Onderzoeksoutput

Onderzoeksoutput per jaar 2005 2013 2014 2016 2017 2018 2019 2020 2021 2022

• 9008 Citaties
• 39 h-index
• 110 Article
• 16 Patent
• 9 Conference paper
• 8 Meeting abstract (Journal)
• 8 Meer
  • 3 Poster
  • 2 Meeting abstract (Book)
  • 1 Chapter
  • 1 Scientific review
  • 1 Other contribution

Onderzoeksoutput per jaar

Onderzoeksoutput per jaar

Zoekresultaten

• 2022

  Mapping inhibitory sites on the RNA polymerase of the 1918 pandemic influenza virus using nanobodies

  Keown, J. R., Zhu, Z., Carrique, L., Fan, H., Walker, A. P., Serna Martin, I., Pardon, E., Steyaert, J., Fodor, E. & Grimes, J. M., 11 jan 2022, In : Nature Communications. 13, 1, 11 blz., 251.

  Onderzoeksoutput: Article

  • influenza 100%
  • Single-Domain Antibodies 98%
  • viruses 77%
  • Viruses 76%
  • DNA-Directed RNA Polymerases 72%

• Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2

  Singh, R. K., Soliman, A., Guaitoli, G., Störmer, E., von Zweydorf, F., Dal Maso, T., Oun, A., Van Rillaer, L., Schmidt, S. H., Chatterjee, D., David, J. A., Pardon, E., Schwartz, T. U., Knapp, S., Kennedy, E. J., Steyaert, J., Herberg, F. W., Kortholt, A., Gloeckner, C. J. & Versées, W., 1 mrt 2022, In : Proceedings of the National Academy of Sciences of the United States of America. 119, 9, blz. 1-12 12 blz., e2112712119.

  Onderzoeksoutput: Article

  Open Access

  Bestand

  • Single-Domain Antibodies 100%
  • Leucine 67%
  • Parkinson Disease 55%
  • Phosphotransferases 51%
  • Adenosine Triphosphate 5%
  46 Downloads (Pure)

• Snapshots of actin and tubulin folding inside the TRiC chaperonin

  Kelly, J. J., Tranter, D., Pardon, E., Chi, G., Kramer, H., Happonen, L., Knee, K. M., Janz, J. M., Steyaert, J., Bulawa, C., Paavilainen, V. O., Huiskonen, J. T. & Yue, W. W., 21 apr 2022, In : Nature Structural & Molecular Biology. 29, blz. 420-429 10 blz.

  Onderzoeksoutput: Article

  • Chaperonins 100%
  • Tubulin 72%
  • Actins 57%
  • Cytoskeletal Proteins 40%
  • Protein Folding 39%

• Stabilization of Meta-I Rhodopsin Conformation by a Nanobody

  Salom, D., Wu, A., Sander, C. L., Pardon, E., Steyaert, J., Kiser, P. D. & Palczewski, K., 1 mei 2022, In : The FASEB Journal. 36, S1

  Onderzoeksoutput: Meeting abstract (Journal)

  • metarhodopsins 100%
  • Single-Domain Antibodies 85%
  • Rhodopsin 71%
  • Conformations 71%
  • Stabilization 47%

• Structural basis of sodium-dependent bile salt uptake into the liver

  Goutam, K., Ielasi, F. S., Pardon, E., Steyaert, J. & Reyes, N., 2022, In : Nature.

  Onderzoeksoutput: Article

  • Taurocholic Acid 100%
  • Bile Acids and Salts 80%
  • Sodium 64%
  • Peptides 49%
  • Liver 39%

• Structure, substrate recognition and initiation of hyaluronan synthase

  Maloney, F. P., Kuklewicz, J., Corey, R. A., Bi, Y., Ho, R., Mateusiak, L., Pardon, E., Steyaert, J., Stansfeld, P. J. & Zimmer, J., 7 apr 2022, In : Nature. 604, 7904, blz. 195-201 7 blz.

  Onderzoeksoutput: Article

  Bestand

  • Hyaluronan Synthases 100%
  • Hyaluronic Acid 67%
  • Polymers 22%
  • Glucuronic Acid 17%
  • Cryoelectron Microscopy 17%
  62 Downloads (Pure)
• 2021

  A topological switch in CFTR modulates channel activity and sensitivity to unfolding

  Scholl, D., Sigoillot, M., Overtus, M., Martinez, R. C., Martens, C., Wang, Y., Pardon, E., Laeremans, T., Garcia-Pino, A., Steyaert, J., Sheppard, D. N., Hendrix, J. & Govaerts, C., 2 aug 2021, In : Nature Chemical Biology. 17, 9, blz. 989-997 9 blz.

  Onderzoeksoutput: Article

  • Cystic Fibrosis Transmembrane Conductance Regulator 100%
  • Mutation 33%
  • Crystallography 28%
  • Fluorescence Resonance Energy Transfer 26%
  • Anions 21%
  2 Citaten (Scopus)

• Constructing and purifying megabodies starting from individual nanobody sequences

  Uchański, T., Fischer, B., Kalichuk, V., Wohlkönig, A., Zögg, T., Pardon, E. & Steyaert, J., 7 jan 2021, 11 blz.

  Onderzoeksoutput: Other contribution

• Development of a universal nanobody-binding Fab module for fiducial-assisted cryo-EM studies of membrane proteins

  Bloch, J. S., Mukherjee, S., Kowal, J., Filippova, E. V., Niederer, M., Pardon, E., Steyaert, J., Kossiakoff, A. A. & Locher, K. P., 23 nov 2021, In : Proceedings of the National Academy of Sciences of the United States of America. 118, 47, e2115435118.

  Onderzoeksoutput: Article

  • Single-Domain Antibodies 100%
  • Electron Microscopy 56%
  • Membrane Proteins 54%
  • New World Camelids 24%
  • Camelus 11%
  2 Citaten (Scopus)

• Dissecting lipid contents in the distinct regions of native retinal rod disk membranes

  Sander, C., Sears, A., Pinto, A., Choi, E., Kahremany, S., Pry, H., Pardon, E., Suh, S., Dong, Z., Steyaert, J., Saghatelian, A., Skowronska-Krawczyk, D., Kiser, P. & Palczewski, K., jun 2021, In : Investigative Ophthalmology & Visual Science. 62, 8

  Onderzoeksoutput: Meeting abstract (Journal)

• HDX-MS-optimized approach to characterize nanobodies as tools for biochemical and structural studies of class IB phosphoinositide 3-kinases

  Rathinaswamy, M. K., Fleming, K. D., Dalwadi, U., Pardon, E., Harris, N. J., Yip, C. K., Steyaert, J. & Burke, J. E., 2 dec 2021, In : Structure. 29, 12, blz. 1371-1381.e6 28 blz.

  Onderzoeksoutput: Article

  Open Access

  • Single-Domain Antibodies 100%
  • Deuterium 91%
  • Hydrogen 72%
  • Phosphatidylinositol 3-Kinase 67%
  • Phosphatidylinositol 3-Kinases 66%

• In Vivo and In Vitro Characterizations of Nanobodies Raised Against the Melibiose Permease melB of Salmonella Typhimurium

  Katsube, S., Willibal, K., Tikhonova, E. B., Parameswaran, H., Vemulapally, S., Pardon, E., Kaback, H. R., Steyaert, J. & Guan, L., 12 feb 2021, In : Biophysical journal. 120, 3, blz. 74A-74A

  Onderzoeksoutput: Meeting abstract (Journal)

• Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM

  Uchański, T., Masiulis, S., Fischer, B., Kalichuk, V., López-Sánchez, U., Zarkadas, E., Weckener, M., Sente, A., Ward, P., Wohlkönig, A., Zögg, T., Remaut, H., Naismith, J. H., Nury, H., Vranken, W., Aricescu, A. R., Pardon, E. & Steyaert, J., jan 2021, In : Nature Methods. 18, 1, blz. 60-68 9 blz.

  Onderzoeksoutput: Article

  • Single-Domain Antibodies 100%
  • Scaffolds 39%
  • Cryoelectron Microscopy 30%
  • Immunoglobulin Domains 28%
  • Proteins 24%
  25 Citaten (Scopus)

• Nanobody-aided crystallization of the transcription regulator PaaR2 from Escherichia coli O157:H7

  De Bruyn, P., Prolic Kalinsek, M., Vandervelde, A., Malfait, M., Sterckx, Y., Sobott, F., Hadzi, S., Pardon, E., Steyaert, J. & Loris, R., 1 okt 2021, In : Acta Crystallographica Section F - Structural Biology Communications. 77, 10, blz. 374-384 11 blz., 11.

  Onderzoeksoutput: Article

  Open Access

  Bestand

  • Single-Domain Antibodies 100%
  • regulators 84%
  • Escherichia coli O157 84%
  • Escherichia coli 83%
  • Crystallization 80%
  10 Downloads (Pure)

• Nanobody exchange chromatography

  Steyaert, J., Pardon, E., Wohlkönig, A., Zögg, T., Kalichuk, V., De Keyser, P. & Fischer, B., 24 jun 2021, Octrooi Nr. WO2021123360A1, 18 dec 2020, Prioriteitsdatum 20 dec 2019, Prioriteitsnummer EP19219043

  Onderzoeksoutput: Patent

  • Single-Domain Antibodies 100%
  • Chromatography 89%
  • Protein Binding 54%
  • Purification 24%
  • Immunoglobulins 19%

• Nano-scale resolution of native retinal rod disk membranes reveals differences in lipid composition

  Sander, C. L., Sears, A. E., Pinto, A. F. M., Choi, E. H., Kahremany, S., Gao, F., Salom, D., Jin, H., Pardon, E., Suh, S., Dong, Z., Steyaert, J., Saghatelian, A., Skowronska-Krawczyk, D., Kiser, P. D. & Palczewski, K., 2 aug 2021, In : The Journal of Cell Biology. 220, 8, e20210106.

  Onderzoeksoutput: Article

  • Retinal Rod Photoreceptor Cells 100%
  • Lipids 49%
  • Membranes 44%
  • Membrane Proteins 24%
  • Rhodopsin 19%
  8 Citaten (Scopus)

• New insights into molecular mechanism of signaling by endocrine FGFs

  Kuzina, E., Ung, P., Mohanty, J., Tome, F., Choi, J., Pardon, E., Steyaert, J., Lax, I., Schlessinger, A. S., Schlessinger, J. & Lee, S., jul 2021, In : FEBS Open Bio. 11, blz. 217-217

  Onderzoeksoutput: Meeting abstract (Journal)

• Positive allosteric modulators of the calcium-sensing receptor

  Steyaert, J., Pardon, E., Wohlkönig, A., Zögg, T., Mos, I., BRÄUNER-OSBORNE, H. & MOSOLFF MATHIESEN, J., 3 jun 2021, Octrooi Nr. WO2021105438A1, 27 nov 2020, Prioriteitsdatum 27 nov 2019, Prioriteitsnummer EP19211709

  Onderzoeksoutput: Patent

  • Calcium-Sensing Receptors 100%
  • Modulators 76%
  • Immunoglobulins 44%
  • Immunoglobulin Fragments 32%
  • Patents and inventions 29%

• Structure, mechanism, and inhibition of Hedgehog acyltransferase

  Coupland, C. E., Andrei, S. A., Ansell, T. B., Carrique, L., Kumar, P., Sefer, L., Schwab, R. A., Byrne, E. F. X., Pardon, E., Steyaert, J., Magee, A. I., Lanyon-Hogg, T., Sansom, M. S. P., Tate, E. W. & Siebold, C., 9 dec 2021, In : Molecular Cell. 81, 24, blz. 5025-5038 14 blz., 5038.e10.

  Onderzoeksoutput: Article

  Open Access

  Bestand

  • Acyltransferases 100%
  • Hedgehog Proteins 38%
  • Membranes 17%
  • Inosine Monophosphate 13%
  • Coenzyme A 12%
  2 Downloads (Pure)

• Structure of autoinhibited Akt1 reveals mechanism of PIP3-mediated activation

  Truebestein, L., Hornegger, H., Anrather, D., Hartl, M., Fleming, K. D., Stariha, J. T. B., Pardon, E., Steyaert, J., Burke, J. E. & Leonard, T. A., 17 aug 2021, In : Proceedings of the National Academy of Sciences of the United States of America. 118, 33, 11 blz., e2101496118.

  Onderzoeksoutput: Article

  Open Access

  • phosphoinositide-3,4-bisphosphate 100%
  • phosphoinositide-3,4,5-triphosphate 94%
  • Pleckstrin Homology Domains 75%
  • Phosphotransferases 63%
  • Phosphorylation 56%
  5 Citaten (Scopus)

• Structure of the phosphoinositide 3-kinase (PI3K) p110γ-p101 complex reveals molecular mechanism of GPCR activation

  Rathinaswamy, M. K., Dalwadi, U., Fleming, K. D., Adams, C., Stariha, J. T. B., Pardon, E., Baek, M., Vadas, O., DiMaio, F., Steyaert, J., Hansen, S. D., Yip, C. K. & Burke, J. E., aug 2021, In : Science Advances. 7, 35, eabj4282.

  Onderzoeksoutput: Article

  Open Access

  • Phosphatidylinositol 3-Kinase 100%
  • Catalytic Domain 35%
  • Single-Domain Antibodies 29%
  • Cryoelectron Microscopy 27%
  • G-Protein-Coupled Receptors 19%
  4 Citaten (Scopus)
• 2020

  Allosteric modulation of the GTPase activity of a bacterial LRRK2 homolog by conformation-specific Nanobodies

  Leemans, M., Galicia, C., Deyaert, E., Daems, E., Krause, L., Paesmans, J., Pardon, E., Steyaert, J., Kortholt, A., Sobott, F., Klostermeier, D. & Versees, W., apr 2020, In : Biochemical Journal. 477, 7, blz. 1203-1218 16 blz.

  Onderzoeksoutput: Article

  Open Access

  Bestand
  6 Citaten (Scopus)

  49 Downloads (Pure)

• A structure of substrate-bound Synaptojanin1 provides new insights in its mechanism and the effect of disease mutations

  Paesmans, J., Martin, E., Deckers, B., Berghmans, M., Sethi, R., Loeys, Y., Pardon, E., Steyaert, J., Verstreken, P., Galicia, C. & Versées, W., 22 dec 2020, In : eLife. 9, blz. 1-27 27 blz., e64922.

  Onderzoeksoutput: Article

  Open Access

  Bestand

  • synaptojanin 100%
  • Substrates 40%
  • Mutation 32%
  • Catalysis 30%
  • Phosphoric Monoester Hydrolases 23%
  1 Citaat (Scopus)

  51 Downloads (Pure)

• Cystic fibrosis transmembrane conductance regulator stabilizing agents

  Steyaert, J., Pardon, E., Laeremans, T., Govaerts, C., Grodecka, M., Sigoillot, M., Overtus, M., CARLON, M. S. & ENSINCK, M., 5 nov 2020, Octrooi Nr. WO2020221888A1

  Onderzoeksoutput: Patent

  • Cystic Fibrosis Transmembrane Conductance Regulator 100%
  • Excipients 93%
  • Cystic Fibrosis 19%
  • Immunoglobulins 17%
  • Nucleotides 16%

• Diversity in kinetics correlated with structure in nano body-stabilized LacY

  Kumar, H., Finer-Moore, J., Smirnova, I., Kasho, V., Pardon, E., Steyaert, J., Kaback, H. R. & Stroud, R. M., mei 2020, In : PLOS ONE. 15, 5, 14 blz., e0232846.

  Onderzoeksoutput: Article

  Open Access

  • Single-Domain Antibodies 100%
  • Kinetics 47%
  • Galactosides 18%
  • lactose permease 10%
  • Symporters 8%
  2 Citaten (Scopus)

• Fusion proteins comprising a cytokine and scaffold protein

  Steyaert, J., Pardon, E., Vranken, W., Uchanski, T., Wohlkönig, A., Kalichuk, V., Chevigné, A. & Szpakowska, M., 25 jun 2020, Octrooi Nr. WO2020127983A1

  Onderzoeksoutput: Patent

  • Cytokines 100%
  • Proteins 59%
  • X Ray Crystallography 36%
  • Preclinical Drug Evaluations 32%
  • Drug Design 31%

• Fusion protein with a toxin and scaffold protein

  Steyaert, J., Pardon, E. & Vranken, W., 25 jun 2020

  Onderzoeksoutput: Patent

  • Proteins 100%
  • X Ray Crystallography 93%
  • Preclinical Drug Evaluations 81%
  • Drug Design 78%
  • Drug Discovery 70%

• In vitro reconstitution of dynamically interacting integral membrane subunits of energy-coupling factor transporters

  Setyawati, I., Stanek, W. K., Majsnerowska, M., Swier, L. J. Y. M., Pardon, E., Steyaert, J., Guskov, A. & Slotboom, D. J., 22 dec 2020, In : eLife. 9, blz. 1-21 21 blz., e64389.

  Onderzoeksoutput: Article

  Open Access

  Bestand

  • Folic Acid Transporters 100%
  • Membranes 94%
  • proteoliposomes 83%
  • Kinetics 81%
  • Substrates 79%
  5 Citaten (Scopus)

  49 Downloads (Pure)

• Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies

  Gormal, R. S., Padmanabhan, P., Kasula, R., Bademosi, A. T., Coakley, S., Giacomotto, J., Blum, A., Joensuu, M., Wallis, T. P., Lo, H. P., Budnar, S., Rae, J., Ferguson, C., Bastiani, M., Thomas, W. G., Pardon, E., Steyaert, J., Yap, A. S., Goodhill, G. J., Hilliard, M. A. & 2 anderen, Parton, R. G. & Meunier, F. A., 1 dec 2020, In : Proceedings of the National Academy of Sciences of the United States of America. 117, 48, blz. 30476-30487 12 blz.

  Onderzoeksoutput: Article

  Open Access

  • Single-Domain Antibodies 100%
  • Adrenergic Receptors 62%
  • Proteins 24%
  • Single Molecule Imaging 20%
  • Dynamins 17%
  11 Citaten (Scopus)

• Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site

  Brams, M., Govaerts, C., Kambara, K., Price, K. L., Spurny, R., Gharpure, A., Pardon, E., Evans, G. L., Bertrand, D., Lummis, S. C., Hibbs, R. E., Steyaert, J. & Ulens, C., 28 jan 2020, In : eLife. 9, e51511.

  Onderzoeksoutput: Article

  Open Access

  • Erwinia 100%
  • Ligand-Gated Ion Channels 82%
  • Receptors, Serotonin, 5-HT3 81%
  • Single-Domain Antibodies 54%
  • Modulators 48%
  2 Citaten (Scopus)

• Nanobodies to study protein conformational states

  Uchański, T., Pardon, E. & Steyaert, J., feb 2020, In : Current Opinion in Structural Biology. 60, blz. 117-123 7 blz.

  Onderzoeksoutput: Scientific review

  • Single-Domain Antibodies 100%
  • Proteins 24%
  • Spatio-Temporal Analysis 19%
  • X Ray Crystallography 18%
  • Biosensing Techniques 16%
  23 Citaten (Scopus)

• Nanobody-enabled monitoring of kappa opioid receptor states

  Che, T., English, J., Krumm, B. E., Kim, K., Pardon, E., Olsen, R. H. J., Wang, S., Zhang, S., Diberto, J. F., Sciaky, N., Carroll, F. I., Steyaert, J., Wacker, D. & Roth, B. L., 1 dec 2020, In : Nature Communications. 11, 1, blz. 1145 12 blz., 1145.

  Onderzoeksoutput: Article

  Open Access
  45 Citaten (Scopus)

• The G-Protein Rab5A Activates VPS34 Complex II, a Class III PI3K, by a Dual Regulatory Mechanism

  Buckles, T. C., Ohashi, Y., Tremel, S., McLaughlin, S. H., Pardon, E., Steyaert, J., Gordon, M. T., Williams, R. L. & Falke, J. J., 1 dec 2020, In : Biophysical Journal. 119, 11, blz. 2205-2218 13 blz.

  Onderzoeksoutput: Article

  Open Access

  • Class III Phosphatidylinositol 3-Kinases 100%
  • phosphatidylinositol 3-phosphate 62%
  • GTP-Binding Proteins 55%
  • Membranes 33%
  • Phosphotransferases 30%
  5 Citaten (Scopus)
• 2019

  A lipid site shapes the agonist response of a pentameric ligand-gated ion channel

  Hénault, C. M., Govaerts, C., Spurny, R., Brams, M., Estrada-Mondragon, A., Lynch, J., Bertrand, D., Pardon, E., Evans, G. L., Woods, K., Elberson, B. W., Cuello, L. G., Brannigan, G., Nury, H., Steyaert, J., Baenziger, J. E. & Ulens, C., 7 okt 2019, In : Nature Chemical Biology. 15, 12, blz. 1156–1164 9 blz.

  Onderzoeksoutput: Article

  • Ligand-Gated Ion Channels 100%
  • Erwinia 72%
  • Lipids 48%
  • Phospholipids 39%
  • Glycine Receptors 20%
  23 Citaten (Scopus)

• An improved yeast surface display platform for the screening of nanobody immune libraries

  Uchański, T., Zögg, T., Yin, J., Yuan, D., Wohlkönig, A., Fischer, B., Rosenbaum, D. M., Kobilka, B. K., Pardon, E. & Steyaert, J., 23 jan 2019, In : Scientific Reports - Nature. 9, 1, blz. 1-12 12 blz., 382.

  Onderzoeksoutput: Article

  Open Access

  Bestand

  • Single-Domain Antibodies 100%
  • Libraries 59%
  • Yeasts 53%
  • Acyl Carrier Protein 14%
  • Antigens 11%
  32 Citaten (Scopus)

  420 Downloads (Pure)

• Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer

  Laverty, D., Desai, R., Uchanski, T., Masiulis, S., Stec, W. J., Malinauskas, T., Zivanov, J., Pardon, E., Steyaert, J., Miller, K. W. & Aricescu, A. R., 24 jan 2019, In : Nature. 565, 7740, blz. 516-520 5 blz.

  Onderzoeksoutput: Article

  • Lipid Bilayers 100%
  • GABA-A Receptors 92%
  • Cryoelectron Microscopy 46%
  • Ligand-Gated Ion Channels 46%
  • Synaptic Transmission 31%
  152 Citaten (Scopus)

• Domain-interface dynamics of CFTR revealed by stabilizing nanobodies

  Sigoillot, M., Overtus, M., Grodecka, M., Scholl, D., Garcia-Pino, A., Laeremans, T., He, L., Pardon, E., Hildebrandt, E., Urbatsch, I., Steyaert, J., Riordan, J. R. & Govaerts, C., 14 jun 2019, In : Nature Communications. 10, 1, 12 blz., 2636.

  Onderzoeksoutput: Article

  Open Access

  • cystic fibrosis 100%
  • Single-Domain Antibodies 84%
  • regulators 71%
  • Cystic Fibrosis Transmembrane Conductance Regulator 70%
  • Cystic Fibrosis 27%
  15 Citaten (Scopus)

• GABAA receptor signalling mechanisms revealed by structural pharmacology

  Masiulis, S., Desai, R., Uchanski, T., Serna Martin, I., Laverty, D., Karia, D., Malinauskas, T., Zivanov, J., Pardon, E., Kotecha, A., Steyaert, J., Miller, K. W. & Aricescu, A. R., 24 jan 2019, In : Nature. 565, 7740, blz. 454-459 6 blz.

  Onderzoeksoutput: Article

  • GABA-A Receptors 100%
  • Pharmacology 61%
  • Benzodiazepines 37%
  • Aminobutyrates 26%
  • Alprazolam 25%
  212 Citaten (Scopus)

• Gβγ COMPLEX ANTIBODIES AND USES THEREOF

  Steyaert, J., Pardon, E., Palczewski, K. & Gulati, S., 15 aug 2019, Octrooi Nr. WO2019155041A1, 11 feb 2019, Prioriteitsdatum 12 okt 2019, Prioriteitsnummer US201862629314P

  Onderzoeksoutput: Patent

  • Immunoglobulin Fragments 100%
  • Patents and inventions 68%
  • Antibodies 64%
  • Dimers 29%
  • Heterotrimeric GTP-Binding Proteins 26%

• Interrogating dense ligand chemical space with a forward-synthetic library

  Chevillard, F., Stotani, S., Karawajczyk, A., Hristeva, S., Pardon, E., Steyaert, J., Tzalis, D. & Kolb, P., 4 jun 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 23, blz. 11496-11501 6 blz.

  Onderzoeksoutput: Article

  Open Access
  12 Citaten (Scopus)

• L amino acid transporter structure and molecular bases for the asymmetry of substrate interaction

  Errasti-Murugarren, E., Fort, J., Bartoccioni, P., Díaz, L., Pardon, E., Carpena, X., Espino-Guarch, M., Zorzano, A., Ziegler, C., Steyaert, J., Fernández-Recio, J., Fita, I. & Palacín, M., 18 apr 2019, In : Nature Communications. 10, 1, 12 blz., 1807.

  Onderzoeksoutput: Article

  Open Access

  • transporter 100%
  • Amino Acid Transport Systems 95%
  • Molecular Structure 84%
  • amino acids 80%
  • Alanine 70%
  25 Citaten (Scopus)

• Muscarinic acetylcholine receptor binding agents and uses thereof

  Steyaert, J., Pardon, E., Kobilka, B. K., Ring, A., Kruse, A. & Manglik, A., 10 jul 2019, IPC-nummer C07K16/28, EPO, Octrooi Nr. EP2953973B, 5 feb 2014, Prioriteitsdatum 5 feb 2013, Prioriteitsnummer 61/961058

  Onderzoeksoutput: Patent

  • X Ray Crystallography 100%
  • Drug Design 84%
  • Muscarinic Receptors 79%
  • Drug Discovery 75%
  • Therapeutics 12%

• Novel Antigen-Binding Chimeric Proteins and Methods and Uses Thereof

  Steyaert, J., Pardon, E., Uchanski, T. & Vranken, W., 9 mei 2019, Octrooi Nr. CA3076791A1, 31 okt 2018, Prioriteitsdatum 31 okt 2017, Prioriteitsnummer EP17199472

  Onderzoeksoutput: Patent

  • Carrier Proteins 100%
  • X Ray Crystallography 81%
  • Immunoglobulin Domains 77%
  • Antigens 74%
  • Diagnostic Imaging 61%

• Protein binding domains stabilizing functional conformational states of gpcrs and uses thereof

  Steyaert, J., Pardon, E., Rasmussen, S. G. F., Fung, J. J., Kobilka, B. K. & Laeremans, T., 13 nov 2019, IPC-nummer C07K14/705, G01N33/543, G01N33/566, G01N33/68, Octrooi Nr. EP2593792B, 18 jul 2011, Prioriteitsdatum 16 jul 2010, Prioriteitsnummer US61/399781

  Onderzoeksoutput: Patent

  • Protein Domains 100%
  • G-Protein-Coupled Receptors 99%
  • Protein Binding 98%
  • Drug Discovery 17%
  • Ligands 11%

• Structural evidence for the critical role of the prion protein hydrophobic region in forming an infectious prion

  Abskharon, R., Wang, F., Wohlkonig, A., Ruan, J., Soror, S., Giachin, G., Pardon, E., Zou, W., Legname, G., Ma, J. & Steyaert, J., 9 dec 2019, In : PLoS Pathogens. 15, 12, blz. e1008139 e1008139.

  Onderzoeksoutput: Article

  Open Access

  Bestand

  • Prions 100%
  • Prion Proteins 98%
  • Prion Diseases 33%
  • Mouse Prnp protein 22%
  • Single-Domain Antibodies 20%
  11 Citaten (Scopus)

  26 Downloads (Pure)

• Structure of Prototypic Peptide Transporter DtpA from E. coli in Complex with Valganciclovir Provides Insights into Drug Binding of Human PepT1

  Ural-Blimke, Y., Flayhan, A., Strauss, J., Rantos, V., Bartels, K., Nielsen, R., Pardon, E., Steyaert, J., Kosinski, J., Quistgaard, E. M. & Löw, C., 15 jan 2019, In : Journal of the American Chemical Society. 141, 6, blz. 2404–2412 9 blz.

  Onderzoeksoutput: Article

  Open Access

  • Valganciclovir 100%
  • peptide permease 99%
  • Ligands 85%
  • Peptides 84%
  • Escherichia coli 81%
  19 Citaten (Scopus)

• Structure of S-layer protein Sap reveals a mechanism for therapeutic intervention in anthrax

  Fioravanti, A., Van Hauwermeiren, F., Van der Verren, S. E., Jonckheere, W., Goncalves, A., Pardon, E., Steyaert, J., De Greve, H., Lamkanfi, M. & Remaut, H., nov 2019, In : Nature Microbiology. 4, 11, blz. 1805–1814 10 blz.

  Onderzoeksoutput: Article

  • S-layer proteins 100%
  • Anthrax 86%
  • Single-Domain Antibodies 76%
  • Bacillus anthracis 52%
  • Bacterial Spores 20%
  12 Citaten (Scopus)

• Structures of influenza A virus RNA polymerase offer insight into viral genome replication

  Fan, H., Walker, A. P., Carrique, L., Keown, J. R., Serna Martin, I., Karia, D., Sharps, J., Hengrung, N., Pardon, E., Steyaert, J., Grimes, J. M. & Fodor, E., 12 sep 2019, In : Nature. 537, blz. 287-290 4 blz.

  Onderzoeksoutput: Article

  • Viral Genome 100%
  • DNA-Directed RNA Polymerases 97%
  • Influenza A virus 96%
  • Viral RNA 95%
  • Complementary RNA 76%
  67 Citaten (Scopus)

• Structures of ligand-occupied β-Klotho complexes reveal a molecular mechanism underlying endocrine FGF specificity and activity

  Kuzina, E. S., Ung, P. M-U., Mohanty, J., Tome, F., Choi, J., Pardon, E., Steyaert, J., Lax, I., Schlessinger, A., Schlessinger, J. & Lee, S., 16 apr 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 16, blz. 7819-7824 6 blz.

  Onderzoeksoutput: Article

  Open Access

  • Fibroblast Growth Factors 100%
  • klotho protein 92%
  • fibroblast growth factor 21 81%
  • Ligands 58%
  • Fibroblast Growth Factor Receptors 35%
  16 Citaten (Scopus)

• The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier

  Ruprecht, J. J., King, M. S., Zögg, T., Aleksandrova, A. A., Pardon, E., Crichton, P. G., Steyaert, J. & Kunji, E. R. S., 24 jan 2019, In : Cell. 176, 3, blz. 435-447.e15 13 blz.

  Onderzoeksoutput: Article

  Open Access

  • ATP Translocases Mitochondrial ADP 100%
  • Adenosine Triphosphate 50%
  • Adenosine Diphosphate 42%
  • Bongkrekic Acid 37%
  • Binding Sites 33%
  119 Citaten (Scopus)