Projecten per jaar
Persoonlijk profiel
Expertise
- Analysis of minor and trace elements in various matrices (biological material, foodstuff) using XRF, NAA, PIXE. Qualitative and quantitative analysis of radioactive contaminations with alpha, beta or gamma emitters. Absolute efficiency calibration of scintillation and proportional flow-through detectors for gaseous beta-emitters. Various qualitative and quantitative chemical analysis using HPLC, GCMS, IR and UV spectrometry. Irradiation of small laboratory animals and objects with calibrated gama sources. Irradiations with charged particle beams (protons, alpha, deuterons). Study and automatisation of separation and purification techniques for radioisotopes.
- Development of radioactive molecules for molecular imaging and radionuclide therapy. Synthesis of precursor molecules. Optimization of the Radiosynthesis Methods with Radiohalogens (123I,131I,125I18F) and Radiometals (111In 3+,201Tl 3+,99mTc(III) and (V), 99mTc1+ - tricarbonyl). New radioiodination and radiobromination procedures applied in radiopharmaceutical industry (patent). Development of new radioactive compounds for diagnosis with SPECT and PET (brain receptors, brain tumors, tumours of periphery )( 4 patents). In vitro evaluation in cell models (over)expressing transporters and/or receptors. In vivo evaluation in rodent models (nude mice with tumours, rats with or without tumours) by means of (animal) SPECT and PET and dissection. European Project ( with Organic Chemistry VUBrussel, PSI Switserland, FZRossendorf Germany, Democritos Center Athene) on Radiometallo- chelated (111In, 201Tl, 99mTc,..) peptides as potential tumor tracers. Eureka project with University Zurich and Mallinckrodt Medi
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop John Mertens actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
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OZR1715: Development of positron emission tomography technologies for cancer diagnosis and new drugs development
Tavernier, S., Bossuyt, A., Bruyndonckx, P., Defrise, M. & Mertens, J.
1/01/08 → 31/12/08
Project: Fundamenteel
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ADSI15: Interne overschrijving voor uitbetaling doctoraatsbeurs.
1/01/04 → 31/12/04
Project: Fundamenteel
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FWOAL281: Ontwikkeling an L- en D- 18F-alkyl - fenylalanine en 18F-leucine analogen als tumor specifieke tracers voor PET.
1/01/04 → 31/12/07
Project: Fundamenteel
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Establishment of a Kinetic Model for the Intramolecular Catalyzed Hydrolysis of [18 F]- Benzylfluoride Containing Amino Acid Analoques by Linking Experimental and DFT Studies
Kersemans, K., Sablon, N., Geerlings, P. & Mertens, J., 2012, In: Intern. J. Chem. Kin.. 44, blz. 705 1 blz.Onderzoeksoutput: Article › peer review
2 Citaten (Scopus) -
Mechanistic approach of the difference in hydrolysis rate between the 2- and 4-isomers of no-carrier added [18F] fluoromethyl-L-phenylalanine
Kersemans, K., Mertens, J., De Proft, F. & Geerlings, P., 2011, In: Journal of Labelled Compounds and Radiopharmaceuticals. 54, blz. 220 1 blz.Onderzoeksoutput: Article › peer review
3 Citaten (Scopus) -
Mechanistic approach of the difference in non-enzymatic hydrolysis rate between the L and D enantiomers of no-carrier added 2-[18F] fluoromethyl-phenylalanine
Kersemans, K., Mertens, J., De Proft, F. & Geerlings, P., 2011, In: Journal of Labelled Compounds and Radiopharmaceuticals. 54, blz. 80 1 blz.Onderzoeksoutput: Article › peer review
2 Citaten (Scopus) -
The impact of HF-rTMS treatment on serotonin(2A) receptors in unipolar melancholic depression
Baeken, C., De Raedt, R., Bossuyt, A., Vanhove, C., Mertens, J., Dobbeleir, A., Blanckaert, P. & Goethals, L., apr. 2011, In: Brain Stimulation. 4, blz. 104-111 8 blz.Onderzoeksoutput: Article › peer review
79 Citaten (Scopus) -
The impact of HF-rTMS treatment on Serotonin 2A receptors in unipolar melancholic depression
Baeken, C., De Raedt, R., Bossuyt, A., Van Hove, C., Mertens, J., Dobbeleir, A., Blanckaert, P. & Goethals, I., 2011, In: Brain Stimul. 4, 2, blz. 104-111 8 blz.Onderzoeksoutput: Article › peer review
Prijzen
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Prijs Stas van de Belgische Academie Wetenschappen
Mertens, John (Recipient), 1997
Prijs: Prize (including medals and awards)
Activiteiten
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Unknown (Externe Organisatie)
John Mertens (Member)
1 jan. 2004 → 30 sep. 2006Activiteit: Membership of external research organisation
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Unknown (Externe Organisatie)
John Mertens (Member)
1 jan. 2004 → 31 dec. 2007Activiteit: Membership of external research organisation
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Unknown (Externe Organisatie)
John Mertens (Member)
1 jan. 2004 → 31 dec. 2007Activiteit: Membership of external research organisation
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University of Zurich (Externe Organisatie)
John Mertens (Member)
1 jan. 2003 → …Activiteit: Membership of external research organisation
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European Association for Nuclear Medicine (Externe Organisatie)
John Mertens (Member)
1 jan. 2002 → 31 dec. 2002Activiteit: Membership of external research organisation