!!Projects per year
Persoonlijk profiel
Onderzoeksinteresses
Prof. S. Tuyaerts has a main interest in immuno-oncology, with a particular focus on cancer vaccines, oncolytic viruses and CAR-T cells. During the development of these therapeutics, the use of innovative in vitro patient-derived 3D models as well as murine models is a key aspect. Besides the development of novel therapies, also immune resistance mechanisms that challenge cancer treatments are studied.
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Sandra Tuyaerts actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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ANI389: Ontwikkeling van een B7-H3 nanoCAR-T-celtherapie voor recidiverend glioblastoom (GlioCAR)
Neyns, B. (Administrative Promotor), Geeraerts, X. (CoI (Co-Promotor)), Tuyaerts, S. (CoI (Co-Promotor)), Breckpot, K. (CoI (Co-Promotor)), Duerinck, J. (CoI (Co-Promotor)) & Smolders, I. (CoI (Co-Promotor))
1/10/24 → 30/09/28
Project: Fundamenteel
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OZR4286: Financiering MZW OZR: DELI-SORT: MACSQuant® Tyto voor steriele SORTing van DELicate Immune cellen
Laoui, D. (Administrative Promotor), Vanginderachter, J. A. (CoI (Co-Promotor)), Magez, S. (CoI (Co-Promotor)), Tuyaerts, S. (CoI (Co-Promotor)), Fioravanti, A. (CoI (Co-Promotor)), Devoogdt, N. (CoI (Co-Promotor)), Van der Henst, C. (CoI (Co-Promotor)), Raes, G. (CoI (Co-Promotor)), Stijlemans, B. (CoI (Co-Promotor)), Hadadi, E. (CoI (Co-Promotor)), De Trez, C. (CoI (Co-Promotor)), Ruytinx, J. (CoI (Co-Promotor)), Brunner, J. (CoI (Co-Promotor)), De Groof, T. (CoI (Co-Promotor)) & De Veirman, K. (CoI (Co-Promotor))
24/04/24 → 24/04/28
Project: Fundamenteel
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AIIFUND115: Unraveling the spatial and longitudinal heterogeneity of glioblastoma tumors and its relationship with treatment response and patient survival
Movahedi, K. (Administrative Promotor), Geeraerts, X. (Medewerker) & Tuyaerts, S. (Medewerker)
1/01/24 → 31/12/27
Project: Fundamenteel
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ANI330: Preklinische ontwikkeling van een door oplosbare factoren afstembaar T-celproduct voor melanoom- en glioblastomapatiënten die refractair zijn voor eerdere intratumorale immunotherapie.
Tuyaerts, S. (Administrative Promotor) & Schaukens, J. (PI (Promotor, Principal Investigator))
1/12/22 → 30/11/23
Project: Fundamenteel
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FWOEOS18: Onderzoek naar de mechanismen van respons en resistentie tegen nieuwe kankerimmunotherapieën bij tumoren die niet reageren op eerdere remming van immuuncontrolepunten
Neyns, B. (Administrative Promotor), Breckpot, K. (Medewerker) & Tuyaerts, S. (Medewerker)
1/01/22 → 31/12/25
Project: Fundamenteel
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Circulating immune cell profiling in advanced cervical and endometrial cancer patients treated with PD-1 blockade, radiotherapy, and immune modulation in the PRIMMO trial
Baiden-Amissah, R. E. M., Tuyaerts, S., Annibali, D., Herreros-Pomares, A., De Wispelaere, W., Benedetto, R. M., De Jaeghere, E. A., Van Nuffel, A. M. T., Vuylsteke, P., Henry, S., Bich Trinh, X., Van Dam, P. A., Aspeslagh, S., De Caluwé, A., Naert, E., Vandecasteele, K., Denys, H. G. & Amant, F., 21 mei 2026, In: Frontiers In Immunology. 17, 16 blz., 1794131.Onderzoeksoutput: Article › peer review
Open Access -
Efficacy and safety of regorafenib in patients with advanced pretreated melanoma: results of the RegoMel phase II clinical trial
Dirven, I., Bertels, C., Moreels, Y., Kessels, J. I., Vanlaer, N., Vander Mijnsbrugge, A.-S., Vounckx, M., Dirks, I., Raes, L., Geeraerts, X., Stevens, L., von Kemp, B., Fasolino, G., Awada, G., Janssen, T., Caljon, B., Lefevre, T., Everaert, H., Rogiers, A. & Vandemeulebroucke, J. & 2 anderen, , apr. 2026, In: ESMO Open. 11, 4, 11 blz., 106941.Onderzoeksoutput: Article › peer review
Open Access -
Reinvigorating the Cancer-Immunity Cycle by Intratumoral Administration of Conventional Dendritic Cells in Melanoma and Other Solid Tumors: A Narrative Review
Vounckx, M., Dirven, I., Bertels, C., Schwarze, J. K., Geeraerts, X., Tuyaerts, S., Boisson, A., Willard-Gallo, K. & Neyns, B., 30 apr. 2026, In: Vaccines. 14, 5, 15 blz., 402.Onderzoeksoutput: Scientific review › peer review
Open Access -
A phase I clinical trial on combined (neo-)adjuvant intravenous plus intracranial administration of ipilimumab and nivolumab in recurrent glioblastoma (NEOGLITIPNI).
Dirven, I., Lescrauwaet, L., Cleo, B., Stevens, L., Geeraerts, X., Vaeyens, F. (Contributor), Vanbinst, A., Everaert, H., Brock, S., Tuyaerts, S., Kockx, M., Duerinck, J. & Neyns, B., jun. 2025, In: Journal of Clinical Oncology. 43, 16, 1 blz.Onderzoeksoutput: Meeting abstract (Journal)
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A phase I clinical trial on combined (neo-) adjuvant intravenous plus intracranial administration of ipilimumab and nivolumab in recurrent glioblastoma (NEO-GLITIPNI).
Dirven, I., Lescrauwaet, L., Bertels, C., Stevens, L., Geeraerts, X., Vaeyens, F., Vanbinst, A.-M., Everaert, H., Brock, S. & Tuyaerts, S., 2025, American Society of Clinical Oncology.Onderzoeksoutput: Other contribution
Datasets
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RNA sequencing human melanoma, glioblastoma and pancreatic adenocarcinoma cell lines
Tuyaerts, S. (Creator), Stevens, L. (Data Manager), Geeraerts, X. (Data Collector) & Neyns, B. (Supervisor), Gene Expression Omnibus (GEO), 21 aug. 2025
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE288221
Dataset
Prijzen
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Beurs Marie-Louise Lottin naar wetenschappelijk onderzoek naar kanker - Sandra Tuyaerts
Tuyaerts, S. (Recipient), Rooman, I. (Recipient), Messaoudi, N. (Recipient) & Breckpot, K. (Recipient), 27 nov. 2025
Prijs: Prize (including medals and awards)
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Wetenschappelijk Fonds Willy Gepts: Correlation of patient outcome with the neoantigen repertoire, the composition of the tumor microenvironment and neoantigen reactivity of T cells in cerebrospinal fluid for recurrent glioblastoma patients treated with intracerebral immune checkpoint blockade and autologous myeloid dendritic cells.
Tuyaerts, S. (Recipient), 2023
Prijs: Prize (including medals and awards)
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Wetenschappelijk Fonds Willy Gepts: Establishment and validation of a PDAC-derived tumor explant platform for preclinical testing of B7-H3 CAR-T cells against PDAC
Tuyaerts, S. (Recipient), Rooman, I. (Recipient), Messaoudi, N. (Recipient) & Breckpot, K. (Recipient), 2025
Prijs: Prize (including medals and awards)
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Wetenschappelijk Fonds Willy Gepts: FLT3L expressing HSV-1 derived oncolytic virus plus myeloid dendritic cells as a combination therapy for advanced melanoma patients refractory to immune checkpoint blockade.
Geeraerts, X. (Recipient), Neyns, B. (Recipient) & Tuyaerts, S. (Recipient), 2022
Prijs: Prize (including medals and awards)
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Wetenschappelijk Fonds Willy Gepts 2023: Correlation of patient outcome with the neoantigen repertoire, the composition of the tumor microenvironment and neoantigen reactivity of T cells in cerebrospinal fluid for recurrent glioblastoma patients treated with intracerebral immune checkpoint blockade and autologous myeloid dendritic cells (29.067€)
Tuyaerts, S. (Recipient), Neyns, B. (Recipient) & Duerinck, J. (Recipient), 2023
Prijs: Prize (including medals and awards)
Activiteiten
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Basis (bio)-medische wetenschappen (Organisatie)
Tuyaerts, S. (Chair)
6 okt. 2025Activiteit: Member of PhD committee
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Cancer vaccines in pancreatic cancer - hope on the horizon? Monitoring cancer vaccine-induced immune responses in patient blood
de Haar-Holleman, A. (Speaker) & Tuyaerts, S. (Speaker)
7 okt. 2025Activiteit: Talk or presentation at a workshop/seminar
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Basis (bio)-medische wetenschappen (Organisatie)
Tuyaerts, S. (Jury)
15 okt. 2024Activiteit: Member of PhD committee
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Basis (bio)-medische wetenschappen (Organisatie)
Tuyaerts, S. (Jury)
30 sep. 2024Activiteit: Member of PhD committee
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Basis (bio)-medische wetenschappen (Organisatie)
Tuyaerts, S. (Jury)
20 okt. 2023Activiteit: Member of PhD committee