Projecten per jaar
Persoonlijk profiel
Expertise
neurofarmacologie
Expertise
neurowetenschappen
Expertise
geneesmiddelenkennis
Expertise
Ilse Smolders (PhD in Pharmaceutical Sciences, full professor, ‘gewoon hoogleraar’) is attached to the VUB Faculty of Medicine and Pharmacy. Being a Pharmacist, she has huge interest in pharmacology and drug discovery, and her main teaching duties are situated within that field of expertise. She is responsible for teaching courses to Medical, Biomedical, Pharmacy and Psychology students. She is head of the Laboratory of Pharmaceutical Chemistry, Drug Analysis and Drug Information, and chair of the Department of Pharmaceutical Sciences. The research expertise of Ilse Smolders lies in the domain of neuroscience and pharmacology. She has expertise with rodent models of seizures, epilepsy, and epilepsy co-morbidities such as cognitive decline, anxiety and depression, as well as with in vivo monitoring of neurotransmitters, gliotransmitters and neuropeptides, ex vivo analysis of rodent brain, slice electrophysiology, and more recently, in vitro culture models. Available techniques in the lab are telemetry-based 24h-electroencephalographic (EEG) monitoring for rodents, and a wide range of behavioral paradigms for measuring epilepsy-related behavior, cognitive decline, locomotor, anxiety and depressive-like behaviors in rodents. In vivo microdialysis in rodents is used, and miniaturized analytical developments for targeted analysis of the dialysates are always ongoing and optimised. Novel state-of-the art technologies such as chemogenetics, optogenetics and untargeted metabolomics were recently introduced in the team.
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Ilse Smolders actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Netwerk
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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FWOTM1061: Chemogenetische modulatie van CX3CR1+ cellen in een muismodel voor farmacoresistente limbische epilepsie.
1/11/21 → 31/10/23
Project: Fundamenteel
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OZR3528: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UAntwerpen, NOUS Amber
5/03/20 → 4/03/24
Project: Fundamenteel
Onderzoeksoutput
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Chemogenetic modulation of astrocytes and microglia: State‐of‐the‐art and implications in neuroscience
Bossuyt, J., Herrewegen, Y. V. D., Nestor, L., Buckinx, A., Bundel, D. D. & Smolders, I., 24 mei 2023, In: Glia. 71, 7, 25 blz., 24390.Onderzoeksoutput: Article › peer review
Open AccessBestand2 Downloads (Pure) -
Epileptiforme activiteit bij de ziekte van Alzheimer
Nous, A., Vande Vyver, M. & Smolders, I., 15 mrt 2023, In: Epilepsie, Periodiek voor Professionals. 22, 1, blz. 13-17 5 blz.Onderzoeksoutput: Letter › peer review
Open Access -
Improving the LC-MS/MS analysis of neuromedin U-8 and neuromedin S by minimizing their adsorption behavior and optimizing UHPLC and MS parameters
Bongaerts, J., De Bundel, D., Smolders, I., Mangelings, D., Vander Heyden, Y. & Van Eeckhaut, A., 10 mei 2023, In: Journal of Pharmaceutical and Biomedical Analysis. 228, 11 blz., 115306.Onderzoeksoutput: Article › peer review
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An Alzheimer’s disease mouse model, with increases in both soluble Aβ1-42 and tau, is more susceptible to induced seizures
Vande Vyver, M., Barker-Haliski, M., Aourz, N., Nagels, G., Bjerke, M., Engelborghs, S., De Bundel, D. & Smolders, I., 11 jul 2022.Onderzoeksoutput: Poster
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Assessment of gliotransmitter concentrations upon chemogenetic modulation of astroglia in mouse hippocampus
Nestor, L., Sahu, S., De Bundel, D., Van Eeckhaut, A. & Smolders, I., 9 mei 2022, (Unpublished).Onderzoeksoutput: Poster
Prijzen
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Bursary Award 6th European Congress on Epileptology Vienna
Smolders, Ilse (Recipient), 2004
Prijs: Prize (including medals and awards)
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Galenusprijs voor Farmacologie
Smolders, Ilse (Recipient), 2001
Prijs: Prize (including medals and awards)
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Laureate of the Prize of the Second Section 2002-2004
Smolders, Ilse (Recipient), 2005
Prijs: Prize (including medals and awards)
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Project grant Wetenschappelijk Fonds Willy Gepts (WFWG)
Custers, Marie-Laure (Recipient), Van Eeckhaut, Ann (Recipient) & Smolders, Ilse (Recipient), 1 dec 2021
Prijs: Prize (including medals and awards)
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Activiteiten
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Chemogenetic modulation of microglia in a mouse model of temporal lobe epilepsy.
Jo Bossuyt (Speaker) & Ilse Smolders (Contributor)
27 apr 2023Activiteit: Talk or presentation at a conference
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Liquid chromatography-mass spectrometry of low-volume samples for the analysis of the brain metabolome using dimethylaminophenacyl bromide derivatization
Liam Nestor (Speaker), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor) & Ann Van Eeckhaut (Contributor)
27 apr 2023Activiteit: Talk or presentation at a conference
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Optimization of a targeted brain metabolomics method for low-volume biological samples using chemical derivatization
Liam Nestor (Speaker), Phaedra Maria Verding (Contributor), Ruben Verhulst (Contributor), Yvan Vander Heyden (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor) & Ann Van Eeckhaut (Contributor)
11 apr 2023Activiteit: Talk or presentation at a conference
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DA-PBA 2022: 12th International Symposium on Drug Analysis & 32nd International Symposium on Pharmaceutical and Biomedical Analysis
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor) & Ilse Smolders (Contributor)
13 sep 2022Activiteit: Talk or presentation at a conference
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Toegepaste Biologische Wetenschappen (Organisatie)
Eveline Peeters (Chair), Janine Brunner (Jury), Ilse Smolders (Jury), Steffen Jung (Jury), Diego Gomez-Nicola (Jury), Kiavash Movahedi (Supervisor) & Jo Van Ginderachter (Supervisor)
8 jun 2022Activiteit: Member of PhD committee
Knipsels
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Expert neurofarmacologie omtrent de vergiftiging van een kleuter met een overdosis van een antipsychoticum
13/11/08
1 Mediabijdrage
Pers / media: !!Other
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Radio interview als expert neurofarmacologie ivm het misbruik van Rilatine® bij scholieren
28/05/08
1 Mediabijdrage
Pers / media: !!Other
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Interview voor het televisiejournaal ivm het misbruik van Rilatine® bij scholieren
28/05/08
1 Mediabijdrage
Pers / media: !!Other
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Gast van HKH prinses Astrid naar aanleiding van de prijsuitreikingen Geneeskundige Stichting Koningin Elisabeth
22/05/07
1 Mediabijdrage
Pers / media: !!Other
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Radio interview omtrent de neurobiologie van het reward circuit
3/08/06
1 Mediabijdrage
Pers / media: !!Other
Scriptie
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Analysis of glutamate transporter expression in post mortem tissue of depressed patients
Auteur: Rubbens, N., Demuyser, T., Massie, A., Smolders, I. & Caveliers, V., 2016Begeleider: Demuyser, T. (Promotor)
Scriptie/Masterproef: Master's Thesis
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Determination of the plasma stability of neuromedin U analogues
Auteur: Santon, S., Smolders, I., Van Eeckhaut, A. & Caveliers, V., 2016Begeleider: De Prins, A. (Promotor)
Scriptie/Masterproef: Master's Thesis
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Evaluation of the convulsant liability and antiepileptic properties of antidepressant
Auteur: Vermoesen, K., Clinckers, R., Massie, A., Smolders, I., Rombaut, B., Vinken, M., Voskuyl, R. & Raedt, R., 29 mei 2012Begeleider: Clinckers, R. (Promotor), Massie, A. (Co-promotor), Smolders, I. (Externe persoon) (Co-promotor), Rombaut, B. (Jury), Vinken, M. (Jury), Voskuyl, R. (Externe persoon) (Jury) & Raedt, R. (Externe persoon) (Jury)
Scriptie/Masterproef: Doctoral Thesis
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Ghrelin receptor involvement in fear extinction
Auteur: De Bundel, D., De Heyn, S. & Smolders, I. J., 2015Scriptie/Masterproef: Master's Thesis
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Het gebruik van microdialyse voor de bepaling van de plasma-eiwitbinding van farmaca
Auteur: Smolders, I. J. & Sarre, S., 1992Begeleider: Sarre, S. (Promotor)
Scriptie/Masterproef: Master's Thesis