Projecten per jaar
Vingerafdruk
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
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IOFPOC71: IOF PoC project - TransEVO: transitie van op EVOZymen-gebaseerde therapeutica van het lab naar preklinische proofof- concept
De Kock, J. (Administrative Promotor) & Vanhaecke, T. (CoI (Co-Promotor))
1/01/26 → 31/12/27
Project: Toegepast
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IOF3035: B-LIVER 2.0 (Brusselse Alliantie voor Leveronderzoek & Valorisatie)
Vanhaecke, T. (Administrative Promotor), van Grunsven, L. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Vinken, M. (CoI (Co-Promotor)), Reynaert, H. (CoI (Co-Promotor)) & Van Goethem, F. (Mandataris)
1/01/25 → 31/12/29
Project: Toegepast
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FWOAL1157: BacTyriAL: Ontwikkeling van een nieuwe therapie voor hypertyrosinemie met behulp van in vitro herontworpen bacteriële tyrosine ammonialyase enzymen
De Kock, J. (Administrative Promotor)
1/12/24 → 31/12/28
Project: Fundamenteel
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HERC66: 3D-CELLMAP: Onthullen van complexe celinteracties in weefsels door middel van 3D super-resolutie proteïne multiplex beeldvorming.
Movahedi, K. (Administrative Promotor), Rooman, I. (CoI (Co-Promotor)), Sermon, K. (CoI (Co-Promotor)), De Bundel, D. (CoI (Co-Promotor)), Fioravanti, A. (CoI (Co-Promotor)), Staels, W. (CoI (Co-Promotor)), Magez, S. (CoI (Co-Promotor)), Breckpot, K. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Laoui, D. (CoI (Co-Promotor)), Goyvaerts, C. (CoI (Co-Promotor)), Smolders, I. (CoI (Co-Promotor)), Van Ginderachter, J. (CoI (Co-Promotor)), Marcelino Rodrigues, R. (CoI (Co-Promotor)), De Leu, N. (CoI (Co-Promotor)), van Grunsven, L. (CoI (Co-Promotor)), Hernot, S. (CoI (Co-Promotor)), Peeters, E. (CoI (Co-Promotor)), Vanhaecke, T. (CoI (Co-Promotor)), De Veirman, K. (CoI (Co-Promotor)), Ruytinx, J. (CoI (Co-Promotor)), Van Schependom, J. (CoI (Co-Promotor)), Kortekaas, I. (CoI (Co-Promotor)) & Goossens, E. (CoI (Co-Promotor))
1/05/24 → 31/05/28
Project: Fundamenteel
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OZR4288: Financiering MZW OZR: Snelle analyse en productie van eiwitten voor klinische translatie met behulp van Biacore en bioreactor systemen.
Devoogdt, N. (Administrative Promotor), Hernot, S. (CoI (Co-Promotor)), De Groof, T. (CoI (Co-Promotor)), Ballet, S. (CoI (Co-Promotor)), Stijlemans, B. (CoI (Co-Promotor)), Massie, A. (CoI (Co-Promotor)), Rooman, I. (CoI (Co-Promotor)), Keyaerts, M. (CoI (Co-Promotor)), Raes, G. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Breckpot, K. (CoI (Co-Promotor)), De Veirman, K. (CoI (Co-Promotor)) & Caveliers, V. (CoI (Co-Promotor))
24/04/24 → 24/04/28
Project: Fundamenteel
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4-HYDROXYPHENYLPYRUVATE DIOXYGENASE VARIANTS
De Kock, J. (Uitvinder), Neuckermans, J. (Uitvinder), Vanhaecke, T. (Uitvinder), Schwaneberg, U. (Uitvinder) & DHOKE, G. (Uitvinder), 2026, Octrooi Nr. EP4720266Onderzoeksoutput: Patent
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Deciphering and Improving Human Homogentisate 1,2-Dioxygenase Function Through Knowledge Gaining Directed Evolution: Implications for Alkaptonuria
Lequeue, S., Neuckermans, J., Desmet, L., Salvi, N. S., Vanhaecke, T., Schwaneberg, U. & Kock, J. D., 3 jun. 2026, 37 blz.Onderzoeksoutput: Other contribution
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Engineering the gut as an auxiliary tyrosine disposal unit in hereditary tyrosinemia type 1
De Kock, J., Paganelli, M. & Neuckermans, J., 5 aug. 2026, In: Molecular Therapy. 34, 8, blz. 4367-4369 3 blz.Onderzoeksoutput: Comment/debate
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Human stem cell-derived hepatic cells recapitulate polygenic risk in MASLD development and highlight CD36 as a key mediator
Gatzios, A., Stinckens, M., Verhoeven, A., Rombaut, M., De Win, D., Heymans, A., Loosen, A., Van Goethem, F., De Kock, J., Rodrigues, R., Boeckmans, J. & Vanhaecke, T., 1 okt. 2026, In: Life Sciences. 402, 16 blz., 124587.Onderzoeksoutput: Article › peer review
Open Access -
Liver-directed AAV gene therapy metabolically corrects AKU in Hgd deficient mice
Lequeue, S., Norman, B. P., Del’haye, G. G., Neuckermans, J., Colemonts-Vroninks, H., Hughes, J. H., Rombaut, M., Claes, P., Heymans, A., Heremans, Y., Leuckx, G., Mortier, A., Ranganath, L., Gallagher, J. A., Vanhaecke, T., Bou-Gharios, G. & Kock, J. D., 2 jun. 2026Onderzoeksoutput: Other contribution
Datasets
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Gene expression profiling of Fah- and Hgd-deficient mouse livers upon short-term nitisinone discontinuation
Neuckermans, J. (Creator), Claes, P. (Researcher), Heymans, A. (Researcher), Colemonts-Vroninks, H. (Project Member), Martens, G. (Project Member), Vanhaecke, T. (Supervisor) & De Kock, J. (Supervisor), NCBI Gene Expression Omnibus, 4 apr. 2023
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE225001
Dataset
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BRBseq of human skin-derived precursor hepatic progenitor-like cells with varying polygenic risk score for hepatic fat content exposed in vitro to vehicle-matched control medium or triggers related to MASH
Gatzios, A. (Creator), Vanhaecke, T. (Creator), Stinckens, M. (Creator), Verhoeven, A. (Creator), Rombaut, M. (Creator), De Win, D. (Creator), Heymans, A. (Creator), Loosen, A. (Creator), Van Goethem, F. (Creator), De Kock, J. (Creator), Rodrigues, R. (Creator) & Boeckmans, J. (Creator), VUB Institutional Data Repository, 14 aug. 2026
Dataset
Prijzen
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33. Forschungspreises zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
De Kock, J. (Recipient), Marcelino Rodrigues, R. (Recipient), Vanhaecke, T. (Recipient) & Rogiers, V. (Recipient), 2014
Prijs: Prize (including medals and awards)
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FixAKUre: High-throughput screening of a chemical compound library with the aim to identify restabilizing compounds for homogentisate 1,2-dioxygenase enzyme variants in the context of rare disease alkaptonuria
De Kock, J. (Recipient) & Lequeue, S. (Recipient), 2022
Prijs: Prize (including medals and awards)
Activiteiten
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Hepatic stellate cell activation: Improving models, biomarkers and therapeutic targets. (Evenement)
Merens, V. (Presenter), Stijlemans, B. (Jury), van Grunsven, L. (Member), Spits, C. (Chair), Verhulst, S. (Member), De Kock, J. (Jury), Al Delbany, D. (Jury), Scott, C. L. (Jury) & Eeckhout, J. (Jury)
27 okt. 2025Activiteit: Member of PhD committee
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Genetic predisposition for anti-MASH drug response: a population-based in vitro study
Gatzios, A. (Speaker), Rombaut, M. (Contributor), De Kock, J. (Contributor), De Win, D. (Contributor), Heymans, A. (Contributor), Rogiers, V. (Contributor), Marcelino Rodrigues, R. (Contributor), Boeckmans, J. (Contributor) & Vanhaecke, T. (Contributor)
25 jun. 2024Activiteit: Talk or presentation at a conference
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Genetic predisposition for anti-MASH drug response: a population-based in vitro study
Gatzios, A. (Speaker), Rombaut, M. (Contributor), De Kock, J. (Contributor), De Win, D. (Contributor), Heymans, A. (Contributor), Rogiers, V. (Contributor), Marcelino Rodrigues, R. (Contributor), Boeckmans, J. (Contributor) & Vanhaecke, T. (Contributor)
5 jun. 2024Activiteit: Talk or presentation at a conference
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A stem cell-based in vitro test battery to predict liver steatotic potential of diverse chemicals
Verhoeven, A. (Speaker), Gatzios, A. (Contributor), Marcelino Rodrigues, R. (Contributor), Sanz Serrano, J. (Contributor), Tabernilla Garcia, A. (Contributor), De Kock, J. (Contributor), Vinken, M. (Contributor) & Vanhaecke, T. (Contributor)
4 jun. 2024Activiteit: Talk or presentation at a conference
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Phd defence of Wissal Allaoui "Shedding light on the expression and function of neuromedin U in the brain" (Evenement)
Vander Heyden, Y. (Jury), De Kock, J. (Jury), Heimberg, H. (Jury), Beets, I. (Jury) & Seuntjens, E. (Jury)
7 sep. 2023Activiteit: Member of PhD committee
Scriptie
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A quest to develop in vitro FAH and SLC7A11 knockout models, and methods to confirm them, in the context of hereditary tyrosinemia type1.
Gül, A. ((PhD) Student) & De Kock, J. (Promotor), Del'Haye, G. (Advisor), 2024Scriptie/Masterproef: Master's Thesis
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Bepaling van de specifieke activiteit van cyclotron geproduceerd F18-fluoride en F18-gemerkt radiofarmacon
Deprez, M. ((PhD) Student), Caveliers, V. (Promotor), Blykers, A. (Co-promotor), De Kock, J. (Jury) & Vander Heyden, Y. (Jury), 10 jun. 2015Scriptie/Masterproef: Master's Thesis
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Bijdrage tot het hepatisch herprogrammeren van humane huid-afgeleide hepatische progenitor cellen (hSKP-HPC) into human skin-derived hepatocytes (hSKP-HEP)
Carini, L. ((PhD) Student), Vanhaecke, T. ((PhD) Student) & De Kock, J. ((PhD) Student), Vanhaecke, T. (Promotor), 2023Scriptie/Masterproef: Master's Thesis
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Casting error prone PCR mutagenesis of 4-hydroxyphenylpyruvate dioxygenase to decrease its sensitivity towards nitisinone
Neuckermans, J. (Co-promotor), De Kock, J. (Promotor) & Cassar, J. ((PhD) Student), 2019Scriptie/Masterproef: Master's Thesis
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Characterization of the cellular damage in the FRG mouse model of hereditary tyrosinemia type 1 after withdrawal of the orphan drug NTBC
Neuckermans, J. (Co-promotor), De Kock, J. (Promotor) & Nysten, L. ((PhD) Student), 2017Scriptie/Masterproef: Master's Thesis