Advances in ultra‐high‐pressure and multi‐dimensional liquid chromatography instrumentation and workflows

Jelle De Vos, Dwight Stoll, Stephan Buckenmaier, Sebastiaan Eeltink, James Grinias

Onderzoeksoutput: Articlepeer review

16 Citaten (Scopus)
140 Downloads (Pure)

Samenvatting

The present contribution discusses recent advances in ultra‐high‐pressure liquid chromatography (UHPLC) and multi‐dimensional liquid chromatography (MDLC) technology. First, new developments in UHPLC column technology and system design are highlighted. The latter includes a description of a novel injector concept enabling method speed‐up, emerging detectors, and instrument diagnostics approaches. Next, online MDLC workflows are reviewed and advances in modulation technology are highlighted. Finally, key applications published in 2020 are reviewed.
Originele taal-2English
Pagina's (van-tot)171-192
Aantal pagina's22
TijdschriftAnalytical Science Advances
Volume2
Nummer van het tijdschrift3-4
Vroegere onlinedatum16 mrt 2021
DOI's
StatusPublished - 9 apr 2021

Bibliografische nota

Funding Information:
JPG acknowledges support for work in this area from the Chemical Measurement and Imaging Program in the National Science Foundation Division of Chemistry under Grant CHE‐2045023. SE acknowledges research project G033018N and support of this work by an Excellence of Science grant (30897864) of the Research Foundation Flanders and the Fonds de la Recherche Scientifique (FWO‐FRNS) is gratefully acknowledged. JDV acknowledges the FWO for support by a senior postdoctoral fellowship 12J6520N.

Funding Information:
JPG acknowledges support for work in this area from the Chemical Measurement and Imaging Program in the National Science Foundation Division of Chemistry under Grant CHE-2045023. SE acknowledges research project G033018N and support of this work by an Excellence of Science grant (30897864) of the Research Foundation Flanders and the Fonds de la Recherche Scientifique (FWO-FRNS) is gratefully acknowledged. JDV acknowledges the FWO for support by a senior postdoctoral fellowship 12J6520N.

Publisher Copyright:
© 2021 The Authors. Analytical Science Advances published by Wiley-VCH GmbH.

Copyright:
Copyright 2023 Elsevier B.V., All rights reserved.

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