Projecten per jaar
Persoonlijk profiel
Expertise
Mathieu Vinken (Belgian; born 1 February 1978) is a professor affiliated with the Department of Pharmaceutical and Pharmacological Sciences at the Faculty of Medicine and Pharmacy of the Vrije Universiteit Brussel-Belgium and a visiting professor at the Department of Pathology of the Faculty of Veterinary Sciences of the University of São Paulo-Brazil. He has a master degree in pharmaceutical sciences (Pharm.D.), holds a doctoral degree in in vitro toxicology (Ph.D.), is a European registered toxicologist (E.R.T.) and a trained European chemical risk assessor. His research focuses on 2 topics, namely (i) the study of mechanisms of liver toxicity to be used for in vitro modelling purposes as well as for prediction of chemical-induced liver toxicity, and (ii) the study of connexins and pannexins as drug targets and diagnostic biomarkers of liver disease. He acquired over €20 million external funding, of which most as promoter and a large portion originating from the European Horizon 2020 excellent science pillar, namely 2 grants (i.e. starting grant and proof-of-concept grant) from the European Research Council (ERC), 1 grant from the Future and Emerging Technologies (FET) program and 1 grant from the Marie Skłodowska-Curie Actions (MSCA) program, as well as national excellent research funding, including from the Flemish Methusalem program and a São Paulo excellence chair grant. He coordinates several (inter)national research projects, among which the 5-years European project called “ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment” (€17 million; 18 European and US partners). He is a regular member of 7 scientific societies in the area of toxicology and hepatology. He is past-president and honorary member of the European Society of Toxicology In Vitro (ESTIV), former steering committee member of the Belgian society of Toxicology (BelTox) and current chair of the In Vitro and In Silico Toxicology Speciality Section of the Association of European Toxicologists and European Societies of Toxicology (EUROTOX). He is a frequently consulted toxicologist by European agencies (i.e. European Food Safety Authority), industry (i.e. Cosmetics Europe) and high-impact factor journals (i.e. Science). He is a regularly invited speaker on international and world conferences. He is promoter of 6 completed and 10 ongoing doctoral projects as well as of 3 completed and 6 ongoing postdoctoral projects. He is author of as much as 200 publications in international peer-reviewed journals (h-index in Web of Science: 43) and books. He is editor of 3 books. He is editor-in-chief of the journals Toxicology, Frontiers in In Vitro Toxicology and MethodsX Pharmacology, Toxicology and Pharmaceutical Science, European editor of Applied In Vitro Toxicology, and associate editor of Current Research in Toxicology, Archives of Toxicology and Journal of Dietary Supplements. He received 10 scientific awards, among which the Galen Award for Pharmacology.
- ORCID ID: 0000-0001-5115-8893
- Researcher ID: H-7513-2013
- Website: www.mathieuvinken.com
Externe posities
Visiting professor, Universidade de São Paulo
15 nov 2013 → …Vingerafdruk
- 1 Soortgelijke profielen
Netwerk
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FWOAL1070: De rol van pannexine1 kanalen in niet-alcoholische steatohepatitis: therapeutische en diagnostische relevantie.
1/01/23 → 31/12/26
Project: Fundamenteel
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OZR4013: OZR opvangmandaat: Mechanistisch onderzoek van de levercholestatische effecten van PFAS: een gecombineerde in vitro-in vivo studie.
1/11/22 → 31/10/23
Project: Fundamenteel
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FWOTM1143: Kunnen microplastics en nanoplastics leverkanker veroorzaken en/of verergeren? Een gecombineerde in vitro-in vivo studie
1/11/22 → 31/10/26
Project: Fundamenteel
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AIIFUND87: Buitenlands Studieprogramma Nationaal Miniterie van Onderwijs - Turkije: Ph.D. Batuhan Yildiz
1/02/22 → 31/12/25
Project: Policy Based
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FWOAL1047: Kunnen voedingsadditieven leverschade veroorzaken? Een mechanistische in vitro modellering studie.
1/01/22 → 31/12/25
Project: Fundamenteel
Onderzoeksoutput
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Effects of acute and chronic disease on cell junctions in mouse liver
Van Campenhout, R., Cogliati, B. & Vinken, M., 3 jan 2023, In: EXCLI Journal. 22, 11 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand9 Downloads (Pure) -
Evaluation of functional candidate biomarkers of non-genotoxic hepatocarcinogenicity in human liver spheroid co-cultures
dos Santos Rodrigues, B., Leroy, K., Mihajlovic, M., De Boever, S., Vanbellingen, S., Cogliati, B., Aerts, J. & Vinken, M., 13 mrt 2023, (Accepted/In press) In: Archives of Toxicology.Onderzoeksoutput: Article › peer review
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Kupffer cells contested as early drivers in the pathogenesis of primary sclerosing cholangitis
De Muynck, K., Vanderborght, B., De Ponti, F. F., Gijbels, E., Van Welden, S., Guilliams, M., Scott, C. L., Beschin, A., Vinken, M., Lefere, S., Geerts, A., Verhelst, X., Van Vlierberghe, H. & Devisscher, L., 11 jan 2023, (Accepted/In press) In: The American Journal of Pathology.Onderzoeksoutput: Article › peer review
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Systematic comparison of experimental and human obstructive cholestasis reveals conservation of canonical pathway activation and biomarkers relevant for cholestatic liver disease
Gijbels, E., De Muynck, K., Vanderborght, B., Meese, T., Van Nieuwerburgh, F., Vanlander, A., Berrevoet, F., Hendrikx, B., Hoorens, A., Van Vlierberghe, H., Vinken, M. & Devisscher, L., 11 jan 2023, (Accepted/In press) In: Genes&Diseases.Onderzoeksoutput: Article › peer review
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Transient Kupffer cell depletion and subsequent replacement by infiltrating monocyte-derived cells does not alter the induction or progression of hepatocellular carcinoma
Vanderborght, B., De Muynck, K., Gijbels, E., Lefere, S., Scott, C. L., Guilliams, M., Beschin, A., Vinken, M., Verhelst, X., Anja, G., Van Vlierberghe, H. & Devisscher, L., 9 feb 2023, (Accepted/In press) In: International Journal of Cancer.Onderzoeksoutput: Article › peer review
Prijzen
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Best oral presentation award
Cooreman, Axelle (Recipient), Caufriez, Anne (Recipient), Tabernilla Garcia, Andres (Recipient), Van Campenhout, Raf (Recipient), Leroy, Kaat (Recipient), Sanz Serrano, Julen (Recipient), Kadam, Prashant (Recipient), dos Santos Rodrigues, Bruna (Recipient), Lamouroux, A. (Recipient), Ballet, Steven (Recipient), Annaert, P. (Recipient) & Vinken, Mathieu (Recipient), 24 nov 2022
Prijs: Prize (including medals and awards)
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Best Poster Presentation Award
Leroy, Kaat (Recipient), Cooreman, Axelle (Recipient), Van Campenhout, Raf (Recipient), Cogliati, B. (Recipient) & Vinken, Mathieu (Recipient), 24 nov 2022
Prijs: Prize (including medals and awards)
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ESTIV honorary membership
Vinken, Mathieu (Recipient), 1 okt 2020
Prijs: National/international honour
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European Association for the Study of the Liver
Vinken, Mathieu (Recipient), 21 mei 2014
Prijs: Fellowship awarded competitively
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Galenus award for pharmacology
Vinken, Mathieu (Recipient), 5 dec 2018
Prijs: Prize (including medals and awards)
Activiteiten
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ONTOX Stakeholder Network Meeting
Mathieu Vinken (Organiser)
13 mrt 2023 → 14 mrt 2023Activiteit: Participation in workshop, seminar
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ONTOX General Assembly meeting
Mathieu Vinken (Chair)
6 mrt 2023 → 7 mrt 2023Activiteit: Participation in workshop, seminar
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International Colloquium on Gap Junctions and Cancer
Mathieu Vinken (Organiser)
10 jul 2023 → 14 jul 2023Activiteit: Participation in conference
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ASPIS chair and SRAB meeting
Mathieu Vinken (Chair)
27 feb 2023Activiteit: Participation in workshop, seminar
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ONTOX webinar “Intellectual property rights”
Mathieu Vinken (Chair)
20 jan 2023Activiteit: Participation in workshop, seminar
Knipsels
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Basic techniques in experimental hepatology at a glance: set-up of 3D spheroid cultures for NASH and liver cancer research
11/01/23
1 Mediabijdrage
Pers / media: !!Research
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EASL video set-up of 3D spheroid cell culture for studying NASH and liver cancer
11/01/23
1 Mediabijdrage
Pers / media: !!Research
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ASPIS open symposium: towards animal-free chemical risk assessment
28/11/22
1 Mediabijdrage
Pers / media: !!Research
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How Non-Animal Testing Can Reshape Health and Environment Policies
23/04/21
1 item van Media-aandacht
Pers / media: !!Research
Scriptie
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Bijdrage tot de studie van de fase I biotransformatie van Trichostatine A bij rat en mens aan de hand van in vitro technieken
Auteur: Vinken, M., Rogiers, V. & Elaut, G., 2001Begeleider: Rogiers, V. (Promotor) & Elaut, G. (Co-promotor)
Scriptie/Masterproef: Master's Thesis
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Characterization of connexins and pannexins in liver of a mouse model of non-alcoholic steatohepatitis
Auteur: Vinken, M., (Decl.:)Gaugie, M. & Willebrords, J., 2018Scriptie/Masterproef: Master's Thesis
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Differentiation of brain like endothelial cells from iPSC and application to BBB toxicity testing
Auteur: Vinken, M., Wellens, S. & d’Artois, U., 24 jun 2021Scriptie/Masterproef: Doctoral Thesis
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Effect of connexin and pannexin mimetic peptides on connexin and pannexin (hemi)channels in cultured primary hepatocytes
Auteur: Vinken, M., 15 jun 2016Begeleider: Rogiers, V. (Promotor), Willebrords, J. (Promotor) & Crespo Yanguas, S. (Promotor)
Scriptie/Masterproef: Master's Thesis
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Effect of COVID-19 drugs on connexin43
Auteur: Willems, O., Cooreman, A. & Vinken, M., 2021Scriptie/Masterproef: Master's Thesis