A role for leptin in the systemic inflammatory response syndrome (SIRS) and in immune response, an update.

W Waelput, P Brouckaert, D Broekaert, J Tavernier

Onderzoeksoutput: Articlepeer review

25 Citaten (Scopus)

Samenvatting

Leptin was originally identified as an adipocyte-derived cytokine with a key role in the regulation of the energy balance. Subsequent research revealed that leptin's biological action is not restricted to its effects on appetite and food intake, but instead has a much more pleiotropic character. There is now ample evidence that leptin has important functions in reproduction, hematopoiesis, HPA-axis endocrinology and angiogenesis. In this review we have focused on the effects of leptin in the antigen-specific immunity and in the inflammatory effector system.
Originele taal-2English
Pagina's (van-tot)465-475
Aantal pagina's11
TijdschriftCurrent Medicinal Chemistry
Volume13
Nummer van het tijdschrift4
StatusPublished - jan 2006

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