Projecten per jaar
Vingerafdruk
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Projecten
- 1 Afgelopen
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FWOSB55: De weg naar een veilige introductie van hESC in de kliniek: de casus van genetisch mozaicisme in hESC-afgeleide retinale cellen
Couvreu De Deckersberg, E. (Mandataris), Spits, C. (Administrative Promotor) & Sermon, K. (Co-Promoter)
1/01/19 → 31/12/22
Project: Fundamenteel
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1q gain bypasses the selective barrier against aneuploidy in RPE differentiation via wild-type co-culture rescue
Couvreu De Deckersberg, E., Lei, Y., Krivec, N., Huyghebaert, A., Duong, M. C., Janssens, C., Regin, M., Tsuiko, O., Movahedi, K., Verhulst, S., van Grunsven, L. A., Sermon, K., Al Delbany, D. & Spits, C., 25 nov. 2025, In: Nature Communications. 16, 1, 15 blz., 11627.Onderzoeksoutput: Article › peer review
Open Access -
GAIN OF CHROMOSOME 20Q11.21 PROMOTES GROWTH ADVANTAGE DURING NEUROECTODERMAL DIFFERENTIATION AND DRIVES LINEAGE MIS-SPECIFICATION THROUGH BCL2L1–ID1 COOPERATION
Krivec, N., Lei, Y., Couvreu De Deckersberg, E., Duong, M. C., Huyghebaert, A., Verhulst, S., van Grunsven, L. A., Sermon, K., Al Delbany, D. & Spits, C., 28 nov. 2025, (Unpublished). 1 blz.Onderzoeksoutput: Poster
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hPSC WITH A GAIN OF 1q OR 20q11.21 RETAIN THEIR GROWTH ADVANTAGE DURING NEUROECTODERM DIFFERENTIATION AND MIS-SPECIFY TOWARDS NON-NEURAL LINEAGES
Krivec, N., Lei, Y., Couvreu De Deckersberg, E., Verhulst, S., van Grunsven, L. A., Sermon, K., Al Delbany, D. & Spits, C., 12 jun. 2025. 1 blz.Onderzoeksoutput: Poster
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Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells
lei, Y., Duong, C. M., Krivec, N., Janssens, C., Regin, M., Huyghebaert, A., Deckersberg, E. C. D., Sermon, K., Delbany, D. A. & Spits, C., 5 feb. 2025, In: Cell Proliferation. 58, 11, 12 blz., e13813.Onderzoeksoutput: Article › peer review
Open Access -
The interplay between mitochondrial DNA genotypes, female infertility, ovarian response, and mutagenesis in oocytes (vol 2025,hoae074,2024)
Van Der Kelen, A., Li Piani, L., Mertens, J., Regin, M., de Deckersberg, E. C., Van de Velde, H., Sermon, K., Tournaye, H., Verpoest, W., Hes, F. J., Blockeel, C. & Spits, C., jul. 2025, In: Human reproduction open. 2025, 3, 1 blz., hoaf037.Onderzoeksoutput: Article › peer review
Open Access
Datasets
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1q Gain Bypasses The Selective Barrier Against Aneuploidy In RPE Differentiation Via Wild-Type Co-Culture Rescue
Spits, C. (Creator), Couvreu De Deckersberg, E. (Creator) & Verloes, A. (Data Manager), OSF, 18 sep. 2023
Dataset
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Loss of 18q Alters TGFβ Signalling Affecting Anteroposterior Neuroectodermal Fate in Human Embryonic Stem Cells
Spits, C. (Creator), Lei, Y. (Creator), Regin, M. (Creator), Krivec, N. (Creator), Huyghebaert, A. (Creator), Couvreu De Deckersberg, E. (Creator), Sermon, K. (Creator), Al Delbany, D. (Creator), Duong, C. M. (Creator) & Janssens, C. (Creator), VUB Institutional Data Repository, 10 okt. 2025
Dataset
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Complex aneuploidy triggers autophagy and p53-mediated apoptosis and impairs the second lineage segregation in human preimplantation embryos
Spits, C. (Creator), Regin, M. (Creator), Lei, Y. (Creator), Couvreu De Deckersberg, E. (Creator), Janssens, C. (Creator), Huyghebaert, A. (Creator), Guns, Y. (Creator), Verheyen, G. (Creator), Van De Velde, H. (Creator) & Sermon, K. (Creator), VUB Institutional Data Repository, 10 okt. 2025
Dataset
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SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss (OPEN)
Spits, C. (Creator), Lei, Y. (Creator), Al Delbany, D. (Creator), Krivec, N. (Creator), Regin, M. (Creator), Couvreu De Deckersberg, E. (Creator), Janssens, C. (Creator), Ghosh, M. (Creator) & Sermon, K. (Creator), VUB Institutional Data Repository, 10 okt. 2025
Dataset
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SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss (RESTRICTED)
Spits, C. (Creator), Lei, Y. (Creator), Al Delbany, D. (Creator), Krivec, N. (Creator), Regin, M. (Creator), Couvreu De Deckersberg, E. (Creator), Janssens, C. (Creator), Ghosh, M. (Creator) & Sermon, K. (Creator), VUB Institutional Data Repository, 10 okt. 2025
Dataset
Activiteiten
- 6 Talk or presentation at a conference
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Maternally inherited differences in mitochondrial DNA genotype between ART and spontaneously conceived individuals associate with low birthweight
Mertens, J. (Speaker), Belva, F. (Contributor), van Montfoort, A. P. (Contributor), Zambelli, F. (Contributor), Seneca, S. (Contributor), Couvreu De Deckersberg, E. (Contributor), Bonduelle, M.-L. (Contributor), Tournaye, H. (Contributor), Stouffs, K. (Contributor), Barbé, K. (Contributor), Smeets, H. J. M. (Contributor), Van De Velde, H. (Contributor), Sermon, K. (Contributor), Blockeel, C. (Contributor) & Spits, C. (Contributor)
30 jun. 2021Activiteit: Talk or presentation at a conference
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Mitochondrial DNA mosaicism in early human development
Mertens, J. (Speaker), Regin, M. (Contributor), De Munck, N. (Contributor), Couvreu De Deckersberg, E. (Contributor), Blockeel, C. (Contributor), Tournaye, H. (Contributor), Van De Velde, H. (Contributor), Sermon, K. (Contributor) & Spits, C. (Contributor)
17 sep. 2021Activiteit: Talk or presentation at a conference
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Aneuploidy induces proteotoxic stress and autophagy-mediated apoptosis in human preimplantation embryos
Regin, M. (Speaker), Couvreu De Deckersberg, E. (Contributor), Guns, Y. (Contributor), Verdyck, P. (Contributor), Verheyen, G. (Contributor), Van De Velde, H. (Contributor), Spits, C. (Contributor) & Sermon, K. (Contributor)
1 jul. 2021Activiteit: Talk or presentation at a conference
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Aneuploidy induces proteotoxic stress and autophagy-mediated apoptosis in human preimplantation embryos
Regin, M. (Speaker), Lei, Y. (Contributor), Couvreu De Deckersberg, E. (Contributor), Guns, Y. (Contributor), Verdyck, P. (Contributor), Verheyen, G. (Contributor), Van De Velde, H. (Contributor), Spits, C. (Contributor) & Sermon, K. (Contributor)
26 nov. 2021 → 27 nov. 2021Activiteit: Talk or presentation at a conference
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Maternally inherited differences in mitochondrial DNA genotype between ART and spontaneously conceived individuals are aggravated by controlled ovarian stimulation and link to low birth weight
Mertens, J. (Speaker), Belva, F. (Contributor), van Montfoort, A. P. (Contributor), Zambelli, F. (Contributor), Couvreu De Deckersberg, E. (Contributor), Bonduelle, M.-L. (Contributor), Tournaye, H. (Contributor), Stouffs, K. (Contributor), Seneca, S. (Contributor), Barbé, K. (Contributor), Smeets, H. J. M. (Contributor), Van De Velde, H. (Contributor), Sermon, K. (Contributor), Blockeel, C. (Contributor) & Spits, C. (Contributor)
28 nov. 2020Activiteit: Talk or presentation at a conference
Scriptie
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Impact of recurrent chromosome abnormalities on the transcriptome of human embryonic stem cells.
Couvreu De Deckersberg, E. ((PhD) Student) & Spits, C. (Promotor), Spits, C. (Promotor), 2018Scriptie/Masterproef: Master's Thesis