TY - CONF
T1 - Applicability and efficacy of non-invasive transcranial brain stimulation in anxiety disorders in dogs : an open-label trial
AU - Salden, Sofie
AU - Xu, Yangfeng
AU - Smet, Stefanie De
AU - Peremans, Kathelijne
AU - Kwik, Jenthe
AU - Dobbeleir, André
AU - Witte, Sara De
AU - Van Eeckhaut, Ann
AU - Saunders, Jimmy
AU - Haverbeke, Anouck
AU - Baeken, Chris
PY - 2024
Y1 - 2024
N2 - Non-invasive brain stimulation techniques, particularly repetitive transcranial magnetic stimulation (rTMS), hold promise as potential treatment for canine behavioural disorders. Building upon previous studies, demonstrating the feasibility of rTMS in healthy dogs (Dockx et al., 2018, 2017; Xu et al., 2023, 2022b, 2022a, Salden et al., under review), this study investigated the effcacy of accelerated high-frequency rTMS (aHF-rTMS) for treating canine anxiety disorders. An open-label clinical trial was conducted involving 20 dogs diagnosed with anxiety disorders. At baseline, patients were compared to a healthy control group using functional brain imaging and behavioural measures (Salden et al., under review). Afterwards, two aHF-rTMS sessions were administered with a one-month interval. Functional brain imaging (single-photon emission computed tomography) and monoaminergic system monitoring (via serum and CSF sampling) were performed 24 hours and 3 weeks after each TMS session to explore acute, chronic, and cumulative neurobiological effects of stimulation. After the trial, clinician assessments revealed a positive response rate, with 42% of patients showing good clinical effects, 37% exhibiting intermediate effects, and 21% showing no effects. Another measure, using a 20% reduction in C-BARQ scale score (based on Dockx et al., 2019), supported these fndings, with 59% of dogs classifed as responders. Statistical analysis will focus on the neurobiological effects of aHF-rTMS, based on brain imaging and monoaminergic metabolites, as well as identifying characteristics of responders and nonresponders. Comprehensive statistical analysis and validation of the results will be presented in detail during the conference.
AB - Non-invasive brain stimulation techniques, particularly repetitive transcranial magnetic stimulation (rTMS), hold promise as potential treatment for canine behavioural disorders. Building upon previous studies, demonstrating the feasibility of rTMS in healthy dogs (Dockx et al., 2018, 2017; Xu et al., 2023, 2022b, 2022a, Salden et al., under review), this study investigated the effcacy of accelerated high-frequency rTMS (aHF-rTMS) for treating canine anxiety disorders. An open-label clinical trial was conducted involving 20 dogs diagnosed with anxiety disorders. At baseline, patients were compared to a healthy control group using functional brain imaging and behavioural measures (Salden et al., under review). Afterwards, two aHF-rTMS sessions were administered with a one-month interval. Functional brain imaging (single-photon emission computed tomography) and monoaminergic system monitoring (via serum and CSF sampling) were performed 24 hours and 3 weeks after each TMS session to explore acute, chronic, and cumulative neurobiological effects of stimulation. After the trial, clinician assessments revealed a positive response rate, with 42% of patients showing good clinical effects, 37% exhibiting intermediate effects, and 21% showing no effects. Another measure, using a 20% reduction in C-BARQ scale score (based on Dockx et al., 2019), supported these fndings, with 59% of dogs classifed as responders. Statistical analysis will focus on the neurobiological effects of aHF-rTMS, based on brain imaging and monoaminergic metabolites, as well as identifying characteristics of responders and nonresponders. Comprehensive statistical analysis and validation of the results will be presented in detail during the conference.
UR - https://biblio.ugent.be/publication/01JCQGF6F32H48M077FCADNDHB
M3 - Unpublished abstract
ER -