Projecten per jaar
Persoonlijk profiel
Expertise
Mathieu Vinken (Belgian; born 1 February 1978) is a professor affiliated with the Department of Pharmaceutical and Pharmacological Sciences at the Faculty of Medicine and Pharmacy of the Vrije Universiteit Brussel-Belgium and a visiting professor at the Department of Pathology of the Faculty of Veterinary Sciences of the University of São Paulo-Brazil. He has a master degree in pharmaceutical sciences (Pharm.D.), holds a doctoral degree in in vitro toxicology (Ph.D.), is a European registered toxicologist (E.R.T.) and a trained European chemical risk assessor. His research focuses on 2 topics, namely (i) the study of mechanisms of liver toxicity to be used for in vitro modelling purposes as well as for prediction of chemical-induced liver toxicity, and (ii) the study of connexins and pannexins as drug targets and diagnostic biomarkers of liver disease. He acquired over €20 million external funding, of which most as promoter and a large portion originating from the European Horizon 2020 excellent science pillar, namely 2 grants (i.e. starting grant and proof-of-concept grant) from the European Research Council (ERC), 1 grant from the Future and Emerging Technologies (FET) program and 1 grant from the Marie Skłodowska-Curie Actions (MSCA) program, as well as national excellent research funding, including from the Flemish Methusalem program and a São Paulo excellence chair grant. He coordinates several (inter)national research projects, among which the 5-years European project called “ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment” (€17 million; 18 European and US partners). He is a regular member of 7 scientific societies in the area of toxicology and hepatology. He is past-president and honorary member of the European Society of Toxicology In Vitro (ESTIV), former steering committee member of the Belgian society of Toxicology (BelTox) and current chair of the In Vitro and In Silico Toxicology Speciality Section of the Association of European Toxicologists and European Societies of Toxicology (EUROTOX). He is a frequently consulted toxicologist by European agencies (i.e. European Food Safety Authority), industry (i.e. Cosmetics Europe) and high-impact factor journals (i.e. Science). He is a regularly invited speaker on international and world conferences. He is promoter of 6 completed and 10 ongoing doctoral projects as well as of 3 completed and 6 ongoing postdoctoral projects. He is author of as much as 200 publications in international peer-reviewed journals (h-index in Web of Science: 43) and books. He is editor of 3 books. He is editor-in-chief of the journals Toxicology, Frontiers in In Vitro Toxicology and MethodsX Pharmacology, Toxicology and Pharmaceutical Science, European editor of Applied In Vitro Toxicology, and associate editor of Current Research in Toxicology, Archives of Toxicology and Journal of Dietary Supplements. He received 10 scientific awards, among which the Galen Award for Pharmacology.
- ORCID ID: 0000-0001-5115-8893
- Researcher ID: H-7513-2013
- Website: www.mathieuvinken.com
Externe posities
Visiting professor, Universidade de São Paulo
15 nov. 2013 → …
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
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FWOSB199: Ontwikkeling en toepassing van een op lever-gebaseerd in vitro testplatform voor de veiligheidsevaluatie van voedingsingrediënten, voedingscontaminanten en hun mengsels.
Avirvarei, A.-C. (Mandataris), Vinken, M. (Administrative Promotor) & Sanz Serrano, J. (CoI (Co-Promotor))
1/11/25 → 31/10/29
Project: Fundamenteel
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FWOTM1338: Inductie en verergering van leversteatose en cholestase door micro- en nanoplastics: een integrale in vitro mechanistische studie.
Xiftou, K. (Mandataris), Vinken, M. (Administrative Promotor), Tabernilla Garcia, A. (CoI (Co-Promotor)) & Sanz Serrano, J. (CoI (Co-Promotor))
1/11/25 → 31/10/29
Project: Fundamenteel
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EU699: Lever Titaandioxide Toxicologie: Onderzoek naar de mechanismen van levertoxiciteit veroorzaakt door het levensmiddelenadditief E171 (titaandioxide, TiO2) met behulp van in vitro, in vivo en in silico benaderingen.
Vinken, M. (Administrative Promotor) & De Paula Dias Moreira, L. (PI (Promotor, Principal Investigator))
1/10/25 → 3/09/27
Project: Fundamenteel
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IOF3035: B-LIVER 2.0 (Brusselse Alliantie voor Leveronderzoek & Valorisatie)
Vanhaecke, T. (Administrative Promotor), van Grunsven, L. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Vinken, M. (CoI (Co-Promotor)), Reynaert, H. (CoI (Co-Promotor)) & Van Goethem, F. (Mandataris)
1/01/25 → 31/12/29
Project: Toegepast
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FWOAL1171: Rol van Panx1 kanalen en Cx43 hemikanalen als nieuwe therapeutische doelwitten in de communicatie tussen leverstellaatcellen en hepatocellulaire carcinoma cellen in de ontwikkeling van metabole dysfunctie-gerelateerde steatohepatitis
Vinken, M. (Administrative Promotor)
1/01/25 → 31/12/27
Project: Fundamenteel
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Development and characterization of a MASH in vitro 3D human liver co-culture spheroid model
Yildiz, B., Orhan, H., Demeyer, K., Vinken, M. & Tabernilla Garcia, A., 2026, (In preparation). 1 blz.Onderzoeksoutput: Poster
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Adverse outcome pathways mechanistically describing hepatotoxicity
Callewaert, E., Louisse, J., Kramer, N., Sanz-Serrano, J. & Vinken, M., 2025, In: Computational Toxicology. Methods in Molecular Biology.. 2834, 2, blz. 249–273 25 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand2 Citaten (Scopus)2 Downloads (Pure) -
A human liver-based in vitro test battery to detect liver steatogenic potential of chemicals from various applicability domains
Verhoeven, A., Drees, A. H., Rodrigues, R., Sanz-Serrano, J., Vanhaecke, T. & Vinken, M., mei 2025, (Unpublished).Onderzoeksoutput: Poster
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A human liver-based in vitro test battery to detect liver steatogenic potential of chemicals from various applicability domains
Verhoeven, A., Drees, A. H., Rodrigues, R., Sanz-Serrano, J., Vanhaecke, T. & Vinken, M., 2025, (Unpublished).Onderzoeksoutput: Poster
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An alternative safety profiling algorithm (ASPA) to transform next generation risk assessment into a structured and transparent process
Leist, M., Tangianu, S., Affourtit, F., Braakhuis, H., Colbourne, J. K., Cöllen, E., Dreser, N., Escher, S., Gardner, I., Hahn, S., Hardy, B., Herzler, M., Islam, B., Kamp, H., Magel, V., Stoelting, P. M., Moné, M., Lundquist, P., Ottenbros, I. & Ouedraogo, G. & 6 anderen, , 8 okt. 2025, (Accepted/In press) In: ALTEX.Onderzoeksoutput: Article › peer review
Datasets
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Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury
Van Campenhout, R. (Creator), De Groof, T. (Creator), Kadam, P. (Researcher), Muyldermans, S. (Supervisor), Devoogdt, N. (Supervisor) & Vinken, M. (Supervisor), Journal of Nanobiotechnology, 2023
DOI: 10.1186/s12951-023-02137-1
Dataset
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Effects of acute and chronic disease on cell junctions in mouse liver
Van Campenhout, R. (Creator) & Vinken, M. (Supervisor), EXCLI Journal, 2023
Dataset
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Data: Optimization of the drug-induced cholestasis index based on advanced modeling for predicting liver toxicity
Drees, A. (Creator), Nassiri, V. (Creator), Tabernilla, A. (Editor), Serroyen, J. (Editor), Gustin, E. (Editor), dos Santos Rodrigues, B. (Editor), Moss, D. M. (Editor), De Smedt, A. (Project Manager), Vinken, M. (Supervisor), Van Goethem, F. (Supervisor) & Sanz-Serrano, J. (Creator), Zenodo, 24 mrt. 2025
DOI: 10.5281/zenodo.14699512, https://zenodo.org/records/14699512
Dataset
Prijzen
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Best oral presentation award
Cooreman, A. (Recipient), Caufriez, A. (Recipient), Tabernilla Garcia, A. (Recipient), Van Campenhout, R. (Recipient), Leroy, K. (Recipient), Sanz Serrano, J. (Recipient), Kadam, P. (Recipient), dos Santos Rodrigues, B. (Recipient), Lamouroux, A. (Recipient), Ballet, S. (Recipient), Annaert, P. (Recipient) & Vinken, M. (Recipient), 24 nov. 2022
Prijs: Prize (including medals and awards)
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Best Poster Presentation Award
Leroy, K. (Recipient), Cooreman, A. (Recipient), Van Campenhout, R. (Recipient), Cogliati, B. (Recipient) & Vinken, M. (Recipient), 24 nov. 2022
Prijs: Prize (including medals and awards)
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European Association for the Study of the Liver
Vinken, M. (Recipient), 21 mei 2014
Prijs: Fellowship awarded competitively
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Galenus award for pharmacology
Vinken, M. (Recipient), 5 dec. 2018
Prijs: Prize (including medals and awards)
Activiteiten
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PhD thesis "From obesity-associated steatosis to liver cancer: the role of transcriptional, posttranslational and immune response networks in disease progression" by Ao Li (Evenement)
Vinken, M. (Jury)
16 jan. 2026Activiteit: Member of PhD committee
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ERC mock presentation (Evenement)
Vinken, M. (Jury)
19 mei 2025Activiteit: Membership of peer-review panel or committee
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ASPIS Coordinator Meeting
Vinken, M. (Chair)
21 nov. 2025Activiteit: Participation in workshop, seminar
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Gap Junction Colloquium
Vinken, M. (Organiser)
8 sep. 2025 → 10 sep. 2025Activiteit: Participation in workshop, seminar
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ASPIS open symposium
Vinken, M. (Chair)
17 sep. 2025 → 18 sep. 2025Activiteit: Participation in workshop, seminar
Knipsels
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How ‘animal methods bias’ is affecting research careers
20/03/25
1 Mediabijdrage
Pers / media: !!Expert Comment
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VUB-Onderzoeker Mathieu Vinken ontvangt prijs
31/10/24
1 item van Media-aandacht
Pers / media: !!Research
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"VUB onderzoeker Mathieu Vinken ontvangt prestigieuze prijs”
10/10/24
1 Mediabijdrage
Pers / media: !!Research
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-“Why is animal testing still with us?”
2/09/24
1 item van Media-aandacht
Pers / media: !!Expert Comment
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VUB team develops breakthrough nanobody technology against liver inflammation
Van Campenhout, R., Vinken, M., Devoogdt, N. & De Groof, T.
8/12/23
1 item van Media-aandacht
Pers / media: !!Other
Scriptie
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An adverse outcome pathway-based approach to assess steatotic and cholestatic effects in vitro
Bougrine, C. ((PhD) Student), Callewaert, E. (Advisor) & Vinken, M. (Promotor), 2025Scriptie/Masterproef: Master's Thesis
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Bijdrage tot de studie van de fase I biotransformatie van Trichostatine A bij rat en mens aan de hand van in vitro technieken
Vinken, M. ((PhD) Student), Rogiers, V. (Promotor) & Elaut, G. (Co-promotor), Rogiers, V. (Promotor) & Elaut, G. (Co-promotor), 2001Scriptie/Masterproef: Master's Thesis
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Biomarkers for psychological adaptation to extreme environments for future space flight: related genes in blood-based in vitro research
Vinken, M. (Jury), 28 jun. 2024Scriptie/Masterproef: Master's Thesis
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Characterization of connexins and pannexins in liver of a mouse model of non-alcoholic steatohepatitis
Vinken, M. (Promotor), (Decl.:)Gaugie, M. ((PhD) Student) & Willebrords, J. (Promotor), 2018Scriptie/Masterproef: Master's Thesis
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Differentiation of brain like endothelial cells from iPSC and application to BBB toxicity testing
Vinken, M. (Jury), Wellens, S. ((PhD) Student) & d’Artois, U. (Promotor), 24 jun. 2021Scriptie/Masterproef: Doctoral Thesis