Visual and Spatial Tissue Analysis

Onderzoeksoutput

Onderzoeksoutput per jaar 2003 2024 2025

• 20 Citaties
• 2 h-index
• 27 Poster
• 7 Article
• 3 Meeting abstract (Journal)
• 3 PhD Thesis
• 4 Meer
  • 2 Scientific review
  • 1 Meeting abstract (Book)
  • 1 Voordruk

Onderzoeksoutput per jaar

Onderzoeksoutput per jaar

Zoekresultaten

• 2025

  ROBO1 Drives Gemcitabine Resistance in Pancreatic Cancer

  Mader, S., Rodriguez Aznar, E. & Rooman, I., 2025, (Unpublished).

  Onderzoeksoutput: Poster
• 2024

  Abstract 3378: Acinar cell susceptibility for tumor development in the pancreas: Targeting the critical regulators for therapy

  Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., 15 mrt 2024, In: Cancer Research. 84, 6_supplement, 1 blz., 3378.

  Onderzoeksoutput: Meeting abstract (Journal)

  Open Access

  • Ferroptosis 80%
  • Pancreas 72%
  • Metaplasia 55%
  • Cell Dedifferentiation 51%
  • Chronic Pancreatitis 38%

• Acinar cell susceptibility for tumor development in the pancreas: targeting the critical regulators for therapy

  Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., apr 2024, (Accepted/In press).

  Onderzoeksoutput: Poster

• Characterization of the long-term effects of lethal total body irradiation followed by bone marrow transplantation on the brain of C57BL/6 mice

  Janssen, P., De Pauw, L., Mambretti, M., Lara, O., Walckiers, J., Mackens, L., Rooman, I., Guillaume, B., De Ridder, M., Ates, G. & Massie, A., 3 mrt 2024, In: International Journal of Radiation Biology. 100, 3, blz. 385-398 14 blz.

  Onderzoeksoutput: Article › peer review

  Open Access

  Bestand

  • Whole-Body Irradiation 100%
  • Bone Marrow Transplantation 87%
  • Inbred C57BL Mouse 80%
  • Brain 41%
  • Neurogenesis 16%
  36 Downloads (Pure)

• Compartmentalized role of xCT in supporting pancreatic tumor growth, inflammation and mood disturbance in mice

  Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Walckiers, J., Pan, Z., Beckers, P., Espinet, E., Sato, H., De Ridder, M., Marks, D. L., Barbé, K., Aerts, J., Hermans, E., Rooman, I. & Massie, A., mei 2024, In: Brain, Behavior, and Immunity. 118, blz. 275-286 12 blz.

  Onderzoeksoutput: Article › peer review

  Open Access

  Bestand

  • Inflammation 100%
  • Growth 85%
  • Tumor Burden 60%
  • Pancreatic Neoplasms 60%
  • Neoplasms 54%
  2 Citaten (Scopus)

  4 Downloads (Pure)

• Critical regulators of pancreatic acinar cell dedifferentiation: options for therapeutic intervention

  Pan, Z., 2024, 152 blz.

  Onderzoeksoutput: PhD Thesis

  • Cell Dedifferentiation 100%
  • Ferroptosis 39%
  • Pancreatitis 16%
  • ferrostatin-1 15%
  • Pancreatic Neoplasms 15%

• High-resolution and quantitative spatial analysis reveal intra-ductal phenotypic and functional diversification in pancreatic cancer

  Michiels, E., Madhloum, H., Van Lint, S., Messaoudi, N., Kunda, R., Martens, S., Giron, P., Olsen, C., Lefesvre, P., Dusetti, N., El Mohajer, L., Tomasini, R., Hawinkels, L. J., Ahsayni, F., Nicolle, R., Arsenijevic, T., Bouchart, C., Van Laethem, J-L. & Rooman, I., jan 2024, In: Journal of pathology. 262, 1, blz. 76-89 14 blz.

  Onderzoeksoutput: Article › peer review

  Open Access

  Bestand

  • Spatial Analysis 100%
  • Pancreatic Neoplasms 73%
  • Cancer-Associated Fibroblasts 27%
  • Organoids 25%
  • Neoplasms 24%
  2 Citaten (Scopus)

  27 Downloads (Pure)

• Overcoming drug tolerance to enhance the efficacy of EGFR tyrosine kinase inhibitors

  Eggermont, C., 2024, 158 blz.

  Onderzoeksoutput: PhD Thesis

  Open Access

  Bestand

  • Drug Tolerance 100%
  • polo-like kinase 1 81%
  • Protein-Serine-Threonine Kinases 70%
  • Protein-Tyrosine Kinases 65%
  • Fibroblast Growth Factor 1 24%
  70 Downloads (Pure)

• Resolution of Acinar Dedifferentiation Regulates Tissue Remodeling in Pancreatic Injury and Cancer Initiation

  Baldan, J., Camacho-Roda, J., Ballester, M., Høj, K., Kurilla, A., Maurer, H. C., Arcila-Barrera, S., Lin, X., Pan, Z., Castro, J. L., Mayorca-Guiliani, A. E., Rift, C. V., Hasselby, J., Bouwens, L., Lefebvre, V., David, C. J., Parnas, O., DelGiorno, K. E., Erler, J. T., Rooman, I. & 1 anderen, Arnes, L., sep 2024, In: Gastroenterology. 167, 4, blz. 718-732.e18 15 blz.

  Onderzoeksoutput: Article › peer review

  Open Access
  1 Citaat (Scopus)

• ROBO1 Drives Gemcitabine Resistance in Pancreatic Cancer

  Mader, S., Rooman, I., Rodriguez Aznar, E., Soubeyran, P., Dusetti, N. & Bousquet Vaysse, C., 17 jun 2024, (Unpublished).

  Onderzoeksoutput: Poster

  • gemcitabine 100%
  • Pancreatic Neoplasms 84%
  • Adenocarcinoma 70%
  • Heterografts 20%
  • 130-nm albumin-bound paclitaxel 17%

• ROBO1 Drives Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma

  Mader, S., Soubeyran, P., Dusetti, N., Bousquet Vaysse, C., Rodriguez Aznar, E. & Rooman, I., 2024, (Unpublished).

  Onderzoeksoutput: Poster

• Spatial Characterization of B7H3 Expression in PDAC reveals increased Expression in Basal-like Tumor Ducts and αSMA-positive Stromal Cells

  De Man, V., Michiels, E., Messaoudi, N., Olsen, C., Giron, P. & Rooman, I., 18 apr 2024.

  Onderzoeksoutput: Poster

• Spatial Characterization of CD276 (B7H3) Expression in PDAC reveals increased Expression in Basal-like Tumor Ducts and αSMA-positive Stromal Cells

  De Man, V., Michiels, E., Messaoudi, N., Olsen, C., Giron, P. & Rooman, I., 23 okt 2024.

  Onderzoeksoutput: Poster

• Spatial transcriptomic analysis of human Pancreatic Basal Cells reveals PTGES as a potential target for the Basal-Like subtype of Pancreatic Ductal Adenocarcinoma.

  Van den Bossche, J-L., Van der Vliet, M., Coolens, K., Michiels, E., Houbracken, I., Baldan, J. & Rooman, I., 18 apr 2024, (Unpublished).

  Onderzoeksoutput: Poster

• Spatial transcriptomic analysis reveals PTGES as a conserved potential therapeutic target for basal cells in Pancreatic Ductal Adenocarcinoma.

  Van der Vliet, M., Van den Bossche, J-L. & Rooman, I., 2024, (Unpublished).

  Onderzoeksoutput: Poster

• Spatial transcriptomic and single cell sequencing data reveals PTGES as a conserved potential therapeutic target for basal cells in pancreatic cancer.

  Van der Vliet, M. & Rooman, I., 2024, (Unpublished).

  Onderzoeksoutput: Poster

• Spatial transcriptomic and single cell sequencing data reveals PTGES as a conserved potential therapeutic target for basal cells in pancreatic cancer.

  Van der Vliet, M., Van den Bossche, J-L., Coolens, K., Van Lint, S., Michiels, E., Houbracken, I., Baldan, J. & Rooman, I., okt 2024, (Unpublished).

  Onderzoeksoutput: Poster

• Specific involvement of system xc- on immune cells in two pathological conditions characterized by a systemic inflammatory phenotype

  Janssen, P., 2024, 199 blz.

  Onderzoeksoutput: PhD Thesis

• Unravel acinar cell subpopulation with propensity for cancer initiation

  Baldan, J., Scheele, C., Jacquemin, P. & Rooman, I., 23 okt 2024, (Unpublished).

  Onderzoeksoutput: Poster

• Unravel proliferative acinar cell subpopulation with propensity for cancer initiation.

  Baldan, J., Scheele, C., Jacquemin, P. & Rooman, I., 29 nov 2024, (Unpublished).

  Onderzoeksoutput: Poster
• 2023

  Axon guidance genes control hepatic artery development

  Gannoun, L., De Schrevel, C., Belle, M., Dauguet, N., Achouri, Y., Loriot, A., Vanderaa, C., Cordi, S., Dili, A., Heremans, Y., Rooman, I., Leclercq, I. A., Jacquemin, P., Gatto, L. & Lemaigre, F. P., 15 aug 2023, In: Development. 150, 16, 15 blz., dev201642.

  Onderzoeksoutput: Article › peer review

  Open Access

  Bestand

  • Axon Guidance 100%
  • Hepatic Artery 89%
  • Mesoderm 84%
  • Bile Ducts 53%
  • neogenin 46%
  1 Citaat (Scopus)

  16 Downloads (Pure)

• Heterotopia of salivary gland tissue in the pancreas

  Martens, S., Coolens, K., Olsen, C., Lefesvre, P. & Rooman, I., dec 2023, In: Diagnostic pathology. 18, 1, 6 blz., 98.

  Onderzoeksoutput: Article › peer review

  Open Access

  Bestand

  • Salivary Glands 100%
  • Pancreas 82%
  • Staining and Labeling 62%
  • Islets of Langerhans 48%
  • calponin 34%
  1 Citaat (Scopus)

  33 Downloads (Pure)

• Pancreatic acinar cell fate relies on system xC- to prevent ferroptosis during stress

  Pan, Z., Van den Bossche, J-L., Rodriguez-Aznar, E., Janssen, P., Lara, O., Ates, G., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., 21 aug 2023, In: Cell & Death Disease. 14, 8, 10 blz., 536.

  Onderzoeksoutput: Article › peer review

  Open Access

  Bestand

  • Ferroptosis 100%
  • Cell Dedifferentiation 27%
  • Pancreatitis 17%
  • ferrostatin-1 17%
  • Lipid Peroxidation 16%
  7 Citaten (Scopus)

  26 Downloads (Pure)

• Systemic deletion of xCT in mice attenuates peripheral inflammation and inflammation-related mood disturbances in a pancreatic cancer model

  Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Sato, H., De Ridder, M., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 6 jun 2023, (Unpublished).

  Onderzoeksoutput: Poster

• Systemic deletion of xCT in mice attenuates peripheral inflammation and inflammation-related mood disturbances in a pancreatic cancer model

  Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Sato, H., De Ridder, M., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 21 apr 2023, (Unpublished).

  Onderzoeksoutput: Poster

• System xc- (xCT) prevents ferroptosis in pancreatic acinar cells as a first step in acinar-to-ductal metaplasia

  Pan, Z., Van den Bossche, J-L., Rodriguez Aznar, E., Janssen, P., Lara, O., Massie, A., De Paep, D. L., Houbracken, I., Mambretti, M. & Rooman, I., nov 2023, (Unpublished).

  Onderzoeksoutput: Poster

  Bestand
  101 Downloads (Pure)

• System xc- prevents ferroptosis in pancreatic acinar cells as a first step in acinar-to-ductal metaplasia

  Pan, Z. & Rooman, I., apr 2023, (Unpublished).

  Onderzoeksoutput: Poster

• Tackling pancreatic cancer from different angles: compartmentalized role of xCT in supporting tumor growth and inflammation-related comorbidities in mice

  Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Walckiers, J., Pan, Z., Beckers, P., Espinet, E., Sato, H., De Ridder, M., Marks, D. L., Barbé, K., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 13 nov 2023, (Unpublished).

  Onderzoeksoutput: Poster
• 2022

  Spatial heterogeneity of mutant KRAS expression in the context of pancreatic cancer subtypes

  Michiels, E., Messaoudi, N., Rooman, I., Giron, P., Olsen, C., Lefesvre, P. & Frederix, K., 29 sep 2022.

  Onderzoeksoutput: Poster

• Spatial heterogeneity of mutant KRAS expression in the context of pancreatic cancer subtypes

  Michiels, E., Rooman, I., Messaoudi, N., Giron, P., Olsen, C., Frederix, K. & Lefesvre, P., 6 nov 2022.

  Onderzoeksoutput: Poster

• Spatial Heterogeneity of Mutant KRAS Expression in the Context of Pancreatic Cancer Subtypes

  Rooman, I., 5 nov 2022.

  Onderzoeksoutput: Poster

• Targeting system xc- in a mouse pancreatic cancer model reduces tumor growth, neuroinflammation and mood disturbances

  Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Njemini, R., Sato, H., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 9 mei 2022, Targeting system xc- in a mouse pancreatic cancer model reduces tumor growth, neuroinflammation and mood disturbances.

  Onderzoeksoutput: Meeting abstract (Book)

• Targeting system xc- in a mouse pancreatic cancer model reduces tumor growth, neuroinflammation and mood disturbances

  Lara, O., Janssen, P., Mambretti, M., De Pauw, L., Ates, G., Mackens, L., De Munck, J., Beckers, P., Njemini, R., Sato, H., Aerts, J., Hermans, E., Rooman, I. & Massie, A., 9 mei 2022, (Unpublished).

  Onderzoeksoutput: Poster
• 2021

  Discovery and 3D imaging of deltaNp63-expressing cells in the human pancreatic duct that share characteristics with an aggressive molecular subtype of pancreatic cancer: poster and video abstract

  Rooman, I., 5 mei 2021.

  Onderzoeksoutput: Poster

• Discovery and 3D imaging of deltaNp63-expressing cells in the human pancreatic duct that share characteristics with the aggressive molecular subtype of pancreatic cancer: Poster Discussion Session for Top Abstracts

  Rooman, I., 9 jun 2021.

  Onderzoeksoutput: Poster

• MECOM permits pancreatic acinar cell dedifferentiation avoiding cell death under stress conditions

  Backx, E., Wauters, E., Baldan, J., Van Bulck, M., Michiels, E., Heremans, Y., De Paep, D. L., Kurokawa, M., Goyama, S., Bouwens, L., Jacquemin, P., Houbracken, I. & Rooman, I., 21 mrt 2021, Biorxiv, 40 blz.

  Onderzoeksoutput: Voordruk

  • Cell Dedifferentiation 100%
  • Cell Death 50%
  • Chronic Pancreatitis 9%
  • RNA Sequence Analysis 9%
  • Pancreatitis 8%

• Robo1 supports actin rich structures in pancreatic tumor cells with particular effects on Rhoa activity at adherens junctions

  Sklyarova, T. & Rooman, I., okt 2021, In: United European Gastroenterology Journal. 9, blz. 108-109 2 blz.

  Onderzoeksoutput: Meeting abstract (Journal)

  Open Access

  Bestand

  • Adherens Junctions 100%
  • Actins 65%
  • Axon Guidance 32%
  • Adenocarcinoma 30%
  • Neoplasms 24%
  207 Downloads (Pure)

• Setting up a PDXO platform for pancreatic cancer with spatial omics characterization

  Michiels, E. & Rooman, I., 5 okt 2021.

  Onderzoeksoutput: Poster

• Setting up a PDXO platform of pancreatic cancer with spatial-omics characterization

  Michiels, E. & Rooman, I., 21 sep 2021.

  Onderzoeksoutput: Poster
• 2020

  A novel basal DeltaNP63 (P40)-expressing pancreatic cell type undergoes expansion and reorganization in chronic pancreatitis

  Martens, S., Van Bulck, M., Coolens, K., Esni, F., Leuckx, G., Heimberg, H., Bouwens, L., Jacquemin, P., Spagnoli, F., Real, F. X., in 't Veld, P., Lesfevre, P. & Rooman, I., okt 2020, In: United European Gastroenterology Journal. 8, blz. 123-124 2 blz.

  Onderzoeksoutput: Meeting abstract (Journal)

  Open Access

  Bestand

  • Chronic Pancreatitis 100%
  • Pancreas 25%
  • Regeneration 7%
  • Adenocarcinoma 6%
  • Software 6%
  3 Citaten (Scopus)

  371 Downloads (Pure)
• 2019

  In vivo investigation of a potential regulator of pancreatic acinar dedifferentiation

  Michiels, E., Backx, E. & Rooman, I., 25 jun 2019, (Unpublished).

  Onderzoeksoutput: Poster

  Bestand
  41 Downloads (Pure)
• 2018

  Drug Repurposing as a Source of Innovative Therapies in Pancreatic Cancer

  Pantziarka, P., Capistrano, R., Bouche, G. & Rooman, I., 2018.

  Onderzoeksoutput: Poster

  • Drug Repositioning 100%
  • Investigational Therapies 89%
  • Pancreatic Neoplasms 68%
  • Pharmaceutical Preparations 30%
  • plerixafor octahydrochloride 28%
• 2016

  Role of the microenvironment in chronic pancreatitis and pancreatic cancer

  Pinho, A. V., Apte, M. V., Wilson, J. S. & Rooman, I., 1 mrt 2016, In: Cancer Forum. 40, 1, blz. 11-15 5 blz.

  Onderzoeksoutput: Scientific review › peer review

  • Chronic Pancreatitis 100%
  • Pancreatic Neoplasms 84%
  • Pancreatic Stellate Cells 34%
  • Adenocarcinoma 34%
  • Exocrine Pancreas 29%
  1 Citaat (Scopus)
• 2003

  Proliferation and differentiation of adult rat pancreatic exocrine cells

  Rooman, I., 2003, In: Verhandelingen - Koninklijke Academie voor Geneeskunde van België. 65, blz. 117-125

  Onderzoeksoutput: Scientific review

  2 Citaten (Scopus)