!!Projects per year
Persoonlijk profiel
Opleiding / Academische kwalificatie
Biology / Toxicology, PhD, Detection and identification of cytogenetic changes during the preneoplastic stages of experimental hepatocarcinogenesis, Vrije Universiteit Brussel
1 jan. 1991 → 30 sep. 1995
Externe posities
Scientific Director - Fellow, Janssen Research and Development
1 okt. 1996 → 30 jun. 2023
Vingerafdruk
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
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IOF3035: B-LIVER 2.0 (Brusselse Alliantie voor Leveronderzoek & Valorisatie)
Vanhaecke, T. (Administrative Promotor), van Grunsven, L. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Vinken, M. (CoI (Co-Promotor)), Reynaert, H. (CoI (Co-Promotor)) & Van Goethem, F. (Mandataris)
1/01/25 → 31/12/29
Project: Toegepast
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IOF3013: GEAR: Brusselse Alliantie voor de Valorisatie van Leveronderzoek (B-Liver): Valorisatie van de levercelbiologie en toxicologie-expertise aan de VUB via een consortium gericht op levertherapie, patiënt- en consumentenveiligheid
Vanhaecke, T. (Administrative Promotor), van Grunsven, L. (Co-Promoter), De Kock, J. (Co-Promoter), Vinken, M. (Co-Promoter), Reynaert, H. (Co-Promoter), Van der Eycken, W. (Mandataris), Van Goethem, F. (Mandataris) & Fernando, R. (Mandataris)
1/01/20 → 1/07/25
Project: Toegepast
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Human stem cell-derived hepatic cells recapitulate polygenic risk in MASLD development and highlight CD36 as a key mediator
Gatzios, A., Stinckens, M., Verhoeven, A., Rombaut, M., De Win, D., Heymans, A., Loosen, A., Van Goethem, F., De Kock, J., Rodrigues, R., Boeckmans, J. & Vanhaecke, T., 1 okt. 2026, In: Life Sciences. 402, 16 blz., 124587.Onderzoeksoutput: Article › peer review
Open Access -
Advancing Genotoxicity Assessment by Building a Global AOP Network
Demuynck, E., Vanhaecke, T., Van Goethem, F., Mertens, B., Thienpont, A., Cappoen, D., Winkelman, L. M. T., Beltman, J., Murugadoss, S., Olsen, A.-K., Marcon, F., Bossa, C., Shaikh, S. M., Nikolopoulou, D., Hatzi, V. I., Pennings, J., Luijten, M., Adam‐Guillermin, C., Paparella, M. & Audebert, M., aug. 2025, In: Environmental and Molecular Mutagenesis. 66, 6-7, blz. 341-366 26 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand4 Citaten (Scopus)3 Downloads (Pure) -
In vitro models for gonadal and placental toxicity: A review and industry survey
Silva, S. M., Cruchten, S. V., Goethem, F. V., Vanhaecke, T., Goossens, E. & Baert, Y., 2025, In: NAM Journal. 1, blz. 1-18 18 blz., 100052.Onderzoeksoutput: Article › peer review
Open AccessBestand2 Downloads (Pure) -
In vitro to in vivo extrapolation modeling to facilitate the integration of transcriptomics data into genotoxicity assessment
Thienpont, A., Cho, E., Williams, A., Meier, M. J., Yauk, C. L., Beal, M. A., Van Goethem, F., Rogiers, V., Vanhaecke, T. & Mertens, B., aug. 2025, In: Toxicology. 515, blz. 1-14 14 blz., 154165.Onderzoeksoutput: Article › peer review
Open AccessBestand2 Citaten (Scopus)15 Downloads (Pure) -
Next Generation Risk Assessment (NGRA) Of Hair Dye HC Yellow No. 13: Ensuring Protection From Liver Steatogenic Effects
Sepehri, S., Cooreman, A., Van Goethem, F., Rodrigues, R., Rogiers, V. & Vanhaecke, T., 31 aug. 2025, (Unpublished). 1 blz.Onderzoeksoutput: Poster
Datasets
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Data: Optimization of the drug-induced cholestasis index based on advanced modeling for predicting liver toxicity
Drees, A. (Creator), Nassiri, V. (Creator), Tabernilla, A. (Editor), Serroyen, J. (Editor), Gustin, E. (Editor), dos Santos Rodrigues, B. (Editor), Moss, D. M. (Editor), De Smedt, A. (Project Manager), Vinken, M. (Supervisor), Van Goethem, F. (Supervisor) & Sanz-Serrano, J. (Creator), Zenodo, 24 mrt. 2025
DOI: 10.5281/zenodo.14699512, https://zenodo.org/records/14699512
Dataset
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BRBseq of human skin-derived precursor hepatic progenitor-like cells with varying polygenic risk score for hepatic fat content exposed in vitro to vehicle-matched control medium or triggers related to MASH
Gatzios, A. (Creator), Vanhaecke, T. (Creator), Stinckens, M. (Creator), Verhoeven, A. (Creator), Rombaut, M. (Creator), De Win, D. (Creator), Heymans, A. (Creator), Loosen, A. (Creator), Van Goethem, F. (Creator), De Kock, J. (Creator), Rodrigues, R. (Creator) & Boeckmans, J. (Creator), VUB Institutional Data Repository, 14 aug. 2026
Dataset
Activiteiten
- 1 Talk or presentation at a workshop/seminar
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Optimization of the drug-induced cholestasis index based on advanced modeling for predicting liver toxicity
Drees, A. H. (Speaker), Nassiri, V. (Contributor), Tabernilla Garcia, A. (Contributor), Serroyen, J. (Contributor), Gustin, E. (Contributor), dos Santos Rodrigues, B. (Contributor), Moss, D. M. (Contributor), De Smedt, A. (Contributor), Vinken, M. (Contributor), Van Goethem, F. (Contributor) & Sanz Serrano, J. (Contributor)
15 mei 2025Activiteit: Talk or presentation at a workshop/seminar