Projecten per jaar
Persoonlijk profiel
Expertise
Mathieu Vinken (Belgian; born 1 February 1978) is a professor affiliated with the Department of Pharmaceutical and Pharmacological Sciences at the Faculty of Medicine and Pharmacy of the Vrije Universiteit Brussel-Belgium and a visiting professor at the Department of Pathology of the Faculty of Veterinary Sciences of the University of São Paulo-Brazil. He has a master degree in pharmaceutical sciences (Pharm.D.), holds a doctoral degree in in vitro toxicology (Ph.D.), is a European registered toxicologist (E.R.T.) and a trained European chemical risk assessor. His research focuses on 2 topics, namely (i) the study of mechanisms of liver toxicity to be used for in vitro modelling purposes as well as for prediction of chemical-induced liver toxicity, and (ii) the study of connexins and pannexins as drug targets and diagnostic biomarkers of liver disease. He acquired over €20 million external funding, of which most as promoter and a large portion originating from the European Horizon 2020 excellent science pillar, namely 2 grants (i.e. starting grant and proof-of-concept grant) from the European Research Council (ERC), 1 grant from the Future and Emerging Technologies (FET) program and 1 grant from the Marie Skłodowska-Curie Actions (MSCA) program, as well as national excellent research funding, including from the Flemish Methusalem program and a São Paulo excellence chair grant. He coordinates several (inter)national research projects, among which the 5-years European project called “ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment” (€17 million; 18 European and US partners). He is a regular member of 7 scientific societies in the area of toxicology and hepatology. He is past-president and honorary member of the European Society of Toxicology In Vitro (ESTIV), former steering committee member of the Belgian society of Toxicology (BelTox) and current chair of the In Vitro and In Silico Toxicology Speciality Section of the Association of European Toxicologists and European Societies of Toxicology (EUROTOX). He is a frequently consulted toxicologist by European agencies (i.e. European Food Safety Authority), industry (i.e. Cosmetics Europe) and high-impact factor journals (i.e. Science). He is a regularly invited speaker on international and world conferences. He is promoter of 6 completed and 10 ongoing doctoral projects as well as of 3 completed and 6 ongoing postdoctoral projects. He is author of as much as 200 publications in international peer-reviewed journals (h-index in Web of Science: 43) and books. He is editor of 3 books. He is editor-in-chief of the journals Toxicology, Frontiers in In Vitro Toxicology and MethodsX Pharmacology, Toxicology and Pharmaceutical Science, European editor of Applied In Vitro Toxicology, and associate editor of Current Research in Toxicology, Archives of Toxicology and Journal of Dietary Supplements. He received 10 scientific awards, among which the Galen Award for Pharmacology.
- ORCID ID: 0000-0001-5115-8893
- Researcher ID: H-7513-2013
- Website: www.mathieuvinken.com
Externe posities
Visiting professor, Universidade de São Paulo
15 nov 2013 → …
Vingerafdruk
- 12 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
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IOF3035: B-LIVER 2.0 (Brusselse Alliantie voor Leveronderzoek & Valorisatie)
Vanhaecke, T., van Grunsven, L., De Kock, J., Vinken, M., Reynaert, H. & Van Goethem, F.
1/01/25 → 31/12/29
Project: Toegepast
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FWOSB171: Optimalisatie van “nanobodies” gericht tegen pannexine1 kanalen voor de behandeling van cholestase
1/11/24 → 31/10/28
Project: Fundamenteel
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Onderzoeksoutput
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A human liver-based in vitro test battery to detect liver steatogenic potential of chemicals from various applicability domains
Verhoeven, A., Drees, A. H., Rodrigues, R., Sanz-Serrano, J., Vanhaecke, T. & Vinken, M., 2025, (Unpublished).Onderzoeksoutput: Poster
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An integrated weight-of-evidence approach to strengthen the application potential of in vitro test batteries
Sanz-Serrano, J., Maerten, A., Drees, A. H., Jiang, J. & Vinken, M., 2025, (Unpublished).Onderzoeksoutput: Poster
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ASPIS definition of new approach methodologies
Colbourne, J. K., Escher, S. E., Lee, R., Vinken, M., Van De Water, B. & Freedman, J. H., 30 jan 2025, (Accepted/In press) In: Environmental Toxicology and Chemistry.Onderzoeksoutput: Article › peer review
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Design and synthesis of cyclic lipidated peptides derived from the C-terminus of Cx43 for hemichannel inhibition and cardiac endothelium targeting
Iaculli, D., Montgomery, J., Lamouroux, A., Caufriez, A., Gozalbes, R., Vinken, M., Molica, F., Kwak, B. R. & Ballet, S., 1 mrt 2025, (Accepted/In press) In: RSC Medicinal Chemistry. blz. 1-15 15 blz., 39829973.Onderzoeksoutput: Article › peer review
Open AccessBestand -
Development and characterization of an advanced MASH in vitro 3D human liver co-culture spheroid model
Yildiz, B., Orhan, H., Demeyer, K., Vinken, M. & Tabernilla Garcia, A., 2025, (Submitted). 1 blz.Onderzoeksoutput: Poster
Datasets
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Effects of acute and chronic disease on cell junctions in mouse liver
Van Campenhout, R. (Creator) & Vinken, M. (Supervisor), EXCLI Journal, 2023
Dataset
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Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury
Van Campenhout, R. (Creator), De Groof, T. (Creator), Kadam, P. (Researcher), Muyldermans, S. (Supervisor), Devoogdt, N. (Supervisor) & Vinken, M. (Supervisor), Journal of Nanobiotechnology, 2023
DOI: 10.1186/s12951-023-02137-1
Dataset
Prijzen
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Best oral presentation award
Cooreman, Axelle (Recipient), Caufriez, A. (Recipient), Tabernilla Garcia, Andres (Recipient), Van Campenhout, Raf (Recipient), Leroy, K. (Recipient), Sanz Serrano, Julen (Recipient), Kadam, Prashant (Recipient), dos Santos Rodrigues, B. (Recipient), Lamouroux, A. (Recipient), Ballet, Steven (Recipient), Annaert, P. (Recipient) & Vinken, Mathieu (Recipient), 24 nov 2022
Prijs: Prize (including medals and awards)
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Best Poster Presentation Award
Leroy, K. (Recipient), Cooreman, Axelle (Recipient), Van Campenhout, Raf (Recipient), Cogliati, B. (Recipient) & Vinken, Mathieu (Recipient), 24 nov 2022
Prijs: Prize (including medals and awards)
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ESTIV honorary membership
Vinken, Mathieu (Recipient), 1 okt 2020
Prijs: National/international honour
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European Association for the Study of the Liver
Vinken, Mathieu (Recipient), 21 mei 2014
Prijs: Fellowship awarded competitively
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Galenus award for pharmacology
Vinken, Mathieu (Recipient), 5 dec 2018
Prijs: Prize (including medals and awards)
Activiteiten
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EUROTOX Executive Committee Meeting
Mathieu Vinken (Participant)
21 feb 2025 → 23 feb 2025Activiteit: Participation in workshop, seminar
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Oral presentation " new approach methodologies used for ground-based life sciences in space research
Mathieu Vinken (Invited speaker)
1 sep 2025Activiteit: Talk or presentation at a conference
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RTD workshop on NAMs future priority research areas
Mathieu Vinken (Organiser)
10 apr 2025 → 11 apr 2025Activiteit: Participation in workshop, seminar
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Microphysiological World Summit
Mathieu Vinken (Chair)
9 jun 2025 → 13 jun 2025Activiteit: Participation in conference
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FWO PhD Fellowship in fundamental research. MUSICALITY: Mechanistic Understanding of SIngle-cell-level Communication Associated with iDILI through phenoTYping
Julia Matyjasiak (Contributor), Jian Jiang (Contributor) & Mathieu Vinken (Supervisor)
2025Activiteit: Written proposal
Knipsels
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VUB-Onderzoeker Mathieu Vinken ontvangt prijs
31/10/24
1 item van Media-aandacht
Pers / media: !!Research
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"VUB onderzoeker Mathieu Vinken ontvangt prestigieuze prijs”
10/10/24
1 Mediabijdrage
Pers / media: !!Research
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-“Why is animal testing still with us?”
2/09/24
1 item van Media-aandacht
Pers / media: !!Expert Comment
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VUB team develops breakthrough nanobody technology against liver inflammation
Raf Van Campenhout, Mathieu Vinken, Nick Devoogdt & Timo De Groof
8/12/23
1 item van Media-aandacht
Pers / media: !!Other
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Scriptie
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Bijdrage tot de studie van de fase I biotransformatie van Trichostatine A bij rat en mens aan de hand van in vitro technieken
Auteur: Vinken, M., Rogiers, V. & Elaut, G., 2001Begeleider: Rogiers, V. (Promotor) & Elaut, G. (Co-promotor)
Scriptie/Masterproef: Master's Thesis
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Biomarkers for psychological adaptation to extreme environments for future space flight: related genes in blood-based in vitro research
Auteur: Vinken, M., 28 jun 2024Scriptie/Masterproef: Master's Thesis
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Characterization of connexins and pannexins in liver of a mouse model of non-alcoholic steatohepatitis
Auteur: Vinken, M., (Decl.:)Gaugie, M. & Willebrords, J., 2018Scriptie/Masterproef: Master's Thesis
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Differentiation of brain like endothelial cells from iPSC and application to BBB toxicity testing
Auteur: Vinken, M., Wellens, S. & d’Artois, U., 24 jun 2021Scriptie/Masterproef: Doctoral Thesis
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Effect of connexin and pannexin mimetic peptides on connexin and pannexin (hemi)channels in cultured primary hepatocytes
Auteur: Vinken, M., 15 jun 2016Begeleider: Rogiers, V. (Promotor), Willebrords, J. (Promotor) & Crespo Yanguas, S. (Promotor)
Scriptie/Masterproef: Master's Thesis