Projecten per jaar
Persoonlijk profiel
Expertise
My main expertise is situated in the field of structural biology, enzymology, steady state and pre-steady state enzyme kinetics and biophysics. Hereby I focus on the elucidation of the structure and function of enzymes and enzyme complexes involved in human disease and neurological disorders in particular. In recent years my group has mainly been investigating enzymes belonging the family of the large multi-domain GTPase and their biological interaction networks. Topics include, among others, Roco proteins such as LRRK2 involved in Parkinson’s disease, the hypothetical Rab GTPase activating protein TBC1D24 implicated in epilepsy and Obg involved in bacterial persistence. Within all these projects we also strive to translate our novel insights into new strategies to fight human diseases.
Externe posities
Staff Scientist, Flanders Institute for Biotechnology
1 okt. 2007 → …
Postdoctoral Researcher, Max Planck Institute of Molecular Physiology
1 okt. 2007 → 30 sep. 2008
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Wim Versées actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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ANI443: Ontdekking van farmaceutische chaperones met behulp van nanolichamen om de functie van het met Parkinson geassocieerde eiwit glucocerebrosidase te herstellen
Versées, W. (Administrative Promotor)
16/02/26 → 16/02/29
Project: Fundamenteel
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FWOAL1206: Bacteriën in slaap wiegen: GTPase ObgE als nucleator van eiwitaggregatie in bacteriële dormantie
Versées, W. (Administrative Promotor)
1/01/26 → 31/12/29
Project: Fundamenteel
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ANI425: Nanobodies als allosterische modulatoren van het LRRK2-eiwit in de strijd tegen de ziekte van Parkinson
Versées, W. (Administrative Promotor)
22/05/25 → 15/12/27
Project: Fundamenteel
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FWOSB191: Verkennen van nieuwe manieren om LRRK2 te targeten in de ziekte van Parkinson: diepgaande karakterisering en optimalisatie van allosterische Nanobodies
Van Mele, F. (Mandataris) & Versées, W. (Administrative Promotor)
1/11/24 → 31/10/28
Project: Fundamenteel
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HERC68: Voordelige 100 kV-cryogene elektronenmicroscoop met hoge resolutie voor de bepaling van bijna atomaire eiwitstructuur
Efremov, R. (Administrative Promotor), Messens, J. (CoI (Co-Promotor)), Vorobieva, A. A. (CoI (Co-Promotor)), Remaut, H. K. (CoI (Co-Promotor)), Van der Henst, C. (CoI (Co-Promotor)), Steyaert, J. (CoI (Co-Promotor)), Versées, W. (CoI (Co-Promotor)), Loris, R. (CoI (Co-Promotor)) & Brunner, J. (CoI (Co-Promotor))
1/05/24 → 30/04/28
Project: Fundamenteel
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The major diagnostic VSG LiTat 1.3 of the human parasite <i>Trypanosoma brucei gambiense</i> is a trimer in solution
Danel, N., Geens, R., Mares-Mejia, I., Versees, W., van den Abbeele, J. & Sterckx, Y. G. J., 10 aug. 2026, In: PLoS Pathogens. 22, 8, 15 blz., e1014530.Onderzoeksoutput: Article › peer review
Open AccessBestand3 Downloads (Pure) -
Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody
Pinto Torres, J. E., Claes, M., Hendrickx, R., Yuan, M., Smiejkowska, N., Van Wielendaele, P., Hacisuleyman, A., De Winter, H., Muyldermans, S., Michels, P. A. M., Walkinshaw, M. D., Versées, W., Caljon, G., Magez, S. & Sterckx, Y.G.-J., 31 mrt. 2025, In: eLife. 13, 27 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand45 Downloads (Pure) -
Characterization of nanobodies as tools for the elucidation of the structure and function of the Rab3GAP1 protein
Denayer, L., Berghmans, M. & Versées, W., 2025, (Unpublished). 1 blz.Onderzoeksoutput: Poster
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Cryo-EM structures of the MnmE-MnmG complex reveal large conformational changes and provide new insights into the mechanism of tRNA modification
Maes, L., Mares-Mejía, I., Martin, E., Bickel, D., Claeys, S., Vranken, W., Fislage, M., Galicia, C. & Versées, W., 9 sep. 2025, In: Nucleic Acids Research. 53, 16, 17 blz., gkaf824.Onderzoeksoutput: Article › peer review
Open AccessBestand1 Citaat (Scopus)8 Downloads (Pure) -
Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2
Dobert, J. P., Schäfer, J.-H., Dal Maso, T., Ravindran, P., Huard, D. J. E., Socher, E., Schildmeyer, L. A., Lieberman, R. L., Versées, W., Moeller, A., Zunke, F. & Arnold, P., 30 mrt. 2025, In: Nature communications. 16, 1, blz. 1-14 14 blz., 3074.Onderzoeksoutput: Article › peer review
Open AccessBestand5 Citaten (Scopus)97 Downloads (Pure)
Datasets
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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Kortholt, A. (Creator), Versées, W. (Creator), Singh, R. (Creator) & Soliman, A. (Creator), Zenodo, 9 feb. 2022
DOI: 10.5281/zenodo.6028265, https://zenodo.org/record/6028265
Dataset
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YbiB: a Novel Interactor of the GTPase ObgE
Deckers, B. (Creator), Vercauteren, S. (Creator), De Kock, V. (Creator), Martin, C. (Creator), Lazar, T. (Creator), Herpels, P. (Creator), Dewachter, L. (Creator), Verstraeten, N. (Creator), Peeters, E. (Creator), Ballet, S. (Creator), Michiels, J. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Zenodo, 8 nov. 2022
Dataset
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Crystal structure of the E. coli TrpD2 protein in complex with a C-terminal peptide from ObgE
Deckers, B. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Protein Data Bank, 22 feb. 2023
Dataset
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Crystal structure of the E. coli TrpD2 protein YbiB at 1.3 A resolution
Deckers, B. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Protein Data Bank, 22 feb. 2023
Dataset
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Roco protein from C. tepidum in the GTP state bound to the activating Nanobodies NbRoco1 and NbRoco2
Versées, W. (Creator) & Galicia Diaz Santana, C. (Creator), Protein Data Bank, 1 mei 2024
DOI: 10.2210/pdb8R4B/pdb
Dataset
Prijzen
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Wetenschappelijk Fonds Willy Gepts 2022-2026: SPARTAN: SLIT-ROBO Library screening for PAncReaTic cANcer
Rooman, I. (Recipient), Ballet, S. (Recipient) & Versées, W. (Recipient), 2022
Prijs: Prize (including medals and awards)
Activiteiten
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Synaptojanin1: From Structural Insights to Therapeutic Targeting
Martin, E. (Speaker) & Versées, W. (Contributor)
14 nov. 2025Activiteit: Talk or presentation at a conference
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Member of PhD committee of Silke Vercauteren “The genetic landscape underlying persistence in Escherichia coli” (Evenement)
Versées, W. (Jury)
22 jan. 2025Activiteit: Member of PhD committee
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PhD defense Kim Mignon - Molecular basis of DNA recognition by Arabidopsis thaliana SOG1: the master regulator for DNA damage control in plants (Evenement)
Mignon, K. (Speaker), Loris, R. (Supervisor), Messens, J. (Chair), Ruytinx, J. (Jury), Versées, W. (Jury), Ezerina, D. (Jury), Hadzi, S. (Jury) & Hendrix, J. (Jury)
3 dec. 2025Activiteit: Member of PhD committee
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National Science Centre (Externe Organisatie)
Versées, W. (Reviewer)
12 sep. 2025Activiteit: Membership of peer-review panel or committee
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PhD Defence Ella Martin (Evenement)
Martin, E. (Presenter), Versées, W. (Supervisor), Laoui, D. (Chair), Hennecke, U. (Jury), Vorobieva, A. A. (Jury), Greggio, E. (Jury) & Ismail, S. (Jury)
29 sep. 2025Activiteit: Member of PhD committee
Knipsels
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VUB/VIB-onderzoek met lama antilichamen kan weg effenen naar nieuwe Parkinson behandelingen
1/05/22
1 Mediabijdrage
Pers / media: !!Other
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Article in the newspaper "De Morgen" (Zeno) "Parkinson bestrijden met antilichamen van Lama"
5/03/22
1 item van Media-aandacht
Pers / media: !!Other
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Article in May issue of Parkoers, the 4-montly magazine of the Flemish Parkinson Liga
1/05/21
1 Mediabijdrage
Pers / media: !!Other
Scriptie
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Analysis of the structure-function relation of trypanosoma vivax nucleoside hydrolase
Versees, W. ((PhD) Student), Steyaert, J. (Promotor), 1998Scriptie/Masterproef: Master's Thesis