Onderzoeksoutput per jaar
Onderzoeksoutput per jaar
Onderzoeksoutput
Zoekresultaten
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2025
Hepatic stellate cell single cell atlas reveals a highly similar activation process across liver disease aetiologies
Merens, V., Knetemann, E., Gürbüz, E., De Smet, V., Messaoudi, N., Reynaert, H., Verhulst, S. & van Grunsven, L. A., jan 2025, In: JHEP reports. 7, 1, blz. 1-12 12 blz., 101223.Onderzoeksoutput: Article › peer review
Open AccessBestand1 Citaat (Scopus)1 Downloads (Pure) -
2024
Gain of 1q confers an MDM4-driven growth advantage to undifferentiated and differentiating hESC while altering their differentiation capacity
Krivec, N., Couvreu De Deckersberg, E., Lei, Y., Al Delbany, D., Regin, M., Verhulst, S., van Grunsven, L. A., Sermon, K. & Spits, C., 21 nov 2024, In: Cell Death and Disease. 15, 14 blz., 852.Onderzoeksoutput: Article › peer review
Open Access -
GPR176 Expression Correlates With Hepatic Stellate Cell Activation In Metabolic Dysfunction-Associated Steatotic Liver Disease And Chronic Viral Hepatitis
De Smet, V., Gürbüz, E., Eysackers, N., Smout, A., Lefesvre, P., Messaoudi, N., Mannaerts, I., Verhulst, S. & van Grunsven, L. A., 2024, In: Acta Gastro-Enterologica Belgica. Vol 87 (S1), 1 blz., A04.Onderzoeksoutput: Meeting abstract (Journal)
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Human iPSC-derived liver co-culture spheroids to model liver fibrosis
Cools, L., Kazemzadeh Dastjerd, M., Smout, A., Merens, V., Yang, Y., Reynaert, H., Messaoudi, N., De Smet, V., Kumar, M., Verhulst, S., Verfaillie, C. & van Grunsven, L. A., 28 jun 2024, In: Biofabrication. 16, 3, blz. 1-18 18 blz., 035032.Onderzoeksoutput: Article › peer review
Open AccessBestand1 Citaat (Scopus)48 Downloads (Pure) -
Metabolic fibrotic profiling during in vitro activation of primary mouse hepatic stellate cells
Kannan, S., Del'Haye, G., Liveyns, A. W., Mortier, A., De Kock, J., Verhulst, S. & van Grunsven, L. A., 4 sep 2024.Onderzoeksoutput: Poster
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Single-cell atlas reveals conserved HSC activation process and therapeutic opportunities
Merens, V., De Smet, V., Verhulst, S. & van Grunsven, L. A., 2024, In: Journal of Hepatology. vol. 80(S1), blz. S78–S836 1 blz., THU-524-YI.Onderzoeksoutput: Meeting abstract (Journal)
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Spatially Self-Organized Three-Dimensional Neural Concentroid as a Novel Reductionist Humanized Model to Study Neurovascular Development
Chai, Y. C., To, S. K., Simorgh, S., Zaunz, S., Zhu, Y., Ahuja, K., Lemaitre, A., Ramezankhani, R., van der Veer, B. K., Wierda, K., Verhulst, S., van Grunsven, L. A., Pasque, V. & Verfaillie, C., feb 2024, In: Advanced Science. 11, 5, 20 blz., e2304421.Onderzoeksoutput: Article › peer review
Open AccessBestand4 Citaten (Scopus)37 Downloads (Pure) -
The orphan receptor GPR176 in hepatic stellate cells exerts a profibrotic role during chronic liver diseases
De Smet, V., Gürbüz, E., Eysackers, N., Dewyse, L., Smout, A., Kazemzadeh Dastjerd, M., Lefesvre, P., Messaoudi, N., Reynaert, H., Verhulst, S., Mannaerts, I. & van Grunsven, L. A., mei 2024, In: JHEP reports. 6, 5, 11 blz., 101036.Onderzoeksoutput: Article › peer review
Open Access1 Citaat (Scopus) -
2023
Fructose and glucose supplementation for the development of NAFLD and NASH in mice
Cools, L., Dumarey, A. A., Reynaert, H., Verhulst, S. & van Grunsven, L., 31 jan 2023, In: Acta Gastro-Enterologica Belgica. 86, S1, A30.Onderzoeksoutput: Meeting abstract (Journal)
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Fully controlled iPSC-derived spheroids to model liver fibrosis
Kazemzadeh Dastjerd, M., Cools, L., Smout, A., Merens, V., Reynaert, H., Messaoudi, N., Verhulst, S. & van Grunsven, L. A., 31 jan 2023, In: Acta Gastro-Enterologica Belgica. 85, S1, 1 blz., A21.Onderzoeksoutput: Meeting abstract (Journal)
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GAIN OF 1Q CONFERS AN MDM4-DRIVEN GROWTH ADVANTAGE TO UNDIFFERENTIATED AND DIFFERENTIATING HESC WHILE ALTERING THEIR DIFFERENTIATION CAPACITY
Krivec, N., Couvreu De Deckersberg, E., Lei, Y., Al Delbany, D., Regin, M., Verhulst, S., van Grunsven, L. A., Sermon, K. & Spits, C., 4 dec 2023.Onderzoeksoutput: Poster
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Loss of CEACAM1 in endothelial cells causes hepatic fibrosis
Muturi, H. T., Ghadieh, H. E., Abdolahipour, R., Stankus, H. L., Belew, G. D., Liu, J. K., Jahromi, M. S., Lee, A. D., Singer, B. B., Angeli-Pahim, I., Sehrawat, T. S., Malhi, H., Verhulst, S., van Grunsven, L. A., Zarrinpar, A., Duarte, S. & Najjar, S. M., jul 2023, In: Metabolism: Clinical and Experimental. 144, blz. 1-11 11 blz., 155562.Onderzoeksoutput: Article › peer review
Open AccessBestand7 Citaten (Scopus)248 Downloads (Pure) -
Novel Prediction Models for Genotoxicity Based on Biomarker Genes in Human HepaRGTM Cells
Thienpont, A., Verhulst, S., Van Grunsven, L. A., Rogiers, V., Vanhaecke, T. & Mertens, B., 29 mrt 2023, In: Altex. 40, 2, blz. 271-286 16 blz., 40.Onderzoeksoutput: Article › peer review
Open AccessBestand7 Citaten (Scopus)39 Downloads (Pure) -
RPE differentiation is a genetic bottleneck eliminating all recurrent aneuploidies except for gains of 1q
Couvreu De Deckersberg, E., Lei, Y., Krivec, N., Huyghebaert, A., Regin, M., Scheyltjens, I., Al Delbany, D., Tsuiko, O., Verhulst, S., Duong, C. M., Al Delbany, D., van Grunsven, L. A., Sermon, K. & Spits, C., 6 dec 2023.Onderzoeksoutput: Poster
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The GENOMARK biomarker in human HepaRGTM cells: a new approach methodology for genotoxicity assessment
Thienpont, A., Verhulst, S., van Grunsven, L. A., Rogiers, V., Vanhaecke, T. & Mertens, B., feb 2023.Onderzoeksoutput: Unpublished abstract
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The GENOMARK transcriptomic biomarker: a new approach methodology for genotoxicity (Qualitative and quantitative aspects).
Thienpont, A., Cho, E., Williams, A., Meier, M. J., Yauk, C. L., Verhulst, S., Rogiers, V., Vanhaecke, T. & Mertens, B., sep 2023.Onderzoeksoutput: Unpublished abstract
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2022
168P Characterization of the lung tumor microenvironment upon anti-PD-L1 therapy reveals an ambiguous role for TNF-α
De Ridder, K., Locy, H., Piccioni, E., Zuazo Ibarra, M., Awad, R. M., Verhulst, S., Van Bulck, M., De Vlaeminck, Y., Lecocq, Q., Reijmen, E., de Mey, W., De Beck, L., Ertveldt, T., Escors, D., Keyaerts, M., Breckpot, K. & Goyvaerts, C., 30 mrt 2022, In: Annals of Oncology. 33, S2, blz. 109-109 1 blz.Onderzoeksoutput: Meeting abstract (Journal)
Open Access -
AP-1 And YAP1-TEAD Drive Independent Transcriptional Programs To Activate Hepatic Stellate Cells
De Smet, V., Van Os, E., Verhulst, S., Mannaerts, I. & van Grunsven, L. A., 2022, In: Acta Gastro-Enterologica Belgica. Vol 85 (S1), 1 blz., A24.Onderzoeksoutput: Meeting abstract (Journal)
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Assessing Tumor-Infiltrating Lymphocytes in Breast Cancer: A Proposal for Combining Immunohistochemistry and Gene Expression Analysis to Refine Scoring
Locy, H., Verhulst, S., Cools, W., Waelput, W., Brock, S., Cras, L., Schiettecatte, A., Jonckheere, J., van Grunsven, L. A., Vanhoeij, M., Thielemans, K. & Breckpot, K., 11 feb 2022, In: Frontiers in Immunology. 13, blz. 1-13 13 blz., 794175.Onderzoeksoutput: Article › peer review
Open AccessBestand15 Citaten (Scopus)78 Downloads (Pure) -
Characterization of the lung tumor microenvironment upon anti-PD-L1 therapy reveals an ambiguous role for TNF-α
De Ridder, K., Locy, H., Piccioni, E., Zuazo, M. I., Awad, R. M., Verhulst, S., Van Bulck, M., De Vlaeminck, Y., Lecocq, Q., Reijmen, E., de Mey, W., De Beck, L., Ertveldt, T., Escors, D., Keyaerts, M., Breckpot, K. & Goyvaerts, C., 6 aug 2022.Onderzoeksoutput: Poster
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Characterization of the lung tumor microenvironment upon anti-PD-L1 therapy reveals an ambiguous role for TNF-α
De Ridder, K., Locy, H., Piccioni, E., Zuazo Ibarra, M., Awad, R. M., Verhulst, S., Van Bulck, M., De Vlaeminck, Y., Reijmen, E., de Mey, W., De Beck, L., Ertveldt, T., Escors, D., Keyaerts, M., Breckpot, K. & Goyvaerts, C., 30 mrt 2022.Onderzoeksoutput: Poster
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Development and comparison of novel prediction models for genotoxicity based on biomarker genes in HepaRGTM cells
Thienpont, A., Verhulst, S., van Grunsven, L. A., Rogiers, V., Vanhaecke, T. & Mertens, B., 16 mei 2022, (Unpublished).Onderzoeksoutput: Unpublished abstract
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GENOMARK, a promising new approach methodology for genotoxicity testing in the cosmetic industry.
Thienpont, A., Verhulst, S., van Grunsven, L. A., Vanhaecke, T., Mertens, B. & Rogiers, V., 3 dec 2022, (Unpublished).Onderzoeksoutput: Unpublished abstract
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GENOMARK gene expression data to compare genotoxic potencies: qualitative and quantitative aspects
Thienpont, A., Verhulst, S., Sanders, J., De Win, D., Tarhonska, K., Rogiers, V., Vanhaecke, T. & Mertens, B., 27 aug 2022, (Unpublished).Onderzoeksoutput: Unpublished abstract
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Hippo signaling instructs ectopic but not normal organ growth
Kowalczyk, W., Romanelli, L., Atkins, M., Hillen, H., Bravo González-Blas, C., Jacobs, J., Xie, J., Soheily, S., Verboven, E., Moya, I. M., Verhulst, S., de Waegeneer, M., Sansores-Garcia, L., van Huffel, L., Johnson, R. L., van Grunsven, L. A., Aerts, S. & Halder, G., 18 nov 2022, In: Science. 378, 6621, blz. eabg3679Onderzoeksoutput: Article › peer review
Open AccessBestand38 Citaten (Scopus)7 Downloads (Pure) -
Improved Precision-Cut Liver Slice Cultures for Testing Drug-Induced Liver Fibrosis
Dewyse, L., De Smet, V., Verhulst, S., Eysackers, N., Kunda, R., Messaoudi, N., Reynaert, H. & van Grunsven, L. A., 30 mrt 2022, In: Frontiers in Medicine. 9, blz. 1-11 11 blz., 862185.Onderzoeksoutput: Article › peer review
Open Access11 Citaten (Scopus) -
Inhibiting Histone and DNA Methylation Improves Cancer Vaccination in an Experimental Model of Melanoma
De Beck, L., Awad, R. M., Basso, V., Casares, N., De Ridder, K., De Vlaeminck, Y., Gnata, A., Goyvaerts, C., Lecocq, Q., San José-Enériz, E., Verhulst, S., Maes, K., Vanderkerken, K., Agirre, X., Prosper, F., Lasarte, J. J., Mondino, A. & Breckpot, K., 12 mei 2022, In: Frontiers in Immunology. 13, blz. 1-15 15 blz., 799636.Onderzoeksoutput: Article › peer review
Open Access5 Citaten (Scopus) -
Inhibition of the Protein Arginine Methyltransferase PRMT5 in High-Risk Multiple Myeloma as a Novel Treatment Approach
Vlummens, P., Verhulst, S., De Veirman, K., Maes, A., Menu, E., Moreaux, J., De Bruyne, E., Hose, D., Vanderkerken, K. & Maes, K., 8 jun 2022, In: Frontiers in cell and developmental biology. 10, 11 blz., 879057.Onderzoeksoutput: Article › peer review
Open AccessBestand3 Citaten (Scopus)13 Downloads (Pure) -
Lipofection of Non-integrative CRISPR/Cas9 Ribonucleoproteins in Male Germline Stem Cells: A Simple and Effective Knockout Tool for Germline Genome Engineering
Obermeier, M., Vadolas, J., Verhulst, S., Goossens, E. & Baert, Y., 14 jun 2022, In: Frontiers in cell and developmental biology. 10, blz. 1-9 9 blz., 891173.Onderzoeksoutput: Article › peer review
Open Access -
Modelling fatty liver disease with mouse liver-derived multicellular spheroids
van Os, E. A., Cools, L., Eysackers, N., Szafranska, K., Smout, A., Verhulst, S., Reynaert, H., McCourt, P., Mannaerts, I. & van Grunsven, L. A., nov 2022, In: Biomaterials. 290, 11 blz., 121817.Onderzoeksoutput: Article › peer review
Open AccessBestand14 Citaten (Scopus)94 Downloads (Pure) -
The evaluation of genotoxicity by using novel prediction models based on biomarker genes in human HepaRGTM cells.
Thienpont, A., Verhulst, S., van Grunsven, L. A., Rogiers, V., Vanhaecke, T. & Mertens, B., sep 2022, (Unpublished).Onderzoeksoutput: Unpublished abstract
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The GENOMARK biomarker, a promising new approach methodology for genotoxicity testing to de-risk misleading positive chemicals in the cosmetic industry.
Thienpont, A., Verhulst, S., van Grunsven, L. A., Mertens, B., Vanhaecke, T. & Rogiers, V., dec 2022.Onderzoeksoutput: Unpublished abstract
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The GENOMARK prediction model
Thienpont, A., Verhulst, S., Rogiers, V., Vanhaecke, T. & Mertens, B., 4 nov 2022Onderzoeksoutput: Web publication/site
Open Access -
THE IMPACT OF RECURRENT CHROMOSOMAL ABNORMALITIES ON GROWTH ADVANTAGE AND DIFFERENTIATION CAPACITY OF HUMAN PLURIPOTENT STEM CELLS
Krivec, N., Lei, Y., Couvreu De Deckersberg, E., Verhulst, S., Sermon, K. & Spits, C., 15 jun 2022.Onderzoeksoutput: Poster
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TNF-alpha-Secreting Lung Tumor-Infiltrated Monocytes Play a Pivotal Role During Anti-PD-L1 Immunotherapy
De Ridder, K., Locy, H., Piccioni, E., Zuazo, M. I., Awad, R. M., Verhulst, S., Van Bulck, M., De Vlaeminck, Y., Lecocq, Q., Reijmen, E., De Mey, W., De Beck, L., Ertveldt, T., Pintelon, I., Timmermans, J-P., Escors, D., Keyaerts, M., Breckpot, K. & Goyvaerts, C., 14 apr 2022, In: Frontiers in Immunology. 13, blz. 1-15 15 blz., 811867.Onderzoeksoutput: Article › peer review
Open AccessBestand14 Citaten (Scopus)99 Downloads (Pure) -
TNF-α-secreting lung tumor-infiltrated monocytes play a pivotal role for effective anti-PD-L1 immunotherapy
De Ridder, K., Locy, H., Piccioni, E., Zuazo, M. I., Awad, R. M., Verhulst, S., Van Bulck, M., De Vlaeminck, Y., Lecocq, Q., Reijmen, E., de Mey, W., De Beck, L., Ertveldt, T., Escors, D., Keyaerts, M., Breckpot, K. & Goyvaerts, C., 5 sep 2022.Onderzoeksoutput: Poster
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2021
A novel prediction model to evaluate genotoxicity based on a gene signature in metabolically competent human HepaRGTM cells.
Thienpont, A., Verhulst, S., Van Grunsven, L. A., Rogiers, V., Vanhaecke, T. & Mertens, B., 2021, (Unpublished).Onderzoeksoutput: Unpublished abstract
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A profibrotic role for the orphan G-protein coupled receptor 176 during hepatic stellate cell activation
De Smet, V., Verhulst, S., Dewyse, L., Dastjerd, M. K., Reynaert, H., Halder, G., Mannaerts, I. & van Grunsven, L. A., jul 2021, In: Journal of Hepatology. 75, S2, blz. S527-S527Onderzoeksoutput: Meeting abstract (Journal)
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Characterization of the lung tumor microenvironment upon anti-PD-L1 therapy reveals an ambiguous role for TNF-α
De Ridder, K., Locy, H., Piccioni, E., Zuazo Ibarra, M., Awad, R. M., Verhulst, S., Van Bulck, M., De Vlaeminck, Y., Lecocq, Q., Reijmen, E., de Mey, W., De Beck, L., Escors, D., Keyaerts, M., Breckpot, K. & Goyvaerts, C., 25 okt 2021, (Unpublished).Onderzoeksoutput: Poster
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Combining dual G9a/DNMTs epigenetic inhibition and immunotherapy to treat metastatic melanoma
De Beck, L., Awad, R. M., De Vlaeminck, Y., Basso, V., Casares, N., Verhulst, S., San José-Enériz, E., De Ridder, K., Goyvaerts, C., Maes, K., Vanderkerken, K., Agirre, X., Prosper, F., Lasarte, J. J., Mondino, A. & Breckpot, K., 11 feb 2021, blz. 1. 1 blz.Onderzoeksoutput: Unpublished abstract
2 Downloads (Pure) -
Development of a novel genotoxicity prediction model based on biomarker genes in human HepaRGTM cells
Thienpont, A., Verhulst, S., van Grunsven, L. A., Rogiers, V., Vanhaecke, T. & Mertens, B., okt 2021, (Unpublished).Onderzoeksoutput: Unpublished abstract
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Directed differentiation of human induced pluripotent stem cells to hepatic stellate cells
Vallverdú, J., Martínez García de la Torre, R. A., Mannaerts, I., Verhulst, S., Smout, A., Coll, M., Ariño, S., Rubio-Tomás, T., Aguilar-Bravo, B., Martínez-Sánchez, C., Blaya, D., Verfaillie, C. M., van Grunsven, L. A. & Sancho-Bru, P., mei 2021, In: Nature Protocols. 16, 5, blz. 2542-2563 22 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand31 Citaten (Scopus)285 Downloads (Pure) -
Endothelial Zeb2 preserves the hepatic angioarchitecture and protects against liver fibrosis
de Haan, W., Dheedene, W., Apelt, K., Décombas-Deschamps, S., Vinckier, S., Verhulst, S., Conidi, A., Deffieux, T., Staring, M. W., Vandervoort, P., Caluwé, E., Lox, M., Mannaerts, I., Takagi, T., Jaekers, J., Berx, G., Haigh, J., Topal, B., Zwijsen, A., Higashi, Y. & 7 anderen, , 28 apr 2021, In: Cardiovascular Research. 118, 5, blz. 1262-1275 14 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand28 Citaten (Scopus)55 Downloads (Pure) -
Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases
Verhulst, S., van Os, E. A., De Smet, V., Eysackers, N., Mannaerts, I. & van Grunsven, L. A., 20 okt 2021, In: Frontiers in Medicine. 8, blz. 1-14 14 blz., 750044.Onderzoeksoutput: Article › peer review
Open AccessBestand11 Citaten (Scopus)82 Downloads (Pure) -
Initiation of hepatic stellate cell activation extends into chronic liver disease
De Smet, V., Eysackers, N., Merens, V., Kazemzadeh Dastjerd, M., Halder, G., Verhulst, S., Mannaerts, I. & van Grunsven, L. A., 27 nov 2021, In: Cell & Death Disease. 12, 12, blz. 1-10 10 blz., 1110.Onderzoeksoutput: Article › peer review
Open AccessBestand38 Citaten (Scopus)143 Downloads (Pure) -
Overcoming the Challenges of High Quality RNA Extraction from Core Needle Biopsy
Locy, H., Correa, R. J. M., Autaers, D., Schiettecatte, A., Jonckheere, J., Waelput, W., Cras, L., Brock, S., Verhulst, S., Kwan, K., Vanhoeij, M., Thielemans, K. & Breckpot, K., mei 2021, In: Biomolecules. 11, 5, 19 blz., 621.Onderzoeksoutput: Article › peer review
Open AccessBestand7 Citaten (Scopus)364 Downloads (Pure) -
PU.1 drives specification of pluripotent stem cell-derived endothelial cells to LSEC-like cells
De Smedt, J., van Os, E. A., Talon, I., Ghosh, S., Toprakhisar, B., Furtado Madeiro Da Costa, R., Zaunz, S., Vazquez, M. A., Boon, R., Baatsen, P., Smout, A., Verhulst, S., van Grunsven, L. A. & Verfaillie, C. M., 14 jan 2021, In: Cell & Death Disease. 12, 1, blz. 1-18 18 blz., 84.Onderzoeksoutput: Article › peer review
Open AccessBestand29 Citaten (Scopus)92 Downloads (Pure) -
Regeneration Defects in Yap and Taz Mutant Mouse Livers are Caused by Bile Duct Disruption and Cholestasis
Verboven, E., Moya, I. M., Sansores-Garcia, L., Xie, J., Hillen, H., Kowalczyk, W., Vella, G., Verhulst, S., Castaldo, S. A., Algueró-Nadal, A., Romanelli, L., Mercader-Celma, C., Souza, N. A., Soheily, S., van Huffel, L., Van Brussel, T., Lambrechts, D., Roskams, T., Lemaigre, F. P., Bergers, G. & 2 anderen, , feb 2021, In: Gastroenterology. 160, 3, blz. 847-862 16 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand45 Citaten (Scopus)132 Downloads (Pure) -
2020
Single cell RNA sequencing analysis did not predict hepatocyte infection by SARS-CoV-2
De Smet, V., Verhulst, S. & van Grunsven, L. A., okt 2020, In: Journal of Hepatology. 73, 4, blz. 993-995 3 blz.Onderzoeksoutput: Letter › peer review
Open AccessBestand31 Citaten (Scopus)51 Downloads (Pure) -
The fibrotic response of primary liver spheroids recapitulates in vivo hepatic stellate cell activation
Mannaerts, I., Eysackers, N., Anne van Os, E., Verhulst, S., Roosens, T., Smout, A., Hierlemann, A., Frey, O., Leite, S. B. & van Grunsven, L. A., 22 aug 2020, In: Biomaterials. 261, 120335.Onderzoeksoutput: Article › peer review
Open AccessBestand25 Citaten (Scopus)256 Downloads (Pure)