Projecten per jaar
Persoonlijk profiel
Expertise
BIO: Joris Messens is since 2012 group leader of the Redox Signaling Lab within the VIB Center for Structural Biology and professor at the Vrije Universiteit Brussel. After several years in Biotech-industry as an Engineer in Biochemistry, he obtained his PhD from the John Moores University of Liverpool (UK, 2003) with structural and functional work on arsenate reductase from Staphyloccocus aureus. In 2006, he created together with Jean-Francois Collet (de Duve Institute, UCL) the Brussels Center for Redox Biology (http://redox.vub.ac.be/) as a platform to stimulate redox and oxidative protein folding research. Joris Messens is frequently invited speaker, session leader, chair and co-chair on international meetings, like GRC, ESF, EMBO, and he was member of the reviewing board for the DFG priority program ‘Dynamics of thiol-based switches in cellular physiology’. As a protein biochemist, he has authored more than 100 peer-reviewed publications (h-index > 40). Most of his studies focus on protein conformational changes induced by thiol-based reaction mechanisms, and the identification of redox-sensitive proteins.
MISSION: The mission of the Redox Signaling Lab is to decipher how cells sense and respond to redox metabolites. The importance of redox signaling for the proper functioning of the cell is being increasingly recognized, and the elucidation of its precise mechanisms and players is becoming critical, as it will allow us to manipulate these pathways with a wide variety of implications, ranging from increasing stress resistance in plants to identifying therapeutic targets in diseases where aberrant redox signaling plays a role.
MORE INFO: http://redox.vub.ac.be and https://messenslab.sites.vib.be/en
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Joris Messens actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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FWOTM1074: Moleculaire en structurele aspecten die de signaaltransductie van Prdx2 controleren
Malo Pueyo, J., Messens, J. & Bolduc, J.
1/11/21 → 31/10/25
Project: Fundamenteel
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OZR3906: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, PEREZ CHAVEZ Israel
1/10/21 → 30/09/25
Project: Fundamenteel
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OZR3904: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, SHEN Tzu-Keng
30/07/21 → 29/07/25
Project: Fundamenteel
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OZR3506: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULiège, CACCAMO Anna
15/10/19 → 13/10/23
Project: Fundamenteel
Onderzoeksoutput
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Ascorbate Peroxidase 2 (APX2) of Chlamydomonas Binds Copper and Modulates the Copper Insertion into Plastocyanin
Caccamo, A., Vega de Luna, F., Wahni, K., Volkov, A. N., Przybyla-Toscano, J., Amelii, A., Kriznik, A., Rouhier, N., Messens, J. & Remacle, C., 31 okt 2023, In: Antioxidants. 12, 11Onderzoeksoutput: Article › peer review
Open Access -
Functionally annotating cysteine disulfides and metal binding sites in the plant kingdom using AlphaFold2 predicted structures
Willems, P., Huang, J., Messens, J. & Van Breusegem, F., jan 2023, In: Free Radical Biology & Medicine. 194, blz. 220-229 10 blz.Onderzoeksoutput: Article › peer review
Open Access -
Functionally annotating cysteine disulfides and metal binding sites in the plant kingdom using AlphaFold2 predicted structures
Willems, P., Huang, J., Messens, J. & Van Breusegem, F., 17 okt 2022, 10 blz.Onderzoeksoutput: Other contribution
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Hypocrates is a genetically encoded fluorescent biosensor for (pseudo)hypohalous acids and their derivatives
Kostyuk, A. I., Tossounian, M-A., Panova, A. S., Thauvin, M., Raevskii, R. I., Ezeriņa, D., Wahni, K., Van Molle, I., Sergeeva, A. D., Vertommen, D., Gorokhovatsky, A. Y., Baranov, M. S., Vriz, S., Messens, J., Bilan, D. S. & Belousov, V. V., 10 jan 2022, In: Nature Communications. 13, 1, 17 blz., 171.Onderzoeksoutput: Article › peer review
Open Access6 Citaten (Scopus) -
Inhibition of basal and glucagon-induced hepatic glucose production by 991 and other pharmacological AMPK activators
Johanns, M., Corbet, C., Jacobs, R., Drappier, M., Bommer, G. T., Herinckx, G., Vertommen, D., Tajeddine, N., Young, D., Messens, J., Feron, O., Steinberg, G. R., Hue, L. & Rider, M. H., 30 jun 2022, In: Biochemical Journal. 479, 12, blz. 1317-1336 20 blz.Onderzoeksoutput: Article › peer review
Open Access2 Citaten (Scopus)
Prijzen
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Winner of the ‘European contest for young scientists on protein purification’, Paris (1999)
Messens, Joris (Recipient), 1999
Prijs: Prize (including medals and awards)
Activiteiten
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Making the invisible visible – Mechanistical insights on biosensor functioning
Joris Messens (Speaker)
9 okt 2022Activiteit: Talk or presentation at a conference
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Summerschool research internship
Joris Messens (Supervisor)
16 aug 2022 → 19 aug 2022Activiteit: Participation in workshop, seminar
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Toegepaste Biologische Wetenschappen (Organisatie)
Joris Messens (Member)
15 dec 2022Activiteit: Member of PhD committee
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Redox Biochemistry and Chemistry (Tijdschrift)
Joris Messens (Editorial board member)
2022 → …Activiteit: Publication peer-review
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Toegepaste Biologische Wetenschappen (Organisatie)
Joris Messens (Member)
2022Activiteit: Member of PhD committee
Knipsels
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'Misisng link' ontdekt in verdedigingsmechanisme van de tuberculoseverwekker
1/12/12
1 Mediabijdrage
Pers / media: !!Other
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Vlaamse biologen stap dichter bij bestrijding tuberculose
14/11/12
1 Mediabijdrage
Pers / media: !!Other
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'Missing Link' Discovered in Defense Mechanism of Tuberculosis Pathogen
14/11/12
1 Mediabijdrage
Pers / media: !!Other
Scriptie
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Analysis of in silico designed calpain inhibitors
Auteur: Nguyen, H. H., Tompa, P., Pauwels, K. & Messens, J., 2013Begeleider: Pauwels, K. (Promotor)
Scriptie/Masterproef: Master's Thesis
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Aqueous size-exclusion chromatography of intact proteins at ultra-high pressures: effect on selectivity and efficiency
Auteur: Peten, F., Eeltink, S., Messens, J. & De Vos, J., 2016Scriptie/Masterproef: Master's Thesis
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Characterisation of the bacterial GTPase Obg, a novel target for drug development
Auteur: Berna, S., Versées, W. & Messens, J., 2014Scriptie/Masterproef: Master's Thesis
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Characterization of a small heat shock protein from rice proteome for putative chaperone activity in vitro
Auteur: Ali, M. M., Tompa, P., Kovacs, S. D. & Messens, J., 2015Scriptie/Masterproef: Master's Thesis
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Characterization of dipeptyl peptidase 4 (DPP-4) and bacterial collagenase
Auteur: Benachour, N., Vanderheyden, P. & Messens, J., 2017Begeleider: Vanderheyden, P. (Promotor)
Scriptie/Masterproef: Master's Thesis