Projecten per jaar
Persoonlijk profiel
Expertise
Timo De Groof studied Biochemistry and Biotechnology at the University of Ghent where he graduated in 2015. During his master studies, he specialized both in Biomedical Biotechnology and Structural Biology and Biochemistry. During his last year of studies, De Groof performed research in the biopharmaceutical company Argenx and gained experience on the identification and characterization of llama-derived antibodies in inflammatory diseases and oncology.
From 2015 to 2019, De Groof worked as a PhD student in the Medicinal Chemistry group at VU University Amsterdam under the supervision of prof. dr. Martine Smit where he focused on development and characterization of nanobodies targeting viral G protein-coupled receptors while also focusing on different applications of these nanobodies as therapeutics and research tools.
Starting from September 2019, De Groof started working as a postdoctoral researcher in the In Vivo Cellular and Molecular Imaging (ICMI) group under the supervision of prof. dr. Nick Devoogdt. His research focuses on the non-invasive clinical imaging of immune cells using nanobodies (as part of the Horizon 2020 Innovative Medicine Initiative “Immune Image project”).
Starting from November 2022, De Groof has obtained a personal FWO junior postdoctoral grant to further investigate the role of viral G protein-coupled receptors in viral immune evasion in oncology using modulatory nanobodies.
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Timo De Groof actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Netwerk
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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FWOTM1119: Onderzoek en inhibitie van Epstein-Barr Virus immuun ontwijking via BILF1-modulerende nanobodies
1/11/22 → 31/10/25
Project: Fundamenteel
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IOFPOC42: IOF proof of Concept: Modificatie van T-cellen in situ om de functionaliteit te wijzigen.
Devoogdt, N., Breckpot, K., Meeus, F., De Groof, T. & De Vlaeminck, Y.
1/01/21 → 31/12/22
Project: Toegepast
Onderzoeksoutput
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Emerging applications of nanobodies in cancer therapy
Awad, R. M., Meeus, F., Ceuppens, H., Ertveldt, T., Hanssens, H., Lecocq, Q., Mateusiak, L., Zeven, K., Valenta, H., De Groof, T. W. M., De Vlaeminck, Y., Krasniqi, A., De Veirman, K., Goyvaerts, C., D'Huyvetter, M., Hernot, S., Devoogdt, N. & Breckpot, K., 2022, In: International review of cell and molecular biology. 369, blz. 143-199 57 blz.Onderzoeksoutput: Article › peer review
Bestand1 Citaat (Scopus)48 Downloads (Pure) -
Imaging and therapeutic targeting of the tumor immune microenvironment with biologics
Arnouk, S., De Groof, T. & Van Ginderachter, J., mei 2022, In: Advanced Drug Delivery Reviews. 184, 114239.Onderzoeksoutput: Scientific review › peer review
Open Access -
In Vitro Assessment of Binding Affinity, Selectivity, Uptake, Intracellular Degradation, and Toxicity of Nanobody-Photosensitizer Conjugates
De Groof, T., Beltrán Hernández, I., Heukers, R. & Oliveira, S., 4 mei 2022, Photodynamic Therapy. Springer, blz. 505-520 16 blz. (Methods in Molecular Biology; vol. 2451).Onderzoeksoutput: Chapter › Research › peer review
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Mechanisms underlying connexin hemichannel activation in disease
Van Campenhout, R., Coelho Gomes, A. R., De Groof, T., Muyldermans, S., Devoogdt, N. & Vinken, M., 1 apr 2021, In: International Journal of Molecular Sciences. 22, 7, blz. 1-13 13 blz., 3503.Onderzoeksoutput: Article › peer review
Open AccessBestand14 Citaten (Scopus)225 Downloads (Pure) -
Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies
De Groof, T., Bergkamp, N. D., Heukers, R., Giap, T., Bebelman, M. P., Goeij-de Haas, R., Piersma, S., Jimenez, C., Garcia, K. C., Ploegh, H., Siderius, M. & Smit, M. J., 16 jul 2021, In: Nature Communications. 12, 1, blz. 4357 17 blz., 4357.Onderzoeksoutput: Article › peer review
Open AccessBestand8 Citaten (Scopus)104 Downloads (Pure)
Prijzen
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AIMMS annual meeting PhD oral presentation competition 2018
De Groof, Timo (Recipient), apr 2018
Prijs: Prize (including medals and awards)
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AIMMS annual meeting poster prize award 2016
De Groof, Timo (Recipient), apr 2016
Prijs: Prize (including medals and awards)
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FIGON DMD Medicinal Chemistry PhD poster prize award 2017
De Groof, Timo (Recipient), okt 2017
Prijs: Prize (including medals and awards)
Activiteiten
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2021-80
Nick Devoogdt (Supervisor), Timo De Groof (Contributor), Fien Meeus (Contributor), Karine Breckpot (Contributor) & Yannick De Vlaeminck (Contributor)
2021 → …Activiteit: Other
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Biomolecules (Tijdschrift)
Nick Devoogdt (Editor), Serge Muyldermans (Editor), Timo De Groof (Editor) & Sophie Hernot (Editor)
2021 → …Activiteit: Editorial activity
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Nanobody discovery and biotechnological applications
Timo De Groof (Speaker)
20 apr 2021Activiteit: Talk or presentation at a workshop/seminar
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Nanobodies in Drug Discovery Research
Timo De Groof (Speaker)
3 dec 2021Activiteit: Talk at an external academic organisation
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Nanobodies targeting and modulating the oncogenic viral GPCR US28
Timo De Groof (Speaker)
12 apr 2018Activiteit: Talk or presentation at a conference
Scriptie
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Characterization of CD69-targeting nanobodies as immunotracers
Auteur: Ndini, T., Van Ginderachter, J., Devoogdt, N., Vincke, C. & De Groof, T., sep 2021Scriptie/Masterproef: Master's Thesis
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Development of a CD8-targeting immunotracer for non-invasive imaging of cytotoxic T-cells
Auteur: Aziz Ouazzani, W., Van Ginderachter, J., Devoogdt, N., Vincke, C. & De Groof, T., 2 sep 2021Begeleider: Lauwers, Y. (Promotor)
Scriptie/Masterproef: Master's Thesis
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US28 nanobodies: A ‘VUN' example of targeting viral GPCRs
Auteur: Devoogdt, N., De Groof, T. & Smit, M. J., 8 mei 2020Scriptie/Masterproef: Doctoral Thesis