Projecten per jaar
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Claudia Spits actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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FWOTM1310: Het gebruik van lever organoïden om te bestuderen of aneuploïdie humane pluripotente stamcelafgeleide hepatocyten voorbereidt voor oncogene transformatie
Huyghebaert, A. (Mandataris), Spits, C. (Administrative Promotor) & Al Delbany, D. (CoI (Co-Promotor))
1/11/25 → 31/10/29
Project: Fundamenteel
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BASGO23: OZR Basisfinanciering voor Grote Onderzoeksgroepen - GRAD
Spits, C. (Administrative Promotor) & Sermon, K. (Administrative Promotor)
1/01/24 → 31/12/30
Project: Fundamenteel
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OZRMETH9: De genetische component in infertiliteit en mislukking van vroege menselijke ontwikkeling
Spits, C. (Administrative Promotor) & Sermon, K. (Administrative Promotor)
1/01/23 → 31/12/29
Project: Fundamenteel
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FWOAL1071: Lever en hersen organoïden als modellen voor humane pluripotente stamcel-tumorogenese
Spits, C. (Administrative Promotor)
1/01/23 → 31/12/26
Project: Fundamenteel
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OZR3565: Seahorse platform: de Agilent Seahorse Flux Analyser met geïntegreerd normalizatie systeem
Massie, A. (Administrative Promotor), Stiens, J. (Co-Promoter), Van Ginderachter, J. (Co-Promoter), Vanommeslaeghe, K. (Co-Promoter), Vinken, M. (Co-Promoter), Menu, E. (Co-Promoter), Spits, C. (Co-Promoter) & Njemini, R. (Co-Promoter)
1/05/20 → 30/04/26
Project: Fundamenteel
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1q gain bypasses the selective barrier against aneuploidy in RPE differentiation via wild-type co-culture rescue
Couvreu De Deckersberg, E., Lei, Y., Krivec, N., Huyghebaert, A., Duong, M. C., Janssens, C., Regin, M., Tsuiko, O., Movahedi, K., Verhulst, S., van Grunsven, L. A., Sermon, K., Al Delbany, D. & Spits, C., 25 nov. 2025, In: Nature Communications. 16, 1, 15 blz., 11627.Onderzoeksoutput: Article › peer review
Open Access -
A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy
Benvenisty, N., Draper, J. S., Gokhale, P. J., Healy, L. E., Hewitt, Z., Hursh, D., Hodgson, A., Ludwig, T., Mah, N., McClelland, S., Mennecozzi, M., Merkle, F. T., Mountford, J. C., Pera, M. F., Prigione, A., Rodriguez, T., Rossi, A., Rouhani, F., Saeb-Parsy, K. & Selfa Aspiroz, L. & 4 anderen, , 3 apr. 2025, In: Cell Stem Cell. 32, 4, blz. 508-512 5 blz.Onderzoeksoutput: Article › peer review
2 Citaten (Scopus)15 Downloads (Pure) -
Aneuploidy as a first genetic hit that enhances the tumorigenic capacity of differentiated human pluripotent stem cells
Al Delbany, D., Mampay, M., Srinivasan, A. N., Krivec, N., Huyghebaert, A., Movahedi, K. & Spits, C., 12 jun. 2025.Onderzoeksoutput: Poster
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Aneuploidy as a first genetic hit that enhances the tumorigenic capacity of differentiated human pluripotent stem cells
Al Delbany, D., Mampay, M., Srinivasan, A. N., Krivec, N., Huyghebaert, A., Movahedi, K. & Spits, C., 11 apr. 2025, (Unpublished).Onderzoeksoutput: Poster
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Aneuploidy as a first genetic hit that enhances the tumorigenic capacity of differentiated human pluripotent stem cells
Al Delbany, D., Mampay, M., Srinivasan, A. N., Krivec, N., Huyghebaert, A., Duong, M. C., Sarkar, A., Brock, S., Movahedi, K. & Spits, C., 28 nov. 2025.Onderzoeksoutput: Poster
Open Access
Datasets
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1q Gain Bypasses The Selective Barrier Against Aneuploidy In RPE Differentiation Via Wild-Type Co-Culture Rescue
Spits, C. (Creator), Couvreu De Deckersberg, E. (Creator) & Verloes, A. (Data Manager), OSF, 18 sep. 2023
Dataset
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Modeling of myogenesis using human embryonic stem cells reveals myotonic dystrophy type 1 specific misregulated cellular processes
Spits, C. (Creator), Gene Expression Omnibus (GEO), 2022
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE160916
Dataset
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Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research
Spits, C. (Creator), OSF, 14 nov. 2024
Dataset
Activiteiten
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Liver organoids to study if aneuploidy primes human pluripotent stem-cell derived hepatocytes for oncogenic transformation
Huyghebaert, A. (Participant), Al Delbany, D. (Supervisor) & Spits, C. (Supervisor)
1 nov. 2025 → 31 okt. 2029Activiteit: Written proposal
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SALL3 drives selective growth advantage and modulates pluripotency in hPSCs with chromosome 18q loss
Duong, C. M. (Presenter), Krivec, N. (Contributor), Al Delbany, D. (Contributor), Huyghebaert, A. (Contributor) & Spits, C. (Contributor)
28 nov. 2025Activiteit: Talk or presentation at a conference
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Hepatic stellate cell activation: Improving models, biomarkers and therapeutic targets. (Evenement)
Merens, V. (Presenter), Stijlemans, B. (Jury), van Grunsven, L. (Member), Spits, C. (Chair), Verhulst, S. (Member), De Kock, J. (Jury), Al Delbany, D. (Jury), Scott, C. L. (Jury) & Eeckhout, J. (Jury)
27 okt. 2025Activiteit: Member of PhD committee
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Regulators of cell fate decisions in human pre-implantation embryos (Evenement)
Leyns, L. (Jury), Regin, M. (Presenter), Sermon, K. (Supervisor) & Spits, C. (Supervisor)
28 mrt. 2024Activiteit: Member of PhD committee
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KU Leuven (Externe Organisatie)
De Mey, J. (Chair), Peeters, E. (Member), Clarke, G. (Member), Smolders, J. (Member), Sabino, J. (Member), Spits, C. (Member), D'Hooghe, M. B. (Supervisor), Raes, J. (Supervisor) & Devolder, L. (Supervisor)
21 nov. 2022Activiteit: Member of PhD committee
Knipsels
Scriptie
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(R)evolution in preimplantation genetic diagnosis : development and clinical application of different approaches to preimplantation genetic diagnosis for monogenic disorders.
Spits, C. ((PhD) Student), Liebaers, I. (Promotor), Sermon, K. (Co-promotor), De Rycke, M. (Co-promotor), Van Schravendijk, C. (Jury), Van Der Auwera, B. (Jury), Geraedts, J. (Jury), Harper, J. (Jury), Santalo Pedro, J. (Jury), De Paepe, A. (Jury), Legius, E. (Jury) & Timmerman, V. (Jury), Liebaers, I. (Promotor), Sermon, K. (Co-promotor), De Rycke, M. (Co-promotor), Van Schravendijk, C. (Jury), Van Der Auwera, B. (Jury), Geraedts, J. (Jury), Harper, J. C. (Jury), Santalo Pedro, J. (Jury), De Paepe, A. (Jury), Legius, E. (Jury) & Timmerman, V. (Jury), 4 dec. 2006Scriptie/Masterproef: Doctoral Thesis
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Assessing tumorigenicity in HESCs carrying Chromosomal abnormalities in brain and liver organoid models
Ghijselings, K. ((PhD) Student), Al Delbany, D. (Co-promotor), Huyghebaert, A. (Co-promotor) & Spits, C. (Promotor), 29 mei 2026Scriptie/Masterproef: Master's Thesis
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Generation of brain organoids and induction of mutagenesis by lentiviral transduction
Mohimi, N. ((PhD) Student), Al Delbany, D. (Promotor) & Spits, C. (Promotor), 2022Scriptie/Masterproef: Master's Thesis
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Study the effect of chromosomal abnormalities on the neuroectoderm differentiation of hESCs in two and three-dimensional culture systems
Asadi, R. ((PhD) Student), Al Delbany, D. (Co-promotor), Krivec, N. (Co-promotor) & Spits, C. (Promotor), 28 jul. 2024Scriptie/Masterproef: Master's Thesis
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The use of brain organoids to study oncogenic transformation of human pluripotent stem cells
Khallouk Temsamani, I. ((PhD) Student), Al Delbany, D. (Co-promotor) & Spits, C. (Promotor), 14 jun. 2024Scriptie/Masterproef: Master's Thesis