Vounsia, E., Vermeulen, I., Demeester, S., Van Dalem, A., Costa, O., Dorchy, H., Tenoutasse, S., Mouraux, T., De Block, C., Gillard, P., Decochez, K., Wenzlau, J., Hutton, J., Pipeleers, D., Weets, I. & Belgian Diabetes Registry, 2013, In: Clin Exp Immunol. 171, blz. 82-90 9 blz.

Onderzoeksoutput: Article › peer review

Open Access

41 Citaten (Scopus)

Sensitive and specific time-resolved fluorescence immunoassay of rat C-peptide for measuring hormone secretory and storage capacity of β-cells in vivo and in vitro

Van Genderen, F., Gorus, F., Pipeleers, D. & Van Schravendijk, C., 2013, In: Endocrinology. 154, blz. 1934-1939 6 blz.

Onderzoeksoutput: Article › peer review

Open Access

3 Citaten (Scopus)

Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr/R-spondin axis

Huch, M., Bonfanti, P., Boj, S., Sato, T., Loomans, C., van de Wetering, M., Sojoodi, M., Li, V., Schuijers, J., Gracanin, A., Ringnalda, F., Begthel, H., Hamer, K., Mulder, J., Van Es, J., De Koning, E., Vries, R., Heimberg, H. & Clevers, H., 16 okt 2013, In: EMBO Journal. 32, 20, blz. 2708-2721 14 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

565 Citaten (Scopus)

258 Downloads (Pure)

2012

An important minority of prediabetic first-degree relatives of type 1 diabetic patients derives from seroconversion to persistent autoantibody positivity after 10 years of age

Vermeulen, I., Weets, I., Costa, O., Asanghanwa, A., Verhaeghen, K., Decochez, K., Ruige, J., Casteels, K., Pipeleers, D. & Gorus, F., feb 2012, In: Diabetologia. 55, blz. 413-420 8 blz.

Onderzoeksoutput: Article › peer review

Open Access

24 Citaten (Scopus)

Oral Presentation: Implementation of an enzyme-linked immunosorbent assay (ELISA) for C-peptide analysis in Yaounde

Van Genderen, F., 12 sep 2012, Workshop on implementation of C-peptide immunioassay in Yaounde, Cameroon. Yaounde, Cameroon: VUB, (Oral Presentation: Implementation of an enzyme-linked immunosorbent assay (ELISA) for C-peptide analysis in Yaounde).

Onderzoeksoutput: Conference paper

Validation of an enzyme-linked immunosorbent assay for C-peptide analysis in Cameroon

Asanghanwa, A., Van Genderen, F., Verhaeghen, K., Van Der Auwera, B. & Van Schravendijk, C., 2012, In: Diabetes Research and Clinical Practice. 98, 3, blz. 459-464 6 blz.

Onderzoeksoutput: Article › peer review

4 Citaten (Scopus)

2011

Contribution of antibodies against IA-2beta and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age

Vermeulen, I., Weets, I., Asanghanwa, A., Ruige, J., Van Gaal, L., Mathieu, C., Keymeulen, B., Lampasona, V., Wenzlau, J., Hutton, J. C., Pipeleers, D. & Gorus, F., 2011, In: Diabetes Care. 34, blz. 1760-1765 6 blz.

Onderzoeksoutput: Article › peer review

Open Access

74 Citaten (Scopus)

Contribution of antibodies against IA-2β and zinc transporter 8 to classification of diabetes diagnosed under 40 years of age

Belgian Diabetes Registry, aug 2011, In: Diabetes Care. 34, 8, blz. 1760-1765 6 blz.

Onderzoeksoutput: Article › peer review

Correlation between IDH1 Gene Mutation Status and Survival of Patients Treated for Recurrent Glioma

Lv, S., Teugels, E., Sadones, J., Quartier, E., Huylebrouck, M., Du Four, S., Le Mercier, M., De Witte, O., Salmon, I. J., Michotte, A., De Greve, J. & Neyns, B., dec 2011, In: Anticancer Research. 31, blz. 4457-4463 7 blz.

Onderzoeksoutput: Article › peer review

34 Citaten (Scopus)

Diabetes Antibody Standardization Program. First evaluation of assays for autoantibodies to IA-2beta.

Schlosser, M., Mueller, P., Achenbach, P., Lampasona, V., Bingley, P., Gorus, F., De Grijse, J. & Goubert, P., 10 aug 2011, In: Diabetes Care. 34, blz. 2410-2412 3 blz.

Onderzoeksoutput: Article › peer review

15 Citaten (Scopus)

267 Citaten (Scopus)

Rare and functional SIAE variants are not associated with autoimmune disease risk in up to 66,924 individuals of European ancestry

Hunt, K., Smyth, D. & Van Der Auwera, B., 2011, In: Nat Genet. 44, blz. 3-5 3 blz.

Onderzoeksoutput: Article › peer review

37 Citaten (Scopus)

Medische Biochemie

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