Onderzoeksoutput per jaar
Onderzoeksoutput per jaar
- 1 - 50 van 82 resultaten
Zoekresultaten
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2021
A nanobody toolbox targeting dimeric coiled-coil modules for functionalization of designed protein origami structures
Majerle, A., Hadzi, S., Aupič, J., Satler, T., Lapenta, F., Strmšek, Ž., Lah, J., Loris, R. & Jerala, R., 27 apr 2021, In: Proc Natl Acad Sci USA. 118, 17, 9 blz., e2021899118.Onderzoeksoutput: Article › peer review
Open AccessBestand13 Citaten (Scopus)136 Downloads (Pure) -
Arabidopsis Casein Kinase 2 triggers stem cell exhaustion under Al toxicity and phosphate deficiency through activation of the DNA damage response pathway
Wei, P., Demulder, M., David, P., Eekhout, T., Yoshiyama, K. O., Nguyen, L., Vercauteren, I., Eeckhout, D., Galle, M., Larsen, P., De Jaeger, G., Audenaert, D., Desnod, T., Nussaume, L., Loris, R. & De Veylder, L., apr 2021, In: Plant Cell. 33, 4, blz. 1361-1380 20 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand27 Citaten (Scopus)79 Downloads (Pure) -
Prokaryote toxin-antitoxin modules: complex regulation of an unclear function
De Bruyn, P., Girardin, Y. & Loris, R., jun 2021, In: Protein Sci. 30, 6, blz. 1103-1113 11 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand20 Citaten (Scopus)135 Downloads (Pure) -
2020
1H, 13C, and 15N backbone and side chain chemical shift assignment of YdaS, a monomeric member of the HigA family
Prolič Kalinšek, M., De Bruyn, P., Jurenas, D., Van Melderen, L., Loris, R. & Volkov, A. N., apr 2020, In: Biomolecular NMR Assignments. 14, 1, blz. 25-30 6 blz.Onderzoeksoutput: Article › peer review
1 Citaat (Scopus) -
The Escherichia coli RnlA–RnlB toxin–antitoxin complex: production, characterization and crystallization
Garcia-Rodriguez, G., Talavera Perez, A., Konijnenberg, A., Sobott, F., Michiels, J. & Loris, R., jan 2020, In: Acta Crystallographica Section F - Structural Biology Communications. 76, blz. 31-39 9 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand2 Citaten (Scopus)30 Downloads (Pure) -
2017
Molecular mechanism governing ratio-dependent transcription regulation in the ccdAB operon
Vandervelde, A., Drobnak, I., Hadzi, S., Sterckx, Y., Welte, T., De Greve, H., Charlier, D., Efremov, R., Loris, R. & Lah, J., 7 apr 2017, In: Nucleic Acids Res. 45, 6, blz. 2937-2950 14 blz.Onderzoeksoutput: Article › peer review
Open Access22 Citaten (Scopus) -
Nanobodies to Study G Protein-Coupled Receptor Structure and Function
Manglik, A., Kobilka, B. K. & Steyaert, J., 5 jan 2017, In: Annual Review of Pharmacology and Toxicology. 57, blz. 19-37 19 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand184 Citaten (Scopus)1039 Downloads (Pure) -
Production, biophysical characterization and crystallization of Pseudomonas putida GraA and its complexes with GraT and the graTA operator
Talavera Perez, A., Tamman, H., Ainelo, A., Hadzi, S., Garcia-Pino, A., Horak, R., Konijnenberg, A. & Loris, R., aug 2017, In: Acta Crystallographica Section F - Structural Biology Communications. F73, 8, blz. 455-462 8 blz.Onderzoeksoutput: Article › peer review
2 Citaten (Scopus) -
Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a beta-strand sliding mechanism
Hadzi, S., Garcia Pino, A., Haesaerts, S., Jurenas, D., Gerdes, K., Lah, J. & Loris, R., 5 mei 2017, In: Nucleic Acids Res. 45, 8, blz. 4972-4983 12 blz.Onderzoeksoutput: Article › peer review
Open Access41 Citaten (Scopus) -
The thermodynamic basis of the fuzzy interaction of an intrinsically disordered protein
Hadzi, S., Mernik, A., Podlipnik, C., Loris, R. & Lah, J., 13 nov 2017, In: Angew. Chem. Int. Ed.. 56, 46, blz. 14494-14497 4 blz.Onderzoeksoutput: Article › peer review
28 Citaten (Scopus) -
2016
Allosteric coupling from G protein to the agonist-binding pocket in GPCRs
DeVree, B. T., Mahoney, J. P., Vélez-Ruiz, G. A., Rasmussen, S. G. F., Kuszak, A. J., Edwald, E., Fung, J-J., Manglik, A., Masureel, M., Du, Y., Matt, R. A., Pardon, E., Steyaert, J., Kobilka, B. K. & Sunahara, R. K., 7 jul 2016, In: Nature. 535, 7610, blz. 182-186 5 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand221 Citaten (Scopus)441 Downloads (Pure) -
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation
Staus, D. P., Strachan, R. T., Manglik, A., Pani, B., Kahsai, A. W., Kim, T. H., Wingler, L. M., Ahn, S., Chatterjee, A., Masoudi, A., Kruse, A. C., Pardon, E., Steyaert, J., Weis, W. I., Prosser, R. S., Kobilka, B. K., Costa, T. & Lefkowitz, R. J., 21 jul 2016, In: Nature. 535, 7612, blz. 448-452 5 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand256 Citaten (Scopus)472 Downloads (Pure) -
An intrinsically disordered entropic switch determines allostery in Phd-Doc regulation
Garcia Pino, A., De Gieter, S., Talavera Perez, A., De Greve, H., Efremov, R. & Loris, R., 2016, In: Nat. Chem. Biol.. 12, blz. 490-496 5 blz.Onderzoeksoutput: Article › peer review
32 Citaten (Scopus) -
A unique hetero-hexadecameric architecture displayed by the E. coli O157 PaaA2-ParE2 antitoxin-toxin complex
Sterckx, Y. G., Jove, T., Shkumatau, A., Garcia Pino, A., Geerts, L., De Kerpel, M., Lah, J., De Greve, H., Van Melderen, L. & Loris, R., 2016, In: J Mol Biol. 428, blz. 1589-1603 14 blz.Onderzoeksoutput: Article › peer review
30 Citaten (Scopus) -
Crystal structure of a LacY-nanobody complex in a periplasmic-open conformation
Jiang, X., Smirnova, I., Kasho, V., Wu, J., Hirata, K., Ke, M., Pardon, E., Steyaert, J., Yan, N. & Kaback, H. R., 1 nov 2016, In: Proceedings of the National Academy of Sciences of the United States of America. 113, 44, blz. 12420-12425 6 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand34 Citaten (Scopus)127 Downloads (Pure) -
Crystal Structures of the Human Doublecortin C- and N-terminal Domains in Complex with Specific Antibodies
Burger, D., Stihle, M., Sharma, A., Di Lello, P., Benz, J., D'Arcy, B., Debulpaep, M., Fry, D., Huber, W., Kremer, T., Laeremans, T., Matile, H., Ross, A., Rufer, A. C., Schoch, G., Steinmetz, M. O., Steyaert, J., Rudolph, M. G., Thoma, R. & Ruf, A., 29 jul 2016, In: Journal of Biological Chemistry. 291, 31, blz. 16292-16306 14 blz., M116.726547.Onderzoeksoutput: Article › peer review
Open Access10 Citaten (Scopus) -
Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor
Peyrassol, X., Laeremans, T., Gouwy, M., Lahura, V., Debulpaep, M., Van Damme, J., Steyaert, J., Parmentier, M. & Langer, I., 15 mrt 2016, In: Journal of Immunology. 196, 6, blz. 2893-2901 9 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand51 Citaten (Scopus)251 Downloads (Pure) -
DNA immunization combined with scFv phage display identifies antagonistic GCGR specific antibodies and reveals new epitopes on the small extracellular loops
van der Woning, B., De Boeck, G., Blanchetot, C., Bobkov, V., Klarenbeek, A., Saunders, M., Waelbroeck, M., Laeremans, T., Steyaert, J., Hultberg, A. & De Haard, H., 17 aug 2016, In: mAbs. 8, 6, blz. 1126-1135 9 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand23 Citaten (Scopus)205 Downloads (Pure) -
Frizzled 7 and PIP2 binding by syntenin PDZ2 domain controls Frizzled 7 trafficking and signaling.
Egea-Jimenez, A., Gallardo, R., Garcia Pino, A., Ivarsson, Y., Wawrzyniak, A. M., Kashyap, R., Loris, R., Schymkowitz, J., Rousseau, F. & Zimmermann, P., 2016, In: Nature Communications. 7, 13 blz., 12101.Onderzoeksoutput: Article › peer review
Open Access33 Citaten (Scopus) -
Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues
Wijckmans, E., Nys, M., Debaveye, S., Brams, M., Pardon, E., Willegems, K., Bertrand, D., Steyaert, J., Efremov, R. & Ulens, C., 21 mrt 2016, In: PLoS ONE. 11, 3, 23 blz., e0151183.Onderzoeksoutput: Article › peer review
Open AccessBestand3 Citaten (Scopus)246 Downloads (Pure) -
Internalized Receptor for Glucose-dependent Insulinotropic Peptide stimulates adenylyl cyclase on early endosomes
Ismail, S., Gherardi, M-J., Froese, A., Zanoun, M., Gigoux, V., Clerc, P., Gaits-Iacovoni, F., Steyaert, J., Nikolaev, V. O. & Fourmy, D., 15 nov 2016, In: Biochemical Pharmacology. 120, blz. 33-45 12 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand43 Citaten (Scopus)688 Downloads (Pure) -
Modular integrated secretory system engineering in Pichia pastoris to enhance G-protein coupled receptor expression
Claes, K., Vandewalle, K., Laukens, B., Laeremans, T., Vosters, O., Langer, I., Parmentier, M., Steyaert, J. & Callewaert, N., 2016, In: ACS Synthetic Biology. 5, 10, blz. 1070-1075 5 blz.Onderzoeksoutput: Article › peer review
Bestand18 Citaten (Scopus)311 Downloads (Pure) -
Reversible FMN dissociation from Escherichia coli respiratory complex I
Holt, P. J., Efremov, R., Nakamaru-Ogiso, E. & Sazanov, L. A., nov 2016, In: Biochimica et Biophysica Acta. 1857, 11, blz. 1777-1785 9 blz.Onderzoeksoutput: Article › peer review
38 Citaten (Scopus) -
Sortase A-mediated site-specific labeling of camelid single-domain antibody-fragments: a versatile strategy for multiple molecular imaging modalities. IF 3.307
Massa, S., Vikani, N., Betti, C., Ballet, S., Vanderhaegen, S., Steyaert, J., Descamps, B., Vanhove, C., Bunschoten, A., van Leeuwen, F. W. B., Hernot, S., Caveliers, V., Lahoutte, T., Muyldermans, S., Xavier, C. & Devoogdt, N., sep 2016, In: Contrast Media & Molecular Imaging. 11, 5, blz. 328-339Onderzoeksoutput: Article › peer review
Open AccessBestand95 Citaten (Scopus)311 Downloads (Pure) -
Structural mimicry of receptor interaction by antagonistic IL-6 antibodies
Blanchetot, C., De Jonge, N., Desmyter, A., Ongenae, N., Hofman, E., Klarenbeek, A., Sadi, A., Hultberg, A., Kretz-Rommel, A., Spinelli, S., Loris, R., Christian, C. & De Haard, H., 2016, In: J. Biol. Chem.. 291, blz. 13846-13854 9 blz.Onderzoeksoutput: Article › peer review
25 Citaten (Scopus) -
Substrate Recognition and Activity Regulation of the Escherichia coli mRNA Endonuclease MazF
Zorzini, V., Mernik, A., Sterckx, Y. G., De Jonge, N., Garcia Pino, A., De Greve, H., Versees, W. & Loris, R., 2016, In: J. Biol. Chem.. 291, blz. 10950-10956 7 blz.Onderzoeksoutput: Article › peer review
44 Citaten (Scopus) -
Thermodynamics of Nanobody Binding to Lactose Permease
Hariharan, P., Andersson, M., Jiang, X., Pardon, E., Steyaert, J., Kaback, H. R. & Guan, L., 26 okt 2016, In: Biochemistry. 55, 42, blz. 5917-5926 9 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand5 Citaten (Scopus)181 Downloads (Pure) -
The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools
Figueroa, M., Sleutel, M., Vandevenne, M., Parvizi, G., Attout, S., Jacquin, O., Vandenameele, J., Fischer, A. W., Damblon, C., Goormaghtigh, E., Valerio-Lepiniec, M., Urvoas, A., Durand, D., Pardon, E., Steyaert, J., Minard, P., Maes, D., Meiler, J., Matagne, A., Martial, J. A. & 1 anderen, , jul 2016, In: Journal of Structural Biology. 195, 1, blz. 19-30Onderzoeksoutput: Article › peer review
Open AccessBestand13 Citaten (Scopus)398 Downloads (Pure) -
2015
An efficient method for the purification of proteins from four distinct toxin–antitoxin modules
Sterckx, Y., De Gieter, S., Zorzini, V., Hadzi, S., Haesaerts, S., Loris, R. & Garcia Pino, A., 2015, In: Prot. Express. Purif.. 108, blz. 30-40 11 blz.Onderzoeksoutput: Article › peer review
15 Citaten (Scopus) -
Architecture and conformational switchmechanism of the ryanodine receptor
Efremov, R., Leitner, A., Aebersold, R. & Raunser, S., 1 jan 2015, In: Nature. 517, 7532, blz. 39-43Onderzoeksoutput: Article › peer review
256 Citaten (Scopus) -
BRET evidence that β2 adrenergic receptors do not oligomerize in cells
Lan, T-H., Liu, Q., Li, C., Wu, G., Steyaert, J. & Lambert, N. A., 2015, In: Scientific Reports - Nature. 5, 12 blz., 10166.Onderzoeksoutput: Article › peer review
Open AccessBestand44 Citaten (Scopus)140 Downloads (Pure) -
Crystallization of two operator complexes from the Vibrio cholerae higBA2 toxin-antitoxin module
Hadzi, S., Garcia Pino, A., Gerdes, K., Lah, J. & Loris, R., 2015, In: Acta Crystallogr F Struct Biol Commun. 71, blz. 226-233 8 blz.Onderzoeksoutput: Article › peer review
Open Access3 Citaten (Scopus) -
Crystal structure of the Bloom's syndrome helicase indicates a role for the HRDC domain in conformational changes
Newman, J. A., Savitsky, P., Allerston, C. K., Bizard, A. H., Özer, Ö., Sarlós, K., Liu, Y., Pardon, E., Steyaert, J., Hickson, I. D. & Gileadi, O., 26 mei 2015, In: Nucleic Acids Res. 43, blz. 5221-5235 15 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand67 Citaten (Scopus)155 Downloads (Pure) -
Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding
Zorzini, V., Buts, L., Schrank, E., Sterckx, Y., Respondek, M., Engelberg-Kulka, H., Loris, R., Zangger, K. & Van Nuland, N., 2015, In: Nucleic Acids Res. 43, blz. 1241-1256 16 blz.Onderzoeksoutput: Article › peer review
Open Access33 Citaten (Scopus) -
Propagation of conformational changes during μ-opioid receptor activation
Sounier, R., Mas, C., Steyaert, J., Laeremans, T., Manglik, A., Huang, W., Kobilka, B. K., Déméné, H. & Granier, S., 5 aug 2015, In: Nature. 524, 7565, blz. 375–378 4 blz., 14680.Onderzoeksoutput: Article › peer review
Open AccessBestand202 Citaten (Scopus)352 Downloads (Pure) -
Structural insights into µ-opioid receptor activation
Huang, W., Manglik, A., Venkatakrishnan, A. J., Laeremans, T., Feinberg, E. N., Sanborn, A. L., Kato, H. E., Livingston, K. E., Thorsen, T. S., Kling, R. C., Granier, S., Gmeiner, P., Husbands, S. M., Traynor, J. R., Weis, W. I., Steyaert, J., Dror, R. O. & Kobilka, B. K., 5 aug 2015, In: Nature. 524, 7565, blz. 315–321 7 blz., 14886.Onderzoeksoutput: Article › peer review
Open AccessBestand679 Citaten (Scopus)761 Downloads (Pure) -
Structure and flexibility of the endosomal Vps34 complex reveals the basis of its function on membranes
Rostislavleva, K., Soler, N., Ohashi, Y., Zhang, L., Pardon, E., Burke, J. E., Masson, G. R., Johnson, C., Steyaert, J., Ktistakis, N. T. & Williams, R. L., 9 okt 2015, In: Science. 350, 6257, 11 blz., aac7365.Onderzoeksoutput: Article › peer review
Open AccessBestand181 Citaten (Scopus)493 Downloads (Pure) -
Structure of a prokaryotic fumarate transporter reveals the architecture of the SLC26 family
Geertsma, E. R., Chang, Y-N., Shaik, F. R., Neldner, Y., Pardon, E., Steyaert, J. & Dutzler, R., 6 okt 2015, In: Nature Structural and Molecular Biology. 22, 10, blz. 803-808 8 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand132 Citaten (Scopus)583 Downloads (Pure) -
Transient conformers of LacY are trapped by nanobodies
Smirnova, I., Kasho, V., Jiang, X., Pardon, E., Steyaert, J. & Kaback, H. R., 10 nov 2015, In: Proceedings of the National Academy of Sciences of the United States of America. 112, 45, blz. 13839-13844 5 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand18 Citaten (Scopus)141 Downloads (Pure) -
2014
1H, 13C, and 15N backbone and side-chain chemical shift assignment of the toxin Doc in the unbound state.
De Gieter, S., Loris, R., Van Nuland, N. & Garcia Pino, A., 2014, In: Biomol. NMR Assign.. 8, blz. 145-148 4 blz.Onderzoeksoutput: Article › peer review
2 Citaten (Scopus) -
A general protocol for the generation of Nanobodies for structural Biology
Pardon, E., Laeremans, T., Triest, S., Rasmussen, S. G. F., Ruf, A., Muyldermans, S., Hol, W. G. J., Kobilka, B. K. & Steyaert, J., 27 feb 2014, In: Nature Protocols. 9, blz. 674-693 20 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand517 Citaten (Scopus)2913 Downloads (Pure) -
A nanobody modulates the p53 transcriptional program without perturbing its functional architecture
Bethuyne, J., De Gieter, S., Zwaenepoel, O., Garcia Pino, A., Durinck, K., Verhelle, A., Hassanzadeh Ghassabeh, G., Speleman, F., Loris, R. & Gettemans, J., 2014, In: Nucleic Acids Res. 42, blz. 12928-12938 11 blz.Onderzoeksoutput: Article › peer review
Open Access27 Citaten (Scopus) -
Characterization of two homologous 2 '-O-methyltransferases showing different specificities for their tRNA substrates
Somme, J., Van Laer, B., Roovers, M., Steyaert, J., Versees, W. & Droogmans, L., 1 aug 2014, In: RNA. 20, blz. 1257-1271 15 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand66 Citaten (Scopus)150 Downloads (Pure) -
Crystallisation and preliminary X-ray analysis of two variants of the Escherichia coli O157 PaaA2-ParE2 antitoxin-toxin complex
Sterckx, Y., Haesaerts, S., Van Melderen, L. & Loris, R., 2014, In: Acta Crystallogr F Struct Biol Commun. 70, blz. 1284-1291 8 blz.Onderzoeksoutput: Article › peer review
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Crystal structure of a SLC11 (NRAMP) transporter reveals the basis for transition-metal ion transport
Ehrnstorfer, I. A., Geerstma, E., Pardon, E., Steyaert, J. & Dutzler, R., 19 okt 2014, In: Nature Structural and Molecular Biology. 21, 11, blz. 990-996 7 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand155 Citaten (Scopus)355 Downloads (Pure) -
Crystal structure of the proteasomal deubiquitylation module Rpn8-Rpn11
Pathare, G., Nagy, I., Sledz, P., Anderson, D., Zhou, H-J., Pardon, E., Steyaert, J., Forster, F., Bracher, A. & Baumeister, W., 25 feb 2014, In: Proc Natl Acad Sci USA. 111, 8, blz. 2984-2989 6 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand112 Citaten (Scopus)455 Downloads (Pure) -
Inhibition of ligand exchange kinetics via active-site trapping with an antibody fragment
Oyen, D., Steyaert, J. & BARLOW, J., 1 apr 2014, In: Biochemistry. 53, 12, blz. 1879-1881 3 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand2 Citaten (Scopus)148 Downloads (Pure) -
Llama immunization with full-length VAR2CSA generates cross-reactive and inhibitory single-domain antibodies against the DBL1X domain
Nunes-Silva, S., Gangnard, S., Vidal, M., Vuchelen, A., Dechavanne, S., Chan, S., Pardon, E., Steyaert, J., Ramboarina, S., Chene, A. & Gamain, B., 9 dec 2014, In: Scientific Reports - Nature. 4, 9 blz., 7373.Onderzoeksoutput: Article › peer review
Open AccessBestand14 Citaten (Scopus)109 Downloads (Pure) -
Outward-facing conformers of LacY stabilized by nanobodies
Smirnova, I., Kasho, V., Jiang, X., Pardon, E., Steyaert, J. & Kaback, R., 30 dec 2014, In: Proc Natl Acad Sci USA. 111, blz. 18548-18553 6 blz.Onderzoeksoutput: Article › peer review
Open AccessBestand20 Citaten (Scopus)124 Downloads (Pure) -
Probing the N-terminal β-sheet conversion in the crystal structure of the human prion protein bound to a nanobody.
Abskharon, RN., Giachin, G., Wohlkonig, A., Soror, SH., Pardon, E., Legname, G. & Steyaert, J., jan 2014, In: J. Am. Chem. Soc.. 136, 136, blz. 937-944 8 blz., 3.Onderzoeksoutput: Article › peer review
Open AccessBestand92 Citaten (Scopus)420 Downloads (Pure)