Projecten per jaar
Persoonlijk profiel
Expertise
Leo van Grunsven is a developmental biologist (Utrecht, NL) and obtained his PhD in life sciences from the Ecole Normale Supérieure de Lyon (France, 1996). He had his postdoctoral training at the NINDS/NIH (Bethesda, USA, ’96-‘98) and the KU Leuven (Belgium, ’98-‘06) before he moved to the Vrije Universiteit Brussel and became head of the Liver Cell Biology research group in 2009.
His group studies molecular mechanisms that drive liver homeostasis, fibrosis, and regeneration, with a particular focus on hepatic stellate cells. He also specialized in developing in vitro models for studying chronic liver disease. His group was the first to identify autophagy, AGE- and Hippo-signaling as key mechanisms involved in hepatic stellate cell activation during liver fibrogenesis. His team also reported on the transcriptional changes that are associated with the activation of mouse and human hepatic stellate cells and established the first hepatocyte-injury dependent in vitro liver fibrosis model by using organoid cultures of human hepatocytes and primary or iPSC-derived hepatic stellate cells. The group currently invests in refining and applying their in vitro models of liver fibrosis and investigates the regulation of stress pathways in hepatic stellate cells and other sinusoidal liver cells during an acute and chronic liver injury in mouse models.
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Leo van Grunsven actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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CONO830: 8st Jaarlijkse meeting van de Belgische Vereniging voor Stamcelonderzoek (organisatie conferentie)
3/03/25 → 31/12/25
Project: Fundamenteel
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IOF3035: B-LIVER 2.0 (Brusselse Alliantie voor Leveronderzoek & Valorisatie)
Vanhaecke, T., van Grunsven, L., De Kock, J., Vinken, M., Reynaert, H. & Van Goethem, F.
1/01/25 → 31/12/29
Project: Toegepast
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FWOTM1257: CATCH - CAR-T cel immunotherapie tegen Chronische leverziekte en Hepatocellulair carcinoom
De Wolf, R., van Grunsven, L. & Breckpot, K.
1/11/24 → 31/10/28
Project: Fundamenteel
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HERC66: 3D-CELLMAP: Onthullen van complexe celinteracties in weefsels door middel van 3D super-resolutie proteïne multiplex beeldvorming.
Movahedi, K., Rooman, I., Sermon, K., De Bundel, D., Fioravanti, A., Staels, W., Magez, S., Breckpot, K., De Kock, J., Laoui, D., Goyvaerts, C., Smolders, I., Van Ginderachter, J., Marcelino Rodrigues, R., De Leu, N., van Grunsven, L., Hernot, S., Peeters, E., Vanhaecke, T., De Veirman, K., Ruytinx, J., Van Schependom, J., Kortekaas, I. & Goossens, E.
1/05/24 → 31/05/28
Project: Fundamenteel
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OZR4233: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - KU Leuven, KIMPS Laurens
20/10/23 → 19/10/27
Project: Fundamenteel
Onderzoeksoutput
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A novel liver organoid model using directed mutagenesis to study the oncogenic potential of human pluripotent stem cell-derived hepatocytes
Huyghebaert, A., Al Delbany, D., Krivec, N., van Grunsven, L. A. & Spits, C., 11 apr 2025, (Unpublished).Onderzoeksoutput: Poster
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Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies
Merens, V., Knetemann, E., Gürbüz, E., De Smet, V., Messaoudi, N., Reynaert, H., Verhulst, S. & van Grunsven, L. A., jan 2025, In: JHEP reports. 7, 1, blz. 1-12 12 blz., 101223.Onderzoeksoutput: Article › peer review
Open AccessBestand1 Citaat (Scopus)9 Downloads (Pure) -
An opto-acousto-fluidic microchip for efficient Raman spectroscopy of microparticles in aqueous environment
Lotfi Choobbari, M., Vandermotten, M., Chalyan, T., Bihi, I., Gelin, P. P., De Malsche, W., Meulebroeck, W., van Grunsven, L. A., Thienpont, H. & Ottevaere, P. D. I. H., 1 nov 2024, In: Sensors and Actuators. B, Chemical. 418, blz. 1-10 10 blz., 136300.Onderzoeksoutput: Article › peer review
Open AccessBestand9 Downloads (Pure) -
Early detection of liver fibrosis through hepatic stellate cell activation monitoring using Raman spectroscopy and machine learning
Vandermotten, M., Knetemann, E., Chalyan, T., Meulebroeck, W., van Grunsven, L. A. & Ottevaere, P. D. I. H., 2024, Early detection of liver fibrosis through hepatic stellate cell activation monitoring using Raman spectroscopy and machine learning. Popp, J. & Gergely, C. (redactie). SPIE, Vol. 13006. blz. 1-6 6 blz. 1300603. (Proceedings of SPIE - The International Society for Optical Engineering; vol. 13006).Onderzoeksoutput: Conference paper › Research
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Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Krivec, N., Couvreu De Deckersberg, E., Lei, Y., Al Delbany, D., Regin, M., Verhulst, S., van Grunsven, L. A., Sermon, K. & Spits, C., 21 nov 2024, In: Cell Death and Disease. 15, 14 blz., 852.Onderzoeksoutput: Article › peer review
Open Access
Datasets
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Human iPSC-derived liver co-culture spheroids to model liver fibrosis
Kazemzadeh Dastjerd, M. (Creator), van Grunsven, L. (Creator) & Cools, L. (Creator), Zenodo, 20 feb 2024
DOI: 10.5281/zenodo.10684185, https://zenodo.org/records/10684185
Dataset
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Intratumoral delivery of lipid nanoparticle-formulated mRNA encoding IL-21, IL-7, and 4-1BBL induces systemic anti-tumor immunity
Laoui, D. (Creator), Hamouda, A. E. I. (Creator), Filtjens, J. (Creator), Brabants, E. (Creator), Kancheva, D. (Creator), Debraekeleer, A. (Creator), Brughmans, J. (Creator), Jacobs, L. (Creator), Bardet, P. (Creator), Knetemann, E. (Creator), Lefesvre, P. (Creator), Allonsius, L. (Creator), Gontsarik, M. (Creator), Varela, I. (Creator), Crabbé, M. (Creator), Clappaert, E. (Creator), Cappellesso, F. (Creator), Caro, A. A. (Creator), Gordún Peiró, A. (Creator), Fredericq, L. (Creator), Hadadi, E. (Creator), Senti, M. E. (Creator), Schiffelers, R. (Creator), van Grunsven, L. (Creator), Nana, F. A. (Creator), De Geest, B. (Creator), Deschoemaeker, S. (Creator), De Koker, S. (Creator) & Lambolez, F. (Creator), NCBI Gene Expression Omnibus, 12 nov 2024
Dataset
Activiteiten
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Drug-induced liver injury in biopsy-scaled Precision-Cut Liver Slices.
Milan Lobo (Speaker) & Leo van Grunsven (Contributor)
13 feb 2025Activiteit: Talk or presentation at a conference
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OZR ZAP selection (Evenement)
Aldo Scafoglieri (Contributor), Eva Swinnen (Contributor), Koen Putman (Chair), Debby Mangelings (Contributor) & Leo van Grunsven (Contributor)
8 jun 2022Activiteit: Membership of peer-review panel or committee
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
28 sep 2021Activiteit: Talk or presentation at a conference
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LSECs in chronic liver disease- Willy Gepts, UZ brussel
Elise Van Os (Recipient) & Leo van Grunsven (Contributor)
1 jan 2021 → 1 jan 2022Activiteit: Written proposal
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
24 jun 2021Activiteit: Talk or presentation at a conference
Scriptie
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Real-Time in vitro Toxicity Monitoring in a Microfluidic Bioreactor for Drug and Chemical Safety Assessment
Auteur: van Grunsven, L. A. & Prill, S., 7 jul 2015Scriptie/Masterproef: Doctoral Thesis
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Real-time in vitro toxicity monitoring in a microfluidic bioreactor for drug and chemical safety assessment.
Auteur: van Grunsven, L. A. & Prill, S., 4 mrt 2015Scriptie/Masterproef: Doctoral Thesis
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The Functional Role of Furin in the Liver during Homeostasis and Pathological Conditions: A Journey of Challenges and Pitfalls in Transgene Technology
Auteur: van Grunsven, L. A. & Pruniau, V., nov 2015Scriptie/Masterproef: Doctoral Thesis