Projecten per jaar
Persoonlijk profiel
Expertise
Sophie Hernot obtained her Master of Science in Bio-engineering from the Vrije Universiteit of Brussels. She completed her PhD thesis in Medical Sciences in 2011 on the use of microbubbles (ultrasound contrast agents) as well as Nanobodies for molecular imaging and drug delivery applications. As post-doctoral researcher, and since 2016 as assistant professor in the Laboratory of In vivo Cellular and Molecular Imaging (ICMI, VUB), her research interests are two-fold: 1) design and validation of nanobodies for optical imaging applications, and in particular towards a clinical translation for image-guided surgery, and 2) validation of nanobody-based molecular probes for identification and characterization of high-risk atherosclerotic lesions. In both cases, particular attention is given to the effects of the nanobody-structure and radioactive or fluorescence labeling of nanobodies on their pharmacokinetics.
Expertise:
- Nanobody labelling
- Non-invasive molecular imaging (optical and nuclear imaging)
- Intra-operative imaging
- Preclinical animal models
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Sophie Hernot actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Netwerk
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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OZR3932: Core facility In Vivo Cellular and Molecular Imaging (ICMI)
16/03/22 → …
Project: Fundamenteel
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OZR3913: Cofinanciering OZR FWO Hercules MZW - Single-cell eiwit analyse in intacte weefsels
Movahedi, K., van Grunsven, L., Rooman, I., Van Ginderachter, J., Smolders, I., Neyns, B., Vanhaecke, T., Laoui, D., Breckpot, K., De Veirman, K., Stijlemans, B., Van Schependom, J., Magez, S., Goyvaerts, C., De Kock, J., De Leu, N., Massie, A., Hellemans, K., Spits, C., De Bundel, D., De Trez, C., Hernot, S., Van Dooren, S., Aerts, J., Staels, W. & Tuyaerts, S.
25/02/22 → 25/02/26
Project: Fundamenteel
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OZR3935: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UGent, HERREIRA DO VALLE Nayra
4/02/22 → 3/02/26
Project: Fundamenteel
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ANI305: Nieuwe fluorescente Nanobodies om kankercellen in beeld te brengen tijdens het heelkundig verwijderen van hoofd- en halstumoren
1/12/21 → 30/11/24
Project: Fundamenteel
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OZR3921: Bilateral cooperation within the framework of a joint doctoral project: benchfee for joint PhD VUB - UBFC (FR), SALIEN Jelena
30/10/21 → 29/10/25
Project: Fundamenteel
Onderzoeksoutput
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A new time-domain camera system optimized for near-infrared fluorescence imaging
Ingelberts, H., Van Den Dries, T., Juliens, A., Lapauw, T., Hernot, S. & Kuijk, M., 2022.Onderzoeksoutput: Poster
Bestand5 Downloads (Pure) -
Custom lifetime phantoms for characterization and benchmarking of a new CAPS fluorescence-lifetime camera
Lapauw, T., Van Den Dries, T., Ingelberts, H., Hernot, S. & Kuijk, M., 7 mrt 2022, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX. California, USA: SPIE, Vol. 11949. 13 blz. 1194902Onderzoeksoutput: Conference paper
Open AccessBestand8 Downloads (Pure) -
Design and Validation of Site-Specifically Labeled Single-Domain Antibody-Based Tracers for in Vivo Fluorescence Imaging and Image-Guided Surgery
Declerck, N. B., Mateusiak, L. & Hernot, S., 2022, Design and Validation of Site-Specifically Labeled Single-Domain Antibody-Based Tracers for in Vivo Fluorescence Imaging and Image-Guided Surgery. Springer, Vol. 2446. blz. 395-407 13 blz. (Methods in Molecular Biology; vol. 2446).Onderzoeksoutput: Chapter
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Group sequential designs for in vivo studies: Minimizing animal numbers and handling uncertainty in power analysis
Blotwijk, S., Hernot, S. & Barbé, K., jul 2022, In : Research in Veterinary Science. 145, blz. 248-254 7 blz.Onderzoeksoutput: Article
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In vivo Visualization of M2 Macrophages in the Myocardium After Myocardial Infarction (MI) Using 68 Ga-NOTA-Anti-MMR Nb: Targeting Mannose Receptor (MR, CD206) on M2 Macrophages
Varasteh, Z., Braeuer, M., Mohanta, S., Steinsiek, A-L., Habenicht, A., Omidvari, N., Topping, G. J., Rischpler, C., Weber, W. A., Sager, H. B., Raes, G., Hernot, S. & Schwaiger, M., 2022, In : Frontiers in Cardiovascular Medicine. 9, blz. 889963Onderzoeksoutput: Article
Open Access
Prijzen
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Best Poster in Category
Sophie Hernot (Recipient), 11 aug 2011
Prijs: Prize (including medals and awards)
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Best Poster in Category
Gezim Bala (Recipient) & Sophie Hernot (Recipient), 28 mei 2013
Prijs: Prize (including medals and awards)
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Finalist Young Investigator Award
Simon Tierens (Recipient) & Sophie Hernot (Recipient), 5 jun 2014
Prijs: Prize (including medals and awards)
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Nomination Marie Curie Award
Zohreh Varasteh (Recipient) & Sophie Hernot (Recipient), 24 okt 2017
Prijs: Prize (including medals and awards)
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Nomination Marie Curie Award
Zohreh Varasteh (Recipient) & Sophie Hernot (Recipient), 24 okt 2017
Prijs: Prize (including medals and awards)
Activiteiten
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Fluorescence-guided surgery using nanobody-based tracers
Sophie Hernot (Speaker)12 jan 2022Activiteit: Talk at an external academic organisation
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Lymphatic mapping and surgical lymphadenectomy guidance using fluorescently labeled mannose-receptor-targeting nanobodies
Lukasz Mateusiak (Speaker), Jens Debacker (Contributor), Pieterjan Debie (Contributor), Noemi Declerck (Contributor), Danny M van Willigen (Contributor), Geert Raes (Contributor), Alex Mottrie (Contributor), Philippe De Sutter (Contributor), Fijs W B van Leeuwen (Contributor), Hilde de Rooster (Contributor), Sophie Hernot (Contributor)15 mrt 2022 → 18 mrt 2022Activiteit: Talk or presentation at a conference
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Near-infrared fluorescent nanobody-based tracers with improved pharmacokinetics for intra-operative cancer imaging
Noemi Declerck (Speaker), Sofie Declercq (Contributor), Pieterjan Debie (Contributor), Julie Du Ville (Contributor), Lukasz Mateusiak (Contributor), Michael Luciano (Contributor), Dong-Hao Li (Contributor), Martin J. Schnermann (Contributor), Bradley Smith (Contributor), Sophie Hernot (Contributor)16 mrt 2022Activiteit: Talk or presentation at a conference
Bestand -
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Knipsels
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VUB-onderzoekers ontwikkelen gel met natuurlijke pijnstillers
Steven Ballet, Charlotte Martin & Sophie Hernot
6/12/18
2 Mediabijdrages
Pers / media: !!Research
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Presentation of data acquired with a novel high-resolution PET imaging system and radiolabeled nanobodies in the context of atherosclerosis
C. Vanhove, Sophie Hernot & Jessica Bridoux
18/04/18
1 Mediabijdrage
Pers / media: !!Research
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Grotere overlevingskansen bij kankeroperaties door fluorescente vloeistof
22/12/17
2 Mediabijdrages
Pers / media: !!Research
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Kikkers gebruiken moleculen als micro-giftanden om roofdieren te vergiftigen
Kim Roelants, Vicky Caveliers, Sophie Hernot & Cindy Peleman
16/11/17
1 Mediabijdrage
Pers / media: !!Research
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Publication of results on the use of the Cellvizio system for in vivo microscopic imaging tumor targeting of fluorescent nanobodies
14/04/14
1 Mediabijdrage
Pers / media: !!Research
Scriptie
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Auteur: Declerck, E., Vanhaecke, T., Marcelino Rodrigues, R. & Hernot, S., 7 sep 2017Scriptie/masterproef: Master's Thesis
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Cancer detection and visualization: Molecular diagnostics and imaging techniques in pancreatic cancer and metastasis
Auteur: Sibling Mulder, B., Van De Velde, C., Vahrmeijer, A., Mieog, S. & Hernot, S., nov 2019Begeleider: van de Velde, C. (Externe persoon) (Promotor), Vahrmeijer, A. (Externe persoon) (Co-promotor), Mieog, S. (Externe persoon) (Co-promotor) & Hernot, S. (Jury)
Scriptie/masterproef: Doctoral Thesis
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Characterization and reprogramming of umbilical cord-derived mesenchymal stromal cells towards the hepatic lineage
Auteur: Buyl, K., De Kock, J., Vanhaecke, T., Rogiers, V., De Bundel, D., Hernot, S., Vinken, M., Roskams, T., Najimi, M. & Castell, J., 28 feb 2017Begeleider: De Kock, J. (Promotor), Vanhaecke, T. (Promotor), Rogiers, V. (Promotor), De Bundel, D. (Jury), Vinken, M. (Jury), Hernot, S. (Jury), Najimi, M. (Externe persoon) (Jury), Roskams, T. (Externe persoon) (Jury) & Castell, J. V. (Externe persoon) (Jury)
Scriptie/masterproef: Doctoral Thesis
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Conception d’agents d’imagerie moléculaire et théranostiques pour la détection et la thérapie ciblée de cancers
Auteur: Renard, E. & Hernot, S., dec 2020Scriptie/masterproef: Doctoral Thesis
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Confirming the applicability of the anti-EGFR Nanobodies for fluorescence-guided surgery in canine and human head and neck cancer
Auteur: Hernot, S. & de Rooster, H., 2025Scriptie/masterproef: Doctoral Thesis