Projecten per jaar
Persoonlijk profiel
Expertise
Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated in 2015. During his master studies, he specialized both in Biomedical Biotechnology and Structural Biology and Biochemistry. During his last year of studies, De Groof performed research in the biopharmaceutical company Argenx and gained experience on the identification and characterization of llama-derived antibodies in inflammatory diseases and oncology.
From 2015 to 2019, De Groof worked as a PhD student in the Medicinal Chemistry group at VU University Amsterdam under the supervision of prof. dr. Martine Smit where he focused on development and characterization of nanobodies targeting viral G protein-coupled receptors while also focusing on different applications of these nanobodies as therapeutics and research tools.
As of 2019, first as a postdoctoral researcher and currently as a professor, De Groof is working at the Vrije Universiteit Brussel (Belgium) in the Molecular Imaging and Therapy group where his research focuses on diagnostic and therapeutic applications of nanobodies in immuno-oncology.
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Timo De Groof actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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IOF3036: INTEGRAL - Integratie van een multimodale aanpak om de huidige uitdagingen in immuuntherapie aan te pakken
Van Ginderachter, J., Laoui, D., Movahedi, K., Hadadi, E., Stijlemans, B., Raes, G., Devoogdt, N., Lahoutte, T., De Groof, T., Goyvaerts, C., D'Huyvetter, M., Debacker, J., Breckpot, K., Franceschini, L., Raes, G. & Revets, H.
1/01/25 → 31/12/29
Project: Toegepast
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OZR4288: Financiering MZW OZR: Snelle analyse en productie van eiwitten voor klinische translatie met behulp van Biacore en bioreactor systemen.
Devoogdt, N., Hernot, S., De Groof, T., Ballet, S., Stijlemans, B., Massie, A., Rooman, I., Keyaerts, M., Raes, G., De Kock, J., Breckpot, K., De Veirman, K. & Caveliers, V.
24/04/24 → 24/04/28
Project: Fundamenteel
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OZR4286: Financiering MZW OZR: DELI-SORT: MACSQuant® Tyto voor steriele SORTing van DELicate Immune cellen
Laoui, D., Vanginderachter, J. A., Magez, S., Tuyaerts, S., Fioravanti, A., Devoogdt, N., Van der Henst, C., Raes, G., Stijlemans, B., Hadadi, E., De Trez, C., Ruytinx, J., Brunner, J., De Groof, T. & De Veirman, K.
24/04/24 → 24/04/28
Project: Fundamenteel
Onderzoeksoutput
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Advancements in Nuclear Imaging Using radiolabeled Nanobody tracers to support Cancer Immunotherapy
Zeven, K., Lauwers, Y., De Mey, L., Debacker, J., De Pauw, T., De Groof, T. & Devoogdt, N., 26 aug 2024, In: Immunotherapy Advances. 4, 1, 11 blz., Itae006.Onderzoeksoutput: Article › peer review
Open AccessBestand6 Downloads (Pure) -
AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia
Vandewalle, N., Satilmis, H., Verheye, E., Fan, R., Wang, Y., De Groof, T., Bridoux, J., kerre, T., De Beule, N., De Becker, A., De Bruyne, E., Menu, E., Vanderkerken, K., Breckpot, K., Devoogdt, N. & De Veirman, K., 15 apr 2024, In: Theranostics. 14, 7, blz. 2656-2674 19 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand5 Citaten (Scopus)5 Downloads (Pure) -
Development of a sdAb-based radiotracer targeting murine Tissue Factor for atherothrombosis imaging
Dumas, L., Lombardi, C., De Groof, T., Raes, F., Ahmadi, M., Seyve, L., Bacot, S., André, C., Debiossat, M., Marlu, R., Lenormand, J-L., Hernot, S., Fagret, D., Devoogdt, N., Ghezzi, C. & Broisat, A., 2024.Onderzoeksoutput: Poster
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Generation and Characterization of Novel Pan-Cancer Anti-uPAR Fluorescent Nanobodies as Tools for Image-Guided Surgery
Mateusiak, Ł., Floru, S., De Groof, T. W. M., Wouters, J., Declerck, N. B., Debie, P., Janssen, S., Zeven, K., Breckpot, K., Puttemans, J., Vincke, C., Devoogdt, N. & Hernot, S., aug 2024, In: Advanced Science. 11, 30, 11 blz., e2400700.Onderzoeksoutput: Article › peer review
Open AccessBestand3 Citaten (Scopus)6 Downloads (Pure) -
Imaging of tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer
De Groof, T., Lauwers, Y., Vincke, C., Van Craenenbroeck, J., Jumapili, A. N., Mora Barthelmess, R., Courtoy, G. E., Waelput, W., De Pauw, T., Raes, G., Devoogdt, N. & Van Ginderachter, J., 18 dec 2024, In: Proceedings of the National Academy of Sciences of the United States of America. 121, 52, 12 blz., e2409668121.Onderzoeksoutput: Article › peer review
Open Access1 Citaat (Scopus)
Datasets
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Dataset Imaging of Tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer
Lauwers, Y. (Creator), Van Ginderachter, J. (Creator), Devoogdt, N. (Creator), De Groof, T. (Creator), Vincke, C. (Creator), Van Craenenbroeck, J. (Creator), Raes, G. (Creator), De Pauw, T. (Creator), Mora Barthelmess, R. (Creator), Jumapili, A. N. (Creator), Courtoy, G. (Creator) & Waelput, W. (Creator), Zenodo, 5 dec 2024
Dataset
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dataset of Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β
De Groof, T. (Creator), Lauwers, Y. (Creator), De Pauw, T. (Creator), Saxena, M. (Creator), Vincke, C. (Creator), Van Craenenbroeck, J. (Creator), Chapon, C. (Creator), Grand, R. L. (Creator), Raes, G. (Creator), Van Ginderachter, J. (Creator) & Devoogdt, N. (Creator), Zenodo, 19 mrt 2025
Dataset
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Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury
Van Campenhout, R. (Creator), De Groof, T. (Creator), Kadam, P. (Researcher), Muyldermans, S. (Supervisor), Devoogdt, N. (Supervisor) & Vinken, M. (Supervisor), Journal of Nanobiotechnology, 2023
DOI: 10.1186/s12951-023-02137-1
Dataset
Prijzen
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AIMMS annual meeting PhD oral presentation competition 2018
De Groof, Timo (Recipient), apr 2018
Prijs: Prize (including medals and awards)
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AIMMS annual meeting poster prize award 2016
De Groof, Timo (Recipient), apr 2016
Prijs: Prize (including medals and awards)
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FIGON DMD Medicinal Chemistry PhD poster prize award 2017
De Groof, Timo (Recipient), okt 2017
Prijs: Prize (including medals and awards)
Activiteiten
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Imaging of Tumor-associated Macrophage Dynamics During Immunotherapy Using a CD163-specific Nanobody-based Immunotracer
Timo De Groof (Speaker)
11 mrt 2025Activiteit: Talk or presentation at a conference
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Development and testing of nanobody-based drug candidates for the treatment of liver inflammation
Daan Peeters (Presenter), Timo De Groof (Contributor), Prashant Kadam (Contributor), Brenda R. Kwak (Contributor), Serge Muyldermans (Contributor), Nick Devoogdt (Contributor), Mathieu Vinken (Contributor) & Raf Van Campenhout (Contributor)
15 mei 2025Activiteit: Talk or presentation at a conference
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Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury
Raf Van Campenhout (Speaker), Timo De Groof (Contributor), Prashant Kadam (Contributor), Brenda R. Kwak (Contributor), Serge Muyldermans (Contributor), Nick Devoogdt (Contributor) & Mathieu Vinken (Contributor)
24 jul 2024 → 31 jul 2024Activiteit: Talk or presentation at a conference
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Evaluation of nanobody-scaffolds as nuclear imaging tracers for noninvasive detection of the next generation immune checkpoint TIGIT
Katty Zeven (Speaker), Herlinde Dierick (Contributor), Matthijs Sevenois (Contributor), Henri Vincent Baudhuin (Contributor), Jessica Bridoux (Contributor), Laurent Navarro (Contributor), Timo De Groof (Contributor), Geert Raes (Contributor), Karine Breckpot (Contributor) & Nick Devoogdt (Contributor)
26 aug 2024 → 30 aug 2024Activiteit: Talk or presentation at a conference
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Nanobodies as non-invasive preclinical and clinical diagnostic imaging tools
Timo De Groof (Speaker)
15 nov 2024Activiteit: Talk or presentation at a conference
Knipsels
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VUB team develops breakthrough nanobody technology against liver inflammation
Raf Van Campenhout, Mathieu Vinken, Nick Devoogdt & Timo De Groof
8/12/23
1 item van Media-aandacht
Pers / media: !!Other
Scriptie
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Characterization of CD69-targeting nanobodies as immunotracers
Auteur: Ndini, T., Van Ginderachter, J., Devoogdt, N., Vincke, C. & De Groof, T., sep 2021Scriptie/Masterproef: Master's Thesis
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Development of a CD8-targeting immunotracer for non-invasive imaging of cytotoxic T-cells
Auteur: Aziz Ouazzani, W., Van Ginderachter, J., Devoogdt, N., Vincke, C. & De Groof, T., 2 sep 2021Begeleider: Lauwers, Y. (Promotor)
Scriptie/Masterproef: Master's Thesis
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Non-invasive imaging of CD8+ T cells using radiolabeled CD8-targeting nanobodies
Auteur: De Pauw, T., Devoogdt, N., Van Ginderachter, J. & De Groof, T., 2 jul 2022Scriptie/Masterproef: Master's Thesis