Projecten per jaar
Persoonlijk profiel
Expertise
Neurochemical and neuropharmacological research is strongly dependent on the availability of sensitive analysis methods for neurotransmitters, neuromodulators and drugs in biological samples. The development of new, faster and sensitive analysis methods remains challenging for the bioanalyst due to the very low concentrations of these compounds in small sample volumes, in addition to the need for higher throughput.
The research group has ample experience in the development of miniaturized LC methods, coupled to fluorescence, electrochemical or tandem mass spectrometric (MS/MS) detection, for the quantification of neurotransmitters and neuromodulators in microdialysis samples. In addition, we have a large experience in the development and validation of analytical methods for the determination of drugs in drug products and biological samples with capillary electrophoresis, LC-UV, LC-fluorescence and LC-MS/MS.
The main research topics are:
- Nano LC tandem mass spectrometry for quantification of neuropeptides in microdialysis samples
- Metabolite profiling for the discovery and analysis of biomarkers of drug resistant epilepsy
- Miniaturized (enantioselective) LC methods for quantification of neuro- and gliotransmitters in biological samples
- Miniaturized LC methods for quantification of drug in biological samples
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Ann Van Eeckhaut actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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FWOAL1076: (A)chirale gerichte metabolietprofilering in volume-gelimiteerde hersenstalen: streven naar brede dekking, gevoeligheid en throughput met behulp van chemische derivatisatie en geminiaturiseerde vloeistofchromatografie-massa spectrometrie
Van Eeckhaut, A. & Vander Heyden, Y.
1/01/23 → 31/12/26
Project: Fundamenteel
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VLOV157: Virtual Lab, ontwikkeling van hogere orde labocompetenties
1/10/21 → 15/10/23
Project: Fundamenteel
Onderzoeksoutput
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Antioxidant, neuroprotective, and neuroblastoma cells (SH-SY5Y) differentiation effects of melanins and arginine-modified melanins from Daedaleopsis tricolor and Fomes fomentarius
Nguyen, H. A. T., Phu Ho, T., Mangelings, D., Van Eeckhaut, A., Vander Heyden, Y. & Tran, H., 11 nov 2024, In: BMC Biotechnology. 24, 14 blz., 89.Onderzoeksoutput: Article › peer review
Open AccessBestand6 Downloads (Pure) -
Applicability and efficacy of non-invasive transcranial brain stimulation in anxiety disorders in dogs : an open-label trial
Salden, S., Xu, Y., Smet, S. D., Peremans, K., Kwik, J., Dobbeleir, A., Witte, S. D., Van Eeckhaut, A., Saunders, J., Haverbeke, A. & Baeken, C., 2024.Onderzoeksoutput: Unpublished abstract
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Chemical derivatization for targeted brain metabolomics of volume-limited samples using LC-MS/MS
Nestor, L., Lella, C., De Bundel, D., Smolders, I., Vander Heyden, Y. & Van Eeckhaut, A., 11 sep 2024, (Unpublished).Onderzoeksoutput: Poster
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Chemical derivatization of polar compounds for analysis in volume-limited biological samples using LC-MS/MS
Nestor, L., Lella, C., De Bundel, D., Smolders, I., Vander Heyden, Y. & Van Eeckhaut, A., 30 apr 2024, (Unpublished).Onderzoeksoutput: Poster
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Chiral targeted brain metabolomics in volume-limited biological samples
Lella, C., Nestor, L., Vander Heyden, Y. & Van Eeckhaut, A., 10 sep 2024, (Unpublished).Onderzoeksoutput: Poster
Prijzen
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Project grant Wetenschappelijk Fonds Willy Gepts (WFWG)
Custers, Marie-Laure (Recipient), Van Eeckhaut, Ann (Recipient) & Smolders, Ilse (Recipient), 1 dec 2021
Prijs: Prize (including medals and awards)
Activiteiten
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Metabolomic profiling of mouse hippocampus to unravel the effects of chemogenetic modulation of astrocytes in a model for temporal lobe epilepsy
Liam Nestor (Speaker), Yvan Vander Heyden (Contributor), Ann Van Eeckhaut (Contributor), Dimitri De Bundel (Contributor) & Ilse Smolders (Contributor)
11 sep 2024Activiteit: Talk or presentation at a conference
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The importance of phytotherapy in the treatment of malaria: estimation of anti-plasmodial activity of Artemisia Samples: A Chemometric Approach
Sarah Bilal (Speaker), Johan Viaene (Contributor), Santina Gorsen (Contributor), Ann Van Eeckhaut (Contributor), Debby Mangelings (Contributor), Yvan Vander Heyden (Contributor) & Kristiaan Demeyer (Contributor)
24 jul 2024 → 25 jul 2024Activiteit: Talk or presentation at a workshop/seminar
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Metabolic profiling of epileptic hippocampal tissue upon chemogenetic modulation of astrocytes using CE-HRMS
Liam Nestor (Speaker), Yvan Vander Heyden (Contributor), Ann Van Eeckhaut (Contributor), Dimitri De Bundel (Contributor) & Ilse Smolders (Contributor)
29 apr 2024Activiteit: Talk or presentation at a conference
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Liquid chromatography-mass spectrometry of low-volume samples for the analysis of the brain metabolome using dimethylaminophenacyl bromide derivatization
Liam Nestor (Speaker), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor) & Ann Van Eeckhaut (Contributor)
27 apr 2023Activiteit: Talk or presentation at a conference
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Optimization of a targeted brain metabolomics method for low-volume biological samples using chemical derivatization
Liam Nestor (Speaker), Phaedra Maria Verding (Contributor), Ruben Verhulst (Contributor), Yvan Vander Heyden (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor) & Ann Van Eeckhaut (Contributor)
11 apr 2023Activiteit: Talk or presentation at a conference
Scriptie
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Analytical Challenges for the Determination of Alpha-Synuclein in the Context of Parkinson Disease.
Auteur: Napp, A., Fillet, M., Servais, A., Hubert, , Garraux, , Merville, , Lipka, & Van Eeckhaut, A., 15 okt 2018Scriptie/Masterproef: Doctoral Thesis
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Applicability of cerebral open flow microperfusion and microdialysis to quantify a brain-penetrating nanobody mice
Auteur: Brock, A. R., Smolders, I. & Van Eeckhaut, A., 1 jul 2021Begeleider: Custers, M. (Advisor)
Scriptie/Masterproef: Master's Thesis
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A quest to increase sensitivity for the LC-MC/MS analysis of peptides from the neuromedin family
Auteur: Del'Haye, G., Van Eeckhaut, A., Vander Heyden, Y. & Mangelings, D., 2021Begeleider: Bongaerts, J. (Co-promotor)
Scriptie/Masterproef: Master's Thesis
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Bepaling van de plasmastabiliteit van een synthetisch peptide en preliminair onderzoek naar het minimaliseren van peptide-adsorptie tijdens microdialyse
Auteur: Van den Borre, L., Van Eeckhaut, A., Caveliers, V. & Doktorova, T., 10 jun 2015Scriptie/Masterproef: Master's Thesis
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Bioanalysis and model based treatment optimization for preclinical and clinical studies of peritoneal carcinomatosis from ovarian cancer.
Auteur: Xie, F., Van Bocxlaer, J., Vermeulen, A., Colin, P., Boussery, K., Remaut, K., Vervaet, C., Ceelen, MD, W., Van Eeckhaut, A. & Jose Perez Ruixo, J., 28 aug 2019Scriptie/Masterproef: Doctoral Thesis