A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Nissim Benvenisty; Jonathan S Draper; Paul J Gokhale; Lyn E Healy; Zoe Hewitt; Deborah Hursh; Adam Hodgson; Tenneille Ludwig; Nancy Mah; Sarah McClelland; Milena Mennecozzi; Florian T Merkle; Joanne C Mountford; Martin F Pera; Alessandro Prigione; Tristan Rodriguez; Andrea Rossi; Foad Rouhani; Kourosh Saeb-Parsy; Lucia Selfa Aspiroz; Nika Shakiba; Claudia Spits; Peter Tonge; Ivana Barbaric

doi:10.1016/j.stem.2025.03.003

A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Nissim Benvenisty, Jonathan S Draper, Paul J Gokhale, Lyn E Healy, Zoe Hewitt, Deborah Hursh, Adam Hodgson, Tenneille Ludwig, Nancy Mah, Sarah McClelland, Milena Mennecozzi, Florian T Merkle, Joanne C Mountford, Martin F Pera, Alessandro Prigione, Tristan Rodriguez, Andrea Rossi, Foad Rouhani, Kourosh Saeb-Parsy, Lucia Selfa AspirozNika Shakiba, Claudia Spits, Peter Tonge, Ivana Barbaric

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Samenvatting

Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.

Originele taal-2	English
Pagina's (van-tot)	508-512
Aantal pagina's	5
Tijdschrift	Cell Stem Cell
Volume	32
Nummer van het tijdschrift	4
DOI's	https://doi.org/10.1016/j.stem.2025.03.003
Status	Published - 3 apr. 2025

Bibliografische nota

Publisher Copyright:
© 2025 Elsevier Inc.

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10.1016/j.stem.2025.03.003

Benvenisty et al 2025Accepted author manuscript, 429 KBLicentie: CC BY

Andere bestanden en links

Link naar publicatie in Scopus

FWOAL1071: Lever en hersen organoïden als modellen voor humane pluripotente stamcel-tumorogenese
Spits, C.
1/01/23 → 31/12/26
Project: Fundamenteel
FWOAL1040: Chromosomale afwijkingen in retinaal pigment epitheel cellen afgeleid van hPSC
Spits, C.
1/01/22 → 31/12/25
Project: Fundamenteel

Citeer dit

Benvenisty, N., Draper, J. S., Gokhale, P. J., Healy, L. E., Hewitt, Z., Hursh, D., Hodgson, A., Ludwig, T., Mah, N., McClelland, S., Mennecozzi, M., Merkle, F. T., Mountford, J. C., Pera, M. F., Prigione, A., Rodriguez, T., Rossi, A., Rouhani, F., Saeb-Parsy, K., ... Barbaric, I. (2025). A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy. Cell Stem Cell, 32(4), 508-512. https://doi.org/10.1016/j.stem.2025.03.003

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title = "A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy",

abstract = "Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.",

author = "Nissim Benvenisty and Draper, {Jonathan S} and Gokhale, {Paul J} and Healy, {Lyn E} and Zoe Hewitt and Deborah Hursh and Adam Hodgson and Tenneille Ludwig and Nancy Mah and Sarah McClelland and Milena Mennecozzi and Merkle, {Florian T} and Mountford, {Joanne C} and Pera, {Martin F} and Alessandro Prigione and Tristan Rodriguez and Andrea Rossi and Foad Rouhani and Kourosh Saeb-Parsy and {Selfa Aspiroz}, Lucia and Nika Shakiba and Claudia Spits and Peter Tonge and Ivana Barbaric",

note = "Funding Information: The authors acknowledge helpful discussion held at the Genetic stability of hPSCs Workshop (May 20\u201322, 2024) funded by the UK Regenerative Medicine Platform ( MR/R015724/1 ), and at a follow-up meeting held at the ISSCR Annual Meeting in Hamburg (July 13 th 2024). Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

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day = "3",

doi = "10.1016/j.stem.2025.03.003",

language = "English",

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Benvenisty, N, Draper, JS, Gokhale, PJ, Healy, LE, Hewitt, Z, Hursh, D, Hodgson, A, Ludwig, T, Mah, N, McClelland, S, Mennecozzi, M, Merkle, FT, Mountford, JC, Pera, MF, Prigione, A, Rodriguez, T, Rossi, A, Rouhani, F, Saeb-Parsy, K, Selfa Aspiroz, L, Shakiba, N, Spits, C, Tonge, P & Barbaric, I 2025, 'A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy', Cell Stem Cell, vol. 32, nr. 4, blz. 508-512. https://doi.org/10.1016/j.stem.2025.03.003

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AU - Benvenisty, Nissim

AU - Draper, Jonathan S

AU - Gokhale, Paul J

AU - Healy, Lyn E

AU - Hewitt, Zoe

AU - Hursh, Deborah

AU - Hodgson, Adam

AU - Ludwig, Tenneille

AU - Mah, Nancy

AU - McClelland, Sarah

AU - Mennecozzi, Milena

AU - Merkle, Florian T

AU - Mountford, Joanne C

AU - Pera, Martin F

AU - Prigione, Alessandro

AU - Rodriguez, Tristan

AU - Rossi, Andrea

AU - Rouhani, Foad

AU - Saeb-Parsy, Kourosh

AU - Selfa Aspiroz, Lucia

AU - Shakiba, Nika

AU - Spits, Claudia

AU - Tonge, Peter

AU - Barbaric, Ivana

N1 - Funding Information: The authors acknowledge helpful discussion held at the Genetic stability of hPSCs Workshop (May 20\u201322, 2024) funded by the UK Regenerative Medicine Platform ( MR/R015724/1 ), and at a follow-up meeting held at the ISSCR Annual Meeting in Hamburg (July 13 th 2024). Publisher Copyright: © 2025 Elsevier Inc.

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AB - Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.

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A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Samenvatting

Bibliografische nota

Toegang tot document

Andere bestanden en links

Projecten

FWOAL1071: Lever en hersen organoïden als modellen voor humane pluripotente stamcel-tumorogenese

FWOAL1040: Chromosomale afwijkingen in retinaal pigment epitheel cellen afgeleid van hPSC

Citeer dit