Projecten per jaar
Persoonlijk profiel
Expertise
Basic research related to the development of in vitro alternative methods:
- Human liver-based in vitro models
- Adult human skin-derived progenitor cells and their hepatic derivatives
- DILI screening, including steatosis, phospholipidosis and acute liver failure
- Flow cytometry-based high throughput screening of various hepatic cell models, for live/dead cell analysis, lipid and phospholipid accumulation
- Microscopy-based high content analysis for lipid and mitochondrial deregulation analysis
- Genotoxicant-specific qPCR array
- Transcriptomics and metabolomics readouts and analysis
- Risk assessment of consumer products
Opleiding / Academische kwalificatie
European Registered Toxicologist, Belgian Society of Toxicology
Datum van toekenning: 1 jan. 2010
Doctor in Pharmaceutical Sciences, Hormonal regulation of and zonation of glutathione S-transferase in rat hepatocyte cultures, Vrije Universiteit Brussel
1994 → 2000
Datum van toekenning: 30 sep. 2000
Certificate of successful pass of the exam of the Safety Assessment of Cosmetics in the EU - Training Course, Certificate of successful pass of the exam of the Safety Assessment of Cosmetics in the EU - Training Course, Vrije Universiteit Brussel
2004
Externe posities
Member, Scientific Committee on Consumer Safety (SCCS) - DG SANCO
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
-
IOF3035: B-LIVER 2.0 (Brusselse Alliantie voor Leveronderzoek & Valorisatie)
Vanhaecke, T. (Administrative Promotor), van Grunsven, L. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Vinken, M. (CoI (Co-Promotor)), Reynaert, H. (CoI (Co-Promotor)) & Van Goethem, F. (Mandataris)
1/01/25 → 31/12/29
Project: Toegepast
-
BASGO40: OZR Basisfinanciering voor Grote Onderzoeksgroepen - In Vitro Toxicology and Dermato-Cosmetology (IVTD)
Vanhaecke, T. (Administrative Promotor)
1/01/25 → 31/12/29
Project: Fundamenteel
-
VLOV234: RE-PLACE III: Onderhouden van het platform voor alternatieve methoden voor dierproeven (RE-Place)
Vanhaecke, T. (Administrative Promotor)
1/09/24 → 30/09/28
Project: Fundamenteel
-
HERC66: 3D-CELLMAP: Onthullen van complexe celinteracties in weefsels door middel van 3D super-resolutie proteïne multiplex beeldvorming.
Movahedi, K. (Administrative Promotor), Rooman, I. (CoI (Co-Promotor)), Sermon, K. (CoI (Co-Promotor)), De Bundel, D. (CoI (Co-Promotor)), Fioravanti, A. (CoI (Co-Promotor)), Staels, W. (CoI (Co-Promotor)), Magez, S. (CoI (Co-Promotor)), Breckpot, K. (CoI (Co-Promotor)), De Kock, J. (CoI (Co-Promotor)), Laoui, D. (CoI (Co-Promotor)), Goyvaerts, C. (CoI (Co-Promotor)), Smolders, I. (CoI (Co-Promotor)), Van Ginderachter, J. (CoI (Co-Promotor)), Marcelino Rodrigues, R. (CoI (Co-Promotor)), De Leu, N. (CoI (Co-Promotor)), van Grunsven, L. (CoI (Co-Promotor)), Hernot, S. (CoI (Co-Promotor)), Peeters, E. (CoI (Co-Promotor)), Vanhaecke, T. (CoI (Co-Promotor)), De Veirman, K. (CoI (Co-Promotor)), Ruytinx, J. (CoI (Co-Promotor)), Van Schependom, J. (CoI (Co-Promotor)), Kortekaas, I. (CoI (Co-Promotor)) & Goossens, E. (CoI (Co-Promotor))
1/05/24 → 31/05/28
Project: Fundamenteel
-
FOD176: Fysicochemische karakterisering en evaluatie van de genotoxiteit van nanomaterialen toegepast in de voedselketen met nieuwe aanpakmethodieken (NAMs)'
Vanhaecke, T. (Administrative Promotor) & Sevenants, L. (PI (Promotor, Principal Investigator))
18/09/23 → 17/09/27
Project: Fundamenteel
-
A benchmark concentration-based strategy for evaluating the combined effects of genotoxic compounds in TK6 cells
Sanders, J., Anthonissen, R., Johnson, G., Vanhaecke, T. & Mertens, B., apr. 2025, In: Archives of Toxicology. 99, 4, blz. 1581-1589 9 blz., 111284.Onderzoeksoutput: Article › peer review
Open AccessBestand7 Downloads (Pure) -
Advancing Genotoxicity Assessment by Building a Global AOP Network
Demuynck, E., Vanhaecke, T., Van Goethem, F., Mertens, B., Thienpont, A., Cappoen, D., Winkelman, L. M. T., Beltman, J., Murugadoss, S., Olsen, A.-K., Marcon, F., Bossa, C., Shaikh, S. M., Nikolopoulou, D., Hatzi, V. I., Pennings, J., Luijten, M., Adam‐Guillermin, C., Paparella, M. & Audebert, M., aug. 2025, In: Environmental and Molecular Mutagenesis. 66, 6-7, blz. 341-366 26 blz.Onderzoeksoutput: Article › peer review
3 Downloads (Pure) -
A human liver-based in vitro test battery to detect liver steatogenic potential of chemicals from various applicability domains
Verhoeven, A., Drees, A. H., Rodrigues, R., Sanz-Serrano, J., Vanhaecke, T. & Vinken, M., 2025, (Unpublished).Onderzoeksoutput: Poster
-
A human liver-based in vitro test battery to detect liver steatogenic potential of chemicals from various applicability domains
Verhoeven, A., Drees, A. H., Rodrigues, R., Sanz-Serrano, J., Vanhaecke, T. & Vinken, M., mei 2025, (Unpublished).Onderzoeksoutput: Poster
-
A new human in vitro model of cytotypic and testosterone-producing organoids derived from testicular tissue of transgender women
Silva, S. M., Chalmel, F., Errico, A., Papageorgiou, K., Richer, G., Peng, E. C. S., Rolland, A., Tilleman, K., T'Sjoen, G., Dando, I., Vanhaecke, T., Goossens, E. & Baert, Y., 20 aug. 2025, In: Human reproduction open. 3, 49 blz., hoaf043.Onderzoeksoutput: Article › peer review
Open AccessBestand5 Downloads (Pure)
Datasets
-
Gene expression profiling of Fah- and Hgd-deficient mouse livers upon short-term nitisinone discontinuation
Neuckermans, J. (Creator), Claes, P. (Researcher), Heymans, A. (Researcher), Colemonts-Vroninks, H. (Project Member), Martens, G. (Project Member), Vanhaecke, T. (Supervisor) & De Kock, J. (Supervisor), NCBI Gene Expression Omnibus, 4 apr. 2023
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE225001
Dataset
-
TOXIN KG-Chemical Identity & Repeat Dose Toxicity Data
Sepehri, S. (Creator), Heymans, A. (Data Collector), De Win, D. (Data Collector) & Vanhaecke, T. (Project Leader), Zenodo, 2025
Dataset
Bestand
Prijzen
-
33. Forschungspreises zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
De Kock, J. (Recipient), Marcelino Rodrigues, R. (Recipient), Vanhaecke, T. (Recipient) & Rogiers, V. (Recipient), 2014
Prijs: Prize (including medals and awards)
-
33. Forschungspreise zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
Vanhaecke, T. (Recipient), 2014
Prijs: National/international honour
-
33. Forschungspreise zur Förderung methodischer Arbeiten mit dem Ziel der Einschränkung und des Ersatzes von Tierversuchen
Vanhaecke, T. (Recipient), 4 dec. 2014
Prijs: Prize (including medals and awards)
-
Best Paper Award 2007 from the Toxicological Society
Vanhaecke, T. (Recipient), 2007
Prijs: Prize (including medals and awards)
-
Best Poster Award
Maushagen, J. (Recipient), Sepehri, S. (Recipient), Sanctorum, A. (Recipient), Vanhaecke, T. (Recipient), De Troyer, O. (Recipient) & Debruyne, C. (Recipient), sep. 2024
Prijs: National/international honour
Activiteiten
-
Genetic predisposition for anti-MASH drug response: a population-based in vitro study
Gatzios, A. (Speaker), Rombaut, M. (Contributor), De Kock, J. (Contributor), De Win, D. (Contributor), Heymans, A. (Contributor), Rogiers, V. (Contributor), Marcelino Rodrigues, R. (Contributor), Boeckmans, J. (Contributor) & Vanhaecke, T. (Contributor)
25 jun. 2024Activiteit: Talk or presentation at a conference
-
TOXIN Project: Authoritative Kgs for Toxicology Research.
Debruyne, C. (Speaker) & Vanhaecke, T. (Speaker)
9 okt. 2024Activiteit: Talk or presentation at a workshop/seminar
-
A Next Generation Risk Assessment Case Study For The Hair Dye HC Yellow 13 Focused On Liver Steatosis
Sepehri, S. (Speaker) & Vanhaecke, T. (Speaker)
3 jun. 2024 → 6 jun. 2024Activiteit: Talk or presentation at a conference
-
A stem cell-based in vitro test battery to predict liver steatotic potential of diverse chemicals
Verhoeven, A. (Speaker), Gatzios, A. (Contributor), Marcelino Rodrigues, R. (Contributor), Sanz Serrano, J. (Contributor), Tabernilla Garcia, A. (Contributor), De Kock, J. (Contributor), Vinken, M. (Contributor) & Vanhaecke, T. (Contributor)
4 jun. 2024Activiteit: Talk or presentation at a conference
-
An optimized adverse outcome pathway network for chemical-induced liver steatosis.
Verhoeven, A. (Speaker), van Ertvelde, J. (Contributor), Boeckmans, J. (Contributor), Gatzios, A. (Contributor), Jover, R. (Contributor), Lindeman, B. (Contributor), Lopez, G. (Contributor), Marcelino Rodrigues, R. (Contributor), Rapisarda, A. (Contributor), Sanz Serrano, J. (Contributor), Stinckens, M. (Contributor), Sepehri, S. (Contributor), Vinken, M. (Contributor), Jiang, J. (Contributor) & Vanhaecke, T. (Contributor)
29 nov. 2024Activiteit: Talk or presentation at a conference
Knipsels
-
Allergenen in geparfumeerde menstruatieproducten
Marcelis, Q., Vanhaecke, T., Desmedt, B., Deconinck, E. & Rogiers, V.
1/05/21
1 Mediabijdrage
Pers / media: !!Research
-
-
Antitumorale farmaca dragen bij tot minder proefdiergebruik.
20/01/05
1 Mediabijdrage
Pers / media: !!Other
-
Scriptie
-
Applicability of the KeratinoSensTM on mixtures
Lee, K. A. ((PhD) Student) & Vanhaecke, T. (Promotor), Desmedt, B. (Advisor) & Marcelis, Q. (Advisor), 2024Scriptie/Masterproef: Master's Thesis
-
Application of a Human stem cell-based in vitro model to investigate the impact of genetic determinants on response to ANTI-MASLD drug candidates
Waegeman, L. ((PhD) Student), Vanhaecke, T. (Promotor) & Boeckmans, J. (Promotor), Gatzios, A. (Advisor), 2024Scriptie/Masterproef: Master's Thesis
-
Bepaling van het optimale mRNA elektroporatieprotocol voor humane huidafgeleide stamcellen.
Neuckermans, J. ((PhD) Student) & Vanhaecke, T. (Promotor), 2016Scriptie/Masterproef: Master's Thesis
-
Bepaling van nicotine en alkaloïden onzuiverheden in e-liquids beschikbaar op de Belgische markt.
Sintobin, M. ((PhD) Student) & Vanhaecke, T. (Promotor), 2017Scriptie/Masterproef: Master's Thesis
-
Bijdrage tot de ontwikkeling van een in vitro ziektemodel voor rhepatische steatose door gebruik te maken van huidafgeleide stamcellen
Declerck, E. ((PhD) Student), Vanhaecke, T. (Promotor), Marcelino Rodrigues, R. (Promotor) & Hernot, S. (Jury), 7 sep. 2017Scriptie/Masterproef: Master's Thesis