3 Citaten (Scopus)


Preoperative chemoradiotherapy and radiotherapy with an integrated boost offer excellent local control rates in patients with rectal cancer. The introduction of intensity-modulated radiotherapy and image-guided radiotherapy has drastically improved the tolerance of these treatments. The new challenge is developing organ-preserving strategies and curative treatments for medically inoperable patients. Contact radiotherapy seems efficient for small tumors. Tumor hypoxia limits the success of radiotherapy for locally advanced cancers. Modulation of the L-arginine/iNOS pathway and implementation of hypoxia imaging in radiotherapy planning may overcome this hurdle.

Originele taal-2English
Pagina's (van-tot)393-397
Aantal pagina's5
TijdschriftExpert Review of Gastroenterology & Hepatology
Nummer van het tijdschrift4
StatusPublished - apr 2015


Duik in de onderzoeksthema's van 'Advances in radiotherapy delivery for rectal cancer: a European perspective'. Samen vormen ze een unieke vingerafdruk.

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