Projecten per jaar
Persoonlijk profiel
Expertise
My main expertise is situated in the field of structural biology, enzymology, steady state and pre-steady state enzyme kinetics and biophysics. Hereby I focus on the elucidation of the structure and function of enzymes and enzyme complexes involved in human disease and neurological disorders in particular. In recent years my group has mainly been investigating enzymes belonging the family of the large multi-domain GTPase and their biological interaction networks. Topics include, among others, Roco proteins such as LRRK2 involved in Parkinson’s disease, the hypothetical Rab GTPase activating protein TBC1D24 implicated in epilepsy and Obg involved in bacterial persistence. Within all these projects we also strive to translate our novel insights into new strategies to fight human diseases.
Externe posities
Staff Scientist, Flanders Institute for Biotechnology
1 okt 2007 → …
Postdoctoral Researcher, Max Planck Institute of Molecular Physiology
1 okt 2007 → 30 sep 2008
Vingerafdruk
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
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OZR4292: Financiering MZW OZR: Biolaag interferometrie voor de studie van eiwit-eiwit en eiwit-ligand interacties
Versées, W., Loris, R., Rooman, I., Laoui, D., Messens, J., Brunner, J., Stijlemans, B. & Ballet, S.
24/04/24 → 24/04/28
Project: Fundamenteel
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OZR4290: Financiering MZW OZR: Voordelige 100 kV-cryogene elektronenmicroscoop met hoge resolutie voor de bepaling van bijna atomaire eiwitstructuur
Efremov, R., Messens, J., Vorobieva, A. A., Remaut, H. K., Van der Henst, C., Steyaert, J., Versées, W., Loris, R. & Brunner, J.
24/04/24 → 24/04/28
Project: Fundamenteel
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SRP95: Exploitatie van Peptiden als Proteïne Binders, Modulatoren, Inhibitoren en Biomaterialen voor Beeldvorming en Therapie
Ballet, S., Caveliers, V., Hernot, S., Versées, W., Devoogdt, N. & Covens, P.
1/03/24 → 28/02/29
Project: Fundamenteel
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A designed ankyrin-repeat protein that targets Parkinson's disease-associated LRRK2
Dederer, V., Sanz Murillo, M., Karasmanis, E. P., Hatch, K. S., Chatterjee, D., Preuss, F., Abdul Azeez, K. R., Vu Nguyen, L., Galicia, C., Dreier, B., Plückthun, A., Versees, W., Mathea, S., Leschziner, A. E., Reck-Peterson, S. L. & Knapp, S., jul 2024, In: Journal of Biological Chemistry. 300, 7, 14 blz., 107469.Onderzoeksoutput: Article › peer review
Open AccessBestand5 Downloads (Pure) -
Allosteric nanobodies to study the interactions between SOS1 and RAS
Fischer, B., Uchański, T., Sheryazdanova, A., Gonzalez, S., Volkov, A. N., Brosens, E., Zögg, T., Kalichuk, V., Ballet, S., Versées, W., Sablina, A. A., Pardon, E., Wohlkönig, A. & Steyaert, J., 23 jul 2024, In: Nature Communications. 15, 1, 8 blz., 6214.Onderzoeksoutput: Article › peer review
Open AccessBestand -
Identification and characterization of nanobodies acting as molecular chaperones for glucocerebrosidase through a novel allosteric mechanism.
Dal Maso, T., Sinisgalli, C., Ballet, S., Greggio, E., Versées, W. & Plotegher, N., 15 mei 2024.Onderzoeksoutput: Poster
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Nanobodies as chaperones for GCase stabilization and activation
Dal Maso, T. & Versées, W., 2024.Onderzoeksoutput: Poster
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Single time-point analysis of product and substrate inhibition
Verlaine, O., Malempré, R., Versées, W., Matagne, A. & Frère, J-M., 5 okt 2024, In: Scientific reports. 14, 1, 10 blz., 23160.Onderzoeksoutput: Article › peer review
Open AccessBestand1 Downloads (Pure)
Datasets
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Focused map on the Roc-COR domains of the Roco protein from C. tepidum in the GTP state bound to the activating Nanobody NbRoco1
Versées, W. (Creator) & Galicia Diaz Santana, C. (Creator), Protein Data Bank, 1 mei 2024
DOI: https://doi.org/10.2210/pdb8R4D/pdb
Dataset
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LRR domain of Roco protein from C. tepidum bound to the activating Nanobody NbRoco2
Versées, W. (Creator) & Galicia Diaz Santana, C. (Creator), Protein Data Bank, 1 mei 2024
DOI: https://doi.org/10.2210/pdb8R4C/pdb
Dataset
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Roco protein from C. tepidum in the GTP state bound to the activating Nanobodies NbRoco1 and NbRoco2
Versées, W. (Creator) & Galicia Diaz Santana, C. (Creator), Protein Data Bank, 1 mei 2024
DOI: https://doi.org/10.2210/pdb8R4B/pdb
Dataset
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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Kortholt, A. (Creator), Versées, W. (Creator), Singh, R. (Creator) & Soliman, A. (Creator), Zenodo, 9 feb 2022
DOI: 10.5281/zenodo.6028265, https://zenodo.org/record/6028265
Dataset
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YbiB: a Novel Interactor of the GTPase ObgE
Deckers, B. (Creator), Vercauteren, S. (Creator), De Kock, V. (Creator), Martin, C. (Creator), Lazar, T. (Creator), Herpels, P. (Creator), Dewachter, L. (Creator), Verstraeten, N. (Creator), Peeters, E. (Creator), Ballet, S. (Creator), Michiels, J. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Zenodo, 8 nov 2022
Dataset
Prijzen
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Wetenschappelijk Fonds Willy Gepts 2022-2026: SPARTAN: SLIT-ROBO Library screening for PAncReaTic cANcer
Rooman, Ilse (Recipient), Ballet, Steven (Recipient) & Versées, Wim (Recipient), 2022
Prijs: Prize (including medals and awards)
Activiteiten
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Deciphering the interactome of ObgE: a widely conserved GTPase acting at the crossroads of cell survival and cell death (Evenement)
Wim Versées (Supervisor) & Babette Deckers (Presenter)
1 mrt 2024Activiteit: Member of PhD committee
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Member of PhD committee of Wout Magits " Cracking the Ubiquitin Code of the RAS GTPases" (Evenement)
Wim Versées (Member), Anna Sablina (Supervisor) & Wout Magits (Presenter)
10 jun 2024Activiteit: Member of PhD committee
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Dendritic cell-based cancer immunotherapy: increasing intratumoral dendritic cell abundance and potential for vaccination (Evenement)
Wim Versées (Chair) & Emile Clappaert (Presenter)
15 dec 2023Activiteit: Member of PhD committee
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From fundamental mechanistic insights to novel allosteric modulators of LRRK2 activity … and back
Wim Versées (Speaker)
30 mrt 2023Activiteit: Talk or presentation at a workshop/seminar
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From fundamental mechanistic insights to novel allosteric modulators of LRRK2 activity … and back
Wim Versées (Speaker)
30 mrt 2023Activiteit: Talk at an external academic organisation
Knipsels
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VUB/VIB-onderzoek met lama antilichamen kan weg effenen naar nieuwe Parkinson behandelingen
1/05/22
1 Mediabijdrage
Pers / media: !!Other
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Article in the newspaper "De Morgen" (Zeno) "Parkinson bestrijden met antilichamen van Lama"
5/03/22
1 item van Media-aandacht
Pers / media: !!Other
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Article in May issue of Parkoers, the 4-montly magazine of the Flemish Parkinson Liga
1/05/21
1 Mediabijdrage
Pers / media: !!Other
Scriptie
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Analysis of the structure-function relation of trypanosoma vivax nucleoside hydrolase
Auteur: Versees, W. & Steyaert, J., 1998Begeleider: Steyaert, J. (Promotor)
Scriptie/Masterproef: Master's Thesis
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Biochemical characterization of interactors of the bacterial GTPase ObgE
Auteur: Versées, W. & Ghaemi, M., 2 sep 2021Scriptie/Masterproef: Master's Thesis
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Biochemical characterization of nanobodies modulating the Chlorobium tepidum Roco proteins’ GTPase activity
Auteur: Janssens, A. & Versees, W., 2 jul 2018Scriptie/Masterproef: Master's Thesis
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Biochemical characterization of the interaction between ObgE and a novel interaction partner relevant for bacterial persistence
Auteur: Versées, W. & Van Rillaer, L., 29 jun 2020Scriptie/Masterproef: Master's Thesis
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Characterisation of the bacterial GTPase Obg, a novel target for drug development
Auteur: Berna, S., Versées, W. & Messens, J., 2014Scriptie/Masterproef: Master's Thesis