Projecten per jaar
Persoonlijk profiel
Expertise
Sophie Hernot obtained her Master of Science in Bio-engineering from the Vrije Universiteit of Brussels. She completed her PhD thesis in Medical Sciences in 2011 on the use of microbubbles (ultrasound contrast agents) as well as Nanobodies for molecular imaging and drug delivery applications. As post-doctoral researcher, and since 2016 as assistant professor in the Laboratory of In vivo Cellular and Molecular Imaging (ICMI, VUB), her research interests are two-fold: 1) design and validation of nanobodies for optical imaging applications, and in particular towards a clinical translation for image-guided surgery, and 2) validation of nanobody-based molecular probes for identification and characterization of high-risk atherosclerotic lesions. In both cases, particular attention is given to the effects of the nanobody-structure and radioactive or fluorescence labeling of nanobodies on their pharmacokinetics.
Expertise:
- Nanobody labelling
- Non-invasive molecular imaging (optical and nuclear imaging)
- Intra-operative imaging
- Preclinical animal models
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Sophie Hernot actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 12 Soortgelijke profielen
Netwerk
Recente externe samenwerking op landenniveau. Duik in de details door op de stippen te klikken.
Projecten
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AIIFUND71: Visiting Researcher Agreement- Farmacokinetische analyse van anti-VEGF enkeldomein antilichamen op macro- en microscopisch niveau
Hernot, S., öktem, I. M. A. & Cobanoglu, N. E. K.
15/05/21 → 9/11/21
Project: Fundamenteel
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ANI286: Peroperatieve ex vivo detectie van kankermarge met behulp van fluorescentie-gelabelde antilichamen met één domein
Hernot, S. & Creytens, D.
1/03/21 → 28/02/23
Project: Fundamenteel
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FWOAL951: Ontrafeling van mechanismsen betrokken bij de renale klaring van nanobodies
1/01/20 → 31/12/23
Project: Fundamenteel
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FWOSB74: Intra-operatieve beeldvorming aan de hand van fluorescent- gelabelde nanobodies tijdens prostaat- en baarmoederhalskanker operaties.
Hernot, S., Devoogdt, N. & Declerck, N.
1/11/19 → 31/10/21
Project: Fundamenteel
Onderzoeksoutput
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Decorating sdAbs with Chelators: Effect of Conjugation on Biodistribution and Functionality
Baudhuin, H., Puttemans, J., Hanssens, H., Vanwolleghem, P., Hernot, S., Raes, G., Xavier, C., Lahoutte, T. & Debie, P., mei 2021, In : Pharmaceuticals. 14, 5, 19 blz., 407.Onderzoeksoutput: Article
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Targeted Repolarization of Tumor-Associated Macrophages via Imidazoquinoline-Linked Nanobodies
Bolli, E., Scherger, M., Arnouk, S., Pombo Antunes, A. R., Straßburger, D., Urschbach, M., Stickdorn, J., De Vlaminck, K., Movahedi, K., Räder, H. J., Hernot, S., Besenius, P., Van Ginderachter, J. & Nuhn, L., 19 mei 2021, In : Advanced Science. 8, 10, 12 blz., 2004574.Onderzoeksoutput: Article
Open AccessBestand -
The Design and Preclinical Evaluation of a Single-Label Bimodal Nanobody Tracer for Image-Guided Surgery
Debie, P., Declerck, N. B., van Willigen, D., Huygen, C. M., De Sloovere, B., Mateusiak, L., Bridoux, J., Puttemans, J., Devoogdt, N., van Leeuwen, F. W. B. & Hernot, S., 26 feb 2021, In : Biomolecules. 11, 3, blz. 1-14 14 blz., 360.Onderzoeksoutput: Article
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The Therapeutic and Diagnostic Potential of Nanobodies
Devoogdt, N. (Gastred.), De Groof, T. (Gastred.), Muyldermans, S. (Gastred.) & Hernot, S. (Gastred.), 2021, In : Biomolecules.Onderzoeksoutput: Special issue
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Identifying Biomarkers in Lymph Node Metastases of Esophageal Adenocarcinoma for Tumor-Targeted Imaging
de Gouw, D. J. J. M., Rijpkema, M., de Bitter, T. J. J., Baart, V. M., Sier, C. F. M., Hernot, S., van Dam, G. M., Nagtegaal, I. D., Klarenbeek, B. R., Rosman, C. & van der Post, R. S., 11 feb 2020, In : Molecular Diagnosis & Therapy. 24, 2, blz. 191-200 10 blz.Onderzoeksoutput: Article
2 Citaten (Scopus)
Prijzen
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Best Poster in Category
Gezim Bala (Recipient) & Sophie Hernot (Recipient), 28 mei 2013
Prijs: Prize (including medals and awards)
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Best Poster in Category
Sophie Hernot (Recipient), 11 aug 2011
Prijs: Prize (including medals and awards)
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Finalist Young Investigator Award
Simon Tierens (Recipient) & Sophie Hernot (Recipient), 5 jun 2014
Prijs: Prize (including medals and awards)
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Nomination Marie Curie Award
Zohreh Varasteh (Recipient) & Sophie Hernot (Recipient), 24 okt 2017
Prijs: Prize (including medals and awards)
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Nomination Marie Curie Award
Zohreh Varasteh (Recipient) & Sophie Hernot (Recipient), 24 okt 2017
Prijs: Prize (including medals and awards)
Activiteiten
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Biomolecules (Tijdschrift)
Nick Devoogdt (Editor), Serge Muyldermans (Editor), Timo De Groof (Editor), Sophie Hernot (Editor)2021 → …Activiteit: Editorial activity
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Knipsels
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VUB-onderzoekers ontwikkelen gel met natuurlijke pijnstillers
Steven Ballet, Charlotte Martin & Sophie Hernot
6/12/18
2 Mediabijdrages
Pers / media: !!Research
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Presentation of data acquired with a novel high-resolution PET imaging system and radiolabeled nanobodies in the context of atherosclerosis
C. Vanhove, Sophie Hernot & Jessica Bridoux
18/04/18
1 Mediabijdrage
Pers / media: !!Research
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Grotere overlevingskansen bij kankeroperaties door fluorescente vloeistof
22/12/17
2 Mediabijdrages
Pers / media: !!Research
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Kikkers gebruiken moleculen als micro-giftanden om roofdieren te vergiftigen
Kim Roelants, Vicky Caveliers, Sophie Hernot & Cindy Peleman
16/11/17
1 Mediabijdrage
Pers / media: !!Research
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Publication of results on the use of the Cellvizio system for in vivo microscopic imaging tumor targeting of fluorescent nanobodies
14/04/14
1 Mediabijdrage
Pers / media: !!Research
Scriptie
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Auteur: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 sep 2017Scriptie/masterproef: Master's Thesis
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Cancer detection and visualization: Molecular diagnostics and imaging techniques in pancreatic cancer and metastasis
Auteur: Sibling Mulder, B., Van De Velde, C., Vahrmeijer, A., Mieog, S. & Hernot, S., nov 2019Begeleider: van de Velde, C. (Externe persoon) (Promotor), Vahrmeijer, A. (Externe persoon) (Co-promotor), Mieog, S. (Externe persoon) (Co-promotor) & Hernot, S. (Jury)
Scriptie/masterproef: Doctoral Thesis
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Characterization and reprogramming of umbilical cord-derived mesenchymal stromal cells towards the hepatic lineage
Auteur: Buyl, K., De Kock, J., Vanhaecke, T., Rogiers, V., De Bundel, D., Hernot, S., Vinken, M., Roskams, T., Najimi, M. & Castell, J., 28 feb 2017Begeleider: De Kock, J. (Promotor), Vanhaecke, T. (Promotor), Rogiers, V. (Promotor), De Bundel, D. (Jury), Vinken, M. (Jury), Hernot, S. (Jury), Najimi, M. (Externe persoon) (Jury), Roskams, T. (Externe persoon) (Jury) & Castell, J. V. (Externe persoon) (Jury)
Scriptie/masterproef: Doctoral Thesis
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Conception d’agents d’imagerie moléculaire et théranostiques pour la détection et la thérapie ciblée de cancers
Auteur: Renard, E. & Hernot, S., dec 2020Scriptie/masterproef: Doctoral Thesis
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Design of fluorescent and hybrid nanobody tracers for image-guided surgery.
Auteur: Debie, P., Hernot, S., Devoogdt, N., Rijpkema, M., de Rooster, H., Raes, G., Duerinck, J., De Sutter, P. & Smolders, I., 13 nov 2019Begeleider: Hernot, S. (Promotor), Devoogdt, N. (Co-promotor), Rijpkema, M. (Externe persoon) (Jury), de Rooster, H. (Externe persoon) (Jury), Raes, G. (Jury), Duerinck, J. (Jury), De Sutter, P. (Jury) & Smolders, I. (Jury)
Scriptie/masterproef: Doctoral Thesis