Projecten per jaar
Persoonlijk profiel
Expertise
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I was trained as a biomedical researcher at the Vrije Universiteit Brussel (VUB), and completed my PhD in 2006 in the Hematology and Immunology (HEIM) lab, headed by Prof. Vanderkerken on the role of chemokines in Multiple Myeloma. Thereafter, I performed a 1-year post-doctoral stay at the Weill Medical College of Cornell University (USA) at the lab of Prof. S. Chen-Kiang on the topic of cell cycle regulation in MM cells. In 2007, I returned to the HEIM lab to set-up my own research team. My team utilizes in-depth cancer biology techniques and has access to the 5TMM models, fully syngeneic in vivo models to investigate MM biology. The goal of my team is to identify novel mechanisms of myeloma development and drug resistance and translate these findings into novel therapeutic targets. Since 2015, I hold a Faculty Position (Research Professor) at the VUB.
My major contributions to the field include the characterization of how exosomal crosstalk is involved in MM pathobiology (8 papers with 1 Blood paper); identification of metabolic vulnerabilities in MM cells as novel therapeutic targets to treat MM patients (6 papers with the latest in Haematologica) and identifying NKT cells as an immunotherapeutic cell type in MM (4 papers, 1 Leukemia, 1 Haematologica).
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Eline Menu actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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ANI374: Targeting pro-tumoral exosomal exchanges with CD138-syntenin inhibitors : a novel therapeutic approach for Multiple Myeloma
1/01/24 → 31/12/27
Project: Fundamenteel
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SRP84: SRP-Onderzoekszwaartepunt: PACT: multi-omics Profilering van T-cellen om Adoptieve Cel Therapie te verbeteren
Vanderkerken, K., Breckpot, K. & Menu, E.
1/11/22 → 31/10/27
Project: Fundamenteel
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OZR3983: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - KU Leuven, TU Chenggong
7/07/22 → 6/07/26
Project: Fundamenteel
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OZR3593: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - NPU, WANG Fang
22/06/20 → 21/06/24
Project: Fundamenteel
Onderzoeksoutput
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Adrenergic signaling activates the tumor immune microenvironment in Multiple Myeloma
Satilmis, H., Verheye, E., Vandewalle, N., De Bruyne, E., Menu, E., Vanderkerken, K. & De Veirman, K., 1 feb 2024, (Unpublished).Onderzoeksoutput: Poster
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Adrenergic signaling activates the tumor immune microenvironment in Multiple Myeloma
Satilmis, H., Verheye, E., Vandewalle, N., De Bruyne, E., Menu, E., Vanderkerken, K. & De Veirman, K., 30 mei 2024, (Unpublished).Onderzoeksoutput: Poster
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AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia
Vandewalle, N., Satilmis, H., Verheye, E., Fan, R., Wang, Y., De Groof, T., Bridoux, J., kerre, T., De Beule, N., De Becker, A., De Bruyne, E., Menu, E., Vanderkerken, K., Breckpot, K., Devoogdt, N. & De Veirman, K., 15 apr 2024, In: Theranostics. 14, 7, blz. 2656-2674 19 blz.Onderzoeksoutput: Article › peer review
Open Access -
Fueling CARs: metabolic strategies to enhance CAR T-cell therapy
Van der Vreken, A., Vanderkerken, K., De Bruyne, E., De Veirman, K., Breckpot, K. & Menu, E., 10 jul 2024, In: Experimental Hematology and Oncology. 13, 1, 17 blz., 66.Onderzoeksoutput: Article › peer review
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Hypoxic bone marrow stromal cells secrete miR-140-5p and miR-28-3p target SPRED1 to confer drug resistance in multiple myeloma
Zhang, H., Du, Z., Tu, C., Zhou, X., Menu, E. & Wang, J., 2 jan 2024, In: Cancer Research. 84, 1, blz. 39-55 17 blz., 23-0189.Onderzoeksoutput: Article › peer review
Prijzen
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ASH abstract achievement award
Oudaert, Inge (Recipient) & Menu, Eline (Recipient), 9 dec 2022
Prijs: Prize (including medals and awards)
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ASH abstract achievement award
Oudaert, Inge (Recipient) & Menu, Eline (Recipient), 12 dec 2021
Prijs: Prize (including medals and awards)
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Best oral presentation
Oudaert, Inge (Recipient) & Menu, Eline (Recipient), 25 jun 2019
Prijs: National/international honour
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Best Oral Presentation - MOSA conference 2021
Janssens, E. M. (Recipient), De Beck, L. (Recipient), Verbeke, R. (Recipient), Lentacker, I. (Recipient), Dewitte, H. (Recipient), Menu, Eline (Recipient) & Breckpot, Karine (Recipient), 23 jun 2021
Prijs: Prize (including medals and awards)
Bestand
Activiteiten
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AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia
Niels Vandewalle (Presenter), Hatice Satilmis (Contributor), Emma Verheye (Contributor), Yanmeng Wang (Contributor), Timo De Groof (Contributor), Nathan De Beule (Contributor), Tessa kerre (Contributor), Nathan De Beule (Contributor), Ann De Becker (Contributor), Elke De Bruyne (Contributor), Eline Menu (Contributor), Karin Vanderkerken (Contributor), Karine Breckpot (Contributor), Nick Devoogdt (Contributor) & Kim De Veirman (Contributor)
12 mrt 2024Activiteit: Talk or presentation at a conference
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AXL targeting using Bemcentinib increases chemosensitivity in Acute Myeloid Leukemia
Niels Vandewalle (Speaker), Laura Meysman (Contributor), Nathan De Beule (Contributor), Ann De Becker (Contributor), Hatice Satilmis (Contributor), Emma Verheye (Contributor), Rong Fan (Contributor), Elke De Bruyne (Contributor), Eline Menu (Contributor), Karin Vanderkerken (Contributor), Karine Breckpot (Contributor), Nick Devoogdt (Contributor) & Kim De Veirman (Contributor)
3 feb 2023Activiteit: Talk or presentation at a conference
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TARGETING MONOCARBOXYLATE TRANSPORTER 4 REDUCES MYELOMA CELL VIABILITY IN VITRO
Inge Oudaert (Contributor), Eline Menu (Presenter) & Lauren Van Droogenbroeck (Presenter)
3 mrt 2021 → 6 mrt 2021Activiteit: Talk or presentation at a conference
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Targeting of pyrroline-5-carboxylate reductase (PYCR) reduces drug resistance in multiple myeloma in vitro.
Inge Oudaert (Speaker) & Eline Menu (Speaker)
29 jan 2021Activiteit: Talk or presentation at a conference
Bestand -
Targeting of pyrroline-5-carboxylate reductase (PYCR) reduces drug resistance in multiple myeloma in vitro.
Inge Oudaert (Speaker), Eline Menu (Contributor) & Kim De Veirman (Contributor)
29 jan 2021 → 30 jan 2021Activiteit: Talk or presentation at a conference