Projecten per jaar
Persoonlijk profiel
Expertise
BIO: Janine Brunner is since 2020 group leader at the VIB-VUB Center for Structural Biology leading the lab Structure and Function of Membrane Proteins and professor at the Vrije Universiteit Brussel. She obtained her PhD in 2015 from the University of Zurich/Switzerland with structural and functional work on phospholipid scramblases in the TMEM16 family. It provided the first atomic insight into the architecture and working mechanism of Ca2+ activated phospholipid scramblases and contributed significant new concepts in this field. During postdoc stays at Universities of Zurich and Basel and the Paul-Scherrer Institute (ETH)/Switzerland she studied non-canonical lysosomal potassium channels that are associated with Parkinson’s disease by combining X-ray crystallography with electrophysiology.Her results have revealed how ion selectivity and gating is achieved in these newly discovered potassium channels.
Janine’s efforts advanced the understanding in several membrane protein classes and her work, published in Nature, Nature Communications, eLife, and Current Opinion in Structural Biology, has been referenced more than 460 times (source scopus). She was invited twice to give a talk at the New and Notable session, prestigious platforms at the Biophysics Society Annual Meeting and the European Biophysics Congress.
MISSION: The Brunner lab (started in 2020) is focusing on the structural biology of membrane proteins, and their functional characterization. With the major topic of membrane proteins in lipid transport and metabolism and their significance for membrane asymmetry we engage in a central theme of cell biology and aim to answer long-standing questions in lipid trafficking and signalling. The second theme covers structural biology and biophysics of ion channels implicated in lysosome physiology and pathological instances such as Parkinson’s disease. Her group is capitalizing from extensive experience in membrane protein biochemistry and structural biology and integrates additional methodologies such as patch-clamp electrophysiology and fluorescence microscopy to achieve a comprehensive understanding of the research subjects.
For more information: https://brunnerlab.sites.vib.be/en
Externe posities
Postdoc in the lab of Michel Steinmetz, Paul Scherrer Institute
jan. 2018 → nov. 2019
Postdoc in the lab of Timm Maier, University of Basel
jan. 2017 → dec. 2017
Postdoc in the lab of Raimund Dutzler, University of Zurich
2015 → 2016
PhD thesis in the Lab or Raimund Dutzler, University of Zurich
2010 → 2015
Vingerafdruk
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
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OZR4290: Financiering MZW OZR: Voordelige 100 kV-cryogene elektronenmicroscoop met hoge resolutie voor de bepaling van bijna atomaire eiwitstructuur
Efremov, R., Messens, J., Vorobieva, A. A., Remaut, H. K., Van der Henst, C., Steyaert, J., Versées, W., Loris, R. & Brunner, J.
24/04/24 → 24/04/28
Project: Fundamenteel
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OZR4286: Financiering MZW OZR: DELI-SORT: MACSQuant® Tyto voor steriele SORTing van DELicate Immune cellen
Laoui, D., Vanginderachter, J. A., Magez, S., Tuyaerts, S., Fioravanti, A., Devoogdt, N., Van der Henst, C., Raes, G., Stijlemans, B., Hadadi, E., De Trez, C., Ruytinx, J., Brunner, J., De Groof, T. & De Veirman, K.
24/04/24 → 24/04/28
Project: Fundamenteel
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OZR4292: Financiering MZW OZR: Biolaag interferometrie voor de studie van eiwit-eiwit en eiwit-ligand interacties
Versées, W., Loris, R., Rooman, I., Laoui, D., Messens, J., Brunner, J., Stijlemans, B. & Ballet, S.
24/04/24 → 24/04/28
Project: Fundamenteel
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A biosensor-based phage display selection method for automated, high-throughput Nanobody discovery
De Keyser, P., Kalichuk, V., Zögg, T., Wohlkönig, A., Schenck, S., Brunner, J., Pardon, E. & Steyaert, J., 1 mrt. 2025, In: Biosensors and Bioelectronics. 271, 14 blz., 116951.Onderzoeksoutput: Article › peer review
6 Citaten (Scopus) -
Structures of native SV2A reveal the binding mode for tetanus neurotoxin and anti-epileptic racetams
Schenck, S., Laeremans, T., Steyaert, J. & Brunner, J., dec. 2025, In: Nature Communications. 16, 1, 14 blz., 4172.Onderzoeksoutput: Article › peer review
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Cryo-EM structures of a LptDE transporter in complex with Pro-macrobodies offer insight into lipopolysaccharide translocation
Botte, M., Ni, D., Schenck, S., Zimmermann, I., Chami, M., Bocquet, N., Egloff, P., Bucher, D., Trabuco, M., Cheng, R. K. Y., Brunner, J., Seeger, M. A., Stahlberg, H. & Hennig, M., dec. 2022, In: Nature Communications. 13, 1, 1826.Onderzoeksoutput: Article › peer review
Open AccessBestand25 Citaten (Scopus)87 Downloads (Pure) -
Insight into Lipopolysaccharide Translocation by Cryo-EM structures of a LptDE Transporter in Complex with Pro-Macrobodies
Botte, M., Ni, D., Schenck, S., Zimmermann, I., Chami, M., Bocquet, N., Egloff, P., Bucher, D., Trabuco, M., Cheng, R. K. Y., Brunner, J., Seeger, M. A., Stahlberg, H. & Hennig, M., 23 mrt. 2021, (BIORXIV).Onderzoeksoutput: Voordruk
Open Access -
Production and Application of Nanobodies for Membrane Protein Structural Biology
Brunner, J. D. & Schenck, S., feb. 2020, Production and Application of Nanobodies for Membrane Protein Structural Biology. Maier, T. & Perez, C. (redactie). Humana Press, Vol. 2127. blz. 167-184 18 blz.Onderzoeksoutput: Chapter › Research › peer review
5 Citaten (Scopus)
Prijzen
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Best PhD thesis of the year (2015), by the University of Zürich, Switzerland
Brunner, Janine (Recipient), 2015
Prijs: National/international honour
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Invited speaker for New and Notable Session Talk at the 10th European Biophysics Congress (2015) Dresden, Germany
Brunner, Janine (Recipient), 2015
Prijs: National/international honour
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New and Notable Session Talk at the Biophysical Society 59th Annual Meeting in Baltimore, USA
Brunner, Janine (Recipient), 2015
Prijs: National/international honour
Activiteiten
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Toegepaste Biologische Wetenschappen (Organisatie)
Janine Brunner (Jury)
1 jul. 2024Activiteit: Membership of peer-review panel or committee
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Toegepaste Biologische Wetenschappen (Organisatie)
Janine Brunner (Jury)
17 dec. 2024Activiteit: Membership of peer-review panel or committee
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Toegepaste Biologische Wetenschappen (Organisatie)
Janine Brunner (Jury)
1 mrt. 2024Activiteit: Membership of peer-review panel or committee
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Toegepaste Biologische Wetenschappen (Organisatie)
Janine Brunner (Jury)
2 okt. 2024Activiteit: Membership of peer-review panel or committee
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Invited speaker at BECM Belgian Cryo-EM meeting 2024
Janine Brunner (Speaker)
11 sep. 2024Activiteit: Talk or presentation at a conference
Scriptie
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Recombinant expression, purification and initial characterization of human BBS2+9
Auteur: Hoenjet, E., Loris, R., Muruganandam, G., Brunner, J. & Leyns, L., 2022Scriptie/Masterproef: Master's Thesis
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Unraveling the structure and function of the synaptic proteins TBC1D24 and Synaptojanin1 and their role in neurological disorders
Auteur: Paesmans, J., Versées, W., Ballet, S., Brunner, J., Smolders, I., Greggio, E., Ismail, S. & Galicia Diaz Santana, C., 29 jun. 2021Scriptie/Masterproef: Doctoral Thesis