An integrative skeletal paleogenomic analysis of stature variation suggests relatively reduced health for early European farmers

Stephanie Marciniak, Christina Bergey, Anna Maria Silva, Agata Haluszko, Miroslaw Furmanek, Barbara Veselka, Petr Veleminsky, Giuseppe Vercellotti, Joachim Wahl, Gunita Zarina, Cristina Longhi, Jan Kolar, Rafael Garrido-Pena, Raul Flores-Fernandez, Anna M. Herrero-Corral, Angela Simalcsik, Werner Muller, Alison Sheridan, Zydrune Miliauskiene, Rimantas JankauskasVyacheslav Moiseyev, Kitti Kohler, Agnes Kiraly, Beatriz Gamarra, Olivia Cheronet, Vajk Szeverenyi, Viktoria Kiss, Tamas Szeniczey, Krisztian Kiss, Zsuzsanna Zoffmann, Judit Koos, Magdolna Hellebrandt, Robert Maier, Laszlo Domboroczki, Cristian Virag, Mario Novak, David Reich, Tamas Hajdu, Noreen Von Cramon-Taubadel, Ron Pinhasi, George Perry

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Samenvatting

SignificanceSubsistence shifts from hunting and gathering to agriculture over the last 12,000 y have impacted human culture, biology, and health. Although past human health cannot be assessed directly, adult stature variation and skeletal indicators of nonspecific stress can serve as proxies for health during growth and development. By integrating paleogenomic genotype and osteological stature data on a per-individual basis for 167 prehistoric Europeans, we observe relatively shorter than expected statures among early farmers after correcting for individual genetic contributions to stature. Poorer nutrition and/or increased disease burdens for early agriculturalists may partly underscore this result. Our integrated osteological-genetic model has exciting potential for studies of past human health and expansion into various other contexts.

Originele taal-2English
Artikelnummere2106743119
Pagina's (van-tot)1-12
Aantal pagina's12
TijdschriftProceedings of the National Academy of Sciences of the United States of America
Volume119
Nummer van het tijdschrift15
DOI's
StatusPublished - 12 apr 2022

Bibliografische nota

Funding Information:
ACKNOWLEDGMENTS. We thank the many researchers and skeletal collections curators for their positive responses to us and their interest in this study, even when materials or data were unavailable for inclusion. Components of this work were supported by Wenner-Gren Foundation Grant 222377 (to S.M.), NIH Grant R01-GM115656 (to G.H.P.), and the Harry J. and Elissa M. Sichi Early Career Professorship in Anthropology (to G.H.P.). P.V. was supported by Ministry of Culture of the Czech Republic Grant DKRVO/2019-2023/7.I.d, National Museum, 00023272. J Kolá≤r was supported by Long-Term Development Project RV67985939 of the Institute of Botany of the Czech Academy of Sciences and Czech Science Foundation Grant 19-20970Y. B.G. was supported by Marie Skłodowska-Curie Grant H2020-MSCA-IF-2015 -703373. T.S., K.K., and T.H. were supported by a grant of Hungarian Research, Development and Innovation Office Projects FK128013 and K124326. M.N. was supported by Croatian Science Fund Grant HRZZ IP-2016-06-1450. G.H.P. thanks the DFG Center for Advanced Studies “Words, Bones, Genes, Tools” at the University of T€ubingen for support. Computations for this research were performed on the Pennsylvania State University’s Institute for Computational and Data Sciences’ supercomputing cluster. This content is solely the responsibility of the authors and does not necessarily represent the views of the Institute for Computational and Data Sciences.

Funding Information:
We thank the many researchers and skeletal collections curators for their positive responses to us and their interest in this study, even when materials or data were unavailable for inclusion. Components of this work were supported by Wenner-Gren Foundation Grant 222377 (to S.M.), NIH Grant R01-GM115656 (to G.H.P.), and the Harry J. and Elissa M. Sichi Early Career Professorship in Anthropology (to G.H.P.). P.V. was supported by Ministry of Culture of the Czech Republic Grant DKRVO/2019-2023/7.I.d, National Museum, 00023272. J Kolar was supported by Long-Term Development Project RV67985939 of the Institute of Botany of the Czech Academy of Sciences and Czech Science Foundation Grant 19-20970Y. B.G. was supported by Marie Skłodowska-Curie Grant H2020-MSCA-IF-2015 -703373. T.S., K.K., and T.H. were supported by a grant of Hungarian Research, Development and Innovation Office Projects FK128013 and K124326. M.N. was supported by Croatian Science Fund Grant HRZZ IP-2016-06-1450. G.H.P. thanks the DFG Center for Advanced Studies “Words, Bones, Genes, Tools” at the University of Tubingen for support. Computations for this research were performed on the Pennsylvania State University's Institute for Computational and Data Sciences' supercomputing cluster. This content is solely the responsibility of the authors and does not necessarily represent the views of the Institute for Computational and Data Sciences.

Publisher Copyright:
Copyright © 2022 the Author(s).

Copyright:
Copyright 2022 Elsevier B.V., All rights reserved.

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