Projecten per jaar
Persoonlijk profiel
Expertise
Leo van Grunsven is a developmental biologist (Utrecht, NL) and obtained his PhD in life sciences from the Ecole Normale Supérieure de Lyon (France, 1996). He had his postdoctoral training at the NINDS/NIH (Bethesda, USA, ’96-‘98) and the KU Leuven (Belgium, ’98-‘06) before he moved to the Vrije Universiteit Brussel and became head of the Liver Cell Biology research group in 2009.
His group studies molecular mechanisms that drive liver homeostasis, fibrosis, and regeneration, with a particular focus on hepatic stellate cells. He also specialized in developing in vitro models for studying chronic liver disease. His group was the first to identify autophagy, AGE- and Hippo-signaling as key mechanisms involved in hepatic stellate cell activation during liver fibrogenesis. His team also reported on the transcriptional changes that are associated with the activation of mouse and human hepatic stellate cells and established the first hepatocyte-injury dependent in vitro liver fibrosis model by using organoid cultures of human hepatocytes and primary or iPSC-derived hepatic stellate cells. The group currently invests in refining and applying their in vitro models of liver fibrosis and investigates the regulation of stress pathways in hepatic stellate cells and other sinusoidal liver cells during an acute and chronic liver injury in mouse models.
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Leo van Grunsven actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Netwerk
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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FWOTM1107: Het bestuderen van de initiatie en de progressie van NASH in een stamcel-gederiveerde lever co-cultuurmodel aan de hand van het onthullen van de activatie van cellulaire stress pathways
Toprakhisar, B. & van Grunsven, L.
1/10/22 → 6/10/25
Project: Fundamenteel
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EUAR78: Langdurige microfysiologische monsterbeeldvorming voor evaluatie van polyfarmacie in de lever: DeLIVERY
1/05/22 → 30/04/26
Project: Toegepast
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OZR4059: Langdurige microfysiologische monsterbeeldvorming voor evaluatie van polyfarmacie in de lever: DeLIVERY (EU BONUS OZR)
1/05/22 → 30/04/26
Project: Fundamenteel
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OZR3913: Cofinanciering OZR FWO Hercules MZW - Single-cell eiwit analyse in intacte weefsels
Movahedi, K., van Grunsven, L., Rooman, I., Van Ginderachter, J., Smolders, I., Neyns, B., Vanhaecke, T., Laoui, D., Breckpot, K., De Veirman, K., Stijlemans, B., Van Schependom, J., Magez, S., Goyvaerts, C., De Kock, J., De Leu, N., Massie, A., Hellemans, K., Spits, C., De Bundel, D., De Trez, C., Hernot, S., Van Dooren, S., Aerts, J., Staels, W. & Tuyaerts, S.
25/02/22 → 25/02/26
Project: Fundamenteel
Onderzoeksoutput
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Assessing Tumor-Infiltrating Lymphocytes in Breast Cancer: A Proposal for Combining Immunohistochemistry and Gene Expression Analysis to Refine Scoring
Locy, H., Verhulst, S., Cools, W., Waelput, W., Brock, S., Cras, L., Schiettecatte, A., Jonckheere, J., van Grunsven, L. A., Vanhoeij, M., Thielemans, K. & Breckpot, K., 11 feb 2022, In: Frontiers in Immunology. 13, 794175.Onderzoeksoutput: Article › peer review
Open AccessBestand3 Citaten (Scopus)45 Downloads (Pure) -
Development and comparison of novel prediction models for genotoxicity based on biomarker genes in HepaRGTM cells
Thienpont, A., Verhulst, S., van Grunsven, L. A., Rogiers, V., Vanhaecke, T. & Mertens, B., 16 mei 2022, (Unpublished).Onderzoeksoutput: Unpublished abstract
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Editorial: Roles of Liver Sinusoidal Endothelial Cells in Liver Homeostasis and Disease
Lalor, P., Huser, T. & van Grunsven, L. A., 8 mrt 2022, In: Frontiers in Physiology. 13, 3 blz., 869473.Onderzoeksoutput: Editorial
Open AccessBestand8 Downloads (Pure) -
Extension of the Virtual Cell Based Assay from a 2-D to a 3-D Cell Culture Model
Bednarczyk, E., Lu, Y., Paini, A., Batista Leite, S., van Grunsven, L. A., Worth, A. & Whelan, M., jan 2022, In: ATLA. Alternatives to Laboratory Animals. 50, 1, blz. 45-56 12 blz.Onderzoeksoutput: Article › peer review
1 Citaat (Scopus) -
GENOMARK, a promising new approach methodology for genotoxicity testing in the cosmetic industry.
Thienpont, A., Verhulst, S., van Grunsven, L. A., Vanhaecke, T., Mertens, B. & Rogiers, V., 3 dec 2022, (Unpublished).Onderzoeksoutput: Unpublished abstract
Activiteiten
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OZR ZAP selection (Evenement)
Aldo Scafoglieri (Contributor), Eva Swinnen (Contributor), Koen Putman (Chair), Debby Mangelings (Contributor) & Leo van Grunsven (Contributor)
8 jun 2022Activiteit: Membership of peer-review panel or committee
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LSECs in chronic liver disease- Willy Gepts, UZ brussel
Elise Van Os (Recipient) & Leo van Grunsven (Contributor)
1 jan 2021 → 1 jan 2022Activiteit: Written proposal
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
4 mrt 2021Activiteit: Talk or presentation at a conference
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
24 jun 2021Activiteit: Talk or presentation at a conference
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Multicellular primary mouse liver spheroids for DILI, NAFLD, NASH and fibrosis studies.
Laura Cools (Speaker), Elise Van Os (Speaker), Nathalie Eysackers (Contributor), Ayla Smout (Contributor), Stefaan Verhulst (Contributor), Hendrik Reynaert (Contributor), Inge Mannaerts (Contributor) & Leo van Grunsven (Contributor)
28 sep 2021Activiteit: Talk or presentation at a conference
Scriptie
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Real-Time in vitro Toxicity Monitoring in a Microfluidic Bioreactor for Drug and Chemical Safety Assessment
Auteur: van Grunsven, L. A. & Prill, S., 7 jul 2015Scriptie/Masterproef: Doctoral Thesis
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Real-time in vitro toxicity monitoring in a microfluidic bioreactor for drug and chemical safety assessment.
Auteur: van Grunsven, L. A. & Prill, S., 4 mrt 2015Scriptie/Masterproef: Doctoral Thesis
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The Functional Role of Furin in the Liver during Homeostasis and Pathological Conditions: A Journey of Challenges and Pitfalls in Transgene Technology
Auteur: van Grunsven, L. A. & Pruniau, V., nov 2015Scriptie/Masterproef: Doctoral Thesis