Farmaceutische en Farmacologische Wetenschappen

2025

A benchmark concentration-based strategy for evaluating the combined effects of genotoxic compounds in TK6 cells

Sanders, J., Anthonissen, R., Johnson, G., Vanhaecke, T. & Mertens, B., 13 feb 2025, In: Archives of Toxicology. 99, blz. 1581-1589 9 blz., 111284.

Onderzoeksoutput: Article › peer review

Open Access

A human liver-based in vitro test battery to detect liver steatogenic potential of chemicals from various applicability domains

Verhoeven, A., Drees, A. H., Rodrigues, R., Sanz-Serrano, J., Vanhaecke, T. & Vinken, M., 2025, (Unpublished).

Onderzoeksoutput: Poster

A human liver-based in vitro test battery to detect liver steatogenic potential of chemicals from various applicability domains

Verhoeven, A., Drees, A. H., Rodrigues, R., Sanz-Serrano, J., Vanhaecke, T. & Vinken, M., mei 2025, (Unpublished).

Onderzoeksoutput: Poster

An integrated weight-of-evidence approach to leverage the application of in vitro test batteries for assessment of hepatotoxic potential of chemicals

Sanz-Serrano, J., Maerten, A., Drees, A. H., Jiang, J. & Vinken, M., 2025, (Unpublished).

Onderzoeksoutput: Poster

A novel 3D-printed sample preparation method for benzodiazepine quantification in human serum

Kroll, D., Ulenberg, S., Georgiev, P., Marciniak, B., Desmet, G., Bączek, T. & Belka, M., 1 feb 2025, In: Analytica Chimica Acta. 1337, 8 blz., 343552.

Onderzoeksoutput: Article › peer review

Open Access

ASPIS definition of new approach methodologies

Colbourne, J. K., Escher, S. E., Lee, R., Vinken, M., Van De Water, B. & Freedman, J. H., 30 jan 2025, (Accepted/In press) In: Environmental Toxicology and Chemistry.

Onderzoeksoutput: Article › peer review

Clinical utility of the Fibrosis-4 index for predicting mortality in patients with heart failure with or without metabolic dysfunction-associated steatotic liver disease: a prospective cohort study

Boeckmans, J., Prochaska, J., Gieswinkel, A., Böhm, M., Wild, P. & Schattenberg, J. M., jan 2025, In: The Lancet Regional Health - Europe. 48, blz. 1-13 13 blz., 101153.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

1 Citaat (Scopus)

5 Downloads (Pure)

Comparison of calcium citrate and calcium carbonate absorption in patients with a Roux-en-Y gastric bypass, sleeve gastrectomy, and one-anastomosis gastric bypass: a double-blind, randomized cross-over trial

Hany, M., Wuyts, S., Abouelnasr, A. A., Zidan, A., Demerdash, H. M., Hussein, H. A. S. M., Arida, R. E., Elsharkawi, S. M., Kramers, C. & Torensma, B., apr 2025, In: Surgery for obesity and related diseases. 21, 4, blz. 471-481 11 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

Deep eutectic solvents in analysis, delivery and chemistry of pharmaceuticals

Ganorkar, S. B., Hadole, P. M., Patil, M. R., Pardeshi, C. V., Bobade, P. S., Shirkhedkar, A. A. & Heyden, Y. V., 15 mrt 2025, In: International Journal of Pharmaceutics. 672, 21 blz., 125278.

Onderzoeksoutput: Scientific review › peer review

Design and synthesis of cyclic lipidated peptides derived from the C-terminus of Cx43 for hemichannel inhibition and cardiac endothelium targeting

Iaculli, D., Montgomery, J., Lamouroux, A., Caufriez, A., Gozalbes, R., Vinken, M., Molica, F., Kwak, B. R. & Ballet, S., 21 mrt 2025, In: RSC Medicinal Chemistry. 16, 3, blz. 1289-1303 15 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

4 Downloads (Pure)

Development and characterization of an advanced MASH in vitro 3D human liver co-culture spheroid model

Yildiz, B., Orhan, H., Demeyer, K., Vinken, M. & Tabernilla Garcia, A., 2025, (Submitted). 1 blz.

Onderzoeksoutput: Poster

Development of a human cell-based test system to evaluate the catalytic activity of ammonia lyase enzymes for therapeutic use in aminoacidopathies

Nulmans, I., Salvi, N. & De Kock, J., 5 mrt 2025, (Unpublished).

Onderzoeksoutput: Poster

Development of a triple cell co-culture spheroid model for cholestatic drug-induced liver injury prediction

Sanz-Serrano, J., Matyjasiak, J., Drees, A. H., Avirvarei, A-C., Rodrigues, P., Olaizola, P., Banales, J. M. & Vinken, M., 2025, (Unpublished).

Onderzoeksoutput: Poster

Dose-Limiting Toxicities of Paclitaxel in Breast Cancer Patients: Studying Interactions Between Pharmacokinetics, Physical Activity, and Body Composition—A Protocol for an Observational Cohort Study

Nys, L. D., Barzegar-Fallah, A., Lanckmans, K., Steurbaut, S., Beckwée, D., Haar-Holleman, A. D., Provyn, S., Gasthuys, E., Casteele, S. V., Sutter, P-J. D., Vermeulen, A., Bocxlaer, J. V., Wuyts, S. C. M. & Adriaenssens, N., jan 2025, In: Cancers. 17, 1, 13 blz., 50.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

6 Downloads (Pure)

Energy and protein nutrition adequacy in general wards among intensive care unit survivors: A systematic review and meta‐analysis

Rosseel, Z., Cortoos, PJ., Leemans, L., Zanten, A. R. H. V., Ligneel, C. & Waele, E. D., jan 2025, In: Journal of Parenteral and Enteral Nutrition. 49, 1, blz. 18-32 15 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

3 Downloads (Pure)

Evaluation of food additive-induced hepatotoxicity using an adverse outcome pathway-guided approach.

Callewaert, E., Maerten, A., Louisse, J., Kramer, N. & Vinken, M., 25 mei 2025, (Unpublished).

Onderzoeksoutput: Poster

Exploring the Phytochemical Diversity and Anti-Plasmodial Potential of Artemisia annua and Artemisia afra from Different Geographical Locations in Cameroon

Shinyuy, L. M., Loe, G. E., Jansen, O., Ledoux, A., Palmaerts, B., Mamede, L., Boussif, N., Bonnet, O., Enone, B. S., Noukimi, S. F., Abenwie, S. N., Demeyer, K., Robert, A., Ghogomu, S. M., Souopgui, J., Hallot, E. & Frederich, M., 28 jan 2025, In: Molecules. 30, 3, 19 blz., 596.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

8 Downloads (Pure)

Exploring the potential short-term and long-term hepatotoxic effects of polystyrene microplastics using 3D human liver spheroid cultures

Tabernilla Garcia, A., Xiftou, K., Jiang, J., Caiment, F., De Kok, T. M., Sanz-Serrano, J. & Vinken, M., 2025, (Unpublished).

Onderzoeksoutput: Poster

Exploring the potential short-term and long-term hepatotoxic effects of polystyrene microplastics using 3D human liver spheroid cultures

Xiftou, K., Jiang, J., Caiment, F., De Kok, T. M., Sanz-Serrano, J., Vinken, M. & Tabernilla Garcia, A., 15 mei 2025, (Unpublished).

Onderzoeksoutput: Poster

From natural defenders to therapeutic warriors: NK cells in HIV immunotherapy

Laeremans, T., Janssens, A. & Aerts, J. L., 5 feb 2025, In: Immunotherapy. 17, 2, blz. 133-145 13 blz.

Onderzoeksoutput: Article › peer review

Genetic predisposition for hepatic fat accumulation impacts the uptake of fatty acids through fatty acid translocase in a human stem cell-based in vitro model

Gatzios, A., Rombaut, M., De Kock, J., Verhoeven, A., De Win, D., Heymans, A., Rogiers, V., Rodrigues, R., Boeckmans, J. & Vanhaecke, T., 9 mei 2025, (Unpublished). 1 blz.

Onderzoeksoutput: Poster

Hazard characterization of the mycotoxins enniatins and beauvericin to identify data gaps and improve risk assessment for human health

Behr, A-C., Kruse Faeste, C., Mertens, B., Sanders, J., Dirven, H. & Dietrich, J., 26 mrt 2025, In: Archives of Toxicology. 51 blz., 112905.

Onderzoeksoutput: Article › peer review

Open Access

Hepatotoxicity in spaceflight: intrinsic and extrinsic risks for astronaut metabolic health

Waisberg, E., Ong, J., Masalkhi, M., Cools, B., Lee, R., Vinken, M. & Lee, A. G., 3 feb 2025, In: Irish Journal of Medical Science. 4 blz.

Onderzoeksoutput: Article › peer review

1 Citaat (Scopus)

Implication of system xc- in Complete Freund's Adjuvant-induced peripheral inflammation and associated nociceptive sensitization

Beckers, P., Charlier, M., Richter, L. A., Braconnier, P., Desmet, N., Massie, A. & Hermans, E., 15 mei 2025, In: Neuropharmacology. 269, 37 blz., 110340.

Onderzoeksoutput: Article › peer review

Improving effective antimicrobial resistance (AMR) prevention in ambulatory care: lessons from secondary appraisal of Belgian anti-infectious treatment care guidelines

Van Laethem, J., Planken, S., Cortoos, P-J., De Scheerder, M-A., Kiselinova, M., Tilmanne, A., Yusuf, E., Vansintejan, J. & Dauby, N., 24 feb 2025, In: European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology. 13 blz.

Onderzoeksoutput: Article › peer review

Integrating Lines of In Silico Toxicological Evidence to Create a Weight-of-Evidence for Adverse Outcomes

T.D. Cronin, M., Chavan, S., Chrysochoou, G., Ecker, G., Enoch, S., Firman, J., Gomatam, A., Helmke, P. S., Kulesza, A., Madden, J. C., Steinbach, A-M., Stoelting, P. M., Verhoeven, A. & Xia, P., apr 2025, (Unpublished).

Onderzoeksoutput: Poster

Interneuron migration impairment and brain region-specific DNA damage response following irradiation during early neurogenesis in mice

Berden, L., Rajan, N., Mbouombouo Mfossa, A. C., De Bie, I., Etlioglu, E., Benotmane, M. A., Verslegers, M., Aourz, N., Smolders, I., Rigo, J-M., Brône, B. & Quintens, R., 17 mrt 2025, In: Cellular and Molecular Life Sciences : CMLS. 82, 1, 27 blz., 118.

Onderzoeksoutput: Article › peer review

Open Access

Investeren in borstvoeding is investeren in gezondheid: een onderschat wapen tegen infecties bij zuigelingen en tegen borstkanker bij moeders

Tommelein, E., apr 2025, De Medische Referentie, 4, blz. 1-3 3 blz.

Onderzoeksoutput: Blog › Specialist › peer review

Open Access

Bestand

2 Downloads (Pure)

Kunstmelk voor kinderen in het eerste levensjaar

Tommelein, E., 1 feb 2025, Medi-Sfeer, blz. 38-41 4 blz.

Onderzoeksoutput: Article › Specialist

Bestand

49 Downloads (Pure)

Mapping physiology: a systems biology approach for the development of alternative methods in toxicology

Staumont, B., Ladeira, L. C. M., Gamba, A., Heusinkveld, H. J., Piersma, A., Fritsche, E., Masereeuw, R., Vanhaecke, T., Teunis, M., Luechtefeld, T. H., Hartung, T., Jover, R., Vinken, M. & Geris, L., 15 apr 2025, In: ALTEX. 42, 2, blz. 301-307 7 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

6 Downloads (Pure)

Minimal Adherence Threshold to Non-Vitamin K Antagonist Oral Anticoagulants in Patients with Atrial Fibrillation to Reduce the Risk of Thromboembolism and Death: A Nationwide Cohort Study

Grymonprez, M., Steurbaut, S., Capiau, A., Vauterin, D., Van Vaerenbergh, F., Mehuys, E., Boussery, K., De Backer, T. L. & Lahousse, L., feb 2025, In: Cardiovascular Drugs and Therapy. 39, 1, blz. 107-117 11 blz.

Onderzoeksoutput: Article › peer review

MolGraph: a Python package for the implementation of molecular graphs and graph neural networks with TensorFlow and Keras

Kensert, A., Desmet, G. & Cabooter, D., dec 2025, In: Journal of Computer-Aided Molecular Design. 39, 1, 11 blz., 3.

Onderzoeksoutput: Article › peer review

Neuroprotective effects of melanins and melanin derivatives from Calvatia Craniiformis and Xylaria plebeja against Parkinsonian toxins

Nguyen, D. T., Nguyen Vo, L. P., Mangelings, D., Van Eeckhaut, A., Vander Heyden, Y. & Tran, H. T. M., 19 feb 2025, In: Scientific reports. 15, 1, 13 blz., 6106.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

3 Downloads (Pure)

Next Generation Risk Assessment of Hair Dye HC Yellow No. 13: Ensuring Protection From Liver Steatogenic Effects

Sepehri, S., De Win, D., Heymans, A., Van Goethem, F., Rodrigues, R. M., Rogiers, V. & Vanhaecke, T., jun 2025, In: Regulatory Toxicology and Pharmacology. 159, blz. 1-14 14 blz., 105794.

Onderzoeksoutput: Article › peer review

Open Access

Partial rejuvenation of the spermatogonial stem cell niche after gender-affirming hormone therapy in trans women

Delgouffe, E., Madureira Silva, S., Chalmel, F., Cools, W., Raets, C., Tilleman, K., T'Sjoen, G., Baert, Y. & Goossens, E., 7 jan 2025, In: eLife. 13, 25 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

7 Downloads (Pure)

Pharmacodynamic Drug-Drug Interactions and Bleeding Outcomes in Patients with Atrial Fibrillation Using Non-Vitamin K Antagonist Oral Anticoagulants: a Nationwide Cohort Study

Grymonprez, M., Capiau, A., Steurbaut, S., Boussery, K., Mehuys, E., Somers, A., Petrovic, M., De Backer, T. L. & Lahousse, L., feb 2025, In: Cardiovascular Drugs and Therapy. 39, 1, blz. 133-143 11 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

5 Citaten (Scopus)

1 Downloads (Pure)

Pharmacological countermeasures for long-duration space missions: addressing cardiovascular challenges and advancing space-adapted healthcare

Derobertmasure, A., Toh, L. S., Wotring, V., Williams, P. M., Morbidelli, L., Stingl, J., Vinken, M., Ramadan, R., Chhun, S. & Boutouyrie, P., 8 mrt 2025, In: European Journal of Pharmaceutical Sciences. 209, 17 blz., 107063.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

Photopharmacological activation of adenosine A1 receptor signaling suppresses seizures in a mouse model for temporal lobe epilepsy

Spanoghe, J., Wynendaele, E., Vergaelen, M., De Colvenaer, M., Mariman, T., Vonck, K., Carrette, E., Wadman, W., Craey, E., Larsen, L. E., Sprengers, M., Missinne, J., Van Calenbergh, S., De Spiegeleer, B., De Bundel, D., Smolders, I., Boon, P. & Raedt, R., 10 mei 2025, In: Journal of Controlled Release. 381, 1, blz. 1-33 33 blz., 113626.

Onderzoeksoutput: Article › peer review

Open Access

Prescriptions of CYP3A4- and P-gp inducers for patients on direct oral anticoagulants: Bridging the gap between epidemiology and patient management for optimal thromboembolic event prevention

Wuyts, S. C. M., Moor, J. D., Jochmans, K., Cortoos, P-J., Vandervorst, F., Steurbaut, S., Dupont, A. G. & Cornu, P., 24 feb 2025, In: British Journal of Clinical Pharmacology. 91, 4, blz. 1114-1131 18 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

2 Downloads (Pure)

Report of the first ONTOX Hackathon: hack to save lives and avoid animal suffering: artificial Intelligence (AI) in toxicology-a potential driver for reducing/replacing laboratory animals in the future

Diemar, M., Krul, C., Teunis, M., Busquet, F., Kandarova, H., Zajac, J. D., Vinken, M. & Roggen, E., 9 jan 2025, In: ATLA. Alternatives to Laboratory Animals. 53, 1, blz. 42-61 20 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

1 Citaat (Scopus)

3 Downloads (Pure)

Revisiting hydrogen peroxide as radiosensitizer for solid tumor cells

Geirnaert, F., Kerkhove, L., Rifi, A. L., Everaert, T., Sanders, J., Coppens, J., Vandenplas, H., Corbet, C., Gevaert, T., Dufait, I. & De Ridder, M., feb 2025, In: Radiotherapy and Oncology. 203, 110692, 10 blz., 110692.

Onderzoeksoutput: Article › peer review

Risk of hepatic decompensation or HCC is similar in patients with ALD- and MASLD-cirrhosis: A population-based cohort study

Boeckmans, J., Widman, L., Shang, Y., Strandberg, R., Wester, A., Schattenberg, J. M. & Hagström, H., apr 2025, In: European Journal of Internal Medicine. 134, blz. 104-113 10 blz.

Onderzoeksoutput: Article › peer review

Open Access

Taking the 3Rs to a higher level: replacement and reduction of animal testing in life sciences in space research

Vinken, M., Grimm, D., Baatout, S., Baselet, B., Beheshti, A., Braun, M., Carstens, A. C., Casaletto, J. A., Cools, B., Costes, S. V., De Meulemeester, P., Doruk, B., Eyal, S., Ferreira, M. J. S., Miranda, S., Hahn, C., Helvacıoğlu Akyüz, S., Herbert, S., Krepkiy, D., Lichterfeld, Y. & 13 anderen, Liemersdorf, C., Krüger, M., Marchal, S., Ritz, J., Schmakeit, T., Stenuit, H., Tabury, K., Trittel, T., Wehland, M., Zhang, Y. S., Putt, K. S., Zhang, Z-Y. & Tagle, D., 8 apr 2025, In: Biotechnology advances. 81, 26 blz., 108574.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

1 Downloads (Pure)

The alarming consequences of workforce reductions at the FDA, EPA, NIH and CDC in the United States

Dietrich, D., Von Aulock, S., Bal-Price, A., Coleman, M., Cronin, M., Jennings, P., Mally, A., Vinken, M., Wright, M. & van den Berg, M., 15 apr 2025, In: ALTEX. 42, 2, blz. 352-353 2 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

The Development of a Framework to Assess the Validity of quantitative Adverse Outcome Pathways (qAOPs) for Chemical Safety Assessment

Cronin, M., Chrysochoou, G., Enoch, S., Gomatam, A., Firman, J., Madden, J. C., Chavan, S., Hardy, B., Schaller, S., Sahlin, U., Marx-Stoelting, P., Steinbach, A-M., Veltman, K., Verhoeven, A. & Zgheib, E., 16 apr 2025, (Unpublished).

Onderzoeksoutput: Poster