Projecten per jaar
Persoonlijk profiel
Expertise
Sophie Hernot obtained her Master of Science in Bio-engineering from the Vrije Universiteit of Brussels. She completed her PhD thesis in Medical Sciences in 2011 on the use of microbubbles (ultrasound contrast agents) as well as Nanobodies for molecular imaging and drug delivery applications. As post-doctoral researcher, and since 2016 as assistant professor in the Laboratory of In vivo Cellular and Molecular Imaging (ICMI, VUB), her research interests are two-fold: 1) design and validation of nanobodies for optical imaging applications, and in particular towards a clinical translation for image-guided surgery, and 2) validation of nanobody-based molecular probes for identification and characterization of high-risk atherosclerotic lesions. In both cases, particular attention is given to the effects of the nanobody-structure and radioactive or fluorescence labeling of nanobodies on their pharmacokinetics.
Expertise:
- Nanobody labelling
- Non-invasive molecular imaging (optical and nuclear imaging)
- Intra-operative imaging
- Preclinical animal models
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Sophie Hernot actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Netwerk
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
-
EUAR96: CoDaFlight: het donker kleuren in fluorescentielicht
Kuijk, M., Van Heijningen, R., Ingelberts, H., Hernot, S., Van Den Dries, T. & Lapauw, T.
1/10/22 → 30/09/26
Project: Toegepast
-
OZR3984: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UGent, JANSSEN Simone
15/06/22 → 14/06/26
Project: Fundamenteel
-
HERC56: Intravitale beeldvorming als technologie om de kloof te dichten tussen macroscopische in vivo beeldvorming en microscopische analyse van weefsels
Hernot, S., Staels, W., Hellemans, K., Smolders, I., Rooman, I., Devoogdt, N., Menu, E., De Bundel, D., Breckpot, K., De Leu, N., Movahedi, K., D'Huyvetter, M. & De Kock, J.
1/05/22 → 30/04/26
Project: Fundamenteel
Onderzoeksoutput
-
A convenient labeling strategy for the preparation of fluorescent/radioactive sdab-based tracers carrying 99mTc and IRDye800CW for intra-operative decision making
Declerck, N., Huygen, C. M., Mateusiak, L., Stroet, M. & Hernot, S., 18 jan 2023, (Unpublished).Onderzoeksoutput: Unpublished abstract
-
In vivo optical imaging of glioma using a novel uPAR-targeting fluorescent single-domain antibody
Mateusiak, L., Floru, S. (redactie), De Groof, T. (redactie), Declerck, N. (redactie), Wouters, J. (redactie), Janssen, S. (redactie), Debie, P. (redactie), Zeven, K. (redactie), Vincke, C. (redactie), Puttemans, J. (redactie), Stroet, M. (redactie), Breckpot, K. (redactie), Devoogdt, N. (redactie) & Hernot, S. (redactie), 17 mrt 2023.Onderzoeksoutput: Unpublished abstract
-
In vivo optical imaging using a novel fluorescently-labeled single-domain antibody targeting a universal tumor marker
Mateusiak, L., Floru, S., Wouters, J., De Groof, T., Declerck, N., Janssen, S., Debie, P., Zeven, K., Puttemans, J., Breckpot, K., Devoogdt, N. & Hernot, S., 28 jan 2023.Onderzoeksoutput: Unpublished abstract
-
Safety assessment of fluorescence-labeled anti-EGFR Nanobody in healthy dogs
Herreira do Valle, N. C., Janssen, S., Stroet, M., Pollenus, S., Van den Block, S., Devoogdt, N., Debacker, J., Hernot, S. & de Rooster, H., 2023.Onderzoeksoutput: Unpublished abstract
-
Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting
Erreni, M., D'Autilia, F., Avigni, R., Bolli, E., Arnouk, S. M., Movahedi, K., Debie, P., Anselmo, A., Parente, R., Vincke, C., van Leeuwen, F. W. B., Allavena, P., Garlanda, C., Mantovani, A., Doni, A., Hernot, S. & Van Ginderachter, J. A., 1 jan 2023, In: Theranostics. 13, 1, blz. 355-373 19 blz.Onderzoeksoutput: Article › peer review
Open Access
Prijzen
-
Best Poster in Category
Bala, Gezim (Recipient) & Hernot, Sophie (Recipient), 28 mei 2013
Prijs: Prize (including medals and awards)
-
Best Poster in Category
Hernot, Sophie (Recipient), 11 aug 2011
Prijs: Prize (including medals and awards)
-
Finalist Young Investigator Award
Tierens, S. (Recipient) & Hernot, Sophie (Recipient), 5 jun 2014
Prijs: Prize (including medals and awards)
-
Nomination Marie Curie Award
Varasteh, Z. (Recipient) & Hernot, Sophie (Recipient), 24 okt 2017
Prijs: Prize (including medals and awards)
-
Nomination Marie Curie Award
Varasteh, Z. (Recipient) & Hernot, Sophie (Recipient), 24 okt 2017
Prijs: Prize (including medals and awards)
Activiteiten
-
-
In vivo optical imaging using a novel fluorescently-labeled single-domain antibody targeting a universal tumor marker
Lukasz Mateusiak (Speaker), Sam Floru (Contributor), Janne Wouters (Contributor), Timo De Groof (Contributor), Noemi Declerck (Contributor), Simone Janssen (Contributor), Pieterjan Debie (Contributor), Katty Zeven (Contributor), Janik Puttemans (Contributor), Karine Breckpot (Contributor), Nick Devoogdt (Contributor) & Sophie Hernot (Contributor)
28 jan 2023Activiteit: Talk or presentation at a conference
-
In vivo optical imaging of glioma using a novel uPAR-targeting fluorescent single-domain antibody
Lukasz Mateusiak (Speaker), Sam Floru (Contributor), Timo De Groof (Contributor), Noemi Declerck (Contributor), Janne Wouters (Contributor), Simone Janssen (Contributor), Pieterjan Debie (Contributor), Katty Zeven (Contributor), Cecile Vincke (Contributor), Janik Puttemans (Contributor), Marcus Stroet (Contributor), Karine Breckpot (Contributor), Nick Devoogdt (Contributor) & Sophie Hernot (Contributor)
16 mrt 2023Activiteit: Talk or presentation at a conference
-
World Molecular Imaging Congress
Sophie Hernot (Participant)
sep 2022Activiteit: Participation in conference
-
Assessment of serum protein binding to predict non-specific uptake in vivo.
Sophie Hernot (Speaker)
21 sep 2022Activiteit: Talk or presentation at a workshop/seminar
Knipsels
-
VUB-onderzoekers ontwikkelen gel met natuurlijke pijnstillers
Steven Ballet, Charlotte Martin & Sophie Hernot
6/12/18
2 Mediabijdrages
Pers / media: !!Research
-
Presentation of data acquired with a novel high-resolution PET imaging system and radiolabeled nanobodies in the context of atherosclerosis
C. Vanhove, Sophie Hernot & Jessica Bridoux
18/04/18
1 Mediabijdrage
Pers / media: !!Research
-
Grotere overlevingskansen bij kankeroperaties door fluorescente vloeistof
22/12/17
2 Mediabijdrages
Pers / media: !!Research
-
Kikkers gebruiken moleculen als micro-giftanden om roofdieren te vergiftigen
Kim Roelants, Vicky Caveliers, Sophie Hernot & Cindy Peleman
16/11/17
1 Mediabijdrage
Pers / media: !!Research
-
Publication of results on the use of the Cellvizio system for in vivo microscopic imaging tumor targeting of fluorescent nanobodies
14/04/14
1 Mediabijdrage
Pers / media: !!Research
Scriptie
-
Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Auteur: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 sep 2017Scriptie/Masterproef: Master's Thesis
-
Conception d’agents d’imagerie moléculaire et théranostiques pour la détection et la thérapie ciblée de cancers
Auteur: Renard, E. & Hernot, S., dec 2020Scriptie/Masterproef: Doctoral Thesis
-
Confirming the applicability of the anti-EGFR Nanobodies for fluorescence-guided surgery in canine and human head and neck cancer
Auteur: Hernot, S. & de Rooster, H., 2025Scriptie/Masterproef: Doctoral Thesis
-
Development of Improved Adeno-Asociated Viral Vector Designs for Gene Therapy of Duchenne Muscular Dystrophy
Auteur: Claeys, L., VandenDriessche, T., Chuah, M. & Hernot, S., 7 sep 2017Begeleider: Chai, Y. C. (Advisor) & Boon, D. (Advisor)
Scriptie/Masterproef: Master's Thesis
-
Development of new Recombinase Polymerase Amplification (RPA) and antigen-based diagnostic tools for the detection of Trypanosoma evansi infections
Auteur: Zeng, L., Magez, S., Sterckx, Y., Versées, W. & Hernot, S., dec 2020Scriptie/Masterproef: Doctoral Thesis