Advances in Ultrahigh-Pressure Liquid Chromatography Technology and System Design

Jelle De Vos; Ken Broeckhoven; Sebastiaan Eeltink

doi:10.1021/acs.analchem.5b04381

Advances in Ultrahigh-Pressure Liquid Chromatography Technology and System Design

Jelle De Vos, Ken Broeckhoven, Sebastiaan Eeltink

Onderzoeksoutput: Article › peer review

105 Citaten (Scopus)

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One decade has passed since the introduction of commercial ultra-high-pressure liquid chromatography (UHPLC) technology and columns packed with sub-2-µm particles, which led to significant improvements in separation efficiency and sample throughput. This review discusses fundamental and practical aspects of ultra-high-pressure liquid chromatography. Advances in system design addressing tubing configuration, pump and injector technology, oven configuration, and detection including MS interfacing are reviewed. In this context, practical aspects of method development are discussed and key UHPLC applications are highlighted.

Originele taal-2	English
Pagina's (van-tot)	262-278
Aantal pagina's	11
Tijdschrift	Analytical Chemistry
Volume	88
Nummer van het tijdschrift	1
DOI's	https://doi.org/10.1021/acs.analchem.5b04381
Status	Published - 5 jan 2016

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10.1021/acs.analchem.5b04381

SRP6: SRP (Zwaartepunt): exploitatie van de voordelen van de Orde in Opsluiting voor een groenere chemie
Desmet, G., Denayer, J., Denayer, J., Desmet, G. & Denayer, J.
1/11/12 → 31/10/22
Project: Fundamenteel

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KW - Mass-Spectrometric Detection

KW - Viscous Heat Dissipation

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Advances in Ultrahigh-Pressure Liquid Chromatography Technology and System Design

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SRP6: SRP (Zwaartepunt): exploitatie van de voordelen van de Orde in Opsluiting voor een groenere chemie

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