Projecten per jaar
Persoonlijk profiel
Expertise
neurofarmacologie
Expertise
neurowetenschappen
Expertise
geneesmiddelenkennis
Expertise
Ilse Smolders (PhD in Pharmaceutical Sciences, full professor, ‘gewoon hoogleraar’) is attached to the VUB Faculty of Medicine and Pharmacy. Being a Pharmacist, she has huge interest in pharmacology and drug discovery, and her main teaching duties are situated within that field of expertise. She is responsible for teaching courses to Medical, Biomedical, Pharmacy and Psychology students. She is head of the Laboratory of Pharmaceutical Chemistry, Drug Analysis and Drug Information, and chair of the Department of Pharmaceutical Sciences. The research expertise of Ilse Smolders lies in the domain of neuroscience and pharmacology. She has expertise with rodent models of seizures, epilepsy, and epilepsy co-morbidities such as cognitive decline, anxiety and depression, as well as with in vivo monitoring of neurotransmitters, gliotransmitters and neuropeptides, ex vivo analysis of rodent brain, slice electrophysiology, and more recently, in vitro culture models. Available techniques in the lab are telemetry-based 24h-electroencephalographic (EEG) monitoring for rodents, and a wide range of behavioral paradigms for measuring epilepsy-related behavior, cognitive decline, locomotor, anxiety and depressive-like behaviors in rodents. In vivo microdialysis in rodents is used, and miniaturized analytical developments for targeted analysis of the dialysates are always ongoing and optimised. Novel state-of-the art technologies such as chemogenetics, optogenetics and untargeted metabolomics were recently introduced in the team.
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Ilse Smolders actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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HERC66: 3D-CELLMAP: Onthullen van complexe celinteracties in weefsels door middel van 3D super-resolutie proteïne multiplex beeldvorming.
Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.
1/05/24 → 31/05/28
Project: Fundamenteel
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BOR85: Brussels onderzoek naar borstvoeding, lactatie en technologie
1/07/23 → 30/09/24
Project: Fundamenteel
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FWOTM1061: Chemogenetische modulatie van CX3CR1+ cellen in een muismodel voor farmacoresistente limbische epilepsie.
1/11/21 → 31/10/25
Project: Fundamenteel
Onderzoeksoutput
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Chemical derivatization for targeted brain metabolomics of volume-limited samples using LC-MS/MS
Nestor, L., Lella, C., De Bundel, D., Smolders, I., Vander Heyden, Y. & Van Eeckhaut, A., 11 sep 2024, (Unpublished).Onderzoeksoutput: Poster
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Chemical derivatization of polar compounds for analysis in volume-limited biological samples using LC-MS/MS
Nestor, L., Lella, C., De Bundel, D., Smolders, I., Vander Heyden, Y. & Van Eeckhaut, A., 30 apr 2024, (Unpublished).Onderzoeksoutput: Poster
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Chemogenetic Approaches to Study Astrocytes at Glutamatergic Synapses
Nestor, L., Van Den Herrewegen, Y., Bortolotto, Z. A., De Bundel, D. & Smolders, I., 22 mrt 2024, New Technologies for Glutamate Interaction. Humana Press, blz. 155-172 18 blz. (Neuromethods).Onderzoeksoutput: Chapter › peer review
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hM4Di-DREADD-based modulation of microglia in the intrahippocampal kainic acid mouse model of drug-resistant temporal lobe epilepsy
Bossuyt, J. & Smolders, I., 2024, (Unpublished).Onderzoeksoutput: Poster
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PS03-27AM-248 DREADD-BASED MANIPULATION OF HIPPOCAMPAL ASTROCYTE GQ SIGNALLING IN A CHRONIC MOUSE MODEL OF MEDIAL TEMPORAL LOBE EPILEPSY
De Bundel, D., Van Den Herrewegen, Y., Nestor, L., Sahu, S., Dyer, M., Van Eeckhaut, A. & Smolders, I., 27 jun 2024, (Unpublished).Onderzoeksoutput: Poster
Prijzen
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Bursary Award 6th European Congress on Epileptology Vienna
Smolders, Ilse (Recipient), 2004
Prijs: Prize (including medals and awards)
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Galenusprijs voor Farmacologie
Smolders, Ilse (Recipient), 2001
Prijs: Prize (including medals and awards)
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Laureate of the Prize of the Second Section 2002-2004
Smolders, Ilse (Recipient), 2005
Prijs: Prize (including medals and awards)
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Project grant Wetenschappelijk Fonds Willy Gepts (WFWG)
Custers, Marie-Laure (Recipient), Van Eeckhaut, Ann (Recipient) & Smolders, Ilse (Recipient), 1 dec 2021
Prijs: Prize (including medals and awards)
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Activiteiten
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Chemogenetic modulation of microglia in a mouse model of drug-resistant limbic epilepsy.
Jo Bossuyt (Participant), Ilse Smolders (Participant) & Sofie Bournons (Participant)
16 jan 2024 → 1 jan 2029Activiteit: Written proposal
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Wetenschappelijk Fonds Willy Gepts
Sofie Bournons (Participant), Jo Bossuyt (Participant) & Ilse Smolders (Participant)
1 jan 2024 → 1 jan 2025Activiteit: Written proposal
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Metabolic profiling of epileptic hippocampal tissue upon chemogenetic modulation of astrocytes using CE-HRMS
Liam Nestor (Speaker), Yvan Vander Heyden (Contributor), Ann Van Eeckhaut (Contributor), Dimitri De Bundel (Contributor) & Ilse Smolders (Contributor)
29 apr 2024Activiteit: Talk or presentation at a conference
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Metabolomic profiling of mouse hippocampus to unravel the effects of chemogenetic modulation of astrocytes in a model for temporal lobe epilepsy
Liam Nestor (Speaker), Yvan Vander Heyden (Contributor), Ann Van Eeckhaut (Contributor), Dimitri De Bundel (Contributor) & Ilse Smolders (Contributor)
11 sep 2024Activiteit: Talk or presentation at a conference
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Optimization of a targeted brain metabolomics method for low-volume biological samples using chemical derivatization
Liam Nestor (Speaker), Phaedra Maria Verding (Contributor), Ruben Verhulst (Contributor), Yvan Vander Heyden (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor) & Ann Van Eeckhaut (Contributor)
11 apr 2023Activiteit: Talk or presentation at a conference
Knipsels
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Expert neurofarmacologie omtrent de vergiftiging van een kleuter met een overdosis van een antipsychoticum
13/11/08
1 Mediabijdrage
Pers / media: !!Other
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Interview voor het televisiejournaal ivm het misbruik van Rilatine® bij scholieren
28/05/08
1 Mediabijdrage
Pers / media: !!Other
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Radio interview als expert neurofarmacologie ivm het misbruik van Rilatine® bij scholieren
28/05/08
1 Mediabijdrage
Pers / media: !!Other
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Gast van HKH prinses Astrid naar aanleiding van de prijsuitreikingen Geneeskundige Stichting Koningin Elisabeth
22/05/07
1 Mediabijdrage
Pers / media: !!Other
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Radio interview omtrent de neurobiologie van het reward circuit
3/08/06
1 Mediabijdrage
Pers / media: !!Other
Scriptie
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Analysis of glutamate transporter expression in post mortem tissue of depressed patients
Auteur: Rubbens, N., Demuyser, T., Massie, A., Smolders, I. & Caveliers, V., 2016Begeleider: Demuyser, T. (Promotor)
Scriptie/Masterproef: Master's Thesis
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Anatomical and functional characterization of the neuromedin U system in mouse brain
Auteur: Kereknaoui, I., De Bundel, D. & Smolders, I., 2021Begeleider: Medrano Moya, M. (Co-promotor) & Allaoui, W. (Advisor)
Scriptie/Masterproef: Master's Thesis
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Applicability of cerebral open flow microperfusion and microdialysis to quantify a brain-penetrating nanobody mice
Auteur: Brock, A. R., Smolders, I. & Van Eeckhaut, A., 1 jul 2021Begeleider: Custers, M. (Advisor)
Scriptie/Masterproef: Master's Thesis
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A road toward photoswitchable cannabinoids as a treatment for focal epilepsy
Auteur: De Bundel, D., Smolders, I. & Tan, S., 2021Scriptie/Masterproef: Master's Thesis
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Assessment of HM3DQ- and HM4DI-DREADD functionality in a model for temporal lobe epilepsy.
Auteur: De Bundel, D., Smolders, I. & Bournons, S., 2019Scriptie/Masterproef: Master's Thesis