Projecten per jaar
Persoonlijk profiel
Expertise
Last years, the Steyaert lab pioneered the use of nanobodies for chaperone-assisted X-ray crystallography (www.steyaertlab.eu), aiming at the highest hanging fruits of structural biology including membrane proteins, amyloidogenic proteins, and now also (transient) multiprotein complexes. The elucidation of the first GPCR structures in the agonist-bound active state demonstrate the power of Nanobodies to stabilize G protein coupled receptor conformational states including transmembrane signalling complexes. Recent work focusses on exploiting the conformational complexity of therapeutic targets for Nanobody-enabled drug discovery.
Appart of his research activities, Jan Steyaert is also a serial entrepreneur. He is a co-founder of Ablynx (now a Sanofi company) and Biotalys and more recently he founded ConfoTherapeutics, three succesful biotech spin-offs that valorize a unique class of single domain antibodies (Nanobodies) derived from camelids.
Externe posities
Director, Flanders Institute for Biotechnology
15 dec 2016 → …Founder & Senior advisor, Confo Therapeutics
15 mei 2015 → …Francqui Research Professor, FRANCQUI Stichting
1 jan 2015 → 1 dec 2017Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Jan Steyaert actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 12 Soortgelijke profielen
Netwerk
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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IOF3011: GEAR: Nanobodies voor de Biotechnologie en de Gezondheid
1/01/20 → 31/12/24
Project: Toegepast
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FWOSB85: Biased G proteïne signalisatie liganden van de µ-opioïde receptoren voor verbeterde pijntherapie
Ballet, S., Steyaert, J. & De Neve, J.
1/11/19 → 31/10/21
Project: Fundamenteel
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ANI220: Nanobody-based approach to inhibit RAS activity by modulating its interactome.
Steyaert, J. & Sablina, A.
1/01/19 → 31/12/22
Project: Fundamenteel
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FWOTM903: Nanobiotics: een nieuw platform voor de ontwikkeling van antimicrobiële biologicals tegen extracellulaire bacteriële targets
Remaut, H. K., Janssens, A. & Steyaert, J.
1/10/18 → 30/09/22
Project: Fundamenteel
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SRP13: Structuur en dynamiek van macromoleculaire complexen in gezondheid en ziekte
Steyaert, J., Remaut, H. K., Loris, R., Efremov, R., Steyaert, J., Loris, R. & Remaut, H. K.
1/11/12 → 31/10/22
Project: Fundamenteel
Onderzoeksoutput
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Megabodies expand the nanobody toolkit for protein structure determination by single-particle cryo-EM
Uchański, T., Masiulis, S., Fischer, B., Kalichuk, V., López-Sánchez, U., Zarkadas, E., Weckener, M., Sente, A., Ward, P., Wohlkönig, A., Zögg, T., Remaut, H., Naismith, J. H., Nury, H., Vranken, W., Aricescu, A. R., Pardon, E. & Steyaert, J., jan 2021, In : Nature Methods. 18, 1, blz. 60-68 9 blz.Onderzoeksoutput: Article
7 Citaten (Scopus) -
Nanobodies to study protein conformational states
Uchański, T., Pardon, E. & Steyaert, J., feb 2020, In : Current Opinion in Structural Biology. 60, blz. 117-123 7 blz.Onderzoeksoutput: Scientific review
16 Citaten (Scopus) -
The Molecular Mechanism of Transport by the Mitochondrial ADP/ATP Carrier
Ruprecht, J. J., King, M. S., Zögg, T., Aleksandrova, A. A., Pardon, E., Crichton, P. G., Steyaert, J. & Kunji, E. R. S., 24 jan 2019, In : Cell. 176, 3, blz. 435-447.e15 13 blz.Onderzoeksoutput: Article
72 Citaten (Scopus) -
Structure of a nanobody-stabilized active state of the b2 adrenoceptor
Rasmussen, S. G. F., Choi, H-J., Fung, J. J., Pardon, E., Casarosa, P., Chae, P. S., Devree, B. T., Rosenbaum, D. M., Thian, F. S., Kobilka, T. S., Schnapp, A., Konetzki, I., Sunahara, R. K., Gellman, S. H., Pautsch, A., Steyaert, J., Weis, W. I. & Kobilka, B. K., 13 apr 2011, In : Nature. 469, 7329, blz. 175-180 5 blz.Onderzoeksoutput: Article
Open AccessBestand1176 Citaten (Scopus)120 Downloads (Pure) -
Crystal structure of the β2 adrenergic receptor–Gs protein complex
Rasmussen, S. G. F., Devree, B. T., Zou, Y., Kruse, A., Chung, K. Y., Kobilka, T. S., Thian, F. S., Chae, P. S., Pardon, E., Calinski, D., Mathiesen, J. M., Shah, S. T. A., Lyons, J. A., Martin, C., Steyaert, J., Skiniotis, G., Weis, W. I., Sunahara, R. K. & Kobilka, B. K., 29 sep 2011, In : Nature. 477, blz. 549-555 6 blz.Onderzoeksoutput: Article
Open AccessBestand2016 Citaten (Scopus)260 Downloads (Pure)
Prijzen
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Highly cited Research Award in the field of Biology and Biochemistry, Web of Science Group
Jan Steyaert (Recipient), 2020
Prijs: National/international honour
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Highly cited Research Award in the field of Biology and Biochemistry, Web of Science Group
Jan Steyaert (Recipient), 2019
Prijs: National/international honour
Activiteiten
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Invited seminar at the Vienna Biocenter
Jan Steyaert (Speaker)12 jan 2017Activiteit: Talk at an external academic organisation
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EU project 731005 - INSTRUCT-ULTRA
Jan Steyaert (Organiser)22 feb 2017 → 23 feb 2017Activiteit: Participation in workshop, seminar
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Lezing voor Internationalisation@Home
Jan Steyaert (Speaker)2 mei 2017Activiteit: Talk at an external academic organisation
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Invited seminar at the University of Ljubljana
Jan Steyaert (Speaker)15 feb 2017Activiteit: Talk at an external academic organisation
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42d FEBS Congress
Jan Steyaert (Invited speaker)11 sep 2017Activiteit: Talk or presentation at a conference
Knipsels
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This scientific ‘power couple’ has one of the largest publishing networks in biology
7/05/20
1 Mediabijdrage
Pers / media: !!Research
Scriptie
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Analysing the structure and function of Ribonuclease T1 using site-directed mutagenesis, X-ray crystallography and substrate mimics
Auteur: Doumen, J. & Steyaert, J., 1998Begeleider: Steyaert, J. (Promotor)
Scriptie/masterproef: Doctoral Thesis
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Analysis of protein-water interactions using RNase T1 as a model system
Auteur: Langhorst, U., Steyaert, J. & Loris, R., 1999Begeleider: Steyaert, J. (Promotor) & Loris, R. (Co-promotor)
Scriptie/masterproef: Doctoral Thesis
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Analysis of the stacking-interactions in proteïn-nucleic acid complexes by protein engineering
Auteur: Loverix, S. & Steyaert, J., 1995Begeleider: Steyaert, J. (Promotor)
Scriptie/masterproef: Master's Thesis
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Analysis of the structure-function relation of trypanosoma vivax nucleoside hydrolase
Auteur: Versees, W. & Steyaert, J., 1998Begeleider: Steyaert, J. (Promotor)
Scriptie/masterproef: Master's Thesis
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Analysis of the transphosphorylation reaction catalyzed by RNase T1 via site-directed mutagenesis and chemically modified substrates
Auteur: Loverix, S. & Steyaert, J., 2000Begeleider: Steyaert, J. (Promotor)
Scriptie/masterproef: Doctoral Thesis