Projecten per jaar
Persoonlijk profiel
Expertise
BIO: Joris Messens is since 2012 group leader of the Redox Signaling Lab within the VIB Center for Structural Biology and professor at the Vrije Universiteit Brussel. After several years in Biotech-industry as an Engineer in Biochemistry, he obtained his PhD from the John Moores University of Liverpool (UK, 2003) with structural and functional work on arsenate reductase from Staphyloccocus aureus. In 2006, he created together with Jean-Francois Collet (de Duve Institute, UCL) the Brussels Center for Redox Biology (http://redox.vub.ac.be/) as a platform to stimulate redox and oxidative protein folding research. Joris Messens is frequently invited speaker, session leader, chair and co-chair on international meetings, like GRC, ESF, EMBO, and he was member of the reviewing board for the DFG priority program ‘Dynamics of thiol-based switches in cellular physiology’. As a protein biochemist, he has authored more than 100 peer-reviewed publications (h-index > 40). Most of his studies focus on protein conformational changes induced by thiol-based reaction mechanisms, and the identification of redox-sensitive proteins.
MISSION: The mission of the Redox Signaling Lab is to decipher how cells sense and respond to redox metabolites. The importance of redox signaling for the proper functioning of the cell is being increasingly recognized, and the elucidation of its precise mechanisms and players is becoming critical, as it will allow us to manipulate these pathways with a wide variety of implications, ranging from increasing stress resistance in plants to identifying therapeutic targets in diseases where aberrant redox signaling plays a role.
MORE INFO: http://redox.vub.ac.be and https://messenslab.sites.vib.be/en
Vingerafdruk
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
-
SRP97: Microfluïdische manipulatie en optische detectie van cellen om inzicht te krijgen in sub-cellulaire dynamiek en metaboliet communicatie
De Malsche, W., Maes, D. & Messens, J.
1/03/24 → 28/02/29
Project: Fundamenteel
-
FWOTM1074: Moleculaire en structurele aspecten die de signaaltransductie van Prdx2 controleren
Malo Pueyo, J., Messens, J. & Bolduc, J.
1/11/21 → 31/10/25
Project: Fundamenteel
-
OZR3906: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - ULB, PEREZ CHAVEZ Israel
1/10/21 → 30/09/25
Project: Fundamenteel
-
A color-tailored fluorogenic sensor for hydrogen peroxide
Potekhina, E. S., Bass, D. I., Ezeriņa, D., Fleckenstein, D. D., Chebotarev, A. S., Sysoeva, V. A., Maltsev, D. I., Pak, V. V., Moshchenko, A. A., Sokolov, A. I., Myasnyanko, I. N., Baranov, M. S., Fedotov, A. B., Zheltikov, A. M., Lanin, A. A., Messens, J. & Belousov, V. V., 16 okt. 2025, In: Nature Chemical Biology. blz. 1-32 32 blz.Onderzoeksoutput: Article › peer review
Bestand1 Citaat (Scopus) -
Examining Arginase-1 Trimerization Uncovers a Promising Allosteric Site for Inhibition
Dechenne, J., Wierzbicka, M., Krimou, R., El Aakchioui, A., Malo Pueyo, J., Messens, J., Fillet, M., Spillier, Q. & Frédérick, R., 23 jan. 2025, In: Journal of medicinal chemistry. 68, 2, blz. 1433-1445 13 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand1 Citaat (Scopus)70 Downloads (Pure) -
Genome editing of TXNIP in human pluripotent stem cells for the generation of hepatocyte-like cells and insulin-producing islet-like aggregates
Traini, L., Negueruela, J., Elvira, B., St-Pierre-Wijckmans, W., Vandenbempt, V., Buss, C. E., Li, A., Pérez-Chávez, I., Ribeiro-Costa, F., Nunes, M., Messens, J., Ezeriņa, D., Hay, D. C., Bansal, M. & Gurzov, E. N., dec. 2025, In: Stem Cell Research & Therapy. 16, 1, 18 blz., 225.Onderzoeksoutput: Article › peer review
Open Access -
Glepaglutide-Loaded Foam for the Induction of Mucosal Healing in the Treatment of Inflammatory Bowel Disease.
Zhang, W., Van den Bossche, W., Yagoubi, H., Kambale, E. K., Wahni, K., Saxena, T., Guilbaud, L., Moreels, T. G., Messens, J. & Beloqui, A., 14 mrt. 2025, In: Advanced Healthcare Materials. 14, 7, blz. 1-11 10 blz., 2403497.Onderzoeksoutput: Article › peer review
Open Access -
Heterooligomerization drives structural plasticity of eukaryotic peroxiredoxins
Zimmermann, J., Lang, L., Pueyo, J. M., Riedel, M., wahni, K., Stobbe, D., Lux, C., Janvier, S., Vertommen, D., Lenhard, S., Hannemann, F., Castro, H., Tomas, A., Herrmann, J., Salvador, A., Mühlhaus, T., Riemer, J., Messens, J., Deponte, M. & Morgan, B., 10 mrt. 2025, 44 blz.Onderzoeksoutput: Other contribution
Prijzen
-
-
Winner of the ‘European contest for young scientists on protein purification’, Paris (1999)
Messens, Joris (Recipient), 1999
Prijs: Prize (including medals and awards)
Activiteiten
-
UNIVERSITE CATHOLIQUE DE LOUVAIN (Externe Organisatie)
Joris Messens (Member)
2 jul. 2025Activiteit: Member of PhD committee
-
Université catholique de Louvain (Externe Organisatie)
Joris Messens (Member)
7 jun. 2024Activiteit: Member of PhD committee
-
Université catholique de Louvain (Externe Organisatie)
Joris Messens (Member)
12 jan. 2024Activiteit: Member of PhD committee
-
Toegepaste Biologische Wetenschappen (Organisatie)
Joris Messens (Member)
30 aug. 2024Activiteit: Member of PhD committee
-
GRC Thiol-Based Redox Regulation and Signaling
Joris Messens (Participant)
14 jul. 2024 → 19 jul. 2024Activiteit: Participation in conference
Knipsels
-
'Misisng link' ontdekt in verdedigingsmechanisme van de tuberculoseverwekker
1/12/12
1 Mediabijdrage
Pers / media: !!Other
-
-
-
'Missing Link' Discovered in the Defense Mechanism of the Tuberculosis Pathogen
14/11/12
1 Mediabijdrage
Pers / media: !!Other
-
'Missing Link' Discovered in Defense Mechanism of Tuberculosis Pathogen
14/11/12
1 Mediabijdrage
Pers / media: !!Other
Scriptie
-
Analysis of in silico designed calpain inhibitors
Auteur: Nguyen, H. H., Tompa, P., Pauwels, K. & Messens, J., 2013Begeleider: Pauwels, K. (Promotor)
Scriptie/Masterproef: Master's Thesis
-
Aqueous size-exclusion chromatography of intact proteins at ultra-high pressures: effect on selectivity and efficiency
Auteur: Peten, F., Eeltink, S., Messens, J. & De Vos, J., 2016Scriptie/Masterproef: Master's Thesis
-
Characterisation of the bacterial GTPase Obg, a novel target for drug development
Auteur: Berna, S., Versées, W. & Messens, J., 2014Scriptie/Masterproef: Master's Thesis
-
Characterization of a small heat shock protein from rice proteome for putative chaperone activity in vitro
Auteur: Ali, M. M., Tompa, P., Kovacs, S. D. & Messens, J., 2015Scriptie/Masterproef: Master's Thesis
-
Characterization of dipeptyl peptidase 4 (DPP-4) and bacterial collagenase
Auteur: Benachour, N., Vanderheyden, P. & Messens, J., 2017Begeleider: Vanderheyden, P. (Promotor)
Scriptie/Masterproef: Master's Thesis