Onderzoeksoutput per jaar
Onderzoeksoutput per jaar
Persoonlijk profiel
Expertise
Liver fibrosis, cirrhosis and cancer are an increasing problem worldwide with a substantial global burden of disease. Liver fibrosis consists of a pathological deposition of extra-cellular matrix, which is produced by hepatic stellate cells who activate upon liver damage. When the liver injury is stopped, reversal of fibrosis is accompanied by inactivation of the HSCs. However, there is only limited knowledge on the mechanisms behind HSC inactivation. My PhD project focusses on sinusoidal cell communication to discover novel mechanisms of fibrosis development and reversal both in mice and human. Novel information gained from my PhD will fuel new treatment strategies for liver fibrosis.
Opleiding / Academische kwalificatie
Medicine, Master, Vrije Universiteit Brussel
20 sep 2013 → 29 jun 2017
Medicine, United States Medical Licensing Examination ® (USMLE®) Step 1
28 sep 2016
Medicine, Bachelor, Vrije Universiteit Brussel
20 sep 2010 → 5 jul 2013
Externe posities
Arts-Specialist in Opleiding, Universitair Ziekenhuis Brussel
1 aug 2017 → 30 sep 2017Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Vincent De Smet actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Netwerk
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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AP-1 and YAP1-TEAD drive independent transcriptional programs to activate hepatic stellate cells
De Smet, V., 2022, (Unpublished).Onderzoeksoutput: Poster
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Improved Precision-Cut Liver Slice Cultures for Testing Drug-Induced Liver Fibrosis
Dewyse, L., De Smet, V., Verhulst, S., Eysackers, N., Kunda, R., Messaoudi, N., Reynaert, H. & van Grunsven, L. A., 30 mrt 2022, In : Frontiers in Medicine. 9, 11 blz., 862185.Onderzoeksoutput: Article
Open Access -
A profibrotic role for the orphan G-protein coupled receptor 176 during hepatic stellate cell activation
De Smet, V., Verhulst, S., Dewyse, L., Dastjerd, M. K., Reynaert, H., Halder, G., Mannaerts, I. & van Grunsven, L. A., jul 2021, In : Journal of Hepatology. 75, S2, blz. S527-S527Onderzoeksoutput: Meeting abstract (Journal)
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Gene Signatures Detect Damaged Liver Sinusoidal Endothelial Cells in Chronic Liver Diseases
Verhulst, S., van Os, E. A., De Smet, V., Eysackers, N., Mannaerts, I. & van Grunsven, L. A., 20 okt 2021, In : Frontiers in Medicine. 8, 14 blz., 750044.Onderzoeksoutput: Article
Open AccessBestand1 Citaat (Scopus)10 Downloads (Pure) -
Initiation of hepatic stellate cell activation extends into chronic liver disease
De Smet, V., Eysackers, N., Merens, V., Kazemzadeh Dastjerd, M., Halder, G., Verhulst, S., Mannaerts, I. & van Grunsven, L. A., 27 nov 2021, In : Cell & Death Disease. 12, 12, 10 blz., 1110.Onderzoeksoutput: Article
Open AccessBestand2 Citaten (Scopus)50 Downloads (Pure)
Prijzen
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BASL best basic abstract award
Vincent De Smet (Recipient), 4 mrt 2021
Prijs: Prize (including medals and awards)
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PhD Fellowship (Research Foundation - Flanders)
Vincent De Smet (Recipient), 28 jun 2017
Prijs: Fellowship awarded competitively
Activiteiten
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XXXIVth Belgian Week of Gastroenterology
Vincent De Smet (Organiser)11 feb 2022Activiteit: Participation in conference
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AP-1 and YAP1-TEAD drive independent transcriptional programs to activate hepatic stellate cells
Vincent De Smet (Speaker)9 feb 2022 → 11 feb 2022Activiteit: Talk or presentation at a conference
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A profibrotic role for the orphan G-protein coupled receptor 176 during hepatic stellate cell activation
Vincent De Smet (Speaker)4 mrt 2021Activiteit: Talk or presentation at a conference
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XXXIIIth Belgian Week of Gastroenterology
Vincent De Smet (Participant)4 mrt 2021 → 5 mrt 2021Activiteit: Participation in conference
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BASL Wintermeeting & Livercourse 2021
Vincent De Smet (Participant)3 dec 2021 → 4 dec 2021Activiteit: Participation in conference
Knipsels
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VUB-onderzoekers waarschuwen voor gevaar van foute conclusies in Covid-19 levercelonderzoek
20/07/20
1 Mediabijdrage
Pers / media: !!Research
Scriptie
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Hepatic sinusoidal cell cross-talk is key to liver fibrosis resolution
Auteur: De Smet, V., Mannaerts, I. & Reynaert, H., jun 2017Begeleider: Mannaerts, I. (Co-promotor) & Reynaert, H. (Promotor)
Scriptie/masterproef: Master's Thesis
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Inhibition of CDK7 reduces YAP downstream signaling in hepatic stellate cell activation
Auteur: Gürbüz, E., 15 jun 2021Begeleider: van Grunsven, L. (Promotor) & De Smet, V. (Co-promotor)
Scriptie/masterproef: Master's Thesis
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The role of Gpr176 in hepatic stellate cell activation.
Auteur: Kazemzadeh Dastjerd, M., 2020Begeleider: van Grunsven, L. (Promotor) & De Smet, V. (Co-promotor)
Scriptie/masterproef: Master's Thesis