Persoonlijk profiel
Expertise
After I obtained my Master degree at Vrije Universiteit Brussels, faculty Medicine & Pharmacy, I was selected as a PhD candidate at the lab of Molecular Oncology under supervision of Prof. Dr. Ilse Rooman. Here I finished my master thesis, which was focused on pancreatic acinar dedifferentiation. Currently, I perform a PhD study aiming to establish patient-derived organoids as a reliable and efficient model to study fundamental biology of pancreatic cancer. Extensive tissue characterization and sequencing methods clarify whether these models are suitable to ensure patient identity.
My PhD project is sponsored by Innoser NV - a biomedical CRO service - located both in Belgium and The Netherlands. I am working on their PDXO project aiming to develop an innovative platform to test oncological drugs in a preclinical setting.
Opleiding / Academische kwalificatie
Pancreatic cancer, Masters degree, Dermining the role of a potential regulator of pancreatic acinar dedifferentiation in vivo, Vrije Universiteit Brussel
Datum van toekenning: 30 jun. 2019
Externe posities
Employee, Innoser NV
1 sep. 2019 → …
Vingerafdruk
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Projecten
- 1 Afgelopen
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ANI356: Ruimtelijke kartering van subtypes van pancreaskanker en hun micro-omgevingsniches
Rooman, I. (Administrative Promotor) & Michiels, E. (PI (Promotor, Principal Investigator))
1/11/23 → 31/10/24
Project: Fundamenteel
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AXL-Specific Single-Domain Antibodies: A Novel Diagnostic and Therapeutic Strategy in PDAC
Denis, A., Michiels, E., Baldan, J., Satilmis, H., Zhan, D., Vandewalle, N., De Bruyne, E., Menu, E., Vanderkerken, K., Breckpot, K., Devoogdt, N., Rooman, I. & De Veirman, K., 6 feb. 2026. 1 blz.Onderzoeksoutput: Poster
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Favorable histo-molecular remodeling of pancreatic ductal adenocarcinoma after neoadjuvant FOLFIRINOX followed by high-dose stereotactic body radiotherapy
Bouchart, C., Azurmendi Senar, O., Navez, J., Verset, L., Boisson, A., Hein, M., Stosic, K., Quertinmont, E., Tafciu, V., Zhao, S., Mas, L., D'Haene, N., Van Gestel, D., Moretti, L., Michiels, E., Rooman, I., Detours, V., Bachet, J.-B., Demetter, P. & Willard-Gallo, K. & 3 anderen, , 5 mrt. 2026, In: British Journal of Cancer. 134, 5, blz. 721-734 14 blz.Onderzoeksoutput: Article › peer review
Open Access -
Spatial map of native duct cell populations in human pancreas and their representation in pancreatic cancers
Van den Bossche, J.-L., Van der Vliet, M., Michiels, E., Azurmendi Senar, O., Madran, Z., Coolens, K., Van Lint, S., Nacher, M., Arsenijevic, T., Messaoudi, N., Lefesvre, P., Montanya, E., Rovira, M., Van Laethem, J.-L., Baldan, J., Houbracken, I. & Rooman, I., 19 jan. 2025, Biorxiv, 31 blz.Onderzoeksoutput: Voordruk
Open AccessBestand20 Downloads (Pure) -
Spatial Mapping of CD276 (B7-H3) in Pancreatic Ductal Adenocarcinoma indicates predominant Expression in Basal-like Tumor Ducts and αSMA⁺ Stromal Cells proximal to Tumor Epithelial Cells
De Man, V., Michiels, E., Brons, J., Espinet, E., Messaoudi, N., Olsen, C., Tuyaerts, S. & Rooman, I., 25 sep. 2025. 1 blz.Onderzoeksoutput: Poster
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Datasets
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Discovery and 3D imaging of a novel ΔNp63-expressing basal cell type in human pancreatic ducts with implications in disease
Rooman, I. (Creator), Michiels, E. (Creator) & Martens, S. (Creator), VUB Institutional Data Repository, 2025
Dataset
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Dataset for 'High-resolution and quantitative spatial analysis reveal intra-ductal phenotypic and functional diversification in pancreatic cancer'
Michiels, E. (Creator) & Rooman, I. (Creator), VUB Institutional Data Repository, 19 mrt. 2025
Dataset
Prijzen
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Best oral presentation award: In situ detection of KRAS(G12D) mutations in the spatial context of pancreatic cancer subtypes
Michiels, E. (Recipient), 11 okt. 2022
Prijs: Prize (including medals and awards)
Activiteiten
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Spatial map of native duct cell populations in human pancreas and their representation in pancreatic cancers
Van den Bossche, J.-L. (Invited speaker), Van der Vliet, M. (Contributor), Michiels, E. (Contributor), Azurmendi Senar, O. (Contributor), Madran, Z. H. (Contributor), Van Lint, S. (Contributor), Coolens, K. (Contributor), Nacher, M. (Contributor), Arsenijevic, T. (Contributor), Lefesvre, P. (Contributor), Rovira, M. (Contributor), Montanya, E. (Contributor), Laethem, Van, J.-L. (Contributor), Baldan, J. (Contributor), Houbracken, I. (Contributor) & Rooman, I. (Contributor)
14 jun. 2025Activiteit: Talk or presentation at a conference
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Spatial map of native duct cell populations in human pancreas and their representation in pancreatic cancers
Van den Bossche, J.-L. (Speaker), Van der Vliet, M. (Contributor), Michiels, E. (Contributor), Azurmendi Senar, O. (Contributor), Van Lint, S. (Contributor), Madran, Z. H. (Contributor), Coolens, K. (Contributor), Nacher, M. (Contributor), Arsenijevic, T. (Contributor), Lefesvre, P. (Contributor), Rovira, M. (Contributor), Montanya, E. (Contributor), Van Laethem, J.-L. (Contributor), Baldan, J. (Contributor), Houbracken, I. (Contributor) & Rooman, I. (Contributor)
4 jul. 2025Activiteit: Talk or presentation at a conference
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A newly identified basal-luminal stratification of human pancreatic ducts is differentially recapitulated in pancreatic cancers
Van den Bossche, J.-L. (Speaker), Van der Vliet, M. (Contributor), Michiels, E. (Contributor), Azurmendi Senar, O. (Contributor), Madran, Z. H. (Contributor), Van Lint, S. (Contributor), Coolens, K. (Speaker), Nacher, M. (Contributor), Arsenijevic, T. (Contributor), Lefesvre, P. (Contributor), Rovira, M. (Contributor), Montanya, E. (Contributor), Van Laethem, J.-L. (Contributor), Baldan, J. (Contributor), Houbracken, I. (Contributor) & Rooman, I. (Contributor)
23 okt. 2024Activiteit: Talk or presentation at a conference
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High resolution and quantitative intra-ductal spatial analysis reveals phenotypic and functional diversification in pancreatic cancer
Michiels, E. (Speaker), Rooman, I. (Contributor), Messaoudi, N. (Contributor), Madhloum, H. (Contributor), Van Lint, S. C. (Contributor), Giron, P. (Contributor), Olsen, C. (Contributor), Dusetti, N. (Contributor) & Van Laethem, J.-L. (Contributor)
30 apr. 2023Activiteit: Talk or presentation at a conference
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Doctoral Derby: The pre-selection trajectory
Michiels, E. (Participant)
1 mrt. 2022 → 31 mrt. 2022Activiteit: Participating in or organizing a public lecture/debate
Knipsels
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Setting up a PDXO platform of pancreatic cancer with spatial-omics characterization
27/09/21
1 Mediabijdrage
Pers / media: !!Public Engagement Activities
Scriptie
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MECOM as a transcriptional regulator of pancreatic acinar dedifferentiation
Michiels, E. ((PhD) Student), Rooman, I. (Promotor), 30 jun. 2019Scriptie/Masterproef: Master's Thesis