Patrick De Baetselier

2024

Infection history imprints prolonged changes to the epigenome, transcriptome and function of Kupffer cells

Musrati, M. A., Stijlemans, B., Azouz, A., Kancheva, D., Mesbahi, S., Hadadi, E., Lebegge, E., Ali, L., Vlaminck, K. D., Scheyltjens, I., Vandamme, N., Zivalj, M., Assaf, N., Elkrim, Y., Ahmidi, I., Huart, C., Lamkanfi, M., Guilliams, M., Baetselier, P. D., Goriely, S. & 2 anderen, Movahedi, K. & Ginderachter, J. A. V., dec 2024, In: Journal of Hepatology. 81, 6, blz. 1023-1039 17 blz.

Onderzoeksoutput: Article › peer review

Open Access

3 Citaten (Scopus)

Q586B2 is a crucial virulence factor during the early stages of Trypanosoma brucei infection that is conserved amongst trypanosomatids

Stijlemans, B., De Baetselier, P., Van Molle, I., Lecordier, L., Hendrickx, E., Romão, E., Vincke, C., Baetens, W., Schoonooghe, S., Hassanzadeh-Ghassabeh, G., Korf, H., Wallays, M., Pinto Torres, J. E., Perez-Morga, D., Brys, L., Campetella, O., Leguizamón, M. S., Claes, M., Hendrickx, S., Mabille, D. & 6 anderen, Caljon, G., Remaut, H., Roelants, K., Magez, S., Van Ginderachter, J. A. & De Trez, C., 27 feb 2024, In: Nature Communications. 15, 1, blz. 1779 16 blz., 1779.

Onderzoeksoutput: Article › peer review

Open Access

2023

Ontogeny, functions and reprogramming of Kupffer cells upon infectious disease

Musrati, M. A., De Baetselier, P., Movahedi, K. & Van Ginderachter, J. A., 25 aug 2023, In: Frontiers in Immunology. 14, 1, 10 blz., 1238452.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

11 Citaten (Scopus)

37 Downloads (Pure)

2022

Infection history imprints long-lasting changes to Kupffer cells

Musrati, M., Stijlemans, B., Azouz, A., Kancheva, D., Mesbahi, S., Lebegge, E., De Vlaminck, K., Hadadi, E., Elkrim, Y., De Baetselier, P., Goriely, S., Movahedi, K. & Van Ginderachter, J., 2022, (Unpublished).

Onderzoeksoutput: Poster

Infection history imprints long-lasting changes to Kupffer cells.

Musrati, M., Stijlemans, B., Kancheva, D., Mesbahi, S., Lebegge, E., De Vlaminck, K., Elkrim, Y., De Baetselier, P., Movahedi, K. & Van Ginderachter, J., 19 sep 2022, (Unpublished).

Onderzoeksoutput: Poster

Targeting the tsetse-trypanosome interplay using genetically engineered Sodalis glossinidius

De Vooght, L., De Ridder, K., Hussain, S., Stijlemans, B., De Baetselier, P., Caljon, G. & Van Den Abbeele, J., 10 mrt 2022, In: PLoS Pathogens. 18, 3, e1010376.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

2 Citaten (Scopus)

19 Downloads (Pure)

The Role of MIF and IL-10 as Molecular Yin-Yang in the Modulation of the Host Immune Microenvironment During Infections: African Trypanosome Infections as a Paradigm

Stijlemans, B., Schoovaerts, M., De Baetselier, P., Magez, S. & De Trez, C., 7 apr 2022, In: Frontiers in Immunology. 13, 21 blz., 865395.

Onderzoeksoutput: Scientific review › peer review

Open Access

Bestand

4 Citaten (Scopus)

26 Downloads (Pure)

2021

Immunoglobulin single variable domains directed against macrophage migration inhibitory factor

Vanlandschoot, P., Cabrito, I., Stijlemans, B., Sparkes, A., Van Ginderachter, J. & De Baetselier, P., 2021, Octrooi Nr. US11098113

Onderzoeksoutput: Patent

Monocytic myeloid-derived suppressor cells home to tumor-draining lymph nodes via CCR2 and locally modulate the immune response

Lahmar, Q., Schouppe, E., Morias, Y., Van Overmeire, E., De Baetselier, P., Movahedi, K., Laoui, D., Sarukhan, A. & Van Ginderachter, J. A., apr 2021, In: Cellular Immunology. 362, 8 blz., 104296.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

9 Citaten (Scopus)

44 Downloads (Pure)

2020

Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection.

Magez, S., Stijlemans, B., Korf, H., De Baetselier, P., Van Ginderachter, J. & De Trez, C., 3 feb 2020, In: PLoS Pathogens. 16, 2, 29 blz., e1008170.

Onderzoeksoutput: Article › peer review

Open Access

Bestand

6 Citaten (Scopus)

174 Downloads (Pure)

2019

Anti-macrophage mannose receptor single variable domains for use in cardiovascular diseases

De Baetselier, P., Raes, G., Schoonooghe, S., De Vos, J., Lahoutte, T., Devoogdt, N., Hernot, S., Bala, G. & Tierens, S., 30 jan 2019, IPC-nummer A61K39/00, C07K16/28, EPO, Octrooi Nr. EP2968487B, 17 mrt 2014, Prioriteitsdatum 15 mrt 2013, Prioriteitsnummer US61/798071

Onderzoeksoutput: Patent

Immunoglobulin single variable domains directed against macrophage migration inhibitory factor

Vanlandschoot, P., Cabrito, I., Stijlemans, B., Sparkes, A., Van Ginderachter, J. & De Baetselier, P., 2019, Octrooi Nr. EP3512880

Onderzoeksoutput: Patent

NIRF-Molecular Imaging with Synovial Macrophages-Targeting Vsig4 Nanobody for Disease Monitoring in a Mouse Model of Arthritis

Zheng, F., Luo, S., Ouyang, Z., Zhou, J., Mo, H., Schoonooghe, S., Muyldermans, S., De Baetselier, P., Raes, G. & Wen, Y., 8 jul 2019, In: International Journal of Molecular Sciences. 20, 13, 3347.

Onderzoeksoutput: Article › peer review

Open Access

13 Citaten (Scopus)

The Fate of Hepatic Macrophages during Parasitic Infection

Musrati, M., Stijlemans, B., De Baetselier, P., Guilliams, M., Movahedi, K. & Van Ginderachter, J., 12 sep 2019, (Unpublished).

Onderzoeksoutput: Poster

2018

African Trypanosomiasis-Associated Anemia: The Contribution of the Interplay between Parasites and the Mononuclear Phagocyte System

Stijlemans, B., De Baetselier, P., Magez, S., Van Ginderachter, J. A. & De Trez, C., 15 feb 2018, In: Frontiers in Immunology. 9, FEB, blz. 218-218 218.

Onderzoeksoutput: Scientific review › peer review

Open Access

72 Citaten (Scopus)

Anti-macrophage mannose receptor immunoglobulin single variable domains for targeting and in vivo imaging of tumor-associated macrophages

Van Ginderachter, J., De Baetselier, P., Devoogdt, N., Lahoutte, T., Laoui, D., Movahedi, K., Raes, G. & Schoonooghe, S., 7 nov 2018, IPC-nummer C07K16/28, A61K39/00, A61K51/10, EPO, Octrooi Nr. EP2855526B, 15 mrt 2013, Prioriteitsdatum 29 mrt 2010, Prioriteitsnummer US61/341356

Onderzoeksoutput: Patent

Immunoglobulin single variable domains directed against macrophage migration inhibitory factor

Vanlandschoot, P., Cabrito, I., Stijlemans, B., Sparkes, A., Van Ginderachter, J. & De Baetselier, P., 2018, Octrooi Nr. WO2018050833

Onderzoeksoutput: Patent

Ly6Clow Monocytes Elicit Pro-restorative Roles during Acetaminophen-induced Liver Failure

Abels, C., Musrati, M., Redmond, A., Van Haele, M., Roskams, T., De Groef, S., De Baetselier, P., Tacke, F., Van Ginderachter, J. & Beschin, A., 8 feb 2018, (Unpublished).

Onderzoeksoutput: Poster

Neutrophils enhance early Trypanosoma brucei infection onset

Caljon, G., Mabille, D., De Trez, C., Mazzone, M., Tacchini-Cottier, F., Malissen, M., A Van Ginderachter, J., Magez, S., De Baetselier, P., Van Den Abbeele, J. & Stijlemans, B., 25 jul 2018, In: Scientific Reports - Nature. 8, 1, 11203.

Onderzoeksoutput: Article › peer review

Open Access

27 Citaten (Scopus)

Novel half-life extended anti-MIF nanobodies protect against endotoxic shock

Sparkes, A., De Baetselier, P., Brys, L., Cabrito, I., Sterckx, Y. G-J., Schoonooghe, S., Muyldermans, S., Raes, G., Bucala, R., Vanlandschoot, P., Van Ginderachter, J. A. & Stijlemans, B., jun 2018, In: The FASEB Journal. 32, 6, blz. 3411-3422 12 blz.

Onderzoeksoutput: Article › peer review

Bestand

35 Citaten (Scopus)

40 Downloads (Pure)

Targeting and in vivo imaging of tumor-associated macrophages

Movahedi, K., Laoui, D., Schoonooghe, S., Raes, G., De Baetselier, P., Van Ginderachter, J., Devoogdt, N. & Lahoutte, T., 2018, Octrooi Nr. US9913920

Onderzoeksoutput: Patent

The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages

Scott, C. L., T'Jonck, W., Martens, L., Todorov, H., Sichien, D., Soen, B., Bonnardel, J., De Prijck, S., Vandamme, N., Cannoodt, R., Saelens, W., Vanneste, B., Toussaint, W., De Bleser, P., Takahashi, N., Vandenabeele, P., Henri, S., Pridans, C., Hume, D. A., Lambrecht, B. N. & 8 anderen, De Baetselier, P., Milling, S. W. F., Van Ginderachter, J. A., Malissen, B., Berx, G., Beschin, A., Saeys, Y. & Guilliams, M., 21 aug 2018, In: IMMUNITY. 49, 2, blz. 312-325.e5

Onderzoeksoutput: Article › peer review

Open Access

181 Citaten (Scopus)

2017

Anti-macrophage mannose receptor single variable domains for targeting and in vivo imaging of tumor-associated macrophages

Van Ginderachter, J., De Baetselier, P., Devoogdt, N., Lahoutte, T., Laoui, D., Movahedi, K., Raes, G. & Schoonooghe, S., 2017, Octrooi Nr. US9556273

Onderzoeksoutput: Patent

Method of imaging a cardiovascular disease with an anti-macrophage mannose receptor immunoglobulin single variable domain

De Baetselier, P., Raes, G., Schoonooghe, S., De Vos, J., Lahoutte, T., Devoogdt, N., Hernot, S., Bala, G. & Tierens, S., 2017, Octrooi Nr. US9617339

Onderzoeksoutput: Patent

Molecular Imaging with Kupffer Cell-Targeting Nanobodies for Diagnosis and Prognosis in Mouse Models of Liver Pathogenesis.

Zheng, F., Sparkes, A., De Baetselier, P., Schoonooghe, S., Stijlemans, B. A., Muyldermans, S., Flamand, V., Van Ginderachter, J., Devoogdt, N., Raes, G. & Beschin, A., feb 2017, In: Molecular Imaging and Biology. 19, 1, blz. 49-58 10 blz.

Onderzoeksoutput: Article › peer review

26 Citaten (Scopus)

Nanobodies As Tools to Understand, Diagnose, and Treat African Trypanosomiasis.

Stijlemans, B., De Baetselier, P., Caljon, G., Van Den Abbeele, J., Van Ginderachter, J. A. & Magez, S., 30 jun 2017, In: Frontiers in Immunology. 8, JUN, 12 blz., 724.

Onderzoeksoutput: Article › peer review

Open Access

17 Citaten (Scopus)

Reprint of: The non-mammalian MIF superfamily

Sparkes, A., De Baetselier, P., Roelants, K., De Trez, C., Magez, S., Van Ginderachter, J. A., Raes, G., Bucala, R. & Stijlemans, B., jun 2017, In: Immunobiology. 222, 6, blz. 858-867 10 blz.

Onderzoeksoutput: Article › peer review

10 Citaten (Scopus)

Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity

Wen, Y., Ouyang, Z., Schoonooghe, S., Luo, S., De Baetselier, P., Lu, W., Muyldermans, S., Raes, G. & Zheng, F., 1 jun 2017, In: Immunobiology. 222, 6, blz. 807-813 7 blz.

Onderzoeksoutput: Article › peer review

18 Citaten (Scopus)

The non-mammalian MIF superfamily

Sparkes, A., De Baetselier, P., Roelants, K., De Trez, C., Magez, S., Van Ginderachter, J. A., Raes, G., Bucala, R. & Stijlemans, B., 1 mrt 2017, In: Immunobiology. 222, 3, blz. 473-482 10 blz.

Onderzoeksoutput: Article › peer review

43 Citaten (Scopus)

2016

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Scott, C. L., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., Lippens, S., Abels, C., Schoonooghe, S., Raes, G., Devoogdt, N., Lambrecht, B. N., Beschin, A. & Guilliams, M., 2016, In: Nature Communications. 7, blz. 10321 10 blz.

Onderzoeksoutput: Article › peer review

Open Access

637 Citaten (Scopus)

M-CSF and GM-CSF receptor signaling differentially regulate monocyte maturation and macrophage polarization in the tumor microenvironment

Van Overmeire, E., Stijlemans, B., Heymann, F., Keirsse, J., Morias, Y., Elkrim, Y., Brys, L., Abels, C., Lahmar, Q., Ergen, C., Vereecke, L., Tacke, F., De Baetselier, P., Van Ginderachter, J. A. & Laoui, D., 1 jan 2016, In: Cancer Research. 76, 1, blz. 35-42 8 blz.

Onderzoeksoutput: Article › peer review

187 Citaten (Scopus)

MIF-Mediated Hemodilution Promotes Pathogenic Anemia in Experimental African Trypanosomosis

Stijlemans, B., Brys, L., Korf, H., Bieniasz-Krzywiec, P., Sparkes, A., Vansintjan, L., Leng, L., Vanbekbergen, N., Mazzone, M., Caljon, G., Van Den Abbeele, J., Odongo, S., De Trez, C., Magez, S., Van Ginderachter, J. A., Beschin, A., Bucala, R. & De Baetselier, P., sep 2016, In: PLoS Pathogens. 12, 9, blz. e1005862

Onderzoeksoutput: Article › peer review

23 Citaten (Scopus)

Specificity Evaluation and Disease Monitoring in Arthritis Imaging with Complement Receptor of the Ig superfamily targeting Nanobodies

Zheng, F., Perlman, H., Matthys, P., Wen, Y., Lahoutte, T., Muyldermans, S., Lu, S., De Baetselier, P., Schoonooghe, S., Devoogdt, N. & Raes, G., 2016, In: Scientific Reports - Nature. 6, blz. 35966

Onderzoeksoutput: Article › peer review

13 Citaten (Scopus)

The tumour microenvironment harbours ontogenically distinct dendritic cell populations with opposing effects on tumour immunity

Laoui, D., Keirsse, J., Morias, Y., Van Overmeire, E., Geeraerts, X., Elkrim, Y., Kiss, M., Bolli, E., Lahmar, Q., Sichien, D., Serneels, J., Scott, C. L., Boon, L., De Baetselier, P., Mazzone, M., Guilliams, M. & Van Ginderachter, J. A., 23 dec 2016, In: Nature Communications. 7, blz. 13720

Onderzoeksoutput: Article › peer review

Open Access

Bestand

220 Citaten (Scopus)

2015

Development of a pHrodo-based assay for the assessment of in vitro and in vivo erythrophagocytosis during experimental trypanosomosis

Stijlemans, B., Cnops, J., Naniima, P., Vaast, A., Bockstal, V., De Baetselier, P. & Magez, S., 2015, In: PLoS Negl Trop Dis. 9, 3, 21 blz., e0003561.

Onderzoeksoutput: Article › peer review

33 Citaten (Scopus)

E-cadherin expression in macrophages dampens their inflammatory responsiveness in vitro, but does not modulate M2-regulated pathologies in vivo

Van den Bossche, J., Laoui, D., Naessens, T., Smits, H. H., Hokke, C. H., Stijlemans, B., Grooten, J., De Baetselier, P. & Van Ginderachter, J. A., 2015, In: Scientific Reports - Nature. 5, 12 blz., 12599.

Onderzoeksoutput: Article › peer review

27 Citaten (Scopus)

Iron Homeostasis and Trypanosoma brucei Associated Immunopathogenicity Development: A Battle/Quest for Iron

Stijlemans, B., Beschin, A., Magez, S., Van Ginderachter, J. A. & De Baetselier, P., 2015, In: BioMed Research International. 2015, 15 blz., 819389.

Onderzoeksoutput: Article › peer review

25 Citaten (Scopus)

Ly6C- Monocytes Regulate Parasite-Induced Liver Inflammation by Inducing the Differentiation of Pathogenic Ly6C+ Monocytes into Macrophages

Morias, Y., Abels, C., Laoui, D., Van Overmeire, E., Guilliams, M., Schouppe, E., Tacke, F., deVries, C. J., De Baetselier, P. & Beschin, A., 2015, In: PLoS Pathog.. 11, 5, 22 blz., e1004873.

Onderzoeksoutput: Article › peer review

37 Citaten (Scopus)

Macrophage dynamics are regulated by local macrophage proliferation and monocyte recruitment in injured pancreas

Van Gassen, N., Van Overmeire, E., Leuckx, G., Heremans, Y., De Groef, S., Cai, Y., Elkrim, Y., Gysemans, C., Stijlemans, B., Van de Casteele, M., De Baetselier, P., De Leu, N., Heimberg, H. & Van Ginderachter, J. A., mei 2015, In: Eur J Immunol. 45, 5, blz. 1482-1493 12 blz.

Onderzoeksoutput: Article › peer review

44 Citaten (Scopus)

Monitoring liver macrophages using nanobodies targeting Vsig4: Concanavalin A induced acute hepatitis as paradigm

Zheng, F., Devoogdt, N., Sparkes, A., Morias, Y., Abels, C., Stijlemans, B., Lahoutte, T., Muyldermans, S., De Baetselier, P., Schoonooghe, S., Beschin, A. & Raes, G., 1 feb 2015, In: Immunobiology. 220, 2, blz. 200-209 10 blz.

Onderzoeksoutput: Article › peer review

32 Citaten (Scopus)

Murine Liver Myeloid Cell Isolation Protocol

Stijlemans, B. A., Sparkes, A., Abels, C., Keirsse, J., Brys, L., Elkrim, Y., De Baetselier, P., Beschin, A. & Van Ginderachter, J., 2015, In: bio-protocol. 5, 10, 10 blz., e1471.

Onderzoeksoutput: Article › peer review

Open Access

PET Imaging of Macrophage Mannose Receptor-Expressing Macrophages in Tumor Stroma Using 18F-Radiolabeled Camelid Single-Domain Antibody Fragments

Blykers, A., Schoonooghe, S., Xavier, C., D'hoe, K., Laoui, D., D'Huyvetter, M., Vaneycken, I., Cleeren, F., Bormans, G., Heemskerk, J., Raes, G., De Baetselier, P., Lahoutte, T., Devoogdt, N., Van Ginderachter, J. A. & Caveliers, V., aug 2015, In: Journal of Nuclear Medicine. 56, 8, blz. 1265-1271 7 blz.

Onderzoeksoutput: Article › peer review

140 Citaten (Scopus)

Targeting dendritic cells with nanobody-displaying lentiviral vectors.

Goyvaerts, C., Heirman, C., Thielemans, K., De Baetselier, P., Raes, G. & Breckpot, K., 30 sep 2015, Zing Conference: Immune System for a Therapeutic Benefit. Oropesa, Spain

Onderzoeksoutput: Meeting abstract (Book) › Research

The transduction pattern of IL-12-encoding lentiviral vectors shapes the immunological outcome

Goyvaerts, C., Broos, K., Escors, D., Heirman, C., Raes, G., De Baetselier, P., Thielemans, K. & Breckpot, K., 17 sep 2015, In: European Journal of Immunology. 45, 12, blz. 3351-3361 11 blz.

Onderzoeksoutput: Article › peer review

Open Access

15 Citaten (Scopus)

2014

African trypanosome control in the insect vector and mammalian host.

Beschin, A., Van Den Abbeele, J., De Baetselier, P. & Pays, E., 1 nov 2014, In: Trends Parasitol. 30, blz. 538-547 10 blz.

Onderzoeksoutput: Article › peer review

30 Citaten (Scopus)

African Trypanosomiasis as paradigm for involvement of the mononuclear phagocyte system in pathogenicity during parasite infection

Stijlemans, B., Beschin, A., De Baetselier, P. & Raes, G., 1 jan 2014, Macrophages: biology and role in the pathology of diseases. Biswas, S. K. & Mantovani, A. (redactie). Springer, blz. 349-374 26 blz.

Onderzoeksoutput: Chapter › Research › peer review

Functional Relationship between Tumor-Associated Macrophages and Macrophage Colony-Stimulating Factor as Contributors to Cancer Progression

Laoui, D., Van Overmeire, E., De Baetselier, P., Van Ginderachter, J. A. & Raes, G., 2014, In: Frontiers in Immunology. 5, 15 blz., 489.

Onderzoeksoutput: Article › peer review

168 Citaten (Scopus)

IL-12 in antitumor immunotherapy: to target or not to target?

Goyvaerts, C., Heirman, C., De Baetselier, P., Raes, G., Thielemans, K. & Breckpot, K., 23 okt 2014, ESGCT. Den Haag, Nederland

Onderzoeksoutput: Meeting abstract (Book) › Research

IL-12 in antitumor immunotherapy: to target or not to target?

Goyvaerts, C., Heirman, C., De Baetselier, P., Raes, G., Thielemans, K. & Breckpot, K., 1 nov 2014, In: Human Gene Therapy. 25, 11, blz. 95-95 1 blz.

Onderzoeksoutput: Meeting abstract (Journal)

Immunogenicity of targeted lentivectors

Goyvaerts, C., De Groeve, K., Van Lint, S., Heirman, C., Van Ginderachter, J., De Baetselier, P., Raes, G., Thielemans, K. & Breckpot, K., 1 feb 2014, Annual BACR meeting, Ghent, Belgium.

Onderzoeksoutput: Meeting abstract (Book) › Research

24 Citaten (Scopus)

Patrick De Baetselier

Onderzoeksoutput

Zoekresultaten