Projecten per jaar
Persoonlijk profiel
Expertise
neurofarmacologie
Expertise
neurowetenschappen
Expertise
geneesmiddelenkennis
Expertise
Ilse Smolders (PhD in Pharmaceutical Sciences, full professor, ‘gewoon hoogleraar’) is attached to the VUB Faculty of Medicine and Pharmacy. Being a Pharmacist, she has huge interest in pharmacology and drug discovery, and her main teaching duties are situated within that field of expertise. She is responsible for teaching courses to Medical, Biomedical, Pharmacy and Psychology students. She is head of the Laboratory of Pharmaceutical Chemistry, Drug Analysis and Drug Information, and chair of the Department of Pharmaceutical Sciences. The research expertise of Ilse Smolders lies in the domain of neuroscience and pharmacology. She has expertise with rodent models of seizures, epilepsy, and epilepsy co-morbidities such as cognitive decline, anxiety and depression, as well as with in vivo monitoring of neurotransmitters, gliotransmitters and neuropeptides, ex vivo analysis of rodent brain, slice electrophysiology, and more recently, in vitro culture models. Available techniques in the lab are telemetry-based 24h-electroencephalographic (EEG) monitoring for rodents, and a wide range of behavioral paradigms for measuring epilepsy-related behavior, cognitive decline, locomotor, anxiety and depressive-like behaviors in rodents. In vivo microdialysis in rodents is used, and miniaturized analytical developments for targeted analysis of the dialysates are always ongoing and optimised. Novel state-of-the art technologies such as chemogenetics, optogenetics and untargeted metabolomics were recently introduced in the team.
Vingerafdruk
- 1 Soortgelijke profielen
Netwerk
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HERC56: Intravitale beeldvorming als technologie om de kloof te dichten tussen macroscopische in vivo beeldvorming en microscopische analyse van weefsels
Hernot, S., Staels, W., Hellemans, K., Smolders, I., Rooman, I., Devoogdt, N., Menu, E., De Bundel, D., Breckpot, K., De Leu, N., Movahedi, K., D'Huyvetter, M. & De Kock, J.
1/05/22 → 30/04/26
Project: Fundamenteel
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OZR3913: Cofinanciering OZR FWO Hercules MZW - Single-cell eiwit analyse in intacte weefsels
Movahedi, K., van Grunsven, L., Rooman, I., Van Ginderachter, J., Smolders, I., Neyns, B., Vanhaecke, T., Laoui, D., Breckpot, K., De Veirman, K., Stijlemans, B., Van Schependom, J., Magez, S., Goyvaerts, C., De Kock, J., De Leu, N., Massie, A., Hellemans, K., Spits, C., De Bundel, D., De Trez, C., Hernot, S., Van Dooren, S., Aerts, J., Staels, W. & Tuyaerts, S.
25/02/22 → 25/02/26
Project: Fundamenteel
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FWOTM1061: Chemogenetische modulatie van CX3CR1+ cellen in een muismodel voor farmacoresistente limbische epilepsie.
1/11/21 → 31/10/23
Project: Fundamenteel
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OZR3528: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UAntwerpen, NOUS Amber
5/03/20 → 4/03/24
Project: Fundamenteel
Onderzoeksoutput
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Current Approaches to Monitor Macromolecules Directly from the Cerebral Interstitial Fluid
Custers, M-L., Nestor, L., De Bundel, D., Van Eeckhaut, A. & Smolders, I., 13 mei 2022, In : Pharmaceutics. 14, 5, 20 blz., 1051.Onderzoeksoutput: Article
Open AccessBestand5 Downloads (Pure) -
Targeting the Ghrelin Receptor as a Novel Therapeutic Option for Epilepsy
Buckinx, A., De Bundel, D., Kooijman, R. & Smolders, I., jan 2022, In : Biomedicines. 10, 1, 20 blz., 53.Onderzoeksoutput: Article
Open AccessBestand2 Citaten (Scopus)19 Downloads (Pure) -
Unraveling the Effects of GSK-3β Isoform Modulation against Limbic Seizures and in the 6 Hz Electrical Kindling Model for Epileptogenesis
Aourz, N., Van Leuven, F., Allaoui, W., Van Eeckhaut, A., De Bundel, D. & Smolders, I., 16 mrt 2022, In : ACS Chemical Neuroscience. 13, 6, blz. 796-805 10 blz.Onderzoeksoutput: Article
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Activation of DREADDed astrocytes attenuates pharmacoresistant spontaneous seizures in a chronic epilepsy model
Smolders, I., Van den Herrewegen, Y., Sahu, S., Nestor, L. & De Bundel, D., jul 2021, In : Glia. 69, S1, blz. E285-E285 1 blz.Onderzoeksoutput: Meeting abstract (Journal)
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Applicability of cerebral open flow microperfusion and microdialysis to quantify a brain-penetrating nanobody in mice
Custers, M-L., Wouters, Y., Jaspers, T., De Bundel, D., Dewilde, M., Van Eeckhaut, A. & Smolders, I., 8 sep 2021, (Unpublished).Onderzoeksoutput: Poster
Prijzen
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Bursary Award 6th European Congress on Epileptology Vienna
Ilse Smolders (Recipient), 2004
Prijs: Prize (including medals and awards)
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Galenusprijs voor Farmacologie
Ilse Smolders (Recipient), 2001
Prijs: Prize (including medals and awards)
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Laureate of the Prize of the Second Section 2002-2004
Ilse Smolders (Recipient), 2005
Prijs: Prize (including medals and awards)
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Project grant Wetenschappelijk Fonds Willy Gepts (WFWG)
Marie-Laure Custers (Recipient), Ann Van Eeckhaut (Recipient) & Ilse Smolders (Recipient), 1 dec 2021
Prijs: Prize (including medals and awards)
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Activiteiten
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Toegepaste Biologische Wetenschappen (Organisatie)
Eveline Peeters (Chair), Janine Brunner (Jury), Ilse Smolders (Jury), Steffen Jung (Jury), Diego Gomez-Nicola (Jury), Kiavash Movahedi (Supervisor), Jo Van Ginderachter (Supervisor)8 jun 2022Activiteit: Member of PhD committee
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PhD day C4N
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor), Ilse Smolders (Contributor)16 dec 2021Activiteit: Talk or presentation at a conference
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Scientific Research Section
Marie-Laure Custers (Speaker), Maria Bjerke (Contributor), Ann Van Eeckhaut (Contributor), Ilse Smolders (Contributor)24 sep 2021Activiteit: Talk or presentation at a conference
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Chemogenetic modulation of CX3CR1+ cells in a mouse model of drug-resistant limbic epilepsy.
Jo Bossuyt (Participant), Ilse Smolders (Supervisor)1 nov 2021 → 31 okt 2025Activiteit: Written proposal
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Targeted metabolomics of the brain – the quest for sensitivity, selectivity and throughput.
Ann Van Eeckhaut (Invited speaker), Jana Bongaerts (Contributor), Marie-Laure Custers (Contributor), Liam Nestor (Contributor), Anouk Pierre (Contributor), Dimitri De Bundel (Contributor), Ilse Smolders (Contributor)29 jan 2020 → 31 jan 2020Activiteit: Talk or presentation at a conference
Knipsels
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Expert neurofarmacologie omtrent de vergiftiging van een kleuter met een overdosis van een antipsychoticum
13/11/08
1 Mediabijdrage
Pers / media: !!Other
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Radio interview als expert neurofarmacologie ivm het misbruik van Rilatine® bij scholieren
28/05/08
1 Mediabijdrage
Pers / media: !!Other
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Interview voor het televisiejournaal ivm het misbruik van Rilatine® bij scholieren
28/05/08
1 Mediabijdrage
Pers / media: !!Other
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Gast van HKH prinses Astrid naar aanleiding van de prijsuitreikingen Geneeskundige Stichting Koningin Elisabeth
22/05/07
1 Mediabijdrage
Pers / media: !!Other
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Radio interview omtrent de neurobiologie van het reward circuit
3/08/06
1 Mediabijdrage
Pers / media: !!Other
Scriptie
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Additie van inuline in de voeding: Effecten op de serotonine- en dopaminevrijgave in de hippocampus van de rat
Auteur: Grauwels, K., Michotte, Y. & Smolders, I. J., 1998Begeleider: Michotte, Y. (Promotor) & Smolders, I. (Co-promotor)
Scriptie/masterproef: Master's Thesis
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Alternative approaches to build quantitative structure-retention relationships
Auteur: Put, R., Vander Heyden, Y., Vanhaecke, T., Foriers, A., Smolders, I. J., Adams, E. & Kaliszan, R., 17 sep 2008Begeleider: Vander Heyden, Y. (Promotor), Vanhaecke, T. (Jury), Foriers, A. (Jury), Smolders, I. (Jury), Adams, E. (Externe persoon) (Jury) & Kaliszan, R. (Externe persoon) (Jury)
Scriptie/masterproef: Doctoral Thesis
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Alternative replication systems for picornaviridae: development and use.
Auteur: Franco, D., Rombaut, B., Vander Heyden, Y., Wimmer, E., Michiels, T., Paul, A., Melchers, W., Smolders, I. J. & Vrijsen, R., 2005Begeleider: Rombaut, B. (Promotor), Vander Heyden, Y. (Jury), Smolders, I. (Jury), Vrijsen, R. (Jury), Michiels, T. (Externe persoon) (Jury), Melchers, W. (Externe persoon) (Jury), Wimmer, E. (Externe persoon) (Co-promotor) & Paul, A. (Externe persoon) (Co-promotor)
Scriptie/masterproef: Doctoral Thesis
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Analysis of glutamate transporter expression in post mortem tissue of depressed patients
Auteur: Rubbens, N., Demuyser, T., Massie, A., Smolders, I. & Caveliers, V., 2016Begeleider: Demuyser, T. (Promotor)
Scriptie/masterproef: Master's Thesis
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Antipicornaviral compounds: modes of action, use as research tools and as vaccine stabilisers
Auteur: Verheyden, B., Rombaut, B., Verbeke, J., Vanden Berghe, D., Van Acker, K., Smolders, I. J. & Vrijsen, R., 1 jun 2006Begeleider: Rombaut, B. (Promotor), Verbeke, J. (Jury), Smolders, I. (Jury), Vrijsen, R. (Jury), Vanden Berghe, D. (Externe persoon) (Jury) & Van Acker, K. (Externe persoon) (Jury)
Scriptie/masterproef: Doctoral Thesis