Projecten per jaar
Persoonlijk profiel
Expertise
Sophie Hernot obtained her Master of Science in Bio-engineering from the Vrije Universiteit of Brussels. She completed her PhD thesis in Medical Sciences in 2011 on the use of microbubbles (ultrasound contrast agents) as well as Nanobodies for molecular imaging and drug delivery applications. As post-doctoral researcher, and since 2016 as assistant professor in the Laboratory of In vivo Cellular and Molecular Imaging (ICMI, VUB), her research interests are two-fold: 1) design and validation of nanobodies for optical imaging applications, and in particular towards a clinical translation for image-guided surgery, and 2) validation of nanobody-based molecular probes for identification and characterization of high-risk atherosclerotic lesions. In both cases, particular attention is given to the effects of the nanobody-structure and radioactive or fluorescence labeling of nanobodies on their pharmacokinetics.
Expertise:
- Nanobody labelling
- Non-invasive molecular imaging (optical and nuclear imaging)
- Intra-operative imaging
- Preclinical animal models
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Sophie Hernot actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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HERC73: Upgrade van confocale FLIM-microscoop met excitatie- en detectiemodules met twee fotonen
Hernot, S. (Administrative Promotor)
1/01/25 → 31/01/28
Project: Fundamenteel
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FWOSB194: NAIROBI: iNjecteerbare suprAmoleculaire peptIde hydRogelen voor gecOntroleerde afgifte van BoactIeve moleculen
Robberechts, I. (Mandataris), Martin, C. (Administrative Promotor), Ballet, S. (CoI (Co-Promotor)) & Hernot, S. (CoI (Co-Promotor))
1/11/24 → 31/10/28
Project: Fundamenteel
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HERC66: 3D-CELLMAP: Onthullen van complexe celinteracties in weefsels door middel van 3D super-resolutie proteïne multiplex beeldvorming.
Movahedi, K. (Administrative Promotor), Rooman, I. (CoI (Co-Promotor)), Sermon, K. (CoI (Co-Promotor)), De Bundel, D. (CoI (Co-Promotor)), Fioravanti, A. (CoI (Co-Promotor)), Staels, W. (CoI (Co-Promotor)), Magez, S. (CoI (Co-Promotor)), Breckpot, K. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Laoui, D. (CoI (Co-Promotor)), Goyvaerts, C. (CoI (Co-Promotor)), Smolders, I. (CoI (Co-Promotor)), Van Ginderachter, J. (CoI (Co-Promotor)), Marcelino Rodrigues, R. (CoI (Co-Promotor)), De Leu, N. (CoI (Co-Promotor)), van Grunsven, L. (CoI (Co-Promotor)), Hernot, S. (CoI (Co-Promotor)), Peeters, E. (CoI (Co-Promotor)), Vanhaecke, T. (CoI (Co-Promotor)), De Veirman, K. (CoI (Co-Promotor)), Ruytinx, J. (CoI (Co-Promotor)), Van Schependom, J. (CoI (Co-Promotor)), Kortekaas, I. (CoI (Co-Promotor)) & Goossens, E. (CoI (Co-Promotor))
1/05/24 → 31/05/28
Project: Fundamenteel
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OZR4288: Financiering MZW OZR: Snelle analyse en productie van eiwitten voor klinische translatie met behulp van Biacore en bioreactor systemen.
Devoogdt, N. (Administrative Promotor), Hernot, S. (CoI (Co-Promotor)), De Groof, T. (CoI (Co-Promotor)), Ballet, S. (CoI (Co-Promotor)), Stijlemans, B. (CoI (Co-Promotor)), Massie, A. (CoI (Co-Promotor)), Rooman, I. (CoI (Co-Promotor)), Keyaerts, M. (CoI (Co-Promotor)), Raes, G. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Breckpot, K. (CoI (Co-Promotor)), De Veirman, K. (CoI (Co-Promotor)) & Caveliers, V. (CoI (Co-Promotor))
24/04/24 → 24/04/28
Project: Fundamenteel
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SRP95: Exploitatie van Peptiden als Proteïne Binders, Modulatoren, Inhibitoren en Biomaterialen voor Beeldvorming en Therapie
Ballet, S. (Administrative Promotor), Caveliers, V. (CoI (Co-Promotor)), Hernot, S. (CoI (Co-Promotor)), Versées, W. (CoI (Co-Promotor)), Devoogdt, N. (CoI (Co-Promotor)), Covens, P. (CoI (Co-Promotor)) & Martin, C. (Medewerker)
1/03/24 → 28/02/29
Project: Fundamenteel
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Bimodal PET/fluorescence imaging with Nanobody tracers: comparison of MOMIP platforms
Saliën, J., Floru, S., Vizier, R., Delalieux, S., Bridoux, J., Goncalves, V., Denat, F. & Hernot, S., 14 mrt. 2025.Onderzoeksoutput: Poster
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Breaking the Nanosecond Barrier: Antibody-Based Tumor Imaging with Extended-Lifetime Fluorescent Tracers – A Promise for Enhanced Multiplexing
Mateusiak, L., Chazeau, E., Al-Sabea, H., Samuelsen Fosse, V., Kleinmanns, K., Goze, C., McCormack, E., Lapauw, T., Van Den Dries, T., Ingelberts, H., Denat, F. & Hernot, S., 12 mrt. 2025.Onderzoeksoutput: Poster
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Cetuximab enhances tumor-to-background ratio during Nanobody-based fluorescence guided surgery in dogs with EGFR-expressing tumors
Herreira do Valle, N. C., Debacker, J., De Cock, H., Pollenus, S., Hernot, S. & de Rooster, H., 14 mrt. 2025.Onderzoeksoutput: Poster
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Comparison of NOTA-derivatives for Nanobody PET imaging
Saliën, J., Floru, S., Van Hove, M., De Pauw, T., Vizier, R., Bridoux, J., Goncalves, V., Denat, F. & Hernot, S., jun. 2025, (Unpublished).Onderzoeksoutput: Unpublished abstract
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Evaluation of a single domain antibody targeting uPAR for molecular imaging of atherosclerosis in ApoE-/-mice
Dumas, L., Raes, F., Adoumou-Limoune, B., André, C., Bezot, M., Bacot, S., Ahmadi, M., N'guessan, E., Mateusiak, L., Ghezzi, C., Hernot, S. & Broisat, A., 2025.Onderzoeksoutput: Poster
Datasets
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Generation and Characterization of Novel Pan-Cancer Anti-uPAR Fluorescent Nanobodies as Tools for Image-Guided Surgery
Mateusiak, L. (Creator), Floru, S. (Researcher), De Groof, T. (Researcher), Wouters, J. (Researcher), Declerck, N. (Researcher), Debie, P. (Researcher), Janssen, S. (Researcher), Zeven, K. (Researcher), Puttemans, J. (Researcher), Vincke, C. (Researcher), Breckpot, K. (Project Member), Devoogdt, N. (Project Member) & Hernot, S. (Supervisor), Zenodo, 26 mrt. 2025
DOI: https://zenodo.org/records/15089920
Dataset
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Fluorescent Nanobodies for enhanced guidance in digestive tumors and liver metastasis surgery
Mateusiak, L. (Creator), Hakuno, S. (Researcher), de Jonge-Muller, E. (Researcher), Floru, S. (Researcher), Sier, C. F. M. (Supervisor), Hawinkels, L. J. (Supervisor) & Hernot, S. (Supervisor), Zenodo, 27 mrt. 2025
DOI: https://zenodo.org/records/15096527
Dataset
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Dataset related to article "Size-advantage of monovalent nanobodies against the macrophage mannose receptor for deep tumor penetration and tumor-associated macrophage targeting"
Movahedi, K. (Creator), Allavena, P. (Creator), Erreni, M. (Creator), Debie, P. (Creator), Mantovani, A. (Creator), D'Autilia, F. (Creator), Doni, A. (Creator), van Leeuwen, F. W. B. (Creator), Avigni, R. (Creator), Arnouk, S. M. (Creator), Vincke, C. (Creator), Van Ginderachter, J. (Creator), Anselmo, A. (Creator), Parente, R. (Creator), Hernot, S. (Creator), Garlanda, C. (Creator) & Bolli, E. (Creator), Zenodo, 4 dec. 2023
DOI: 10.5281/zenodo.10254683, https://zenodo.org/records/10254683
Dataset
Prijzen
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Best Poster in Category
Bala, G. (Recipient) & Hernot, S. (Recipient), 28 mei 2013
Prijs: Prize (including medals and awards)
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Best Poster in Category
Hernot, S. (Recipient), 11 aug. 2011
Prijs: Prize (including medals and awards)
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Finalist Young Investigator Award
Tierens, S. (Recipient) & Hernot, S. (Recipient), 5 jun. 2014
Prijs: Prize (including medals and awards)
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Nomination Marie Curie Award
Varasteh, Z. (Recipient) & Hernot, S. (Recipient), 24 okt. 2017
Prijs: Prize (including medals and awards)
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Nomination Marie Curie Award
Varasteh, Z. (Recipient) & Hernot, S. (Recipient), 24 okt. 2017
Prijs: Prize (including medals and awards)
Activiteiten
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Educational talk: Tracer Design: Enhancing Intraoperative Imaging for Precision Surgery.
Hernot, S. (Speaker)
11 mrt. 2025Activiteit: Talk or presentation at a conference
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Nanobody-based Fluorescent Contrast Agents for Rapid and Specific Intra-Operative Tumor Visualization.
Hernot, S. (Invited speaker)
30 sep. 2025Activiteit: Talk or presentation at a conference
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Ontwikkeling en preklinische validatie van fluorescente tracers
Hernot, S. (Keynote speaker)
17 mei 2025Activiteit: Talk or presentation at a conference
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Enhancing Fluorescence-Guided Surgery with Nanobodies and Fluorescence Lifetime Imaging.
Hernot, S. (Keynote speaker)
21 apr. 2025Activiteit: Talk or presentation at a conference
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Imaging with Nanobody-based bimodal PET/fluorescence tracers for improved clinical decision making
Saliën, J. (Speaker), Floru, S. (Contributor), Vizier, R. (Contributor), Stroet, M. (Contributor), Bridoux, J. (Contributor), Hernot, S. (Contributor), Goncalves, V. (Contributor) & Denat, F. (Contributor)
mei 2025Activiteit: Talk or presentation at a conference
Knipsels
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VUB-onderzoekers ontwikkelen gel met natuurlijke pijnstillers
Ballet, S., Martin, C. & Hernot, S.
6/12/18
2 Mediabijdrages
Pers / media: !!Research
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Presentation of data acquired with a novel high-resolution PET imaging system and radiolabeled nanobodies in the context of atherosclerosis
Vanhove, C., Hernot, S. & Bridoux, J.
18/04/18
1 Mediabijdrage
Pers / media: !!Research
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Grotere overlevingskansen bij kankeroperaties door fluorescente vloeistof
22/12/17
2 Mediabijdrages
Pers / media: !!Research
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Kikkers gebruiken moleculen als micro-giftanden om roofdieren te vergiftigen
Roelants, K., Caveliers, V., Hernot, S. & Peleman, C.
16/11/17
1 Mediabijdrage
Pers / media: !!Research
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Publication of results on the use of the Cellvizio system for in vivo microscopic imaging tumor targeting of fluorescent nanobodies
14/04/14
1 Mediabijdrage
Pers / media: !!Research
Scriptie
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Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Declerck, E. ((PhD) Student), Vanhaecke, T. (Promotor), Marcelino Rodrigues, R. (Promotor) & Hernot, S. (Jury), 7 sep. 2017Scriptie/Masterproef: Master's Thesis
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Conception d’agents d’imagerie moléculaire et théranostiques pour la détection et la thérapie ciblée de cancers
Renard, E. ((PhD) Student) & Hernot, S. (Jury), dec. 2020Scriptie/Masterproef: Doctoral Thesis
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Confirming the applicability of the anti-EGFR Nanobodies for fluorescence-guided surgery in canine and human head and neck cancer
Hernot, S. (Promotor) & de Rooster, H. (Promotor), 2025Scriptie/Masterproef: Doctoral Thesis
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Development of Improved Adeno-Asociated Viral Vector Designs for Gene Therapy of Duchenne Muscular Dystrophy
Claeys, L. ((PhD) Student), VandenDriessche, T. (Promotor), Chuah, M. (Promotor) & Hernot, S. (Jury), Chai, Y. C. (Advisor) & Boon, D. (Advisor), 7 sep. 2017Scriptie/Masterproef: Master's Thesis
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Enhancing brain tumor visualization for surgical resection using fluorescent labeled nanobodies.
Floru, S. ((PhD) Student) & Hernot, S. (Promotor), Mateusiak, L. (Co-promotor), 2022Scriptie/Masterproef: Master's Thesis