Projecten per jaar
Persoonlijk profiel
Expertise
My main expertise is situated in the field of structural biology, enzymology, steady state and pre-steady state enzyme kinetics and biophysics. Hereby I focus on the elucidation of the structure and function of enzymes and enzyme complexes involved in human disease and neurological disorders in particular. In recent years my group has mainly been investigating enzymes belonging the family of the large multi-domain GTPase and their biological interaction networks. Topics include, among others, Roco proteins such as LRRK2 involved in Parkinson’s disease, the hypothetical Rab GTPase activating protein TBC1D24 implicated in epilepsy and Obg involved in bacterial persistence. Within all these projects we also strive to translate our novel insights into new strategies to fight human diseases.
Externe posities
Staff Scientist, Flanders Institute for Biotechnology
1 okt 2007 → …Postdoctoral Researcher, Max Planck Institute of Molecular Physiology
1 okt 2007 → 30 sep 2008Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Wim Versées actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Netwerk
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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FWOTM1139: Ontrafeling van de structuur, het mechanisme en de cellulaire functie van het Parkinson-eiwit DNAJC13
1/11/22 → 31/10/26
Project: Fundamenteel
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FWOTM1123: Ontrafeling van de structuur en het mechanisme van het Rab3GAP1- Rab3GAP2 enzymcomplex en de implicaties voor humane ziekten
Versées, W., Verstreken, P. & Berghmans, M.
1/11/22 → 31/10/26
Project: Fundamenteel
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FWOAL1054: Inzicht in de structuur, functie en het mechanisme van Synaptojanin1 in de context van neurologische ziekten
1/01/22 → 31/12/25
Project: Fundamenteel
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FWOEOS16: Ontcijferen van bacteriële persistentie in individuele cellen tot op atomair niveau
1/01/22 → 31/12/25
Project: Fundamenteel
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AIIFUND83: GBA-stabilisatie en -activering door nanobodies en afgeleide peptidemimetica in neuronale modellen
30/06/21 → 31/12/23
Project: Fundamenteel
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Deep mutational scanning of essential bacterial proteins can guide antibiotic development
Dewachter, L., Brooks, A. N., Noon, K., Cialek, C., Clark-ElSayed, A., Schalck, T., Krishnamurthy, N., Versées, W., Vranken, W. & Michiels, J., 16 jan 2023, In: Nature Communications. 14, 1, 16 blz., 241.Onderzoeksoutput: Article › peer review
Open AccessBestand28 Downloads (Pure) -
EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation
Bademosi, A. T., Decet, M., Kuenen, S., Calatayud, C., Swerts, J., Gallego, S. F., Schoovaerts, N., Karamanou, S., Louros, N., Martin, E., Sibarita, J-B., Vints, K., Gounko, N. V., Meunier, F. A., Economou, A., Versées, W., Rousseau, F., Schymkowitz, J., Soukup, S-F. & Verstreken, P., 15 feb 2023, In: Neuron. 111, blz. 1-21 21 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand3 Downloads (Pure) -
YbiB: a novel interactor of the GTPase ObgE
Deckers, B., Vercauteren, S., De Kock, V., Martin, C., Lazar, T., Herpels, P., Dewachter, L., Verstraeten, N., Peeters, E., Ballet, S., Michiels, J., Galicia, C. & Versées, W., 2 mrt 2023, In: Nucleic Acids Research. 16 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand2 Downloads (Pure) -
Downsizing Nanobodies: Towards CDR3 Loop Mimetics Modulating Intracellular Protein-Protein Interactions
Van Holsbeeck, K., Fischer, B., Gonzalez, S., Gadais, C., Versées, W., Martins, J. C., Martin, C., Wohlkönig, A., Steyaert, J. & Ballet, S., 4 nov 2022, Proceedings of the 36th European and the 12th International Peptide Symposium.Onderzoeksoutput: Conference paper
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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Singh, R. K., Soliman, A., Guaitoli, G., Störmer, E., von Zweydorf, F., Dal Maso, T., Oun, A., Van Rillaer, L., Schmidt, S. H., Chatterjee, D., David, J. A., Pardon, E., Schwartz, T. U., Knapp, S., Kennedy, E. J., Steyaert, J., Herberg, F. W., Kortholt, A., Gloeckner, C. J. & Versées, W., 1 mrt 2022, In: Proceedings of the National Academy of Sciences of the United States of America. 119, 9, blz. 1-12 12 blz., e2112712119.Onderzoeksoutput: Article › peer review
Open AccessBestand6 Citaten (Scopus)134 Downloads (Pure)
Datasets
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YbiB: a Novel Interactor of the GTPase ObgE
Deckers, B. (Creator), Peeters, E. (Creator), Ballet, S. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Zenodo, 8 nov 2022
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMS).
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 jun 2018
DOI: 10.2210/pdb6EMS/pdb
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMT).
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 jun 2018
DOI: 10.2210/pdb6EMT/pdb
Dataset
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Crystal Structure of dual specific Trm10 construct from Thermococcus kodakaraensis (PDB 6EMU)
Versées, W. (Project Leader) & Singh, R. K. (Creator), Protein Data Bank in Europe, 13 jun 2018
DOI: 10.2210/pdb6EMU/pdb
Dataset
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Crystal structure of the 5-phosphatase domain of Synaptojanin1 bound to its substrate diC8-PI(3,4,5)P3 in complex with a nanobody.
Paesmans, J. (Creator), Versées, W. (Supervisor), Galicia Diaz Santana, C. (Creator) & Martin, E. (Creator), Protein Data Bank in Europe, 30 dec 2020
DOI: 10.2210/pdb7A17/pdb
Dataset
Activiteiten
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Llama-derived nanobodies in the fight against Parkinson’s disease-associated neurodegeneration
Wim Versées (Speaker)
13 feb 2023Activiteit: Talk or presentation at a workshop/seminar
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Optimized AAV systems for the treatment of CNS-related diseases (Evenement)
Wim Versées (Jury), Marika Marino (Presenter), Patrick Callaerts (Supervisor), Matthew Holt (Supervisor) & Inge Depoortere (Chair)
1 sep 2022Activiteit: Member of PhD committee
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Trends in Biochemical Sciences (Tijdschrift)
Wim Versées (Peer reviewer)
4 jun 2022Activiteit: Editorial activity
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From fundamental mechanistic insights toward therapeutic targeting of LRRK2 in Parkinson’s disease
Wim Versées (Speaker)
31 mrt 2022Activiteit: Talk or presentation at a conference
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Nature Webcasts series: Llama-derived nanobodies in the fight against Parkinson’s disease
Wim Versées (Invited speaker)
31 mei 2022Activiteit: Talk or presentation at a workshop/seminar
Knipsels
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VUB/VIB-onderzoek met lama antilichamen kan weg effenen naar nieuwe Parkinson behandelingen
1/05/22
1 Mediabijdrage
Pers / media: !!Other
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Article in the newspaper "De Morgen" (Zeno) "Parkinson bestrijden met antilichamen van Lama"
5/03/22
1 item van Media-aandacht
Pers / media: !!Other
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Article in May issue of Parkoers, the 4-montly magazine of the Flemish Parkinson Liga
1/05/21
1 Mediabijdrage
Pers / media: !!Other
Scriptie
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Analysis of the structure-function relation of trypanosoma vivax nucleoside hydrolase
Auteur: Versees, W. & Steyaert, J., 1998Begeleider: Steyaert, J. (Promotor)
Scriptie/Masterproef: Master's Thesis
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Bifidogenic and butyrogenic effects of arabinoxylan-oligosaccharides, a kinetic and molecular approach
Auteur: Rivière, A., De Vuyst, L., Desmet, G., Van Driessche, E., Remaut, H. K., Versees, W., Eeltink, S., Vande Wiele, T. & Van Sinderen, D., 25 sep 2015Scriptie/Masterproef: Doctoral Thesis
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Biochemical characterization of interactors of the bacterial GTPase ObgE
Auteur: Versées, W. & Ghaemi, M., 2 sep 2021Scriptie/Masterproef: Master's Thesis
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Biochemical characterization of nanobodies modulating the Chlorobium tepidum Roco proteins’ GTPase activity
Auteur: Janssens, A. & Versees, W., 2 jul 2018Scriptie/Masterproef: Master's Thesis
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Biochemical characterization of the interaction between ObgE and a novel interaction partner relevant for bacterial persistence
Auteur: Versées, W. & Van Rillaer, L., 29 jun 2020Scriptie/Masterproef: Master's Thesis