Analysis of the recovery phase after maximal exercise in children with repaired tetralogy of Fallot and the relationship with ventricular function

Ilse Coomans, Sara De Kinder, Hannah Van Belleghem, Katya De Groote, JOSEPH PANZER, Hans De Wilde, Laura Muiño Mosquera, Katrien François, Thierry Bove, Thomas Martens, Daniel De Wolf, Jan Boone, Kristof Vandekerckhove, Elena G. Tolkacheva (Redacteur)

Onderzoeksoutput: Articlepeer review

2 Citaten (Scopus)

Samenvatting

Background Few studies demonstrate delayed recovery after exercise in children and adults with heart disease. We assess the recovery patterns of gas exchange parameters and heart rate (HR) in children with repaired Tetralogy of Fallot (rToF) compared to healthy peers and investigate the correlation with ventricular function and QRS duration. Methods 45 children after rToF and 45 controls performed a maximal incremental cardiopulmonary exercise test. In the subsequent recovery period, patterns of VO 2, VCO 2 and HR were analysed. Half-life time (T 1/2) of the exponential decay and drop per minute (Rec min) were compared between groups. In the rToF group, correlations were examined between the recovery parameters and QRS-duration and ventricular function, described by fractional shortening (FS) and tricuspid annular plane systolic excursion (TAPSE) measured at baseline prior to exercise. Results Recovery of VO 2 and VCO 2 was delayed in rToF patients, half-life time values were higher compared to controls (T 1/2VO 2 52.51 ±11.29 s vs. 44.31 ± 10.47 s; p = 0.001 and T 1/2VCO 2 68.28 ± 13.84 s vs. 59.41 ± 12.06 s; p = 0.002) and percentage drop from maximal value was slower at each minute of recovery (p<0.05). Correlations were found with FS (T 1/2VO 2: r = -0.517; p<0.001; Rec 1minVO 2: r = -0.636, p<0.001; Rec 1minVCO 2: r = -0.373, p = 0.012) and TAPSE (T 1/2VO 2: r = -0.505; p<0.001; Rec 1minVO 2: r = -0.566, p<0.001; T 1/2VCO 2: r = -0.466; p = 0.001; Rec 1minVCO 2: r = -0.507, p<0.001), not with QRS-duration. No difference was found in HR recovery between patients and controls. Conclusions Children after rToF show a delayed gas exchange recovery after exercise. This delay correlates to ventricular function, demonstrating its importance in recovery after physical activity.

Originele taal-2English
Artikelnummere0244312
Pagina's (van-tot)e0244312
Aantal pagina's13
TijdschriftPLOS ONE
Volume15
Nummer van het tijdschrift12
DOI's
StatusPublished - dec 2020

Bibliografische nota

Publisher Copyright:
© 2020 Coomans et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.

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