Alexandre Wohlkönig

Van Holsbeeck, K., Fischer, B., Gonzalez, S., Gadais, C., Versées, W., Martins, J. C., Martin, C., Wohlkönig, A., Steyaert, J. & Ballet, S., 4 nov 2022, Proceedings of the 36th European and the 12th International Peptide Symposium. Lebl, M. (redactie). European Peptide Society , blz. 141-142

Onderzoeksoutput: Conference paper

Means and methods for selection of specific binders

Steyaert, J., Pardon, E., Wohlkönig, A., Zögg, T. & Kalichuk, V., 2022, Octrooi Nr. WO2022268993

Onderzoeksoutput: Patent

Nanobody CDR3 mimetics enhance SOS1-catalyzed nucleotide exchange on RAS

Van Holsbeeck, K., Fischer, B., Gonzalez, S., Gadais, C., Versées, W., Martins, J. C., Martin, C., Wohlkönig, A., Steyaert, J. & Ballet, S., 2022.

Onderzoeksoutput: Voordruk

Nanobody exchange chromatography

Steyaert, J., Pardon, E., Wohlkönig, A., Zögg, T., Kalichuk, V., De Keyser, P. & Fischer, B., 2022, Octrooi Nr. EP4077372

Onderzoeksoutput: Patent

Positive allosteric modulators of the calcium-sensing receptor

Steyaert, J., Pardon, E., Wohlkönig, A., Zögg, T., Mos, I., BRÄUNER-OSBORNE, H. & MOSOLFF MATHIESEN, J., 2022, Octrooi Nr. EP4065603

Onderzoeksoutput: Patent

2021

Constructing and purifying megabodies starting from individual nanobody sequences

Uchański, T., Fischer, B., Kalichuk, V., Wohlkönig, A., Zögg, T., Pardon, E. & Steyaert, J., 7 jan 2021, 11 blz.

Onderzoeksoutput: Other contribution

Fusion proteins comprising a cytokine and scaffold protein

Steyaert, J., Pardon, E., Wohlkönig, A., Kalichuk, V., Vranken, W., Uchanski, T., Chevigné, A. & Szpakowska, M., 2021, Octrooi Nr. EP3898664

Onderzoeksoutput: Patent

Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

Uchański, T., Masiulis, S., Fischer, B., Kalichuk, V., López-Sánchez, U., Zarkadas, E., Weckener, M., Sente, A., Ward, P., Wohlkönig, A., Zögg, T., Remaut, H., Naismith, J. H., Nury, H., Vranken, W., Aricescu, A. R., Pardon, E. & Steyaert, J., jan 2021, In: Nature Methods. 18, 1, blz. 60-68 9 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

79 Citaten (Scopus)

347 Downloads (Pure)

2020

Fragment-Based Optimized EthR Inhibitors with in Vivo Ethionamide Boosting Activity

Villemagne, B., Machelart, A., Tran, N. C., Flipo, M., Moune, M., Leroux, F., Piveteau, C., Wohlkönig, A., Wintjens, R., Li, X., Gref, R., Brodin, P., Deprez, B., Baulard, A. R. & Willand, N., 13 mrt 2020, In: ACS Infectious Diseases. 6, 3, blz. 366-378 13 blz.

Onderzoeksoutput: Article › peer review

16 Citaten (Scopus)

Fusion proteins comprising a cytokine and scaffold protein

Steyaert, J., Pardon, E., Wohlkönig, A., Kalichuk, V., Vranken, W., Uchanski, T., Chevigné, A. & Szpakowska, M., 2020, Octrooi Nr. WO2020127983

Onderzoeksoutput: Patent

Methods to select agents that stabilize protein complexes

Steyaert, J., Wohlkönig, A. & Triest, S., 1 apr 2020, Octrooi Nr. EP3194976B, 17 jul 2015, Prioriteitsdatum 22 jul 2014, Prioriteitsnummer EP14178012.2

Onderzoeksoutput: Patent

Methods to select for agents that stabilize protein complexes

Steyaert, J., Wohlkönig, A. & Triest, S., 2020, Octrooi Nr. US10641779

Onderzoeksoutput: Patent

Methyl arachidonyl fluorophosphonate inhibits Mycobacterium tuberculosis thioesterase TesA and globally affects vancomycin susceptibility

Yang, D., Vandenbussche, G., Vertommen, D., Evrard, D., Abskharon, R., Cavalier, JF., Berger, G., Canaan, S., Khan, M. S., Zeng, S., Wohlkönig, A., Prévost, M., Soumillion, P. & Fontaine, V., jan 2020, In: FEBS Letters. 594, 1, blz. 79-93 15 blz.

Onderzoeksoutput: Article › peer review

Open Access

5 Citaten (Scopus)

2019

A comprehensive analysis of the protein-ligand interactions in crystal structures of Mycobacterium tuberculosis EthR

Tanina, A., Wohlkönig, A., Soror, S. H., Flipo, M., Villemagne, B., Prevet, H., Déprez, B., Moune, M., Perée, H., Meyer, F., Baulard, A. R., Willand, N. & Wintjens, R., 1 mrt 2019, In: Biochimica et Biophysica Acta - Proteins and Proteomics. 1867, 3, blz. 248-258 11 blz.

Onderzoeksoutput: Article › peer review

10 Citaten (Scopus)

A fragment-based approach towards the discovery of N-substituted tropinones as inhibitors of Mycobacterium tuberculosis transcriptional regulator EthR2

Prevet, H., Moune, M., Tanina, A., Kemmer, C., Herledan, A., Frita, R., Wohlkönig, A., Bourotte, M., Villemagne, B., Leroux, F., Gitzinger, M., Baulard, A. R., Déprez, B., Wintjens, R., Willand, N. & Flipo, M., 1 apr 2019, In: European Journal of Medicinal Chemistry. 167, blz. 426-438 13 blz.

Onderzoeksoutput: Article › peer review

Open Access

14 Citaten (Scopus)

An improved yeast surface display platform for the screening of nanobody immune libraries

Uchański, T., Zögg, T., Yin, J., Yuan, D., Wohlkönig, A., Fischer, B., Rosenbaum, D. M., Kobilka, B. K., Pardon, E. & Steyaert, J., 23 jan 2019, In: Scientific Reports - Nature. 9, 1, blz. 1-12 12 blz., 382.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

70 Citaten (Scopus)

644 Downloads (Pure)

2017

reverse resistance

Blondiaux, N., Moune, M., Desroses, M., Frita, R., Flipo, M., Mathys, V., Soetaert, K., Kiass, M., Delorme, V., Djaout, K., Trebosc, V., Kemmer, C., Wintjens, R., Wohlkönig, A., Antoine, R., Huot, L., Hot, D., Coscolla, M., Feldmann, J., Gagneux, S. & 6 anderen, Locht, C., Brodin, P., Gitzinger, M., Déprez, B., Willand, N. & Baulard, A. R., 2017, In: Science. 355, 6330, blz. 1206-1211 6 blz.

Onderzoeksoutput: Article › peer review

117 Citaten (Scopus)

Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2

Wohlkönig, A., Remaut, H., Moune, M., Tanina, A., Meyer, F., Desroses, M., Steyaert, J., Willand, N., Baulard, A. R. & Wintjens, R., 27 mei 2017, In: Biochemical and Biophysical Research Communications. 487, 2, blz. 403-408 6 blz.

Onderzoeksoutput: Article › peer review

10 Citaten (Scopus)

2015

Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide

Srikannathasan, V., Wohlkonig, A., Shillings, A., Singh, O., Chan, P. F., Huang, J., Gwynn, M. N., Fosberry, A. P., Homes, P., Hibbs, M., Theobald, A. J., Spitzfaden, C. & Bax, B. D., 2015, In: Acta Crystallographica Section F - Structural Biology Communications. 71, Pt 10, blz. 1242-1246 5 blz.

Onderzoeksoutput: Article › peer review

21 Citaten (Scopus)

2014

Ligand efficiency driven design of new inhibitors of Mycobacterium tuberculosis transcriptional repressor EthR using fragment growing, merging, and linking approaches.

Villemagne, B., Flipo, M., Blondiaux, N., Crauste, C., Malaquin, S., Leroux, F., Piveteau, C., Villeret, V., Brodin, P., Villoutreix, BO., Sperandio, O., Soror, SH., Wohlkönig, A., Wintjens, R., Deprez, B., Baulard, AR. & Willand, N., jun 2014, In: Journal of Medicinal Chemistry. 57, blz. 4876–4888 13 blz., 11.

Onderzoeksoutput: Article › peer review

62 Citaten (Scopus)

Production, crystallization and preliminary X-ray diffraction of the Gαs α-helical domain in complex with a nanobody

Triest, S., Wohlkönig, A., Pardon, E. & Steyaert, J., 1 nov 2014, In: Acta Crystallographica Section F - Structural Biology Communications. 70, 11, blz. 1504-1507 4 blz.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

1 Citaat (Scopus)

111 Downloads (Pure)

The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation

Leiba, J., Carrère-Kremer, S., Blondiaux, N., Dimala, M. M., Wohlkönig, A., Baulard, A., Kremer, L. & Molle, V., 18 apr 2014, In: Biochemical and Biophysical Research Communications. 446, 4, blz. 1132-1138 7 blz.

Onderzoeksoutput: Article › peer review

19 Citaten (Scopus)

2013

Expression, Purification, Characterization, and Solution NMR Study of Highly‐Deuterated Recombinant Yeast Cytochrome c Peroxidase with Enhanced Solubility

Volkov, A. N., Wohlkönig, A., Soror, S. & Van Nuland, N., 21 mrt 2013, In: Biochemistry. 52, 13, blz. 2166-2175 10 blz.

Onderzoeksoutput: Article › peer review

High-resolution structure of a papaya plant-defense barwin-like protein solved by in-house sulfur-SAD phasing

Huet, J., Teinkela Mbosso, E. J., Soror, S., Meyer, F., Looze, Y., Wintjens, R. & Wohlkönig, A., 2013, In: Acta crystallographica. Section D : Biological crystallography (1993-2015). 69, Pt 10, blz. 2017-2026 10 blz.

Onderzoeksoutput: Article › peer review

13 Citaten (Scopus)

2012

Discovery of novel N -phenylphenoxyacetamide derivatives as EthR inhibitors and ethionamide boosters by combining high-throughput screening and synthesis

Flipo, M., Willand, N., Lecat-Guillet, N., Hounsou, C., Desroses, M., Leroux, F., Lens, Z., Villeret, V., Wohlkönig, A., Wintjens, R., Christophe, T., Kyoung Jeon, H., Locht, C., Brodin, P., Baulard, A. R. & Déprez, B., 26 jul 2012, In: Journal of Medicinal Chemistry. 55, 14, blz. 6391-6402 12 blz.

Onderzoeksoutput: Article › peer review

41 Citaten (Scopus)

Ethionamide boosters. 2. Combining bioisosteric replacement and structure-based drug design to solve pharmacokinetic issues in a series of potent 1,2,4-oxadiazole EthR inhibitors

Flipo, M., Desroses, M., Lecat-Guillet, N., Villemagne, B., Blondiaux, N., Leroux, F., Piveteau, C., Mathys, V., Flament, M. P., Siepmann, J., Villeret, V., Wohlkönig, A., Wintjens, R., Soror, S. H., Christophe, T., Jeon, H. K., Locht, C., Brodin, P., Déprez, B., Baulard, A. R. & 1 anderen, Willand, N., 12 jan 2012, In: Journal of Medicinal Chemistry. 55, 1, blz. 68-83 16 blz.

Onderzoeksoutput: Article › peer review

70 Citaten (Scopus)

2011

Crystallization and preliminary X-ray diffraction analysis of kanamycin-binding β-lactamase in complex with its ligand

Van De Water, K., Soror, S., Wohlkönig, A., Van Nuland, N. & Volkov, A. N., 26 mei 2011, In: Acta Crystallographica Section F. 67, blz. 703-706 4 blz.

Onderzoeksoutput: Article › peer review

1 Citaat (Scopus)

2010

Structural basis of quinolone inhibition of type IIA topoisomerases and target-mediated resistance

Wohlkonig, A., Chan, P. F., Fosberry, A. P., Homes, P., Huang, J., Kranz, M., Leydon, V. R., Miles, T. J., Pearson, N. D., Perera, R. L., Shillings, A. J., Gwynn, M. N. & Bax, B. D., sep 2010, In: Nature Structural & Molecular Biology. 17, 9, blz. 1152-1153 2 blz.

Onderzoeksoutput: Article › peer review

252 Citaten (Scopus)

Structural relationships in the lysozyme superfamily: Significant evidence for glycoside hydrolase signature motifs

Wohlkönig, A., Huet, J., Looze, Y. & Wintjens, R., 2010, In: PLoS ONE. 5, 11, 10 blz.

Onderzoeksoutput: Article › peer review

86 Citaten (Scopus)

Type IIA topoisomerase inhibition by a new class of antibacterial agents

Bax, B. D., Chan, P. F., Eggleston, D. S., Fosberry, A., Gentry, D. R., Gorrec, F., Giordano, I., Hann, M. M., Hennessy, A., Hibbs, M., Huang, J., Jones, E., Jones, J., Brown, K. K., Lewis, C. J., May, E. W., Saunders, M. R., Singh, O., Spitzfaden, C. E., Shen, C. & 5 anderen, Shillings, A., Theobald, A. J., Wohlkonig, A., Pearson, N. D. & Gwynn, M. N., 19 aug 2010, In: Nature. 466, 7309, blz. 935-940 6 blz.

Onderzoeksoutput: Article › peer review

695 Citaten (Scopus)

2009

Structure and plasticity of the peptidyl-prolyl isomerase Par27 of Bordetella pertussis revealed by X-ray diffraction and small-angle X-ray scattering.

Clantin, B., Leyrat, C., Wohlkönig, A., Hodak, H., Ribeiro, E. A., Martinez, N., Baud, C., Smet-Nocca, C., Villeret, V., Jacob-Dubuisson, F. & Jamin, M., nov 2009, In: Journal of Structural Biology. 169, 3, blz. 253-265 13 blz.

Onderzoeksoutput: Article › peer review

7 Citaten (Scopus)

2008

Crystallization and preliminary X-ray diffraction analysis of the peptidylprolyl isomerase Par27 of Bordetella pertussis.

Wohlkönig, A., Hodak, H., Clantin, B., Sénéchal, M., Bompard, C., Jacob-Dubuisson, F. & Villeret, V., aug 2008, In: Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. F64, blz. 809-812 4 blz.

Onderzoeksoutput: Article › peer review

1 Citaat (Scopus)

2007

Biphenyl 2,3',4,5',6-pentakisphosphate, a novel inositol polyphosphate surrogate, modulates Ca2+ responses in rat hepatocytes.

Vandeput, F., Combettes, L., Mills, SJ., Backers, K., Wohlkönig, A., Parys, JB., De, S. H., Missiaen, L., Dupont, G., Potter, BV. & Erneux, C., jan 2007, In: The FASEB journal. 21, 7, blz. 1481-1491 11 blz.

Onderzoeksoutput: Article › peer review

29 Citaten (Scopus)

Expression and purification in high yield of a functionally active recombinant human Type I inositol(1,4,5)P3 5-phosphatase.

Wohlkönig, A., Sénéchal, M., Dewitte, F., Backers, K., Erneux, C. & Villeret, V., apr 2007, In: Protein Expression and Purification. 55, 1, blz. 69-74 6 blz.

Onderzoeksoutput: Article › peer review

2 Citaten (Scopus)

Multiples modifications post-traductionnelles impliquées dans la régulation de l'expression génique: exemple de la sumoylation des facteurs Ets

de Launoit, Y., Degerny, C., Wohlkonig, A. & Baert, J. L., 2007, In: Bulletin et memoires de l'Academie royale de medecine de Belgique. 162, 5-6, blz. 299-305 7 blz., discussion 306.

Onderzoeksoutput: Article › peer review

The peptidyl-prolyl isomerase and chaperone Par27 of Bordetella pertussis as the prototype for a new group of parvulins.

Hodak, H., Wohlkönig, A., Smet-Nocca, C., Drobecq, H., Wieruszeski, JM., Sénéchal, M., Landrieu, I., Locht, C., Jamin, M. & Jacob-Dubuisson, F., nov 2007, In: Journal of Molecular Biology. 376, 2, blz. 414-426 13 blz.

Onderzoeksoutput: Article › peer review

26 Citaten (Scopus)

2004

Purification of ArcR, an oxidation-sensitive regulatory protein from Bacillus licheniformis

Wohlkönig, A., Stalon, V. & Wauven, C. V., sep 2004, In: Protein Expression and Purification. 37, 1, blz. 32-38 7 blz.

Onderzoeksoutput: Article › peer review

5 Citaten (Scopus)

Alexandre Wohlkönig

Onderzoeksoutput

Zoekresultaten