Projecten per jaar
Persoonlijk profiel
Expertise
My main expertise is situated in the field of structural biology, enzymology, steady state and pre-steady state enzyme kinetics and biophysics. Hereby I focus on the elucidation of the structure and function of enzymes and enzyme complexes involved in human disease and neurological disorders in particular. In recent years my group has mainly been investigating enzymes belonging the family of the large multi-domain GTPase and their biological interaction networks. Topics include, among others, Roco proteins such as LRRK2 involved in Parkinson’s disease, the hypothetical Rab GTPase activating protein TBC1D24 implicated in epilepsy and Obg involved in bacterial persistence. Within all these projects we also strive to translate our novel insights into new strategies to fight human diseases.
Externe posities
Staff Scientist, Flanders Institute for Biotechnology
1 okt. 2007 → …
Postdoctoral Researcher, Max Planck Institute of Molecular Physiology
1 okt. 2007 → 30 sep. 2008
Vingerafdruk
Verdiep u in de onderzoeksgebieden waarop Wim Versées actief is. Deze onderwerplabels komen uit het werk van deze persoon. Samen vormen ze een unieke vingerafdruk.
- 1 Soortgelijke profielen
Samenwerkingen en hoofdonderzoeksgebieden uit de afgelopen vijf jaar
Recente externe samenwerking op landen-/regioniveau. Duik in de details door op de stippen te klikken of
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ANI425: Nanobodies als allosterische modulatoren van het LRRK2-eiwit in de strijd tegen de ziekte van Parkinson
22/05/25 → 15/12/27
Project: Fundamenteel
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OZR4290: Financiering MZW OZR: Voordelige 100 kV-cryogene elektronenmicroscoop met hoge resolutie voor de bepaling van bijna atomaire eiwitstructuur
Efremov, R., Messens, J., Vorobieva, A. A., Remaut, H. K., Van der Henst, C., Steyaert, J., Versées, W., Loris, R. & Brunner, J.
24/04/24 → 24/04/28
Project: Fundamenteel
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OZR4292: Financiering MZW OZR: Biolaag interferometrie voor de studie van eiwit-eiwit en eiwit-ligand interacties
Versées, W., Loris, R., Rooman, I., Laoui, D., Messens, J., Brunner, J., Stijlemans, B. & Ballet, S.
24/04/24 → 24/04/28
Project: Fundamenteel
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Allosteric inhibition of trypanosomatid pyruvate kinases by a camelid single-domain antibody
Pinto Torres, J. E., Claes, M., Hendrickx, R., Yuan, M., Smiejkowska, N., Van Wielendaele, P., Hacisuleyman, A., De Winter, H., Muyldermans, S., Michels, P. A. M., Walkinshaw, M. D., Versées, W., Caljon, G., Magez, S. & Sterckx, Y. G-J., 31 mrt. 2025, In: eLife. 13, 27 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand37 Downloads (Pure) -
Cryo-EM structures of the MnmE-MnmG complex reveal large conformational changes and provide new insights into the mechanism of tRNA modification
Maes, L., Mares-Mejía, I., Martin, E., Bickel, D., Claeys, S., Vranken, W., Fislage, M., Galicia, C. & Versées, W., 9 sep. 2025, In: Nucleic Acids Research. 53, 16, 17 blz., gkaf824.Onderzoeksoutput: Article › peer review
Open Access -
Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2
Dobert, J. P., Schäfer, J-H., Dal Maso, T., Ravindran, P., Huard, D. J. E., Socher, E., Schildmeyer, L. A., Lieberman, R. L., Versées, W., Moeller, A., Zunke, F. & Arnold, P., 30 mrt. 2025, In: Nature communications. 16, 1, blz. 1-14 14 blz., 3074.Onderzoeksoutput: Article › peer review
Open AccessBestand2 Citaten (Scopus)46 Downloads (Pure) -
Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function
Dal Maso, T., Sinisgalli, C., Zilio, G., Franzin, E., Tessari, I., Pardon, E., Steyaert, J., Ballet, S., Greggio, E., Versées, W. & Plotegher, N., 27 mei 2025, In: Nature communications. 16, 1, 19 blz., 4890.Onderzoeksoutput: Article › peer review
Open AccessBestand12 Downloads (Pure) -
Discovery and Characterization of a Selective Inhibitor of Synaptojanin1 5-Phosphatase Activity
Martin, E., Giakoumakis, D., Paesmans, J., Bisi, N., Drozdzecki, A., Audenaert, D., Haustraete, J., Verstreken, P., Galicia, C., Ballet, S. & Versées, W., 12 sep. 2025, In: ACS Pharmacology and Translational Science. 8, 9, blz. 2996-3006 11 blz.Onderzoeksoutput: Article › peer review
Datasets
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Nanobodies as allosteric modulators of Parkinson's disease-associated LRRK2
Kortholt, A. (Creator), Versées, W. (Creator), Singh, R. (Creator) & Soliman, A. (Creator), Zenodo, 9 feb. 2022
DOI: 10.5281/zenodo.6028265, https://zenodo.org/record/6028265
Dataset
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YbiB: a Novel Interactor of the GTPase ObgE
Deckers, B. (Creator), Vercauteren, S. (Creator), De Kock, V. (Creator), Martin, C. (Creator), Lazar, T. (Creator), Herpels, P. (Creator), Dewachter, L. (Creator), Verstraeten, N. (Creator), Peeters, E. (Creator), Ballet, S. (Creator), Michiels, J. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Zenodo, 8 nov. 2022
Dataset
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Crystal structure of the E. coli TrpD2 protein YbiB at 1.3 A resolution
Deckers, B. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Protein Data Bank, 22 feb. 2023
Dataset
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Crystal structure of the E. coli TrpD2 protein in complex with a C-terminal peptide from ObgE
Deckers, B. (Creator), Galicia Diaz Santana, C. (Creator) & Versées, W. (Creator), Protein Data Bank, 22 feb. 2023
Dataset
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LRR domain of Roco protein from C. tepidum bound to the activating Nanobody NbRoco2
Versées, W. (Creator) & Galicia Diaz Santana, C. (Creator), Protein Data Bank, 1 mei 2024
DOI: 10.2210/pdb8R4C/pdb
Dataset
Prijzen
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Wetenschappelijk Fonds Willy Gepts 2022-2026: SPARTAN: SLIT-ROBO Library screening for PAncReaTic cANcer
Rooman, Ilse (Recipient), Ballet, Steven (Recipient) & Versées, Wim (Recipient), 2022
Prijs: Prize (including medals and awards)
Activiteiten
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Member of PhD committee of Silke Vercauteren “The genetic landscape underlying persistence in Escherichia coli” (Evenement)
Wim Versées (Jury)
22 jan. 2025Activiteit: Member of PhD committee
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National Science Centre (Externe Organisatie)
Wim Versées (Reviewer)
12 sep. 2025Activiteit: Membership of peer-review panel or committee
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Identification and characterization of nanobodies acting as molecular chaperones for glucocerebrosidase through a novel allosteric mechanism.
Wim Versées (Contributor) & Thomas Dal Maso (Speaker)
13 mei 2024 → 17 mei 2024Activiteit: Talk or presentation at a conference
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Member of PhD committee of Wout Magits " Cracking the Ubiquitin Code of the RAS GTPases" (Evenement)
Wim Versées (Member), Anna Sablina (Supervisor) & Wout Magits (Presenter)
10 jun. 2024Activiteit: Member of PhD committee
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Deciphering the interactome of ObgE: a widely conserved GTPase acting at the crossroads of cell survival and cell death (Evenement)
Wim Versées (Supervisor), Babette Deckers (Presenter) & Christian Galicia Diaz Santana (Advisor)
1 mrt. 2024Activiteit: Member of PhD committee
Knipsels
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VUB/VIB-onderzoek met lama antilichamen kan weg effenen naar nieuwe Parkinson behandelingen
1/05/22
1 Mediabijdrage
Pers / media: !!Other
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Article in the newspaper "De Morgen" (Zeno) "Parkinson bestrijden met antilichamen van Lama"
5/03/22
1 item van Media-aandacht
Pers / media: !!Other
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Article in May issue of Parkoers, the 4-montly magazine of the Flemish Parkinson Liga
1/05/21
1 Mediabijdrage
Pers / media: !!Other
Scriptie
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Analysis of the structure-function relation of trypanosoma vivax nucleoside hydrolase
Auteur: Versees, W. & Steyaert, J., 1998Begeleider: Steyaert, J. (Promotor)
Scriptie/Masterproef: Master's Thesis
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Biochemical characterization of interactors of the bacterial GTPase ObgE
Auteur: Versées, W. & Ghaemi, M., 2 sep. 2021Scriptie/Masterproef: Master's Thesis
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Biochemical characterization of nanobodies modulating the Chlorobium tepidum Roco proteins’ GTPase activity
Auteur: Janssens, A. & Versees, W., 2 jul. 2018Scriptie/Masterproef: Master's Thesis
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Biochemical characterization of the interaction between ObgE and a novel interaction partner relevant for bacterial persistence
Auteur: Versées, W. & Van Rillaer, L., 29 jun. 2020Scriptie/Masterproef: Master's Thesis
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Characterisation of the bacterial GTPase Obg, a novel target for drug development
Auteur: Berna, S., Versées, W. & Messens, J., 2014Scriptie/Masterproef: Master's Thesis